Cheng-yi Chen

发表

Practical asymmetric synthesis of Efavirenz (DMP 266), an HIV-1 reverse transcriptase inhibitor

James R. Moore, L. Tan, A. Choudhury, 1998 .

Use of Dibutyl[14C]formamide as a Formylating Reagent in the Vilsmeier–Haack Reaction and Synthesis of a 14C‐Labeled Novel Phosphodiesterase‐4 (PDE‐4) Inhibitor

D. Dean, D. Melillo, M. Braun, 2005 .

Highly enantioselective hydrogenation of aromatic-heteroaromatic ketones.

Cheng-yi Chen, R. Reamer, C. McWilliams, 2003, Organic letters.

Preparation of enamides via palladium-catalyzed amidation of enol tosylates.

R. Volante, Cheng-yi Chen, A. Klapars, 2005, Organic letters.

Synthesis of bis-macrocyclic HCV protease inhibitor MK-6325 via intramolecular sp²-sp³ Suzuki-Miyaura coupling and ring closing metathesis.

Jeremy P. Scott, L. Tan, Cheng-yi Chen, 2015, Organic letters.

Synthesis of the HCV protease inhibitor Vaniprevir (MK-7009) using ring-closing metathesis strategy.

J. Janey, Cheng-yi Chen, Hongmei Li, 2012, The Journal of organic chemistry.

Application of Ring-Closing Metathesis Strategy to the Synthesis of Vaniprevir (MK-7009), a 20-Membered Macrocyclic HCV Protease Inhibitor

Cheng-yi Chen, 2012 .

Asymmetric Formal Synthesis of the Long-Acting DPP-4 Inhibitor Omarigliptin.

L. Tan, E. Sherer, Yonggang Chen, 2017, The Journal of organic chemistry.

Asymmetric synthesis of cyclic indole aminals via 1,3-stereoinduction.

M. Reibarkh, I. Mangion, Cheng-yi Chen, 2014, The Journal of organic chemistry.

A Concise and Atom-Economical Suzuki-Miyaura Coupling Reaction Using Unactivated Trialkyl- and Triarylboranes with Aryl Halides.

Cheng-yi Chen, Hongmei Li, Y. Zhong, 2015, Organic letters.

Ligand-free palladium-catalyzed cyanation of aryl halides.

D. Zewge, Cheng-yi Chen, S. Weissman, 2005, The Journal of organic chemistry.

Practical Asymmetric Synthesis of a Chiral Piperazinone Derivative

M. McLaughlin, Cheng-yi Chen, R. Reamer, 2013 .

Asymmetric Synthesis of a Glucagon Receptor Antagonist via Friedel–Crafts Alkylation of Indole with Chiral α-Phenyl Benzyl Cation

Jeremy P. Scott, L. Tan, R. Ball, 2012 .

Enantioselective, palladium-catalyzed alpha-arylation of N-Boc-pyrrolidine.

Cheng-yi Chen, A. Klapars, P. Dormer, 2006, Journal of the American Chemical Society.

Enantioselective, Palladium-Catalyzed α-Arylation of N-Boc-pyrrolidine

Cheng-yi Chen, A. Klapars, P. Dormer, 2006 .

Stereospecific cross-coupling of secondary alkyl β-trifluoroboratoamides.

G. Molander, L. Jean‐Gérard, Cheng-yi Chen, 2010, Journal of the American Chemical Society.

Enantioselective Synthesis of (1R,2S)-1-Amino-2-vinylcyclopropanecarboxylic Acid Ethyl Ester (Vinyl-ACCA-OEt) by Asymmetric Phase-Transfer Catalyzed Cyclopropanation of (E)-N-Phenylmethyleneglycine Ethyl Ester

Cheng-yi Chen, P. Bulger, Jingjun Yin, 2010 .

Practical asymmetric synthesis of a potent PDE4 inhibitor via stereoselective enolate alkylation of a chiral aryl-heteroaryl secondary tosylate.

L. Tan, E. Grabowski, Cheng-yi Chen, 2005, The Journal of organic chemistry.

Practical enantioselective synthesis of a COX-2 specific inhibitor

L. Tan, P. Reider, E. Grabowski, 2002 .

Enantioselective Pd-catalyzed alpha-arylation of N-Boc-pyrrolidine: the key to an efficient and practical synthesis of a glucokinase activator.

D. Zewge, Cheng-yi Chen, A. Klapars, 2008, The Journal of organic chemistry.

Rizatriptan (Maxalt®): A 5‐HT1D Receptor Agonist

Cheng-yi Chen, 2010 .

Identification and structural elucidation of process impurities generated in the end-game synthesis of taranabant (MK-0364) via cyanuric chloride.

Yadan W. Chen, Cheng-yi Chen, L. Frey, 2009, Journal of pharmaceutical and biomedical analysis.

Reaction d'addition enantioselective efficace a reactif de type complexe organate-zinc

L. Tan, Cheng-yi Chen, R. Tillyer, 1998 .

A facile synthesis of N,3-disubstituted indoles and 3-hydroxyl indolines via an intramolecular SNAr of fluorinated amino alcohols

Cheng-yi Chen, R. Reamer, 2009 .

A divergent and selective synthesis of isomeric benzoxazoles from a single N-Cl imine.

Cheng-yi Chen, Hongmei Li, T. Andreani, 2011, Organic letters.

Effective synthesis of (S)-3,5-bistrifluoromethylphenyl ethanol by asymmetric enzymatic reduction

Jeffrey C. Moore, M. Truppo, D. Pollard, 2006 .

Mild and Practical Method for the α-Arylation of Nitriles with Heteroaryl Halides

M. McLaughlin, Cheng-yi Chen, John Y. L. Chung, 2005 .

Synthesis of benzo[b]furans via CuI-catalyzed ring closure.

Cheng-yi Chen, P. Dormer, 2005, The Journal of organic chemistry.

An efficient asymmetric synthesis of a potent COX-2 inhibitor L-784,512

L. Tan, P. Reider, Cheng-yi Chen, 1998 .

A practical enantioselective synthesis of odanacatib, a potent Cathepsin K inhibitor, via triflate displacement of an alpha-trifluoromethylbenzyl triflate.

F. Gosselin, G. Hughes, R. Volante, 2009, The Journal of organic chemistry.

Efficient Synthesis of Losartan, A Nonpeptide Angiotensin II Receptor Antagonist

James R. Moore, P. Reider, Y. Lo, 1994 .

New Efficient Asymmetric Synthesis of Taranabant, a CB1R Inverse Agonist for the Treatment of Obesity

D. Zewge, Yong-kui Sun, Cheng-yi Chen, 2009 .

Enantioselective hydrogenation of N-H imines.

I. Davies, F. Gosselin, Xumu Zhang, 2009, Journal of the American Chemical Society.

Palladium-catalyzed amidation of enol triflates: a new synthesis of enamides.

David J. Klauber, R. Volante, Cheng-yi Chen, 2003, Organic letters.

[1,2]-Aryl migration in the synthesis of substituted indoles: scope, mechanism, and high throughput experimentation

D. Tellers, I. Davies, Cheng-yi Chen, 2009 .

Expanding the [1,2]-aryl migration to the synthesis of substituted indoles.

I. Davies, Cheng-yi Chen, P. Dormer, 2008, Angewandte Chemie.

Improved Fischer Indole Reaction for the Preparation of N,N-Dimethyltryptamines: Synthesis of L-695,894, a Potent 5-HT1D Receptor Agonist

C. Senanayake, P. Reider, Cheng-yi Chen, 1994 .

A Novel, Highly Enantioselective Ketone Alkynylation Reaction Mediated by Chiral Zinc Aminoalkoxides.

L. Tan, P. Reider, E. Grabowski, 1999, Angewandte Chemie.

Enantioselective synthesis of an HCV NS5a antagonist.

Melodie Christensen, Ryan Cohen, Yonggang Chen, 2014, Organic letters.

A mild and efficient synthesis of 4-quinolones and quinolone heterocycles.

D. Zewge, Cheng-yi Chen, P. Dormer, 2007, The Journal of organic chemistry.

Synthesis of the 5-HT1D receptor agonist MK-0462 via a Pd-catalyzed coupling reaction

P. Reider, Cheng-yi Chen, R. Reamer, 1994 .

A practical preparation of 5-(ketoaryl)thiazoles

Cheng-yi Chen, L. Frey, J. Murry, 2002 .

A Synthesis of 1H-Indazoles via a Cu(OAc)2-Catalyzed N-N Bond Formation.

Cheng-yi Chen, Zhao-yang Wang, G. Tang, 2016, Organic letters.

Synthesis of Adagrasib (MRTX849), a Covalent KRASG12C Inhibitor Drug for the Treatment of Cancer.

M. McLaughlin, Cheng-yi Chen, T. Scattolin, 2023, Organic letters.

Nucleophilic displacement at benzhydryl centers: asymmetric synthesis of 1,1-diarylalkyl derivatives.

F. Gosselin, D. Mathre, Cheng-yi Chen, 2004, Organic letters.

A Novel, Highly Enantioselective Ketone Alkynylation Reaction Mediated by Chiral Zinc Aminoalkoxides.

L. Tan, P. Reider, E. Grabowski, 1999, Angewandte Chemie.

Efficient syntheses of 2-(3′,5′-difluorophenyl)-3-(4′-methylsulfonylphenyl)cyclopent-2-enone, a potent COX-2 inhibitor

P. Prasit, P. Reider, E. Grabowski, 1999 .

Synthesis of α-hydroxyacetophenones.

M. McLaughlin, Cheng-yi Chen, R. Reamer, 2012, The Journal of organic chemistry.

An Efficient Synthesis of Substituted Pyrazoles from One-Pot Reaction of Ketones, Aldehydes, and Hydrazine Monohydrochloride

Jie Liu, Cheng-yi Chen, Wanggui Yang, 2018, Synlett.

A simple, modular method for the synthesis of 3,4,5-trisubstituted pyrazoles.

I. Davies, M. McLaughlin, Cheng-yi Chen, 2008, The Journal of organic chemistry.

Practical synthesis of a highly functionalized thiazole ketone

L. Tan, E. Grabowski, Cheng-yi Chen, 2003 .

Synthesis of Quinazolines via an Iron-Catalyzed Oxidative Amination of N-H Ketimines.

Jinmin Wang, N. Li, Cheng-yi Chen, 2018, The Journal of organic chemistry.

Cyclopropylboronic acid: synthesis and Suzuki cross-coupling reactions

Cheng-yi Chen, D. J. Wallace, 2002 .

Unprecedented catalytic asymmetric reduction of N-H imines.

F. Gosselin, R. Volante, Cheng-yi Chen, 2005, Organic letters.

Enantioselective Syntheses of (S)-Ketamine and (S)-Norketamine.

Cheng-yi Chen, Xiaowei Lu, 2019, Organic letters.

An investigation into causes and effects of high cyanide levels in the palladium-catalyzed cyanation reaction.

Y. Liu, Yadan W. Chen, Jeff Strine, 2004, Organic letters.

An Efficient Synthesis of the Indole Acetic Acid Metabolite of MK-0462

Cheng-yi Chen, L. Street, T. Verhoeven, 1996 .

Enantioselective, Palladium-Catalyzed α-Arylation of N-Boc-pyrrolidine.

Cheng-yi Chen, A. Klapars, P. Dormer, 2006 .

Stereospecific Cross‐Coupling of Secondary Alkyl β‐Trifluoroboratoamides.

G. Molander, L. Jean‐Gérard, Cheng-yi Chen, 2011 .

A mild and efficient synthesis of 4-quinolones and quinolone heterocycles.

D. Zewge, Cheng-yi Chen, P. Dormer, 2007, The Journal of organic chemistry.

Synthesis of functionalized 3-chloro-1-naphthols via Friedel–Crafts acylation of vinyl chlorides

I. Davies, M. McLaughlin, Cheng-yi Chen, 2012 .

Developing an atroposelective dynamic kinetic resolution of MRTX1719 by resolving incompatible chemical operations.

Michal M. Achmatowicz, Cheng-yi Chen, David R. Snead, 2022, Chemical communications.

Practical Asymmetric Synthesis of a Bicyclic Pyrrolidinol

Cheng-yi Chen, T. Gharbaoui, Yuanpeng Chen, 2022, Organic Process Research & Development.

Oxazolidine Ring Opening and Isomerization to (E)-Imines. Asymmetric Synthesis of Aryl-α-fluoroalkyl Amino Alcohols.

F. Gosselin, R. Volante, Cheng-yi Chen, 2004 .

Oxazolidine ring opening and isomerization to (E)-imines. Asymmetric synthesis of aryl-alpha-fluoroalkyl amino alcohols.

F. Gosselin, R. Volante, Cheng-yi Chen, 2004, Organic letters.

Highly Efficient CarbamateFormation from Alcohols and Hindered Amino Acids or Esters Using N,N′-DisuccinimidylCarbonate (DSC)

Cheng-yi Chen, Hongmei Li, J. Padros, 2011 .

Highly Efficient Carbamate Formation from Alcohols and Hindered Amino Acids or Esters Using N,N′-Disuccinimidyl Carbonate (DSC).

Cheng-yi Chen, Hongmei Li, J. Padros, 2011 .

Practical asymmetric synthesis of a potent Cathepsin K inhibitor. Efficient palladium removal following Suzuki coupling.

P. Prasit, R. Oballa, E. Grabowski, 2003, The Journal of organic chemistry.

Diastereoselective arylithium addition to an alpha-trifluoromethyl imine. Practical synthesis of a potent cathepsin K inhibitor.

F. Gosselin, Cheng-yi Chen, A. Roy, 2006, The Journal of organic chemistry.

Catalytic, Enantioselective Synthesis of Taranabant, a Novel, Acyclic Cannabinoid-1 Receptor Inverse Agonist for the Treatment of Obesity

Alex M. Chen, Jeff Strine, Cheng-yi Chen, 2007 .

Synthesis of 2-Substituted 1,2,3-Triazoles via an Intramolecular N -N Bond Formation

M. C. Holland, Jie Liu, Wei Liu, 2020 .

Copper-Catalyzed Asymmetric Hydroamination of Styrenes with piv ZPhos as Ligand

Yuwen Wang, Cheng-yi Chen, Linglin Wu, 2020, Synthesis.

A Copper‐Catalyzed Tandem C–H ortho‐Hydroxylation and N–N Bond‐Formation Transformation: Expedited Synthesis of 1‐(ortho‐Hydroxyaryl)‐1H‐indazoles

Cheng-yi Chen, Dawei Li, Lujiang Deng, 2017 .

A cascade approach to cyclic aminonitrones: reaction discovery, mechanism, and scope.

James F Cuff, R. Ball, Cheng-yi Chen, 2009, Organic letters.

Stereocontrolled functionalization of the diene system of compactin

C. Senanayake, P. Reider, Cheng-yi Chen, 1993 .

Controlled synthesis of 2- and 3-substituted benzo[b]furans.

I. Davies, Cheng-yi Chen, T. Pei, 2010, Organic letters.

A Concise and Atom-Economical Suzuki-Miyaura Coupling Reaction Using Unactivated Trialkyl- and Triarylboranes with Aryl Halides.

Cheng-yi Chen, Hongmei Li, Y. Zhong, 2015, Organic Letters.