Z. Sweeney

发表

Design of annulated pyrazoles as inhibitors of HIV-1 reverse transcriptase.

Taraneh Mirzadegan, Klaus Klumpp, S. Tsing, 2008, Journal of medicinal chemistry.

Potent and highly selective benzimidazole inhibitors of PI3-kinase delta.

P. Savy, E. Bradley, M. Ultsch, 2012, Journal of medicinal chemistry.

Discovery of highly potent, selective, and brain-penetrable leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitors.

K. Scearce-Levie, A. Beresford, A. Medhurst, 2012, Journal of medicinal chemistry.

Prognostic Value of Fluorine-19 MRI Oximetry Monitoring in cancer

Z. Sweeney, R. Gedaly, Fanny Chapelin, 2021, Molecular Imaging and Biology.

High-Throughput Liquid Chromatography–Tandem Mass Spectrometry Quantification of Glycosaminoglycans as Biomarkers of Mucopolysaccharidosis II

K. Gunasekaran, S. Poda, G. Astarita, 2020, International journal of molecular sciences.

Promiscuity and the Conformational Rearrangement of Drug‐Like Molecules: Insight from the Protein Data Bank

Patrick S. Lee, Z. Sweeney, Patrick S Lee, 2015, ChemMedChem.

Preclinical and clinical evaluation of the LRRK2 inhibitor DNL201 for Parkinson’s disease

Nicholas E. Propson, R. Maciuca, K. Scearce-Levie, 2022, Science Translational Medicine.

Function and Physiology Lysosomal Storage Disease: Revealing Lysosomal

Sean P. Dougherty, M. Yaylaoglu, L. Honigberg, 2015 .

Discovery of highly potent, selective, and brain-penetrant aminopyrazole leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitors.

K. Scearce-Levie, A. Beresford, A. Medhurst, 2014, Journal of medicinal chemistry.

ACS chemical neuroscience spotlight on CEP-1347.

Z. Sweeney, Joseph W. Lewcock, 2011, ACS chemical neuroscience.

Discovery of a Highly Selective, Brain-Penetrant Aminopyrazole LRRK2 Inhibitor.

K. Scearce-Levie, A. Beresford, A. Medhurst, 2013, ACS medicinal chemistry letters.

Structure-based drug design of RN486, a potent and selective Bruton's tyrosine kinase (BTK) inhibitor, for the treatment of rheumatoid arthritis.

A. Kuglstatter, D. Davis, Jaehyeon Park, 2015, Journal of medicinal chemistry.

Brain delivery of therapeutic proteins using an Fc fragment blood-brain barrier transport vehicle in mice and monkeys

Adam P. Silverman, Jennifer A. Getz, T. Miyamoto, 2020, Science Translational Medicine.

Small‐Molecule Inhibitors of Store‐Operated Calcium Entry

Z. Sweeney, A. Minatti, Donald C. Button, 2009, ChemMedChem.

Dihydrogen Activation by Titanium Sulfide Complexes.

R. Bergman, R. Andersen, Z. Sweeney, 1999, Organometallics.

Potent and selective inhibitors of PI3Kδ: obtaining isoform selectivity from the affinity pocket and tryptophan shelf.

Steve Price, A. Nadin, BinQing Wei, 2013, Bioorganic & medicinal chemistry letters.

From chemical tools to clinical medicines: nonimmunosuppressive cyclophilin inhibitors derived from the cyclosporin and sanglifehrin scaffolds.

B. Wiedmann, Z. Sweeney, Jiping Fu, 2014, Journal of medicinal chemistry.

Antiviral Nucleotide Incorporation by Recombinant Human Mitochondrial RNA Polymerase Is Predictive of Increased In Vivo Mitochondrial Toxicity Risk

K. Mansfield, W. Zhong, M. Fenaux, 2016, Antimicrobial Agents and Chemotherapy.

Synthesis and biological activity of new pyridone diaryl ether non-nucleoside inhibitors of HIV-1 reverse transcriptase

N. Arora, S. Harris, Mark Smith, 2010 .

Diphenyl Ether Non‐Nucleoside Reverse Transcriptase Inhibitors with Excellent Potency Against Resistant Mutant Viruses and Promising Pharmacokinetic Properties

Y. Li, D. Stefanidis, N. Arora, 2009, ChemMedChem.

Discovery and optimization of pyridazinone non-nucleoside inhibitors of HIV-1 reverse transcriptase.

Y. Li, W. Huber, T. Mirzadegan, 2008, Bioorganic & medicinal chemistry letters.

Discovery of triazolinone non-nucleoside inhibitors of HIV reverse transcriptase.

Yu Li, Andrew Briggs, Klaus Klumpp, 2008, Bioorganic & medicinal chemistry letters.

Finding the perfect spot for fluorine: improving potency up to 40-fold during a rational fluorine scan of a Bruton's Tyrosine Kinase (BTK) inhibitor scaffold.

A. Kuglstatter, D. Davis, R. Kondru, 2015, Bioorganic & medicinal chemistry letters.

Highly enantioselective syntheses of homopropargylic alcohols and dihydrofurans catalyzed by a bis(oxazolinyl)pyridine-scandium triflate complex.

J. Tedrow, Z. Sweeney, D. Evans, 2001, Journal of the American Chemical Society.

Rearrangements and stereomutations of metallacycles derived from allenes and imidozirconium complexes.

R. Bergman, Z. Sweeney, F. Michael, 2005, Journal of the American Chemical Society.

Synthesis of chiral, enantiopure zirconocene imido complexes: highly selective kinetic resolution and stereoinversion of allenes, and evidence for a stepwise cycloaddition/retrocycloaddition reaction mechanism.

R. Bergman, R. Andersen, Z. Sweeney, 2000, Angewandte Chemie.

Synthesis, Structure, and Reactivity of Monomeric Titanocene Sulfido and Disulfide Complexes. Reaction of H2 with a Terminal MS Bond

M. Kubinec, R. Andersen, Z. Sweeney, 1997 .

Mechanisms of allene stereoinversion by imidozirconium complexes.

R. Bergman, Z. Sweeney, F. Michael, 2003, Journal of the American Chemical Society.

Small‐Molecule Inhibitors of Store‐Operated Calcium Entry

Z. Sweeney, A. Minatti, Donald C. Button, 2009, ChemMedChem.

A Flexible and Scalable High-Throughput Platform for Recombinant Membrane Protein Production.

Hui Xu, C. Koth, J. Payandeh, 2019, Methods in molecular biology.

Improving non-nucleoside reverse transcriptase inhibitors for first-line treatment of HIV infection: the development pipeline and recent clinical data.

Z. Sweeney, K. Klumpp, 2008, Current opinion in drug discovery & development.

Development of a cyclosporin A derivative with excellent anti-hepatitis C virus potency.

Li Cao, R. L. Simmons, Aregahegn Yifru, 2017, Bioorganic & medicinal chemistry.

Potent nonimmunosuppressive cyclophilin inhibitors with improved pharmaceutical properties and decreased transporter inhibition.

D. Bednarczyk, Imad Hanna, K. Leung, 2014, Journal of medicinal chemistry.

Effect of selective LRRK2 kinase inhibition on nonhuman primate lung

Paula Katavolos, Brian K. Fiske, Reina N. Fuji, 2015, Science Translational Medicine.

Discovery of novel PI3-kinase δ specific inhibitors for the treatment of rheumatoid arthritis: taming CYP3A4 time-dependent inhibition.

P. Savy, Steve Price, A. Nadin, 2012, Journal of medicinal chemistry.

Correction to: Prognostic Value of Fluorine-19 MRI Oximetry Monitoring in cancer

Z. Sweeney, R. Gedaly, Fanny Chapelin, 2021, Molecular Imaging and Biology.

Discovery of potent azaindazole leucine-rich repeat kinase 2 (LRRK2) inhibitors possessing a key intramolecular hydrogen bond - Part 2.

A. Beresford, A. Medhurst, Xingrong Liu, 2019, Bioorganic & medicinal chemistry letters.

From Human Genetics to Drug Candidates: An Industrial Perspective on LRRK2 Inhibition as a Treatment for Parkinson's Disease

Haitao Zhu, Huifen Chen, Z. Sweeney, 2013 .

Ser1292 Autophosphorylation Is an Indicator of LRRK2 Kinase Activity and Contributes to the Cellular Effects of PD Mutations

K. Scearce-Levie, M. P. van der Brug, Xingrong Liu, 2012, Science Translational Medicine.

Discovery of selective LRRK2 inhibitors guided by computational analysis and molecular modeling.

Jason Drummond, Xingrong Liu, Yichin Liu, 2012, Journal of medicinal chemistry.

Targeting of nonlipidated, aggregated apoE with antibodies inhibits amyloid accumulation

Adam P. Silverman, Jennifer A. Getz, D. Holtzman, 2018, The Journal of clinical investigation.

Brain delivery and activity of a lysosomal enzyme using a blood-brain barrier transport vehicle in mice

Adam P. Silverman, Jennifer A. Getz, Michelle L. Reyzer, 2020, Science Translational Medicine.

Chemical Biology of Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors.

Anthony A Estrada, Zachary K Sweeney, Z. Sweeney, 2015, Journal of medicinal chemistry.

Application of Virtual Screening to the Identification of New LpxC Inhibitor Chemotypes, Oxazolidinone and Isoxazoline.

W. Shu, C. Bellamacina, G. Tonn, 2018, Journal of medicinal chemistry.

Cycloaddition and Nucleophilic Substitution Reactions of the Monomeric Titanocene Sulfido Complex (η5-C5Me5)2(C5H5N)TiS

R. Bergman, R. Andersen, Z. Sweeney, 1998 .

Rab12 regulates LRRK2 activity by promoting its localization to lysosomes

M. Maloney, G. Di Paolo, D. Joy, 2023, bioRxiv.

Discovery of Potent and Selective Dual Leucine Zipper Kinase/Leucine Zipper-Bearing Kinase Inhibitors with Neuroprotective Properties in In Vitro and In Vivo Models of Amyotrophic Lateral Sclerosis.

Katrina W. Lexa, K. Scearce-Levie, T. Miyamoto, 2022, Journal of medicinal chemistry.

Identification of GNE-293, a potent and selective PI3Kδ inhibitor: navigating in vitro genotoxicity while improving potency and selectivity.

Steve Price, BinQing Wei, D. Sutherlin, 2013, Bioorganic & medicinal chemistry letters.

Design of annulated pyrazoles as inhibitors of HIV-1 reverse transcriptase.

S. Tsing, T. Mirzadegan, S. Harris, 2008, Journal of medicinal chemistry.