A. Villaseñor

发表

Design of annulated pyrazoles as inhibitors of HIV-1 reverse transcriptase.

Taraneh Mirzadegan, Klaus Klumpp, S. Tsing, 2008, Journal of medicinal chemistry.

Discovery of S-[5-amino-1-(4-fluorophenyl)-1H-pyrazol-4-yl]-[3-(2,3-dihydroxypropoxy)phenyl]methanone (RO3201195), an orally bioavailable and highly selective inhibitor of p38 MAP kinase.

D. Rotstein, C. Ramesha, M. Browner, 2006, Journal of medicinal chemistry.

2,4,6-Triaminopyrimidine as a Novel Hinge Binder in a Series of PI3Kδ Selective Inhibitors.

J. Chandrasekhar, J. R. Somoza, M. Mcgrath, 2016, Journal of medicinal chemistry.

The crystal structure of JNK2 reveals conformational flexibility in the MAP kinase insert and indicates its involvement in the regulation of catalytic activity.

A. Kuglstatter, D. Shaw, S. Tsing, 2008, Journal of molecular biology.

Discovery of N-[4-[6-tert-butyl-5-methoxy-8-(6-methoxy-2-oxo-1H-pyridin-3-yl)-3-quinolyl]phenyl]methanesulfonamide (RG7109), a potent inhibitor of the hepatitis C virus NS5B polymerase.

D. Davis, A. Railkar, Amy D. Fung, 2014, Journal of medicinal chemistry.

Rational design of highly selective spleen tyrosine kinase inhibitors.

Johannes C. Hermann, A. Kuglstatter, K. Luk, 2012, Journal of medicinal chemistry.

The characterization of idelalisib binding to PI3Kδ 1 Structural, biochemical and biophysical characterization of idelalisib binding to phosphoinositide 3-kinase delta*

J. R. Somoza, Melanie H. Wong, M. Mcgrath, 2015 .

Discovery of GS-9688 (Selgantolimod), as a Potent and Selective Oral Toll-like Receptor 8 Agonist for the Treatment of Chronic Hepatitis B.

Helen Yu, R. Mackman, T. Appleby, 2020, Journal of medicinal chemistry.

Discovery of the pan-genotypic hepatitis C virus NS3/4A protease inhibitor voxilaprevir (GS-9857): A component of Vosevi®.

T. Appleby, G. Cheng, Tetsuya Kobayashi, 2019, Bioorganic & medicinal chemistry letters.

Synthesis and biological activity of new pyridone diaryl ether non-nucleoside inhibitors of HIV-1 reverse transcriptase

N. Arora, S. Harris, Mark Smith, 2010 .

Diphenyl Ether Non‐Nucleoside Reverse Transcriptase Inhibitors with Excellent Potency Against Resistant Mutant Viruses and Promising Pharmacokinetic Properties

Y. Li, D. Stefanidis, N. Arora, 2009, ChemMedChem.

Discovery and optimization of pyridazinone non-nucleoside inhibitors of HIV-1 reverse transcriptase.

Y. Li, W. Huber, T. Mirzadegan, 2008, Bioorganic & medicinal chemistry letters.

Design and synthesis of 4-azaindoles as inhibitors of p38 MAP kinase.

Michelle Browner, Stephen D Warren, Eva Papp, 2003, Journal of medicinal chemistry.

Nanolitre-scale crystallization using acoustic liquid-transfer technology

T. Donohue, A. Kuglstatter, S. Harris, 2012, Acta crystallographica. Section D, Biological crystallography.

Insights into the conformational flexibility of Bruton's tyrosine kinase from multiple ligand complex structures

J. M. Bradshaw, April Wong, Jim W Barnett, 2011, Protein science : a publication of the Protein Society.

Rational design of 6-methylsulfonylindoles as selective cyclooxygenase-2 inhibitors.

C. Broka, C. Ramesha, M. Browner, 2004, Bioorganic & medicinal chemistry letters.

Atropisomerism by Design: Discovery of a Selective and Stable Phosphoinositide 3-Kinase (PI3K) β Inhibitor.

J. Chandrasekhar, J. R. Somoza, M. Mcgrath, 2018, Journal of medicinal chemistry.

Discovery of Orally Efficacious Phosphoinositide 3-Kinase δ Inhibitors with Improved Metabolic Stability.

J. Chandrasekhar, J. R. Somoza, M. Mcgrath, 2016, Journal of medicinal chemistry.

The structure of mammalian 15-lipoxygenase reveals similarity to the lipases and the determinants of substrate specificity

Robert Fletterick, R. Fletterick, E. Sigal, 1997, Nature Structural Biology.