F. Ruiz

发表

Discovery and Characterization of Fluorine-Substituted Diarylpyrimidines Derivatives as Novel HIV-1 NNRTIs with Highly Improved Resistance Profiles and Low Activity for the hERG Ion Channel.

Peng Zhan, Dongwei Kang, Yanying Sun, 2020, Journal of medicinal chemistry.

A missense mutation in ALDH1A3 causes isolated microphthalmia/anophthalmia in nine individuals from an inbred Muslim kindred

R. Gershoni-baruch, E. Dagan, A. Kurolap, 2013, European Journal of Human Genetics.

Substrate Specificity, Inhibitor Selectivity and Structure-Function Relationships of Aldo-Keto Reductase 1B15: A Novel Human Retinaldehyde Reductase

M. Kolář, A. Podjarny, J. Farrés, 2015, PloS one.

Structural analysis of sulindac as an inhibitor of aldose reductase and AKR1B10.

A. Mitschler, A. Podjarny, J. Farrés, 2015, Chemico-biological interactions.

Perspective on the Structural Basis for Human Aldo-Keto Reductase 1B10 Inhibition

J. Farrés, X. Parés, F. Ruiz, 2021, Metabolites.

Design, synthesis, structure-activity relationships and X-ray structural studies of novel 1-oxopyrimido[4,5-c]quinoline-2-acetic acid derivatives as selective and potent inhibitors of human aldose reductase.

D. Kletsas, H. Pratsinis, A. Mitschler, 2018, European journal of medicinal chemistry.

Biological Role of Aldo–Keto Reductases in Retinoic Acid Biosynthesis and Signaling

J. Farrés, X. Parés, F. Ruiz, 2012, Front. Pharmacol..

Aldo-keto reductases from the AKR1B subfamily: retinoid specificity and control of cellular retinoic acid levels.

R. Álvarez, C. Rovira, A. D. de Lera, 2009, Chemico-biological interactions.

Comparative functional analysis of human medium-chain dehydrogenases, short-chain dehydrogenases/reductases and aldo-keto reductases with retinoids.

Elena V Shabrova, J. Farrés, O. Gallego, 2006, The Biochemical journal.

Evolution of the SARS-CoV-2 proteome in three dimensions (3D) during the first six months of the COVID-19 pandemic

Joseph H. Lubin, Jonathan K. Williams, Bonnie L. Hall, 2020, bioRxiv.

Resolving the Dynamic Motions of SARS-CoV-2 nsp7 and nsp8 Proteins Using Structural Proteomics

E. Arnold, P. Griffin, R. Yadav, 2021, bioRxiv.

IDD388 Polyhalogenated Derivatives as Probes for an Improved Structure-Based Selectivity of AKR1B10 Inhibitors.

A. Mitschler, A. Podjarny, P. Hobza, 2016, ACS chemical biology.

Biochemical and structural insights into SARS-CoV-2 polyprotein processing by Mpro

S. Sarafianos, E. Arnold, P. Griffin, 2022, bioRxiv.

2,4,5-Trisubstituted Pyrimidines as Potent HIV-1 NNRTIs: Rational Design, Synthesis, Activity Evaluation, and Crystallographic Studies.

E. De Clercq, Dongwei Kang, C. Pannecouque, 2021, Journal of medicinal chemistry.

Eukaryotic translation-initiation factor eIF2β binds to protein kinase CK2: effects on CK2α activity

F. Miró, N. Roher, M. Plana, 2003 .

HIV-1 gp120 Antagonists Also Inhibit HIV-1 Reverse Transcriptase by Bridging the NNRTI and NRTI Sites.

A. Debnath, E. Arnold, K. Das, 2021, Journal of medicinal chemistry.

Structural basis for the inhibition of AKR1B10 by the C3 brominated TTNPB derivative UVI2008.

A. Mitschler, A. Podjarny, A. D. de Lera, 2017, Chemico-biological interactions.

Halo Library, a Tool for Rapid Identification of Ligand Binding Sites on Proteins Using Crystallographic Fragment Screening

E. Arnold, F. Ruiz, J. Bauman, 2022, bioRxiv.

2-Substituted-2-amino-6-boronohexanoic acids as arginase inhibitors.

A. Mazur, A. Mitschler, M. V. Van Zandt, 2013, Bioorganic & medicinal chemistry letters.

Discovery of (R)-2-amino-6-borono-2-(2-(piperidin-1-yl)ethyl)hexanoic acid and congeners as highly potent inhibitors of human arginases I and II for treatment of myocardial reperfusion injury.

E. Howard, A. Mitschler, M. V. Van Zandt, 2013, Journal of medicinal chemistry.

Modulation of aldose reductase inhibition by halogen bond tuning.

Martin Lepšík, Jindřich Fanfrlík, Pavel Hobza, 2013, ACS chemical biology.

Synthesis of quaternary α-amino acid-based arginase inhibitors via the Ugi reaction.

A. Mitschler, M. V. Van Zandt, A. Podjarny, 2013, Bioorganic & medicinal chemistry letters.

Structural basis of HIV inhibition by L-nucleosides: opportunities for drug development and repurposing.

E. Arnold, J. DeStefano, F. Ruiz, 2022, Drug discovery today.

Structural Basis of HIV-1 Inhibition by the Nucleotide-Competing Reverse Transcriptase Inhibitor INDOPY-1.

E. Arnold, K. Das, F. Ruiz, 2019, Journal of medicinal chemistry.

Crystal Structure of a Retroviral Polyprotein: Prototype Foamy Virus Protease-Reverse Transcriptase (PR-RT)

S. Tuske, P. Boyer, S. Hughes, 2020, Viruses.

Crystal structure of prototype foamy virus (PFV) protease-reverse transcriptase fusion (PR-RT) reveals conformational plasticity: implications for function

S. Tuske, P. Boyer, S. Hughes, 2020, bioRxiv.

Cryo-EM Structure of the Pol Polyprotein Provides Insights into HIV Maturation

E. Arnold, J. DeStefano, D. Lyumkis, 2021, bioRxiv.

Structure of the E6/E6AP/p53 complex required for HPV-mediated degradation of p53

M. Masson, J. Ramirez-Ramos, G. Travé, 2015, Nature.

Cryo-EM structure of the HIV-1 Pol polyprotein provides insights into virion maturation

E. Arnold, J. DeStefano, D. Lyumkis, 2022, Science advances.

Evolution of the SARS‐CoV‐2 proteome in three dimensions (3D) during the first 6 months of the COVID‐19 pandemic

Joseph H. Lubin, Jonathan K. Williams, Bonnie L. Hall, 2021, Proteins.

X-Ray Crystal Structure of the Full Length Human Chitotriosidase (CHIT1) Reveals Features of Its Chitin Binding Domain

Firas Fadel, A. Mitschler, A. Podjarny, 2016, PloS one.

New insights into the enzymatic mechanism of human chitotriosidase (CHIT1) catalytic domain by atomic resolution X-ray diffraction and hybrid QM/MM.

K. Harlos, Firas Fadel, R. Cachau, 2015, Acta crystallographica. Section D, Biological crystallography.

Identification of a novel polyfluorinated compound as a lead to inhibit the human enzymes aldose reductase and AKR1B10: structure determination of both ternary complexes and implications for drug design.

G. Klebe, A. Mitschler, A. Podjarny, 2014, Acta crystallographica. Section D, Biological crystallography.

Structural basis for the high all-trans-retinaldehyde reductase activity of the tumor marker AKR1B10

Angel R de Lera, Ignacio Fita, C. Rovira, 2007, Proceedings of the National Academy of Sciences.

Retinaldehyde is a substrate for human aldo-keto reductases of the 1C subfamily.

C. Rovira, J. Farrés, O. Gallego, 2011, The Biochemical journal.

Crystal packing modifies ligand binding affinity: The case of aldose reductase

Alain Van Dorsselaer, Isabelle Hazemann, Alberto Podjarny, 2012, Proteins.

X-ray structure of the V301L aldo-keto reductase 1B10 complexed with NADP(+) and the potent aldose reductase inhibitor fidarestat: implications for inhibitor binding and selectivity.

A. Mitschler, A. Podjarny, J. Farrés, 2013, Chemico-biological interactions.

Human and rodent aldo-keto reductases from the AKR1B subfamily and their specificity with retinaldehyde.

C. Rovira, J. Farrés, O. Gallego, 2011, Chemico-biological interactions.

Structural Determinants of the Selectivity of 3‐Benzyluracil‐1‐acetic Acids toward Human Enzymes Aldose Reductase and AKR1B10

G. Klebe, A. Mitschler, A. Podjarny, 2015, ChemMedChem.

Targeting HIV-1 Reverse Transcriptase Using a Fragment-Based Approach

E. Arnold, M. Gunzburg, N. Sluis-Cremer, 2023, Molecules.

Integrative structural biology studies of HIV-1 reverse transcriptase binding to a high-affinity DNA aptamer

S. Tuske, E. Arnold, K. Musier-Forsyth, 2020, Current research in structural biology.

The Effect of Halogen-to-Hydrogen Bond Substitution on Human Aldose Reductase Inhibition.

Martin Lepšík, Jindřich Fanfrlík, Pavel Hobza, 2015, ACS chemical biology.

Eukaryotic translation-initiation factor eIF2beta binds to protein kinase CK2: effects on CK2alpha activity.

F. Miró, N. Roher, M. Plana, 2003, The Biochemical journal.

New insights into the enzymatic mechanism of human chitotriosidase (CHIT1) catalytic domain by atomic resolution X-ray diffraction and hybrid QM/MM.

K. Harlos, Firas Fadel, R. Cachau, 2015, Acta crystallographica. Section D, Biological crystallography.

Discovery of diarylpyrimidine derivatives bearing piperazine sulfonyl as potent HIV-1 nonnucleoside reverse transcriptase inhibitors

E. De Clercq, Dongwei Kang, Boshi Huang, 2023, Communications chemistry.

Halo Library, a Tool for Rapid Identification of Ligand Binding Sites on Proteins Using Crystallographic Fragment Screening

E. Arnold, F. Ruiz, J. Bauman, 2023, Journal of medicinal chemistry.