Tong Zhao

发表

Discovery and Characterization of Fluorine-Substituted Diarylpyrimidines Derivatives as Novel HIV-1 NNRTIs with Highly Improved Resistance Profiles and Low Activity for the hERG Ion Channel.

Peng Zhan, Dongwei Kang, Yanying Sun, 2020, Journal of medicinal chemistry.

Discovery of piperidine-substituted thiazolo[5,4-d]pyrimidine derivatives as potent and orally bioavailable HIV-1 non-nucleoside reverse transcriptase inhibitors

E. De Clercq, Dongwei Kang, Boshi Huang, 2019, Communications Chemistry.

Discovery of Thiophene[3,2-d]pyrimidine Derivatives as Potent HIV-1 NNRTIs Targeting the Tolerant Region I of NNIBP.

E. De Clercq, Dongwei Kang, C. Pannecouque, 2017, ACS medicinal chemistry letters.

Further Exploring Solvent-Exposed Tolerant Regions of Allosteric Binding Pocket for Novel HIV-1 NNRTIs Discovery.

Dongwei Kang, Boshi Huang, C. Pannecouque, 2018, ACS medicinal chemistry letters.

Overview of Recent Strategic Advances in Medicinal Chemistry.

Peng Zhan, Yuning Song, Dongwei Kang, 2019, Journal of medicinal chemistry.

Discovery of novel indolylarylsulfones as potent HIV-1 NNRTIs via structure-guided scaffold morphing.

E. De Clercq, Dongwei Kang, C. Pannecouque, 2019, European journal of medicinal chemistry.

Discovery of Novel Bicyclic Imidazolopyridine-Containing Human Urate Transporter 1 Inhibitors as Hypouricemic Drug Candidates with Improved Efficacy and Favorable Druggability.

P. Zhan, Xinyong Liu, Jianbo Ji, 2022, Journal of medicinal chemistry.

A N-propionylsulfonamide prodrug of K-5a2 provided improved aqueous solubility and hERG inhibition

Dongwei Kang, C. Pannecouque, P. Zhan, 2020 .

Novel Human Urate Transporter 1 Inhibitors as Hypouricemic Drug Candidates with Favorable Druggability.

Dongwei Kang, P. Zhan, Xinyong Liu, 2020, Journal of medicinal chemistry.

Design, synthesis and activity evaluation of novel lesinurad analogues containing thienopyrimidinone or pyridine substructure as human urate transporter 1 inhibitors.

P. Zhan, Xinyong Liu, Jian Zhang, 2022, European journal of medicinal chemistry.

Medicinal chemistry strategies towards the development of effective SARS-CoV-2 inhibitors

Dongwei Kang, P. Zhan, Xinyong Liu, 2021, Acta Pharmaceutica Sinica B.

Novel urate transporter 1 (URAT1) inhibitors: a review of recent patent literature (2016–2019)

Dongwei Kang, P. Zhan, Xinyong Liu, 2019, Expert opinion on therapeutic patents.

Design, synthesis, and antiviral evaluation of novel hydrazone‐substituted thiophene[3,2‐d]pyrimidine derivatives as potent human immunodeficiency virus‐1 inhibitors

E. De Clercq, Dongwei Kang, C. Pannecouque, 2018, Chemical biology & drug design.

1-Hydroxypyrido[2,3-d]pyrimidin-2(1H)-ones as novel selective HIV integrase inhibitors obtained via privileged substructure-based compound libraries.

Lingzi Zhang, C. Pannecouque, P. Zhan, 2017, Bioorganic & medicinal chemistry.

Exploring the hydrophobic channel of NNIBP leads to the discovery of novel piperidine-substituted thiophene[3,2-d]pyrimidine derivatives as potent HIV-1 NNRTIs

E. De Clercq, Dongwei Kang, Boshi Huang, 2019, Acta pharmaceutica Sinica. B.

Exploiting the Tolerant Region I of the Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI) Binding Pocket: Discovery of Potent Diarylpyrimidine-Typed HIV-1 NNRTIs against Wild-Type and E138K Mutant Virus with Significantly Improved Water Solubility and Favorable Safety Profiles.

Peng Zhan, F. J. Luque, Ye Tian, 2019, Journal of medicinal chemistry.

Identification of Dihydrofuro[3,4- d]pyrimidine Derivatives as Novel HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors with Promising Antiviral Activities and Desirable Physicochemical Properties.

Peng Zhan, Jian Zhang, F. J. Luque, 2019, Journal of medicinal chemistry.

Synthesis and biological evaluation of esculetin derivatives as potential anti-HBV agents

Guangbo Ge, Tong Zhao, Z. Ye, 2023, Medicinal Chemistry Research.

Novel urate transporter 1 (URAT1) inhibitors: a review of recent patent literature (2020–present)

P. Zhan, Xinyong Liu, E. D. da Silva-Júnior, 2022, Expert opinion on therapeutic patents.

Design, synthesis and biological evaluation of macrocyclic derivatives as TRK inhibitors.

Huibin Zhang, Jinpei Zhou, Tong Zhao, 2021, Bioorganic & medicinal chemistry letters.

Design, synthesis and preliminary SAR studies of novel N-arylmethyl substituted piperidine-linked aniline derivatives as potent HIV-1 NNRTIs.

Peng Zhan, Jan Balzarini, Xuwang Chen, 2014, Bioorganic & medicinal chemistry.

Design, synthesis and biological evaluation of KRASG12C-PROTACs.

Huibin Zhang, Jinpei Zhou, Tong Zhao, 2023, Bioorganic & medicinal chemistry.