F. De Clerck

发表

In search of a novel anti-HIV drug: multidisciplinary coordination in the discovery of 4-[[4-[[4-[(1E)-2-cyanoethenyl]-2,6-dimethylphenyl]amino]-2- pyrimidinyl]amino]benzonitrile (R278474, rilpivirine).

Stephen H Hughes, Peter Williams, Paul J Lewi, 2005, Journal of medicinal chemistry.

Detection of Proarrhythmia in the Female Rabbit Heart:

Hua-rong Lu, L. Hondeghem, F. De Clerck, 2003, Journal of cardiovascular electrophysiology.

In vivo measurement of QT prolongation, dispersion and arrhythmogenesis: application to the preclinical cardiovascular safety pharmacology of a new chemical entity

Hua-rong Lu, A. Hermans, K. van Ammel, 2002, Fundamental & clinical pharmacology.

Endogenous prostaglandin endoperoxides and prostacyclin modulate the thrombolytic activity of tissue plasminogen activator. Effects of simultaneous inhibition of thromboxane A2 synthase and blockade of thromboxane A2/prostaglandin H2 receptors in a canine model of coronary thrombosis.

M. Rosolowsky, J. Willerson, P. Golino, 1990, The Journal of clinical investigation.

Drug-Induced QTC Prolongation Dangerously Underestimates Proarrhythmic Potential: Lessons From Terfenadine

B. Dumotier, P. Hoffmann, L. Hondeghem, 2011, Journal of cardiovascular pharmacology.

Review of the predictive value of the Langendorff heart model (Screenit system) in assessing the proarrhythmic potential of drugs.

Jean-Pierre Valentin, J. Valentin, T. Hammond, 2004, Journal of pharmacological and toxicological methods.

Phase 2 prolongation, in the absence of instability and triangulation, antagonizes class III proarrhythmia.

L. Hondeghem, F. De Clerck, K. Dujardin, 2001, Cardiovascular research.

QT and JT dispersion in the drug-induced long QT syndrome in anaesthetized rabbits is accurately detected by a three-lead surface ECG measurement.

H. R. Lu, K. van Ammel, F. De Clerck, 2004, Journal of pharmacological and toxicological methods.

Maternal food restriction in the second half of pregnancy affects vascular function but not blood pressure of rat female offspring

L. Poston, F. De Clerck, K. Meurrens, 1999, British Journal of Nutrition.

In vitro effects of risperidone and 9-hydroxy-risperidone on human platelet function, plasma coagulation, and fibrinolysis.

A. Greenspan, E. Mannaert, F. De Clerck, 2004, Clinical therapeutics.

Overexpression of endothelial nitric oxide synthase suppresses features of allergic asthma in mice

I. van Ark, G. Folkerts, R. van Haperen, 2006, Respiratory research.

Effects of Serotonin on Platelets and Blood Vessels

F. De Clerck, F. de Clerck, 1991, Journal of cardiovascular pharmacology.

Platelet-mediated vascular permeability in the rat: a predominant role for 5-hydroxytryptamine.

R. Reneman, F. De Clerck, J. Beetens, 1985, Thrombosis Research.

Direct evidence for the contractile capacity of endothelial cells.

M. De Brabander, F. De Clerck, H. Neels, 1981, Thrombosis research.

Modulation of airway hyperresponsiveness by thiols in a murine in vivo model of allergic asthma

I. van Ark, G. Folkerts, N. Bloksma, 2003, Inflammation Research.

Differential responsiveness of proximal and distal parts of isolated guinea pig trachea.

G. Folkerts, N. Bloksma, F. De Clerck, 2002, European journal of pharmacology.

Fitz-Hugh-Curtis syndrome associated with tuberculous salpingitis and peritonitis: a case presentation and review of literature

F. De Clerck, L. Coremans, F. de Clerck, 2018, BMC Gastroenterology.

Ischemia/reperfusion-induced arrhythmias in anaesthetized rats: a role of Na+ and Ca2+ influx.

H. R. Lu, F. De Clerck, D. Dai, 1999, European journal of pharmacology.

Streptozotocin diabetes in the pregnant rat induces cardiovascular dysfunction in adult offspring

L. Poston, F. De Clerck, K. Meurrens, 1999, Diabetologia.

Differential effects of thromboxane A2 synthase inhibition, singly or combined with thromboxane A2/prostaglandin endoperoxide receptor antagonism, on occlusive thrombosis elicited by endothelial cell injury or by deep vascular damage in canine coronary arteries.

K. van Ammel, F. De Clerck, A. Van de Water, 1991, Circulation research.

Evidence that phospholipid turnover is the signal transducing system coupled to serotonin-S2 receptor sites.

J. Leysen, P. Janssen, F. De Clerck, 1985, Journal of Biological Chemistry.

Combined thromboxane A2 synthetase inhibition and receptor blockade are effective in preventing spontaneous and epinephrine-induced canine coronary cyclic flow variations.

M. Rosolowsky, H. Anderson, J. Willerson, 1990, Journal of the American College of Cardiology.

Selective vasoconstriction by alniditan in the carotid vascular bed of anaesthetized dogs.

K. van Ammel, F. De Clerck, A. Van de Water, 1996, European journal of pharmacology.

Glutathione and other low-molecular-weight thiols relax guinea pig trachea ex vivo: interactions with nitric oxide?

I. van Ark, G. Folkerts, N. Bloksma, 2002, American journal of physiology. Lung cellular and molecular physiology.

Betamethasone prevents virus‐induced airway inflammation but not airway hyperresponsiveness in guinea pigs

G. Folkerts, F. De Clerck, F. Nijkamp, 1999, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Synthetic inhibitors of human tissue kallikrein.

D. Evans, F. De Clerck, M. Szelke, 1996, Immunopharmacology.

Localization of calcium in red blood cells.

F. De Clerck, M. Borgers, B. Xhonneux, 1983, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

Class IV Ca2+ antagonists do not affect lipid peroxidation in singlet oxygen challenged cardiomyocytes.

M. Borgers, F. De Clerck, L. Ver Donck, 1990, Cell biology international reports.

Nonselective I(Kr)-blockers do not induce torsades de pointes in the anesthetized rabbit during alpha1-adrenoceptor stimulation.

H. R. Lu, F. De Clerck, P. Remeysen, 2000, Journal of cardiovascular pharmacology.

5-hydroxytryptamine and platelet aggregation.

A. Herman, F. De Clerck, 1983, Federation proceedings.

R 68 070: Thromboxane A2 Synthetase Inhibition and Thromboxane A2/Prostaglandin Endoperoxide Receptor Blockade Combined in One Molecule - I. Biochemical Profile In Vitro

P. Janssen, F. De Clerck, F. Clerck, 1989, Thrombosis and Haemostasis.

Preclinical cardiovascular safety evaluations of biologics: optimizing the approach and follow-up.

L. Hondeghem, F. De Clerck, 2012, BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy.

Functional expression of the amplification reaction between serotonin and epinephrine on platelets.

F. De Clerck, B. Xhonneux, D. de Chaffoy de Courcelles, 1988, Journal of cardiovascular pharmacology.

Evidence for functional 5-HT2 receptor sites on human blood platelets.

J. Leysen, P. Janssen, F. De Clerck, 1984, Biochemical pharmacology.

Enhanced platelet turnover and prostaglandin production in spontaneously hypertensive rats.

F. De Clerck, B. Xhonneux, Y. Somers, 1982, Thrombosis research.

Ketoconazole inhibits the biosynthesis of leukotrienes in vitro and in vivo.

F. De Clerck, M. Coene, Y. Somers, 1986, Biochemical pharmacology.

Inhibition of Na+/Ca2+ overload with R 56,865 protects against cardiac arrhythmias elicited by ouabain in vivo in guinea-pigs.

H. R. Lu, F. De Clerck, P. Remeysen, 1993, European journal of pharmacology.

The synergistic effect of serotonin and epinephrine on the human platelet at the level of signal transduction

F. De Clerck, H. van Belle, P. Roevens, 1987, FEBS letters.

Effect of flunarizine on the human red cell shape changes and calcium deposition induced by A 23187.

M. Borgers, F. De Clerck, F. Thoné, 1981, Thrombosis research.

The Rheological Effects of Cinnarizine and Flunarizine in Normal and Pathologic Conditions

J. de Cree, F. De Clerck, J. Crée, 1979, Angiology.

R 68 070: Thromboxane A2 Synthetase Inhibition and Thromboxane A2/Prostaglandin Endoperoxide Receptor Blockade Combined in One Molecule - II. Pharmacological Effects In Vivo and Ex Vivo

P. Janssen, E. Vercammen, F. De Clerck, 1989, Thrombosis and Haemostasis.

S2-serotonergic receptor inhibition (ketanserin), combined with thromboxane A2/prostaglandin endoperoxide receptor blockade (BM 13.177): enhanced anti-platelet effect.

F. De Clerck, 1986, Thrombosis and haemostasis.

Serotonergic receptor subtypes and vascular reactivity.

J. Leysen, P. Vanhoutte, F. De Clerck, 1984, Journal of Cardiovascular Pharmacology.

Blood hyperviscosity in spontaneously hypertensive rats.

F. De Clerck, R. Xhonneux, L. Van Gorp, 1980, Thrombosis research.

Effect of lidoflazine (R 7904) on human platelet function in vitro.

F. De Clerck, 1972, Thrombosis et diathesis haemorrhagica.

The role of endogenously formed diacylglycerol in the propagation and termination of platelet activation. A biochemical and functional analysis using the novel diacylglycerol kinase inhibitor, R 59 949.

F. De Clerck, L. Kennis, H. van Belle, 1989, The Journal of biological chemistry.

Dependence of the antagonism at human platelet 5-HT2 receptors by ketanserin on the reaction pH.

P. Janssen, F. De Clerck, J. Tollenaere, 1985, Thrombosis research.

Dual disseminated infection with Nocardia farcinica and Mucor in a patient with systemic lupus erythematosus: a case report

J. Decruyenaere, P. Cools, G. Claeys, 2014, Journal of Medical Case Reports.

A Suspicious Pancreatic Mass in Chronic Pancreatitis: Pancreatic Actinomycosis

F. De Clerck, H. Orlent, J. Van Huysse, 2015, Case reports in oncological medicine.

The Inhibition of Ischemic Lesions of the Rat Gastric Mucosa by a Novel Serotonin- Antagonist: a Light and Electron Microscopic Study

F. De Clerck, M. Borgers, F. Awouters, 1981, Angiology.

Microvascular permeability increase in rat skin: inhibition by flunarizine, a Ca2+ entry blocker.

F. De Clerck, L. Van Gorp, F. Verheyen, 1986, Blood vessels.

Protection by Flunarizine against Endothelial Cell Injury in vivo

F. De Clerck, J. Hladovec, F. de Clerck, 1981, Angiology.

Restoration of post-thrombotic peripheral collateral circulation in the cat by ketanserin, a selective 5-HT2-receptor antagonist.

F. De Clerck, A. Nevelsteen, W. Loots, 1984, Archives internationales de pharmacodynamie et de therapie.

Demonstration of S2-receptor binding sites on cat blood platelets using [3H]ketanserin.

J. Leysen, F. De Clerck, W. Gommeren, 1983, European journal of pharmacology.

Oversensitivity to serotonin of the collateralized vascular bed in rat hindquarters: mechanisms of increased vasoconstriction.

F. Lauwers, A. Verheyen, F. De Clerck, 1991, European journal of pharmacology.

The role of serotonin in thrombogenesis.

F. De Clerck, 1990, Clinical physiology and biochemistry.

Amplification mechanisms in platelet activation and arterial thrombosis.

P. Janssen, F. De Clerck, 1990, Journal of hypertension. Supplement : official journal of the International Society of Hypertension.

Effects of anti-inflammatory, anticoagulant and vasoactive compounds on tail bleeding time, whole blood coagulation time and platelet retention by glass beads in rats.

R. Reneman, F. De Clerck, J. Goossens, 1976, Thrombosis research.

Effect of lorcainide, a new antiarrhythmic compound, on the changes in heart rhythm induced by intravenous injection of adenosine-5'-diphosphate in rats.

F. De Clerck, R. Xhonneux, L. Van Gorp, 1978, Archives internationales de pharmacodynamie et de therapie.

Modification of venous stasis thrombosis in the rat by platelet-active drugs and by heparin.

R. Reneman, J. Vermylen, F. De Clerck, 1976, Archives internationales de pharmacodynamie et de therapie.

Correction by ketanserin of the platelet‐mediated inhibition of peripheral collateral circulation in the cat: Measurement of blood flow with radioactive microspheres

F. De Clerck, A. Jageneau, A. Nevelsteen, 1986 .

Successful Treatment of HCV-associated B-Cell Non-Hodgkin Lymphomas With Direct-acting Antiviral Agents.

A. Geerts, H. Van Vlierberghe, T. Boterberg, 2016, Journal of clinical gastroenterology.

Short patent lives jeopardize drug and patient safety.

J. Camm, L. Hondeghem, F. De Clerck, 2007, Journal of cardiovascular pharmacology.

A man with abdominal pain and eosinophilia : tissue is the issue.

F. De Clerck, E. Cesmeli, B. Strubbe, 2019, Acta gastro-enterologica Belgica.

Combined thromboxane A2 synthase inhibition and prostaglandin endoperoxide receptor antagonism limits myocardial infarct size after mechanical coronary occlusion and reperfusion at doses enhancing coronary thrombolysis by streptokinase.

F. Van de Werf, F. De Clerck, G. Vandeplassche, 1993, Journal of the American College of Cardiology.

The involvement of 5-HT2-receptor sites in the activation of cat platelets.

J. Leysen, P. Janssen, F. De Clerck, 1984, Thrombosis research.

The synergistic effect of 5-hydroxytryptamine and epinephrine on the human platelet is related to the activation of phospholipase C.

F. De Clerck, P. Roevens, D. de Chaffoy de Courcelles, 1993, European journal of pharmacology.

Inhibition by suprofen and other non-narcotic analgesic drugs of the effects of prostaglandin precursor on isolated tissues and platelets.

J. Hoebeke, F. De Clerck, F. Awouters, 1976, Archives internationales de pharmacodynamie et de therapie.

Synthesis and biological evaluation of imidazol-2-one and 2-cyanoiminoimidazole derivatives: novel series of PDE4 inhibitors.

A. Megens, J. M. Alonso, D. Peeters, 2002, Bioorganic & medicinal chemistry letters.

The Effect of the Intracellular Calcium Chelator Quin-2 on the Platelet Phosphoinositide Metabolism, Protein Phosphorylation and Morphology

F. De Clerck, H. van Belle, P. Roevens, 1987, Thrombosis and Haemostasis.

Thromboxane A2-induced vascular endothelial cell damage and respiratory smooth muscle cell contraction: inhibition by flunarizine, a Ca2+-overload blocker.

A. Verheyen, F. De Clerck, Y. Somers, 1985, Archives internationales de pharmacodynamie et de therapie.

Antiarrhythmic effects of nebivolol in experimental models in vivo.

H. R. Lu, F. De Clerck, P. Remeysen, 1994, Journal of cardiovascular pharmacology.

Are there sex-specific differences in ventricular repolarization or in drug-induced early afterdepolarizations in isolated rabbit purkinje fibers?

H. R. Lu, F. De Clerck, A. Saels, 2000, Journal of cardiovascular pharmacology.

Intermittent adult ileocecal intussusception: a case report and review of literature

C. Van Steenkiste, F. De Clerck, F. Muysoms, 2014, Acta clinica Belgica.

Calcium sensors as new therapeutic targets for airway hyperresponsiveness and asthma

J. Blalock, M. Villain, G. Folkerts, 2001, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Effects of pharmacological agents on erythrocyte deformability and endothelial cell injury.

F. De Clerck, 1982, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Ridogrel Inhibits Systemic and Renal Formation of Thromboxane A2 and Antagonizes Platelet Thromboxane A2/Prostaglandin Endoperoxide Receptors upon Chronic Administration to Man

E. Vercammen, F. De Clerck, F. Tegtmeier, 1992, Thrombosis and Haemostasis.

Arachidonic acid metabolites, ADP and thrombin modulate occlusive thrombus formation over extensive arterial injury in the rat.

A. Verheyen, F. De Clerck, P. Janssen, 1990, Blood Coagulation and Fibrinolysis.

Differential effects of verapamil and flunarizine on epinephrine-induced vasoconstriction and on spontaneous vasomotion of arterioles in skeletal muscle in the rat in vivo.

J. Voeten, P. Janssen, F. De Clerck, 1989, Journal of cardiovascular pharmacology.

Blood platelets in human essential hypertension.

F. De Clerck, 1986, Agents and actions.

5-Hydroxytryptamine and thromboxane A2 in ischaemic heart disease.

P. Janssen, F. De Clerck, 1990, Blood Coagulation and Fibrinolysis.

Drug-induced long QT in isolated rabbit Purkinje fibers: importance of action potential duration, triangulation and early afterdepolarizations.

Hua-rong Lu, K. van Ammel, F. De Clerck, 2002, European journal of pharmacology.

Continuous inhibition of the platelet S2-serotonergic receptors during the long term administration of ketanserin.

J. Vermylen, J. Arnout, H. Deckmyn, 1986, Thrombosis Research.

S2-SEROTONERGIC RECEPTOR INHIBITION (KETANSERIN), COMBINED WITH THROMBOXANE A2/PROSTAGLANDIN ENDOPEROXIDE RECEPTOR BLOCKADE (BM 13177) : ENHANCED ANTI-PLATELET EFFECT

F. De Clerck, B. Xhonneux, J. Beetens, 1986, Thrombosis and Haemostasis.