K. Weaver

发表

Structural basis for the resilience of efavirenz (DMP-266) to drug resistance mutations in HIV-1 reverse transcriptase.

D I Stuart, J Milton, D. Stuart, 2000, Structure.

Structural mechanisms of drug resistance for mutations at codons 181 and 188 in HIV-1 reverse transcriptase and the improved resilience of second generation non-nucleoside inhibitors.

D I Stuart, D. Stuart, D. Stammers, 2001, Journal of molecular biology.

Crystal structures of HIV-1 reverse transcriptases mutated at codons 100, 106 and 108 and mechanisms of resistance to non-nucleoside inhibitors.

P P Chamberlain, D. Stammers, C. Nichols, 2004, Journal of molecular biology.

Structural basis for the improved drug resistance profile of new generation benzophenone non-nucleoside HIV-1 reverse transcriptase inhibitors.

D. Stammers, L. Boone, Jingshan Ren, 2008, Journal of medicinal chemistry.

Relationship of potency and resilience to drug resistant mutations for GW420867X revealed by crystal structures of inhibitor complexes for wild-type, Leu100Ile, Lys101Glu, and Tyr188Cys mutant HIV-1 reverse transcriptases.

D. Stammers, C. Nichols, Jingshan Ren, 2007, Journal of medicinal chemistry.

Dolutegravir (S/GSK1349572) Exhibits Significantly Slower Dissociation than Raltegravir and Elvitegravir from Wild-Type and Integrase Inhibitor-Resistant HIV-1 Integrase-DNA Complexes

T. Seki, K. Weaver, F. Deanda, 2011, Antimicrobial Agents and Chemotherapy.

Rational design of potent non-nucleoside inhibitors of HIV-1 reverse transcriptase.

Liping Wang, R. Nolte, E. Stewart, 2012, Journal of medicinal chemistry.

Discovery of a potent boronic acid derived inhibitor of the HCV RNA-dependent RNA polymerase.

R. Hamatake, Z. Hong, Shawn P. Williams, 2014, Journal of medicinal chemistry.

Purification and Characterization of a Membrane Bound Neutral pH Optimum Magnesium-dependent and Phosphatidylserine-stimulated Sphingomyelinase from Rat Brain*

B. Liu, Y. Hannun, K. Weaver, 1998, The Journal of Biological Chemistry.

An intrinsic ATPase activity of phospho-MEK-1 uncoupled from downstream ERK phosphorylation.

R. Copeland, E. May, R. Gontarek, 2007, Archives of biochemistry and biophysics.

Characterization of Apo‐Form Selective Inhibition of Indoleamine 2,3‐Dioxygenase **

Douglas W. Thomson, Rodrigo F. Ortiz-Meoz, G. Bergamini, 2020, Chembiochem : a European journal of chemical biology.

Characterization of apo-form selective inhibition of indoleamine 2,3-dioxygenase

Douglas W. Thomson, Rodrigo F. Ortiz-Meoz, G. Bergamini, 2020, bioRxiv.

Characterization of novel inhibition of indoleamine 2,3-dioxygenase by targeting its apo form.

Douglas W. Thomson, Rodrigo F. Ortiz-Meoz, G. Bergamini, 2018 .

Novel benzophenones as non-nucleoside reverse transcriptase inhibitors of HIV-1.

L. Boone, S. Short, K. Weaver, 2004, Journal of medicinal chemistry.

Structural insights into mechanisms of non‐nucleoside drug resistance for HIV‐1 reverse transcriptases mutated at codons 101 or 138

D. Stammers, C. Nichols, Jingshan Ren, 2006, The FEBS journal.

Antiviral Activity of GW678248, a Novel Benzophenone Nonnucleoside Reverse Transcriptase Inhibitor

L. Boone, S. Short, K. Weaver, 2005, Antimicrobial Agents and Chemotherapy.

Discovery of an inhibitor of insulin-like growth factor 1 receptor activation: implications for cellular potency and selectivity over insulin receptor.

E. Alvarez, L. Shewchuk, H. Xie, 2009, Biochemical pharmacology.

Expression, preparation, and high-throughput screening of caspase-8: discovery of redox-based and steroid diacid inhibition.

Michael Cory, K. Blackburn, W. Dallas, 2002, Archives of biochemistry and biophysics.

Crystallization of protein–ligand complexes

Lisa M. Shewchuk, L. Shewchuk, W. Rocque, 2006, Acta crystallographica. Section D, Biological crystallography.

Potent inhibitors of HIV-1 integrase display a two-step, slow-binding inhibition mechanism which is absent in a drug-resistant T66I/M154I mutant.

E. Garvey, S. Lang, W. Halsey, 2009, Biochemistry.

2-Amino-6-arylsulfonylbenzonitriles as non-nucleoside reverse transcriptase inhibitors of HIV-1.

D I Stuart, R J Ott, D. Stuart, 2001, Journal of medicinal chemistry.