J. Markwalder

发表

The species-dependent metabolism of efavirenz produces a nephrotoxic glutathione conjugate in rats.

G T Miwa, R. Robertson, A. Mutlib, 2000, Toxicology and applied pharmacology.

Lipid II: total synthesis of the bacterial cell wall precursor and utilization as a substrate for glycosyltransfer and transpeptidation by penicillin binding protein (PBP) 1b of Escherichia coli.

J. Markwalder, Y. Wang, B. Schwartz, 2001, Journal of the American Chemical Society.

Synthesis and NMR conformational analysis of a β-turn mimic incorporated into gramicidin S : a general approach to evaluate β-turn peptidomimetics

A. Bach, J. Markwalder, W. Ripka, 2009 .

Identification of selective inhibitors of cyclin dependent kinase 4.

G. Trainor, S. Cox, S. P. Seitz, 2001, Bioorganic & medicinal chemistry letters.

A kinetic characterization of the glycosyltransferase activity of Eschericia coli PBP1b and development of a continuous fluorescence assay.

S. P. Seitz, R. Stein, J. Markwalder, 2002, Biochemistry.

Synthesis and evaluation of analogs of Efavirenz (SUSTIVATM) as HIV-1 reverse transcriptase inhibitors

G. Trainor, S. P. Seitz, A. Srivastava, 1999 .

Remote double stereodiffrentiation in macrocylizations of α-alkoxyallylstannanes

J. A. Marshall, J. Markwalder, 1988 .

3,3a-Dihydropyrano[4,3,2-de]quinazolin-2(1H)-ones are potent non-nucleoside reverse transcriptase inhibitors.

R. Klabe, J. Rodgers, J. Markwalder, 2001, Bioorganic & medicinal chemistry letters.

Synthesis and biological evaluation of 1-aryl-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-4-one inhibitors of cyclin-dependent kinases.

Chong-Hwan Chang, Chong-Hwan Chang, G. Trainor, 2004, Journal of medicinal chemistry.

Template-Constrained Cyclic Peptides: Design of High-Affinity Ligands for GPIIb/IIIa

W. DeGrado, S. Jackson, J. Markwalder, 1994 .

Identification and optimization of a novel series of indoleamine 2,3-dioxygenase inhibitors.

J. Hunt, S. P. Seitz, K. Covello, 2017, Bioorganic & medicinal chemistry letters.

Cyclic HIV protease inhibitors: synthesis, conformational analysis, P2/P2' structure-activity relationship, and molecular recognition of cyclic ureas.

Chong-Hwan Chang, P. Lam, P. Jadhav, 1996, Journal of medicinal chemistry.

Identification and characterization of efavirenz metabolites by liquid chromatography/mass spectrometry and high field NMR: species differences in the metabolism of efavirenz.

A. Mutlib, D. Christ, H. Chen, 1999, Drug metabolism and disposition: the biological fate of chemicals.

Understanding and modulating cyclin-dependent kinase inhibitor specificity: molecular modeling and biochemical evaluation of pyrazolopyrimidinones as CDK2/cyclin A and CDK4/cyclin D1 inhibitors

Pieter F. W. Stouten, Sarah Cox, Karen A. Rossi, 2005, J. Comput. Aided Mol. Des..

Synthesis and evaluation of indenopyrazoles as cyclin-dependent kinase inhibitors. Part 4: Heterocycles at C3.

Chong-Hwan Chang, G. Trainor, S. Cox, 2004, Bioorganic & medicinal chemistry letters.

Identification of a nonkinase target mediating cytotoxicity of novel kinase inhibitors

P. Ross-Macdonald, H. de Silva, Charles Tilford, 2008, Molecular Cancer Therapeutics.

Regulated Expression of the Escherichia coli lepB Gene as a Tool for Cellular Testing of Antimicrobial Compounds That Inhibit Signal Peptidase I In Vitro

David L. Pompliano, Jay A. Markwalder, Joseph A. DeVito, 2002, Antimicrobial Agents and Chemotherapy.

Synthesis and Biological Evaluation of Biaryl Alkyl Ethers as Inhibitors of IDO1.

Xin Li, J. Hunt, L. Jayaraman, 2023, Bioorganic & medicinal chemistry letters.

Synthesis and biological activities of potential metabolites of the non-nucleoside reverse transcriptase inhibitor efavirenz.

A. Mutlib, S. P. Seitz, R. Klabe, 2001, Bioorganic & Medicinal Chemistry Letters.

Development of a series of novel o-phenylenediamine-based indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors.

J. Hunt, David K. Williams, Weifang Shan, 2018, Bioorganic & medicinal chemistry letters.

Pyrazolo[3,4-d]pyrimidin-4-ones: Exploring the Structural Determinants of Potency and Selectivity in Cyclin-Dependent Kinase Inhibition

S. P. Seitz, J. Markwalder, 2006 .