A. Kashuba

发表

Preexposure prophylaxis for HIV infection among African women.

Katrien Fransen, Douglas J. Taylor, Amy Corneli, 2012, The New England journal of medicine.

High-performance liquid chromatography assay for the determination of the HIV-protease inhibitor tipranavir in human plasma in combination with nine other antiretroviral medications.

A. Kashuba, Sun-Ok Choi, N. Rezk, 2007, Journal of pharmaceutical and biomedical analysis.

Mechanisms of Drug Interactions I

A. Kashuba, J. Bertino, Joseph S. Bertino, 2005 .

HIV Persistence in Gut-Associated Lymphoid Tissues: Pharmacological Challenges and Opportunities.

A. Kashuba, Corbin G Thompson, C. Gay, 2017, AIDS research and human retroviruses.

K. Brouwer, K. Boggess, Craig R. Lee, 2021, Frontiers in Pharmacology.

Antiretroviral Pharmacology in Mucosal Tissues

Myron S. Cohen, A. Kashuba, Corbin G Thompson, 2013, Journal of acquired immune deficiency syndromes.

Lack of viral control and development of combination antiretroviral therapy escape mutations in macaques after bone marrow transplantation

Roger E Bumgarner, J. Mullins, Shiu-Lok Hu, 2015, AIDS.

Antiretroviral drug exposure in lymph nodes is heterogeneous and drug dependent

P. Luciw, J. Estes, A. Kashuba, 2022, Journal of the International AIDS Society.

Quantitative Imaging Analysis of the Spatial Relationship between Antiretrovirals, Reverse Transcriptase Simian-Human Immunodeficiency Virus RNA, and Collagen in the Mesenteric Lymph Nodes of Nonhuman Primates

P. Luciw, K. Busman-Sahay, J. Estes, 2021, Antimicrobial Agents and Chemotherapy.

CCR5 inhibitor as novel acute graft versus host disease prophylaxis in children and young adults undergoing allogeneic stem cell transplant: results of the phase II study

K. Myers, S. Davies, P. Mehta, 2020, Bone Marrow Transplantation.

Translational Approach to Predicting the Efficacy of Maraviroc-Based Regimens as HIV Preexposure Prophylaxis

J. Nelson, N. Shaheen, E. Dellon, 2019, Antimicrobial Agents and Chemotherapy.

Heterogeneous antiretroviral drug distribution and HIV/SHIV detection in the gut of three species

P. Luciw, N. Shaheen, E. Dellon, 2019, Science Translational Medicine.

A Pharmacokinetic and Pharmacodynamic Study of Maraviroc as Acute Graft-versus-Host Disease Prophylaxis in Pediatric Allogeneic Stem Cell Transplant Recipients with Nonmalignant Diagnoses.

A. Vinks, Kana Mizuno, S. Davies, 2016, Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.

Title Effects of Combined CCR 5 / Integrase Inhibitors-Based Regimen on Mucosal Immunity in HIV-Infected Patients Naïve to Antiretroviral Therapy : A Pilot Randomized Trial

Christopher J. Miller, A. Somasunderam, E. Sinclair, 2016 .

Single and multiple dose pharmacokinetics of maraviroc in saliva, semen, and rectal tissue of healthy HIV-negative men.

Myron S. Cohen, N. Shaheen, M. Spacek, 2011, The Journal of infectious diseases.

Drug Interactions with New and Investigational Antiretrovirals

A. Kashuba, Kevin C. Brown, Sunita Paul, 2009, Clinical pharmacokinetics.

Penetration of Tenofovir and Emtricitabine in Mucosal Tissues: Implications for Prevention of HIV-1 Transmission

Myron S. Cohen, N. Shaheen, J. Rooney, 2011, Science Translational Medicine.

A Phenotype–Genotype Approach to Predicting CYP450 and P‐Glycoprotein Drug Interactions With the Mixed Inhibitor/Inducer Tipranavir/Ritonavir

M. Wagner, T. Macgregor, M. Vourvahis, 2010, Clinical pharmacology and therapeutics.

Variability in drug metabolizing enzyme activity in HIV-infected patients

A. Gaedigk, A. Kashuba, D. Hein, 2010, European Journal of Clinical Pharmacology.

Mapping Antiretroviral Drugs in Tissue by IR-MALDESI MSI Coupled to the Q Exactive and Comparison with LC-MS/MS SRM Assay

D. Muddiman, A. Kashuba, Corbin G Thompson, 2014, Journal of The American Society for Mass Spectrometry.

Mechanisms of Pharmacokinetic and Pharmacodynamic Drug Interactions Associated with Ritonavir‐Enhanced Tipranavir

M. Vourvahis, A. Kashuba, 2007, Pharmacotherapy.

Marginal Effects of Systemic CCR5 Blockade with Maraviroc on Oral Simian Immunodeficiency Virus Transmission to Infant Macaques

B. Keele, C. Apetrei, I. Pandrea, 2018, Journal of Virology.

Marginal Effects of Systemic CCR5 Blockade with Maraviroc on Oral Simian Immunodeficiency Virus Transmission to Infant Macaques

B. Keele, C. Apetrei, I. Pandrea, 2018, Journal of Virology.

Simultaneous determination of six HIV nucleoside analogue reverse transcriptase inhibitors and nevirapine by liquid chromatography with ultraviolet absorbance detection.

R. Tidwell, A. Kashuba, N. Rezk, 2003, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Prevention of SIV Rectal Transmission and Priming of T Cell Responses in Macaques after Local Pre-exposure Application of Tenofovir Gel

J. Heeney, C. Herrera, R. Shattock, 2008, PLoS medicine.

Darunavir for use in pregnant women with HIV

R. Pope, A. Kashuba, 2017, Expert review of clinical pharmacology.

Population Pharmacokinetics of Intravenous Acyclovir in Preterm and Term Infants

P. Smith, M. Sampson, D. Benjamin, 2013, The Pediatric infectious disease journal.

Pharmacokinetic Modeling of Lamivudine and Zidovudine Triphosphates Predicts Differential Pharmacokinetics in Seminal Mononuclear Cells and Peripheral Blood Mononuclear Cells

Myron S. Cohen, S. Fiscus, A. Kashuba, 2015, Antimicrobial Agents and Chemotherapy.

Population Pharmacokinetics of Piperacillin Using Scavenged Samples From Preterm Infants

M. Walsh, N. Newman, D. Ouellet, 2012, Therapeutic drug monitoring.

Population Pharmacokinetics of Metronidazole Evaluated Using Scavenged Samples from Preterm Infants

M. Walsh, N. Newman, P. Smith, 2012, Antimicrobial Agents and Chemotherapy.

Combining fosamprenavir with lopinavir/ritonavir substantially reduces amprenavir and lopinavir exposure: ACTG protocol A5143 results

J. Mellors, A. Collier, E. Acosta, 2005, AIDS.

Pharmacology of Drug Resistance

A. Kashuba, E. R. Andrews, 2017 .

Limited Sampling Strategy to Predict AUC of the CYP3A Phenotyping Probe Midazolam in Adults: Application to Various Assay Techniques

D. Greenblatt, E. Choo, G. Wilkinson, 2002, Journal of clinical pharmacology.

Single Plasma Concentrations of 1′‐Hydroxymidazolam or the Ratio of 1′‐Hydroxymidazolam: Midazolam Do Not Predict Midazolam Clearance in Healthy Subjects

E. Choo, G. Wilkinson, A. Kashuba, 2002, Journal of clinical pharmacology.

Poor correlation between 6beta-hydroxycortisol:cortisol molar ratios and midazolam clearance as measure of hepatic CYP3A activity.

S. Gotzkowsky, A. Kashuba, Ya-Chi Chen, 2006, British journal of clinical pharmacology.

The Influence of CYP3A5 Genotype on Dexamethasone Induction of CYP3A Activity in African Americans

P. Roberts, E. Schuetz, E. E. Williams, 2008, Drug Metabolism and Disposition.

Title: The Influence of CYP3A5 Genotype on Dexamethasone Induction of CYP3A Activity in

P. Roberts, E. Schuetz, E. E. Williams, 2008 .

Coadministration of Lopinavir/Ritonavir and Phenytoin Results in Two-Way Drug Interaction Through Cytochrome P-450 Induction

A. Gaedigk, R. Bertz, J. Eron, 2004, Journal of acquired immune deficiency syndromes.

Effects of fluvastatin and cigarette smoking on CYP2C9 activity measured using the probe S-warfarin

A. Gaedigk, J. Kirchheiner, A. Kashuba, 2006, European Journal of Clinical Pharmacology.

Effect of a Triphasic Oral Contraceptive on Drug‐Metabolizing Enzyme Activity as Measured by the Validated Cooperstown 5+1 Cocktail

E. Sellers, G. Kearns, A. Gaedigk, 2005, Journal of clinical pharmacology.

Limited Sampling Strategy of S‐Warfarin Concentrations, but Not Warfarin S/R Ratios, Accurately Predicts S‐Warfarin AUC during Baseline and Inhibition in CYP2C9 Extensive Metabolizers

A. Gaedigk, A. Kashuba, A. Nafziger, 2004, Journal of clinical pharmacology.

Combined phenotypic assessment of cytochrome P450 1A2, 2C9, 2C19, 2D6, and 3A, N‐acetyltransferase‐2, and xanthine oxidase activities with the “Cooperstown 5+1 cocktail”

E. Sellers, G. Kearns, A. Gaedigk, 2003, Clinical pharmacology and therapeutics.

HIV prevention by oral preexposure prophylaxis.

W. Heneine, A. Kashuba, 2012, Cold Spring Harbor perspectives in medicine.

Effect of Low-Dose Ritonavir on the Pharmacokinetics of the CXCR4 Antagonist AMD070 in Healthy Volunteers

J. Park, C. Flexner, C. Hendrix, 2008, Antimicrobial Agents and Chemotherapy.

Drug concentrations after topical and oral antiretroviral pre-exposure prophylaxis: implications for HIV prevention in women

Q. A. Karim, S. Karim, L. Werner, 2011, The Lancet.

AIDS diarrhea and antiretroviral drug concentrations: a matched-pair cohort study in Port au Prince, Haiti.

R. Guerrant, J. Pape, R. Dillingham, 2011, The American journal of tropical medicine and hygiene.

A Multi-Compartment Single and Multiple Dose Pharmacokinetic Comparison of Rectally Applied Tenofovir 1% Gel and Oral Tenofovir Disoproxil Fumarate

C. Hendrix, N. Richardson-Harman, C. Mauck, 2014, PloS one.

Antiretroviral concentrations and surrogate measures of efficacy in the brain tissue and CSF of preclinical species

P. Luciw, J. Garcia, A. Kashuba, 2018, Xenobiotica; the fate of foreign compounds in biological systems.

Food insecurity is associated with lower levels of antiretroviral drug concentrations in hair among a cohort of women living with HIV in the United States.

Mardge H. Cohen, A. Adimora, L. Metsch, 2019, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Smartphone-Based Contingency Management Intervention to Improve Pre-Exposure Prophylaxis Adherence: Pilot Trial

F. J. McClernon, John T. Mitchell, A. Kashuba, 2018, JMIR mHealth and uHealth.

Accuracy of Self-Report and Pill-Count Measures of Adherence in the FEM-PrEP Clinical Trial: Implications for Future HIV-Prevention Trials

Douglas J. Taylor, L. van Damme, K. Agot, 2014, AIDS and Behavior.

Differences in Local and Systemic TFV PK Among Premenopausal Versus Postmenopausal Women Exposed to TFV 1% Vaginal Gel

G. Doncel, A. Thurman, J. Schwartz, 2018, Journal of acquired immune deficiency syndromes.

Patient and clinician perspectives on optimizing graphical displays of longitudinal medication adherence data.

C. Golin, M. Gandhi, Jessica Carda-Auten, 2019, Patient education and counseling.

The Lymph Node Reservoir: Physiology, HIV Infection, and Antiretroviral Therapy

A. Kashuba, Erin M. B. Scholz, 2021, Clinical pharmacology and therapeutics.

Virological and Immunological Responses to Raltegravir and Dolutegravir in the Gut-Associated Lymphoid Tissue of HIV-Infected Men and Women

J. Nelson, N. Shaheen, E. Dellon, 2018, Antiviral therapy.

Plasma Bile Acid Concentrations in Patients with Human Immunodeficiency Virus Infection Receiving Protease Inhibitor Therapy: Possible Implications for Hepatotoxicity

K. Brouwer, A. Kashuba, H. Tien, 2010, Pharmacotherapy.

Ritonavir, Saquinavir, and Efavirenz, but Not Nevirapine, Inhibit Bile Acid Transport in Human and Rat Hepatocytes

K. Brouwer, R. Kim, B. Leake, 2006, Journal of Pharmacology and Experimental Therapeutics.

Single and Multiple Dose Pharmacokinetics of Dolutegravir in the Genital Tract of HIV-Negative Women

A. Kashuba, C. Sykes, K. Patterson, 2013, Antiviral therapy.

Non-initiation of hepatitis C virus antiviral therapy in patients with human immunodeficiency virus/hepatitis C virus co-infection.

A. Adimora, D. Wohl, L. Mao, 2016, World journal of hepatology.

Analysis of Antiretrovirals in Single Hair Strands for Evaluation of Drug Adherence with Infrared-Matrix-Assisted Laser Desorption Electrospray Ionization Mass Spectrometry Imaging.

D. Muddiman, A. Kashuba, C. Sykes, 2016, Analytical chemistry.

Mass Spectroscopy Imaging of Hair Strands Captures Short-Term and Long-Term Changes in Emtricitabine Adherence

A. Kashuba, L. Hightow-Weidman, Joseph N. Mwangi, 2022, Antimicrobial agents and chemotherapy.

Seminal Tenofovir Concentrations, Viral Suppression, and Semen Quality With Tenofovir Alafenamide Compared with Tenofovir Disoproxil Fumarate (Spanish HIV/AIDS Research Network, PreEC/RIS 40).

D. Podzamczer, J. Niubó, A. Kashuba, 2018, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Saquinavir Loaded Acetalated Dextran Microconfetti – a Long Acting Protease Inhibitor Injectable

K. Ainslie, A. Kashuba, E. Bachelder, 2016, Pharmaceutical Research.

Clinical Pharmacokinetic, Pharmacodynamic and Drug-Interaction Profile of the Integrase Inhibitor Dolutegravir

A. Kashuba, Mackenzie L Cottrell, T. Hadzic, 2013, Clinical Pharmacokinetics.

Raltegravir Pharmacokinetics in Treatment-Naive Patients Is Not Influenced by Race: Results from the Raltegravir Early Therapy in African-Americans Living with HIV (REAL) Study

M. Hudgens, J. Eron, D. Wohl, 2012, Antimicrobial Agents and Chemotherapy.

Modest but Variable Effect of Rifampin on Steady-State Plasma Pharmacokinetics of Efavirenz in Healthy African-American and Caucasian Volunteers

D. Greenblatt, K. Tashima, A. Kashuba, 2011, Antimicrobial Agents and Chemotherapy.

Combined Oral Contraceptives and Antiretroviral PK/PD in Malawian Women: Pharmacokinetics and Pharmacodynamics of a Combined Oral Contraceptive and a Generic Combined Formulation Antiretroviral in Malawi

Myron S. Cohen, G. Stuart, M. Hosseinipour, 2011, Journal of acquired immune deficiency syndromes.

Interindividual Variability in Pharmacokinetics of Generic Nucleoside Reverse Transcriptase Inhibitors in TB/HIV‐Coinfected Ghanaian Patients: UGT2B7*1c Is Associated With Faster Zidovudine Clearance and Glucuronidation

E. Kenu, A. Kashuba, A. Kwara, 2009, Journal of clinical pharmacology.

Effect of omeprazole on the plasma concentrations of indinavir when administered alone and in combination with ritonavir.

A. Kashuba, H. Tien, N. Rezk, 2008, American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists.

The warfarin–cranberry juice interaction revisited: A systematic in vitro–in vivo evaluation

E. Dees, N. Oberlies, D. Kroll, 2010, Journal of experimental pharmacology.

Lopinavir/Ritonavir Induces the Hepatic Activity of Cytochrome P450 Enzymes CYP2C9, CYP2C19, and CYP1A2 But Inhibits the Hepatic and Intestinal Activity of CYP3A as Measured by a Phenotyping Drug Cocktail in Healthy Volunteers

V. Gaver, J. Eron, A. Kashuba, 2006, Journal of acquired immune deficiency syndromes.

Quantitation of three‐month intraindividual variability and influence of sex and menstrual cycle phase on CYP1A2, N‐acetyltransferase‐2, and xanthine oxidase activity determined with caffeine phenotyping

G. Kearns, J. Leeder, A. Kashuba, 1998, Clinical pharmacology and therapeutics.

Cisapride: A potential model substrate to assess cytochrome P4503A4 activity in vivo

E. Schuetz, G. Kearns, J. Leeder, 2003, Clinical pharmacology and therapeutics.

Topical microbicides and HIV prevention in the female genital tract

A. Kashuba, Mackenzie L Cottrell, A. Kashuba, 2014, Journal of clinical pharmacology.

The ex vivo pharmacology of HIV-1 antiretrovirals differs between macaques and humans

Clare F. McCoy, P. Ziprin, C. Herrera, 2022, iScience.

Pharmacokinetics and pharmacodynamics in HIV prevention; current status and future directions: a summary of the DAIDS and BMGF sponsored think tank on pharmacokinetics (PK)/pharmacodynamics (PD) in HIV prevention.

J. Cummins, A. Kashuba, J. Turpin, 2013, AIDS research and human retroviruses.

Co-localized confocal Raman spectroscopy and optical coherence tomography (CRS-OCT) for depth-resolved analyte detection in tissue.

Adam Wax, Jason R. Maher, Matthew T Rinehart, 2015, Biomedical optics express.

Development of an LC-MS method for measuring TNF in human vaginal tissue.

A. Kashuba, N. Rezk, S. O. Choi, 2010, Journal of chromatographic science.

Optimizing Therapy for Patients With Multidrug-Resistant HIV Review and Updates to the 2005 ICAAC Satellite

S. Walmsley, C. Hicks, A. Kashuba, 2006 .

Predicting Efavirenz Concentrations in the Brain Tissue of HIV‐Infected Individuals and Exploring their Relationship to Neurocognitive Impairment

R. Swanstrom, R. Price, P. Luciw, 2019, Clinical and translational science.

IR-MALDESI Mass Spectrometry Imaging of Human Hair to Characterize Longitudinal Profiles of the Antiretroviral Maraviroc for Adherence Monitoring.

A. Kashuba, E. Rosen, William M. Gilliland, 2019, Analytical chemistry.

Predicting HIV Pre-exposure Prophylaxis Efficacy for Women using a Preclinical Pharmacokinetic-Pharmacodynamic In Vivo Model

M. Hudgens, J. Garcia, P. Ho, 2017, Scientific Reports.

Dose Frequency Ranging Pharmacokinetic Study of Tenofovir-Emtricitabine After Directly Observed Dosing in Healthy Volunteers to Establish Adherence Benchmarks (HPTN 066).

K. Mayer, E. Fuchs, C. Hendrix, 2016, AIDS research and human retroviruses.

Cervicovaginal and Rectal Fluid as a Surrogate Marker of Antiretroviral Tissue Concentration: Implications for Clinical Trial Design

M. Hudgens, N. Shaheen, E. Dellon, 2016, Journal of acquired immune deficiency syndromes.

Immunologic, Virologic, and Pharmacologic Characterization of the Female Upper Genital Tract in HIV-Infected Women

S. Young, Myron S. Cohen, J. Nelson, 2015, Journal of acquired immune deficiency syndromes.

Pharmacokinetics of antiretrovirals in mucosal tissue

A. Kashuba, Mackenzie L Cottrell, N. Srinivas, 2015, Expert opinion on drug metabolism & toxicology.

Randomized Pharmacokinetic Crossover Study Comparing 2 Curcumin Preparations in Plasma and Rectal Tissue of Healthy Human Volunteers

R. Sandler, Ying Xie, M. Sanghvi, 2017, Journal of clinical pharmacology.

Correction: Effects of Combined CCR5/Integrase Inhibitors-Based Regimen on Mucosal Immunity in HIV-Infected Patients Naïve to Antiretroviral Therapy: A Pilot Randomized Trial

Christopher J. Miller, A. Somasunderam, E. Sinclair, 2017, PLoS pathogens.

Suppression of Human Immunodeficiency Virus Type 1 (HIV-1) Viremia with Reverse Transcriptase and Integrase Inhibitors, CD4+ T-Cell Recovery, and Viral Rebound upon Interruption of Therapy in a New Model for HIV Treatment in the Humanized Rag2−/−γc−/− Mouse

R. Swanstrom, D. Margolis, William L. Ince, 2009, Journal of Virology.

Post-exposure Prophylaxis and Antiretroviral Pharmacokinetics In the Genital Tract

A. Kashuba, M. Roland, J. Dumond, 2007 .

The Influence of Sex, Ethnicity, and CYP2B6 Genotype on Bupropion Metabolism as an Index of Hepatic CYP2B6 Activity in Humans

E. Schuetz, P. Stewart, C. Lindley, 2013, Drug Metabolism And Disposition.

Pharmacokinetics and Pharmacodynamics of Anti-infective Agents

A. Kashuba, J. Bertino, M. Pai, 2014 .

Measurement of antiretroviral drugs in the lungs of HIV-infected patients.

H. Twigg, R. Collman, F. Valentine, 2010, HIV therapy.

Effect of Hormonal Contraception on Pharmacokinetics of Vaginal Tenofovir in Healthy Women: Increased Tenofovir Diphosphate in Injectable Depot Medroxyprogesterone Acetate Users

G. Doncel, D. Weiner, C. Mauck, 2019, Journal of acquired immune deficiency syndromes.

Addition of 7 Days of Zidovudine Plus Lamivudine to Peripartum Single-Dose Nevirapine Effectively Reduces Nevirapine Resistance Postpartum in HIV-Infected Mothers in Malawi

J. Nelson, S. Farr, J. Wiener, 2010, Journal of acquired immune deficiency syndromes.

High-performance liquid chromatography assay for the quantification of HIV protease inhibitors and non-nucleoside reverse transcriptase inhibitors in human plasma.

R. Tidwell, A. Kashuba, N. Rezk, 2004, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Can antiretroviral therapy be used to prevent sexual transmission of human immunodeficiency virus type 1?

P. Vernazza, Myron S. Cohen, M. Hosseinipour, 2002, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Injectable long‐acting human immunodeficiency virus antiretroviral prodrugs with improved pharmacokinetic profiles

Jason R. Pirone, Erica N Pino, K. Ainslie, 2018, International journal of pharmaceutics.

Unreported antiretroviral use by HIV-1-infected participants enrolling in a prospective research study.

J. Baeten, S. Delany-Moretlwe, A. Wald, 2014, Journal of acquired immune deficiency syndromes.

Antiretroviral treatment of HIV-1 prevents transmission of HIV-1: where do we go from here?

Timothy B Hallett, T. Hallett, Myron S. Cohen, 2013, The Lancet.

Brief Report: Blood and Genital Fluid Viral Load Trajectories Among Treated and Untreated Persons With Acute HIV Infection in Malawi

W. Miller, I. Hoffman, Myron S. Cohen, 2022, Journal of acquired immune deficiency syndromes.

Poor Correlation Between 24 hr Urinary 6β‐Hydroxy Cortisol: Cortisol Molar Ratios (CMR) and Plasma Midazolam Clearance (MDZ CL) as Measures of Hepatic CYP3A Activity

A. Kashuba, A. Nafziger, M. Rocci, 1999 .

Comparison of Various Urine Collection Intervals for Caffeine and Dextromethorphan Phenotyping in Children

J. Leeder, S. Abdel‐Rahman, A. Kashuba, 2004, Journal of clinical pharmacology.

Correction: Effects of Combined CCR5/Integrase Inhibitors-Based Regimen on Mucosal Immunity in HIV-Infected Patients Naïve to Antiretroviral Therapy: A Pilot Randomized Trial

Christopher J. Miller, T. Chun, A. Somasunderam, 2016, PLoS pathogens.

Randomized pharmacokinetic cross-over study comparing two curcumin preparations in plasma and rectal tissue of healthy human volunteers

R. Sandler, Ying Xie, M. Sanghvi, 2016 .

P. Watkins, K. Brouwer, K. Boggess, 2020, Journal of pharmaceutical sciences.

Domestic Cat Model for Predicting Human Nucleoside Analogue Pharmacokinetics in Blood and Seminal Plasma

Myron S. Cohen, A. Kashuba, Arlene S Pereira, 2001, Antimicrobial Agents and Chemotherapy.

Absence of Sustained Hyperlactatemia in HIV-Infected Patients With Risk Factors for Mitochondrial Toxicity

S. Evans, G. McComsey, S. Koletar, 2004, Journal of acquired immune deficiency syndromes.

Antiretroviral drug exposure in the female genital tract: implications for oral pre- and post-exposure prophylaxis

Myron S. Cohen, P. Stewart, B. Jung, 2007, AIDS.

Feasibility, Acceptability, and Preliminary Efficacy of a Gamified Mobile Health Contingency Management Intervention for PrEP Adherence Among Black MSM

F. J. McClernon, John T. Mitchell, A. Kashuba, 2022, AIDS and Behavior.

Biological Correlates of Sexual Transmission of HIV Practical Consequences and Potential Targets for Public Health

P. Vernazza, M. Cohen, A. Kashuba, 2002, Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz.

Association between Use of Methadone, Other Central Nervous System Depressants, and QTc Interval–Prolonging Medications and Risk of Mortality in a Large Cohort of Women Living with or at Risk for Human Immunodeficiency Virus Infection

R. Greenblatt, S. Gange, P. Bacchetti, 2019, Pharmacotherapy.

S-Warfarin Limited Sampling Models to Estimate Area Under the Concentration Versus Time Curve for Cytochrome P450 2C9 Baseline Activity and After Induction

L. Lewis, A. Kashuba, Joseph D. Ma, 2016, Therapeutic drug monitoring.

Differential Extracellular and Intracellular Concentrations of Zidovudine and Lamivudine in Semen and Plasma of HIV-1-Infected Men

Myron S. Cohen, S. Fiscus, A. Kashuba, 2008, Journal of acquired immune deficiency syndromes.

Nucleoside analogues achieve high concentrations in seminal plasma: relationship between drug concentration and virus burden.

J. Hall, J. Eron, S. Fiscus, 1999, The Journal of infectious diseases.

The Pharmacokinetics of Silymarin Is Altered in Patients with Hepatitis C Virus and Nonalcoholic Fatty Liver Disease and Correlates with Plasma Caspase-3/7 Activity

S. J. Schrieber, M. Fried, M. Vourvahis, 2008, Drug Metabolism and Disposition.

Darunavir, Ritonavir, and Etravirine Pharmacokinetics in the Cervicovaginal Fluid and Blood Plasma of HIV-Infected Women

J. Mrus, A. Kashuba, K. Patterson, 2010, Antimicrobial Agents and Chemotherapy.

Ending the evidence gap for pregnancy, HIV and co‐infections: ethics guidance from the PHASES project

B. Chi, L. Myer, L. Mofenson, 2021, Journal of the International AIDS Society.

FEM-PrEP: Adherence Patterns and Factors Associated With Adherence to a Daily Oral Study Product for Pre-exposure Prophylaxis

L. van Damme, S. Kapiga, K. Agot, 2014, Journal of acquired immune deficiency syndromes.

Studies on Antiretroviral Drug Concentrations in Breast Milk: Validation of a Liquid Chromatography-Tandem Mass Spectrometric Method for the Determination of 7 Anti-Human Immunodeficiency Virus Medications

S. Moselhy, A. Kashuba, N. Rezk, 2008, Therapeutic drug monitoring.

Development of a Highly Efficient Extraction Technique and Specific Multiplex Assay for Measuring Antiretroviral Drug Concentrations in Breast Milk

A. Kashuba, N. Rezk, M. Abdel-megeed, 2007, Therapeutic drug monitoring.

Hormonal Contraceptives Differentially Suppress TFV and TAF Inhibition of HIV Infection and TFV-DP in Blood and Genital Tract CD4+ T cells

A. Kashuba, C. Wira, M. Rodriguez-Garcia, 2017, Scientific Reports.

HIV PrEP Trials: The Road to Success.

M. Nicol, A. Kashuba, J. Adams, 2013, Clinical investigation.

Formulation, pharmacokinetics and pharmacodynamics of topical microbicides.

A. Kashuba, J. Adams, 2012, Best practice & research. Clinical obstetrics & gynaecology.

Plasma and breast milk pharmacokinetics of tenofovir alafenamide in mothers with chronic hepatitis B infection

E. Gane, A. Kashuba, M. Levy, 2022, Alimentary pharmacology & therapeutics.

Decreased tenofovir diphosphate concentrations in a transgender female cohort: Implications for HIV pre-exposure prophylaxis (PrEP).

T. Chun, E. Dellon, A. Peery, 2019, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Differential Extracellular, but Similar Intracellular, Disposition of two Tenofovir Formulations in the Male Genital Tract

Myron S. Cohen, J. Nelson, A. Kashuba, 2019, Antiviral therapy.

Simultaneous determination of 17 antiretroviral drugs in human plasma for quantitative analysis with liquid chromatography-tandem mass spectrometry.

B. Jung, A. Kashuba, N. Rezk, 2007, Biomedical chromatography : BMC.

Cytokine Regulation of P-Glycoprotein

K. Brouwer, A. Kashuba, M. McRae, 2003, Drug metabolism reviews.

Activities of Cytochrome P450 1A2, N‐acetyltransferase 2, Xanthine oxidase, and Cytochrome P450 2D6 are Unaltered in Children with Cystic Fibrosis

G. Kearns, A. Gaedigk, A. Kashuba, 2004, Clinical pharmacology and therapeutics.

Simultaneous quantification of emtricitabine and tenofovir in human plasma using high-performance liquid chromatography after solid phase extraction.

A. Kashuba, N. Rezk, R. Crutchley, 2005, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

The Pharmacokinetics and Viral Activity of Tenofovir in the Male Genital Tract

Myron S. Cohen, B. Kearney, J. Rooney, 2008, Journal of acquired immune deficiency syndromes.

Identification of a Cranberry Juice Product that Inhibits Enteric CYP3A-Mediated First-Pass Metabolism in Humans

E. Dees, N. Oberlies, M. Paine, 2009, Drug Metabolism and Disposition.

Fosamprenavir. Vertex Pharmaceuticals/GlaxoSmithKline.

A. Kashuba, A. Corbett, 2002, Current opinion in investigational drugs.

Contemporary Drug–Drug Interactions in HIV Treatment

A. Kashuba, E. Burgunder, M. Cottrell, 2019, Clinical pharmacology and therapeutics.

Sex Hormones Regulate Tenofovir-Diphosphate in Female Reproductive Tract Cells in Culture

A. Kashuba, J. Fahey, C. Wira, 2014, PloS one.

Pre-exposure prophylaxis for HIV prevention: how to predict success

Myron S. Cohen, A. Kashuba, K. Patterson, 2012, The Lancet.

Narrative Review: Antiretroviral Therapy to Prevent the Sexual Transmission of HIV-1

S. Blower, Myron S. Cohen, A. Kashuba, 2007, Annals of Internal Medicine.

A simple and sensitive bioanalytical assay for simultaneous determination of omeprazole and its three major metabolites in human blood plasma using RP-HPLC after a simple liquid-liquid extraction procedure.

A. Kashuba, N. Rezk, Kevin C. Brown, 2006, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Roundtable report: importance of antiretroviral drug concentrations in sanctuary sites and viral reservoirs.

V. Miller, J. Gerber, A. Kashuba, 2003, AIDS research and human retroviruses.

Antiretroviral-Drug Concentrations in Semen: Implications for Sexual Transmission of Human Immunodeficiency Virus Type 1

Myron S. Cohen, J. Eron, A. Kashuba, 2000, Antimicrobial Agents and Chemotherapy.

Plasma and Intracellular Concentrations in HIV-Infected Patients Requiring Hemodialysis Dosed With Tenofovir Disoproxil Fumarate and Emtricitabine.

Samir K. Gupta, J. Slaven, B. Decker, 2016, Journal of acquired immune deficiency syndromes.

Mechanisms of Drug Interactions I: Absorption, Metabolism, and Excretion

A. Kashuba, Angela D. M. Kashuba, Kevin C. Brown, 2011 .

Optimizing Aminoglycoside Therapy for Nosocomial Pneumonia Caused by Gram-Negative Bacteria

G. Drusano, A. Kashuba, A. Nafziger, 1999, Antimicrobial Agents and Chemotherapy.

Absence of Effect of Terbinafine on the Activity of CYP1A2, NAT‐2, and Xanthine Oxidase

G. Kearns, A. Kashuba, A. Nafziger, 1998, Journal of clinical pharmacology.

Antiretroviral Therapy for Prevention of HIV Infection: New Clues From an Animal Model

Myron S. Cohen, A. Kashuba, M. Cohen, 2008, PLoS medicine.

Effects of Combined CCR5/Integrase Inhibitors-Based Regimen on Mucosal Immunity in HIV-Infected Patients Naïve to Antiretroviral Therapy: A Pilot Randomized Trial

A. Somasunderam, E. Sinclair, D. Asmuth, 2016, PLoS pathogens.

Bronchopulmonary Pharmacokinetics of Clarithromycin and Azithromycin

A. Kashuba, G. Amsden, 1998, Antimicrobial Agents and Chemotherapy.

Antiretroviral-Drug Concentrations in Semen: Implications for Sexual Transmission of Human Immunodeficiency Virus Type 1

J. Eron, J. Eron, A. Kashuba, 1999, Antimicrobial Agents and Chemotherapy.

Virus Type 1 Transmission of Human Immunodeficiency Semen : Implications for Sexual Antiretroviral-Drug Concentrations in

J. Eron, A. Kashuba, J. Dyer, 1999 .

A mechanism‐based pharmacokinetic model of remdesivir leveraging interspecies scaling to simulate COVID‐19 treatment in humans

T. Sheahan, A. Kabanov, A. Hickey, 2020, CPT: pharmacometrics & systems pharmacology.

Evaluation of the genetic component of variability in CYP3A4 activity: a repeated drug administration method.

A. Paterson, L. Endrenyi, B. Tang, 2000, Pharmacogenetics.

Antiretroviral Pharmacokinetics in Mothers and Breastfeeding Infants from 6 to 24 Weeks Post-Partum: Results of the Ban Study

M. Hudgens, F. Martinson, J. Nelson, 2014, Antiviral therapy.

Genital Tract, Cord Blood, and Amniotic Fluid Exposures of Seven Antiretroviral Drugs during and after Pregnancy in Human Immunodeficiency Virus Type 1-Infected Women

S. Fiscus, A. Horton, M. Vourvahis, 2009, Antimicrobial Agents and Chemotherapy.

A Translational Pharmacology Approach to Predicting Outcomes of Preexposure Prophylaxis Against HIV in Men and Women Using Tenofovir Disoproxil Fumarate With or Without Emtricitabine.

M. Hudgens, J. Nelson, N. Shaheen, 2016, The Journal of infectious diseases.

Long-Acting Rilpivirine (RPV) Preexposure Prophylaxis Does Not Inhibit Vaginal Transmission of RPV-Resistant HIV-1 or Select for High-Frequency Drug Resistance in Humanized Mice

B. Keele, K. Shutt, P. Pennings, 2020, Journal of Virology.

Updated guideline to perform therapeutic drug monitoring for antiretroviral agents.

J. Schapiro, C. Flexner, T. Blaschke, 2006 .

Validation of an LC–MS/MS assay to simultaneously monitor the intracellular active metabolites of tenofovir, emtricitabine, and lamivudine in dried blood spots

A. Kashuba, C. Sykes, Heather M. A. Prince, 2018, Journal of pharmaceutical and biomedical analysis.

A Multi-Compartment, Single and Multiple Dose Pharmacokinetic Study of the Vaginal Candidate Microbicide 1% Tenofovir Gel

J. Schwartz, B. Kearney, A. Poindexter, 2011, PloS one.

Simian Immunodeficiency Virus Persistence in Cellular and Anatomic Reservoirs in Antiretroviral Therapy-Suppressed Infant Rhesus Macaques

R. Schinazi, G. Silvestri, M. Paiardini, 2018, Journal of Virology.

Simple and rapid quantification of the non-nucleoside reverse transcriptase inhibitors nevirapine, delavirdine, and efavirenz in human blood plasma using high-performance liquid chromatography with ultraviolet absorbance detection.

R. Tidwell, A. Kashuba, N. Rezk, 2002, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Pharmacokinetics of generic and trade formulations of lamivudine, stavudine and nevirapine in HIV-infected Malawian children

P. Kazembe, M. Hosseinipour, A. Kashuba, 2010, Antiviral therapy.

Pharmacokinetic comparison of generic and trade formulations of lamivudine, stavudine and nevirapine in HIV-infected Malawian adults

M. Hosseinipour, A. Kashuba, C. M. van der Horst, 2007, AIDS.

Validation of an LC-MS/MS Assay for the Simultaneous Determination of Bictegravir, Doravirine, and Raltegravir in Human Plasma

A. Kashuba, C. Sykes, M. Cottrell, 2020, bioRxiv.

The Pharmacokinetics, Safety, and Initial Virologic Response of a Triple–Protease Inhibitor Salvage Regimen Containing Amprenavir, Saquinavir, and Ritonavir

J. Eron, S. Fiscus, A. Kashuba, 2004, Journal of acquired immune deficiency syndromes.

RMP-02/MTN-006: A phase 1 rectal safety, acceptability, pharmacokinetic, and pharmacodynamic study of tenofovir 1% gel compared with oral tenofovir disoproxil fumarate.

A. Carballo-Diéguez, W. Cumberland, C. Hendrix, 2012, AIDS research and human retroviruses.

Mucosal tissue pharmacokinetics of the integrase inhibitor raltegravir in a humanized mouse model: Implications for HIV pre-exposure prophylaxis.

A. Kashuba, R. Akkina, C. Sykes, 2016, Virology.

Brief Report: Significant Decreases in Both Total and Unbound Lopinavir and Amprenavir Exposures During Coadministration: ACTG Protocol A5143/A5147s Results.

A. Collier, J. Rigdon, F. Aweeka, 2015, Journal of acquired immune deficiency syndromes.

Significant Decreases in both Total and Unbound Lopinavir and Amprenavir Exposures during Co-administration: ACTG Protocol A5143/A5147s Results

A. Collier, J. Rigdon, F. Aweeka, 2015 .

Antiretroviral drug concentrations and HIV RNA in the genital tract of HIV-infected women receiving long-term highly active antiretroviral therapy.

J. Hogan, A. Caliendo, S. Cu-Uvin, 2008, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Effects of the H2-receptor antagonist famotidine on the pharmacokinetics of atazanavir-ritonavir with or without tenofovir in HIV-infected patients.

P. Tebas, M. Boffito, R. Bertz, 2011, AIDS patient care and STDs.

Biodegradable Polymeric Solid Implants for Ultra-Long-Acting Delivery of Single or Multiple Antiretroviral Drugs.

S. Montgomery, Panita Maturavongsadit, A. Kashuba, 2021, International journal of pharmaceutics.

Ultra-long-acting tunable biodegradable and removable controlled release implants for drug delivery

Paul A Dayton, Russell J Mumper, Anush Sridharan, 2019, Nature Communications.

Drug resistance and plasma viral RNA level after ineffective use of oral pre-exposure prophylaxis in women

Douglas J. Taylor, L. van Damme, R. Grant, 2015, AIDS.

Rilpivirine Plasma and Cervicovaginal Concentrations in Women During Pregnancy and Postpartum

E. Capparelli, A. Kashuba, M. Mirochnick, 2018, Journal of acquired immune deficiency syndromes.

Full Validation of an Analytical Method for the HIV-Protease Inhibitor Atazanavir in Combination With 8 Other Antiretroviral Agents and its Applicability to Therapeutic Drug Monitoring

A. Kashuba, N. Rezk, R. Crutchley, 2006, Therapeutic drug monitoring.

Protease Inhibitor and Nonnucleoside Reverse Transcriptase Inhibitor Concentrations in the Genital Tract of HIV-1-Infected Women

S. Cu-Uvin, L. Petch, S. Fiscus, 2004, Journal of acquired immune deficiency syndromes.

Pharmacokinetic and pharmacodynamic investigation of efavirenz in the semen and blood of human immunodeficiency virus type 1-infected men.

J. Eron, J. Eron, S. Gotzkowsky, 2002, The Journal of infectious diseases.

Low Frequency of Drug-Resistant Variants Selected by Long-Acting Rilpivirine in Macaques Infected with Simian Immunodeficiency Virus Containing HIV-1 Reverse Transcriptase

J. Mellors, Z. Ambrose, C. Kline, 2015, Antimicrobial Agents and Chemotherapy.

HIV pre-exposure prophylaxis: mucosal tissue drug distribution of RT inhibitor Tenofovir and entry inhibitor Maraviroc in a humanized mouse model.

A. Kashuba, R. Akkina, C. Sykes, 2014, Virology.

Maraviroc Concentrates in the Cervicovaginal Fluid and Vaginal Tissue of HIV-Negative Women

B. Damle, A. Kashuba, R. Tressler, 2009, Journal of acquired immune deficiency syndromes.

Tenofovir Diphosphate and Emtricitabine Triphosphate Concentrations in Blood Cells Compared With Isolated Peripheral Blood Mononuclear Cells: A New Measure of Antiretroviral Adherence?

L. van Damme, K. Fransen, P. Menezes, 2013, Journal of acquired immune deficiency syndromes.

Antiretroviral Penetration and Drug Transporter Concentrations in the Spleens of Three Preclinical Animal Models and Humans

Jason R. Pirone, P. Luciw, J. Garcia, 2020, Antimicrobial Agents and Chemotherapy.

Antiretroviral Drug Concentrations in Lymph Nodes: A Cross-Species Comparison of the Effect of Drug Transporter Expression, Viral Infection, and Sex in Humanized Mice, Nonhuman Primates, and Humans

P. Luciw, J. Garcia, A. Kashuba, 2019, The Journal of Pharmacology and Experimental Therapeutics.

Saquinavir Loaded Acetalated Dextran Microconfetti – a Long Acting Protease Inhibitor Injectable

K. Ainslie, A. Kashuba, E. Bachelder, 2016, Pharmaceutical Research.

Dynamics of the decay of HIV RNA and distribution of bictegravir in the genital tract and rectum in antiretroviral-naïve HIV-1-infected adults treated with bictegravir/emtricitabine/tenofovir alafenamide (Spanish HIV/AIDS Research Network, PreEC/RIS 58).

D. Podzamczer, J. Martinez-Picado, E. Negredo, 2020, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Pharmacokinetic Modelling of Efavirenz, Atazanavir, Lamivudine and Tenofovir in the Female Genital Tract of HIV-Infected Pre-Menopausal Women

M. Nicol, A. Kashuba, A. Forrest, 2012, Clinical Pharmacokinetics.

Pharmacology of HIV integrase inhibitors

A. Kashuba, J. Adams, Benjamin N. Greener, 2012, Current opinion in HIV and AIDS.

Physiological Changes During the Menstrual Cycle and Their Effects on the Pharmacokinetics and Pharmacodynamics of Drugs

A. Kashuba, A. Nafziger, Angela D. M. Kashuba, 1998, Clinical pharmacokinetics.

Bottlenecks in HIV-1 transmission: insights from the study of founder viruses

R. Swanstrom, A. Kashuba, S. Joseph, 2015, Nature Reviews Microbiology.

Dolutegravir Pharmacokinetics in the Genital Tract and Colorectum of HIV-Negative Men After Single and Multiple Dosing

N. Shaheen, E. Dellon, R. Madanick, 2013, Journal of acquired immune deficiency syndromes.

HIV-1-RNA Decay and Dolutegravir Concentrations in Semen of Patients Starting a First Antiretroviral Regimen.

D. Podzamczer, J. Martinez-Picado, J. Niubó, 2016, The Journal of infectious diseases.

Pharmacokinetics of Antiretrovirals in Genital Secretions and Anatomic Sites of HIV Transmission: Implications for HIV Prevention

A. Kashuba, C. Trezza, 2014, Clinical Pharmacokinetics.

Differential penetration of raltegravir throughout gastrointestinal tissue: implications for eradication and cure

N. Shaheen, E. Dellon, R. Madanick, 2013, AIDS.

Single- and Multiple-Dose Pharmacokinetics of Darunavir Plus Ritonavir and Etravirine in Semen and Rectal Tissue of HIV-Negative Men

N. Shaheen, M. Spacek, A. Kashuba, 2012, Journal of acquired immune deficiency syndromes.

The differential short- and long-term effects of HIV-1 latency-reversing agents on T cell function

M. Hudgens, D. Margolis, N. Archin, 2016, Scientific Reports.

A spatio-temporal assessment of simian/human immunodeficiency virus (SHIV) evolution reveals a highly dynamic process within the host

D. Petrov, B. Keele, Shiu-Lok Hu, 2017, PLoS pathogens.

An In-Depth Comparison of Latent HIV-1 Reactivation in Multiple Cell Model Systems and Resting CD4+ T Cells from Aviremic Patients

Eric Verdin, Celsa A. Spina, Alberto Bosque, 2013, PLoS pathogens.

Evaluating nurses' implementation of an infant-feeding counseling protocol for HIV-infected mothers: The Ban Study in Lilongwe, Malawi.

Rodney J. Knight, M. Hudgens, M. Sandelowski, 2009, AIDS education and prevention : official publication of the International Society for AIDS Education.

The role of menopause in tenofovir diphosphate and emtricitabine triphosphate concentrations in cervical tissue

M. Nicol, A. Kashuba, C. Sykes, 2018, AIDS.

Pharmacokinetics and Immunological Effects of Romidepsin in Rhesus Macaques

C. Apetrei, I. Pandrea, A. Kashuba, 2020, Frontiers in Immunology.

Pharmacotherapy of human immunodeficiency virus infection

A. Kashuba, J. Adams, Julie B. Dumond, 2013 .

Application of a Scavenger Receptor A1 Targeted Polymeric Prodrug Platform for Lymphatic Drug Delivery in HIV.

Nimit L. Patel, M. Dobrovolskaia, Timothy M. Potter, 2020, Molecular pharmaceutics.

Proof-of-Principle for Immune Control of Global HIV-1 Reactivation In Vivo

Alan S. Perelson, Paul R. Grant, Deenan Pillay, 2015, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Targeted Cytotoxic Therapy Kills Persisting HIV Infected Cells During ART

M. Hudgens, I. Pastan, A. Haase, 2014, PLoS pathogens.

CYP2B6 variants and plasma efavirenz concentrations during antiretroviral therapy in Port-au-Prince, Haiti.

D. Haas, J. Pape, R. Dillingham, 2009, The Journal of infectious diseases.

Leveraging a Previously Published Population Pharmacokinetic Model to Predict Rivaroxaban Exposure in Real‐World Patients

J. Powell, J. H. Patterson, D. Weiner, 2022, Journal of clinical pharmacology.

Rivaroxaban Precision Dosing Strategy for Real‐World Atrial Fibrillation Patients

P. Watkins, J. Powell, D. Weiner, 2020, Clinical and translational science.

Ultra-long-acting removable drug delivery system for HIV treatment and prevention

R. Mumper, J. Garcia, K. Mollan, 2018, Nature Communications.

Genital inflammation undermines the effectiveness of tenofovir gel in preventing HIV acquisition in women

N. Nagelkerke, L. McKinnon, S. A. Abdool Karim, 2018, Nature Medicine.

Precision Dosing: Public Health Need, Proposed Framework, and Anticipated Impact

T. Wiltshire, K. Brouwer, J. Powell, 2017, Clinical and translational science.

Disparate effects of Cytotoxic Chemotherapy on the Antiviral Activity of Antiretroviral Therapy: Implications for Treatments of HIV-Infected Cancer Patients

E. Sausville, A. Heredia, N. Le, 2019, Antiviral therapy.

Protein Binding of Lopinavir and Ritonavir During 4 Phases of Pregnancy: Implications for Treatment Guidelines

M. Hudgens, A. Kashuba, A. Jenkins, 2013, Journal of acquired immune deficiency syndromes.

Maternal-Fetal Pharmacokinetics and Dynamics of a Single Intrapartum Dose of Maraviroc in Rhesus Macaques

M. Winters, M. Holodniy, K. V. Van Rompay, 2010, Antimicrobial Agents and Chemotherapy.

High resolution spatio-temporal assessment of simian/human immunodeficiency virus (SHIV) evolution reveals a highly dynamic process within the host

D. Petrov, B. Keele, Shiu-Lok Hu, 2017, bioRxiv.

HIV-1 RNA Detected in the CNS after Years of Suppressive Antiretroviral Therapy Can Originate from a Replicating CNS Reservoir or Clonally Expanded Cells.

R. Swanstrom, R. Price, N. Archin, 2018, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Clinical Pharmacokinetics and Pharmacodynamics of Drugs in the Central Nervous System

A. Kashuba, N. Srinivas, Kaitlyn A. Maffuid, 2018, Clinical Pharmacokinetics.

Intracellular islatravir pharmacology differs between species in an in vitro model: implications for preclinical study design.

A. van der Straten, A. Kashuba, C. Sykes, 2022, The Journal of antimicrobial chemotherapy.

Interval dosing with the HDAC inhibitor vorinostat effectively reverses HIV latency

Nancie M Archin, D. Margolis, N. Archin, 2017, The Journal of clinical investigation.

Antiretroviral Therapy Concentrations Differ in Gut vs. Lymph Node Tissues and Are Associated With HIV Viral Transcription by a Novel RT-ddPCR Assay.

H. Hatano, S. Deeks, T. Liegler, 2020, Journal of acquired immune deficiency syndromes.

A cross-species comparison of antiretroviral penetration into lymph nodes using novel physiologically based pharmacokinetic models.

Yanguang Cao, A. Kashuba, Erin M. B. Scholz, 2021, The Journal of antimicrobial chemotherapy.

Effect of fluvoxamine therapy on the activities of CYP1A2, CYP2D6, and CYP3A as determined by phenotyping

G. Kearns, J. Leeder, A. Kashuba, 1998, Clinical pharmacology and therapeutics.

Antiviral agents and HIV prevention: controversies, conflicts, and consensus.

K. Muessig, A. Kashuba, M. Smith, 2012, AIDS.

HIV-1 treatment as prevention: the good, the bad, and the challenges

A. Kashuba, K. Powers, Kumi M Smith, 2011, Current opinion in HIV and AIDS.

HIV pre-exposure prophylaxis trials: the road to success

M. Nicol, A. Kashuba, J. Adams, 2013 .

Challenges and Solutions for Future Pharmacy Practice in the Era of Precision Medicine

Rachel M Howard, T. Wiltshire, F. Innocenti, 2017, American Journal of Pharmaceutical Education.

Measuring Adherence by Visual Inspection of Returned Empty Gel Applicators in the CAPRISA 004 Microbicide Trial

S. Karim, L. Mansoor, T. Gengiah, 2014, AIDS and Behavior.

Development of a Composite Measure of Product Adherence, Protocol Compliance, and Semen Exposure Using DNA and Protein Biomarkers for Topical HIV Prevention Studies

G. Doncel, A. Thurman, D. Archer, 2014, PloS one.

Correlation between Compartmental Tenofovir Concentrations and an Ex Vivo Rectal Biopsy Model of Tissue Infectibility in the RMP-02/MTN-006 Phase 1 Study

Ross D. Cranston, C. Hendrix, N. Richardson-Harman, 2014, PloS one.

Quantitative Analysis of Microbicide Concentrations in Fluids, Gels and Tissues Using Confocal Raman Spectroscopy

D. Katz, A. Kashuba, C. Sykes, 2013, PloS one.

Pharmacokinetics of Tenofovir following Intravaginal and Intrarectal Administration of Tenofovir Gel to Rhesus Macaques

Joseph P. Romano, P. Allen, J. Nuttall, 2011, Antimicrobial Agents and Chemotherapy.

Short communication: cheminformatics analysis to identify predictors of antiviral drug penetration into the female genital tract.

Alexander Tropsha, Denis Fourches, Eugene Muratov, 2014, AIDS research and human retroviruses.

Expression of six drug transporters in vaginal, cervical, and colorectal tissues: Implications for drug disposition in HIV prevention

D. Kroetz, E. Geller, K. Mollan, 2014, Journal of clinical pharmacology.

Influence of hair treatments on detection of antiretrovirals by mass spectrometry imaging.

A. Kashuba, Joseph N. Mwangi, A. Weideman, 2020, The Analyst.

Estimating Human Immunodeficiency Virus (HIV) Prevention Effects in Low-incidence Settings

S. Cole, A. Adimora, J. Eron, 2019, Epidemiology.

Sensitive tenofovir resistance screening of HIV-1 from the genital and blood compartments of women with breakthrough infections in the CAPRISA 004 tenofovir gel trial.

W. Heneine, L. Morris, V. Naranbhai, 2014, The Journal of infectious diseases.

Critical need for appropriate mucosal sample collection to determine relational animal pharmacokinetic-pharmacodynamic models in HIV prevention.

J. Cummins, A. Kashuba, H. Spiegel, 2013, AIDS research and human retroviruses.

Effects of formulation and dosing strategy on amprenavir concentrations in the seminal plasma of human immunodeficiency virus type 1-infected men.

J. Eron, S. Fiscus, O. Naderer, 2002, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Pharmacokinetic parameters of protease inhibitors and the Cmin/IC50 ratio: call for consensus.

R. Haubrich, C. Flexner, S. Piscitelli, 2001, Journal of acquired immune deficiency syndromes.

Using Real-Time Adherence Feedback to Enhance Communication About Adherence to Antiretroviral Therapy: Patient and Clinician Perspectives.

C. Golin, M. Gandhi, Jessica Carda-Auten, 2020, The Journal of the Association of Nurses in AIDS Care : JANAC.

Using antiretrovirals to prevent HIV transmission

A. Kashuba, M. Cohen, M. Cohen, 2009 .

HIV antiretroviral postexposure prophylaxis: a cautionary note.

A. Kashuba, C. Gay, M. Cohen, 2005, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Evaluation of Digital Image Recognition Methods for Mass Spectrometry Imaging Data Analysis

Kenneth P. Garrard, David C. Muddiman, D. Muddiman, 2018, Journal of The American Society for Mass Spectrometry.

Mass Spectrometry Imaging Reveals Heterogeneous Efavirenz Distribution within Putative HIV Reservoirs

P. Luciw, D. Muddiman, A. Kashuba, 2015, Antimicrobial Agents and Chemotherapy.

Antiretroviral Penetration across Three Preclinical Animal Models and Humans in Eight Putative HIV Viral Reservoirs

Jason R. Pirone, P. Luciw, J. Garcia, 2019, Antimicrobial Agents and Chemotherapy.

Tissue Pharmacologic and Virologic Determinants of Duodenal and Rectal Gastrointestinal-Associated Lymphoid Tissue Immune Reconstitution in HIV-Infected Patients Initiating Antiretroviral Therapy

T. Chun, J. García, D. Asmuth, 2017, The Journal of infectious diseases.

Multimodal analysis of drug transporter expression in gastrointestinal tissue

P. Luciw, J. Garcia, A. Kashuba, 2017, AIDS.

Quantitative mass spectrometry imaging of emtricitabine in cervical tissue model using infrared matrix-assisted laser desorption electrospray ionization

D. Muddiman, A. Kashuba, C. Sykes, 2015, Analytical and Bioanalytical Chemistry.

Exploration of CYP450 and drug transporter genotypes and correlations with nevirapine exposure in Malawians.

H. McLeod, E. Schuetz, M. Hosseinipour, 2012, Pharmacogenomics.

Randomized Study of Dual Versus Single Ritonavir-Enhanced Protease Inhibitors for Protease Inhibitor-Experienced Patients with HIV

J. Mellors, A. Collier, K. Klingman, 2008, HIV clinical trials.

Co-trimoxazole Prophylaxis, Asymptomatic Malaria Parasitemia, and Infectious Morbidity in Human Immunodeficiency Virus–Exposed, Uninfected Infants in Malawi: The BAN Study

Rodney J. Knight, M. Hudgens, L. Adair, 2017, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

HIV-1 Tat and opioids act independently to limit antiretroviral brain concentrations and reduce blood–brain barrier integrity

P. Knapp, A. Kashuba, M. Halquist, 2019, Journal of NeuroVirology.

Antiretroviral Activity and Safety of Once-Daily Etravirine in Treatment-Naive HIV-Infected Adults: 48-Week Results

J. Eron, D. Wohl, K. Mollan, 2016, Antiviral therapy.

HIV-1 expression within resting CD4+ T cells after multiple doses of vorinostat.

D. Hazuda, D. Richman, J. Coffin, 2014, The Journal of infectious diseases.

Quantification of 3‐month intraindividual variability and the influence of sex and menstrual cycle phase on CYP3A activity as measured by phenotyping with intravenous midazolam

A. Kashuba, A. Nafziger, J. Bertino, 1998, Clinical pharmacology and therapeutics.

Efficacy, pharmacokinetics and neurocognitive performance of dual, NRTI-sparing antiretroviral therapy in acute HIV-infection.

D. Margolis, G. Ferrari, K. Robertson, 2020, AIDS.

Effects of Combined CCR5/Integrase Inhibitors-Based Regimen on Mucosal Immunity in HIV-Infected Patients Naïve to Antiretroviral Therapy: A Pilot Randomized Trial

A. Somasunderam, E. Sinclair, D. Asmuth, 2016, PLoS pathogens.

Delayed GALT reconstitution in duodenum compared to rectum in hiv-infected patients initiating antiretroviral therapy.

T. Chun, A. Somasunderam, E. Sinclair, 2019, AIDS.

Effects of Injection Volume and Route of Administration on Dolutegravir In Situ Forming Implant Pharmacokinetics

P. Dayton, A. Kashuba, Jordan B. Joiner, 2022, Pharmaceutics.

Dose Separation Does Not Overcome the Pharmacokinetic Interaction between Fosamprenavir and Lopinavir/Ritonavir

J. Eron, A. Kashuba, H. Tien, 2006, Antimicrobial Agents and Chemotherapy.

Tenofovir Gel for the Prevention of Herpes Simplex Virus Type 2 Infection.

S. A. Abdool Karim, A. Grobler, C. Baxter, 2015, The New England journal of medicine.

Effect of Low-Dose Ritonavir on the Pharmacokinetics of the CXCR 4 Antagonist AMD 070 in Healthy Volunteers †

J. Park, C. Flexner, C. Hendrix, 2008 .

Effect of Low-Dose Ritonavir on the Pharmacokinetics of the CXCR4 Antagonist AMD070 in Healthy Volunteers (cid:1) †

J. Park, C. Flexner, C. Hendrix, 2008 .

Effect of HIV Infection and Menopause Status on Raltegravir Pharmacokinetics in the Blood and Genital Tract

A. Kashuba, N. White, K. Patterson, 2015, Antiviral therapy.

An accurate and precise high-performance liquid chromatography method for the rapid quantification of the novel HIV integrase inhibitor raltegravir in human blood plasma after solid phase extraction.

A. Kashuba, N. Rezk, N. White, 2008, Analytica chimica acta.

Quantifying the HIV-1 integrase inhibitor raltegravir in female genital tract secretions using high-performance liquid chromatography with ultraviolet detection.

A. Kashuba, N. Rezk, J. Talameh, 2010, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Kupffer cell-mediated IL-2 suppression of CYP3A activity in human hepatocytes.

A. Kashuba, Angela D M Kashuba, Edward L LeCluyse, 2004, Drug metabolism and disposition: the biological fate of chemicals.

Human Immunodeficiency Virus Type 1 RNA Detected in the Central Nervous System (CNS) After Years of Suppressive Antiretroviral Therapy Can Originate from a Replicating CNS Reservoir or Clonally Expanded Cells

R. Swanstrom, N. Archin, K. Robertson, 2019 .

Use of antiretroviral drugs to prevent sexual transmission of HIV.

M. Hosseinipour, A. Kashuba, S. Butera, 2002, Current clinical topics in infectious diseases.

Comparison of once-daily versus twice-daily combination antiretroviral therapy in treatment-naive patients: results of AIDS clinical trials group (ACTG) A5073, a 48-week randomized controlled trial.

C. Flexner, R. Gross, J. Aberg, 2010, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

CYP 2 B 6 Variants and Plasma Efavirenz Concentrations during Antiretroviral Therapy in Port-au-Prince , Haiti

D. Haas, J. Pape, R. Dillingham, 2009 .

S-warfarin limited sampling strategy with a population pharmacokinetic approach to estimate exposure and cytochrome P450 (CYP) 2C9 activity in healthy adults

E. Capparelli, A. Kashuba, Joseph D. Ma, 2021, European Journal of Clinical Pharmacology.

A novel LC-ESI-MS method for the simultaneous determination of etravirine, darunavir and ritonavir in human blood plasma.

A. Kashuba, N. Rezk, N. White, 2009, Talanta.

Leveraging physiologically based pharmacokinetic modeling to optimize dosing for lopinavir/ritonavir with rifampin in pediatric patients

P. Denti, D. Gonzalez, E. Capparelli, 2022, Pharmacotherapy.

Development and validation of an LC-MS/MS assay for the quantification of dolutegravir extracted from human hair

A. Kashuba, B. Tamraz, C. Sykes, 2018, Analytical and Bioanalytical Chemistry.

Pediatric Phase II Study of Maraviroc for Acute Graft Versus Host Disease Prophylaxis

A. Vinks, K. Myers, S. Davies, 2019, Biology of Blood and Marrow Transplantation.

Hormonal Contraceptives Differentially Suppress TFV and TAF Inhibition of HIV Infection and TFV-DP in Blood and Genital Tract CD4+ T cells

A. Kashuba, C. Wira, M. Rodriguez-Garcia, 2017, Scientific Reports.

Title: The Pharmacokinetics of Tenofovir Following Intravaginal and Intrarectal

P. Allen, J. Nuttall, A. Kashuba, 2011 .

Prediction of midazolam (MDZ) clearance (CL) using minimized sampling (MS) of 1-OHM and 1-OHM/MDZ in healthy subjects (HS)

E. Choo, G. Wilkinson, A. Kashuba, 2001 .

Preexposure prophylaxis for HIV infection among African women.

Douglas J. Taylor, L. van Damme, S. Kapiga, 2012, The New England journal of medicine.

DHHS GUIDELINES FOR THE USE OF ANTIRETROVIRAL AGENTS IN PATIENTS WITH HIV-1 INFECTION —

A. Kashuba, 2008 .

Correction: Effects of Combined CCR5/Integrase Inhibitors-Based Regimen on Mucosal Immunity in HIV-Infected Patients Naïve to Antiretroviral Therapy: A Pilot Randomized Trial

T. Chun, A. Somasunderam, E. Sinclair, 2016, PLoS pathogens.

Interactions of the hepatitis C virus protease inhibitor faldaprevir with cytochrome P450 enzymes: In vitro and in vivo correlation

D. Tweedie, M. Battegay, Naitee Ting, 2015, Journal of clinical pharmacology.

Simian Immunodeficiency Virus Persistence in Cellular and Anatomic Reservoirs in Antiretroviral Therapy-Suppressed Infant Rhesus Macaques

R. Schinazi, G. Silvestri, M. Paiardini, 2018, Journal of Virology.

Exploration of CYP450 and drug transporter genotypes and correlations with nevirapine exposure in Malawians.

H. McLeod, E. Schuetz, M. Hosseinipour, 2012, Pharmacogenomics.

Legionella urinary antigen testing: potential impact on diagnosis and antibiotic therapy.

A. Kashuba, C. Ballow, A. Kashuba, 1996, Diagnostic microbiology and infectious disease.

Drug Interactions with New and Investigational Antiretrovirals

A. Kashuba, Kevin C. Brown, Sunita Paul, 2009, Clinical pharmacokinetics.

The Influence of Sex, Ethnicity, and CYP2B6 Genotype on Bupropion Metabolism as an Index of Hepatic CYP2B6 Activity in Humans

E. Schuetz, P. Stewart, C. Lindley, 2013, Drug Metabolism and Disposition.

Challenges and Solutions for Future Pharmacy Practice in the Era of Precision Medicine

Rachel M Howard, T. Wiltshire, F. Innocenti, 2017, American Journal of Pharmaceutical Education.

Antiretroviral Pharmacology in Mucosal Tissues

A. Kashuba, Corbin G. Thompson, M. Cohen, 2013, Journal of acquired immune deficiency syndromes.

RMP-02/MTN-006: A phase 1 rectal safety, acceptability, pharmacokinetic, and pharmacodynamic study of tenofovir 1% gel compared with oral tenofovir disoproxil fumarate.

Ross D. Cranston, A. Carballo-Diéguez, W. Cumberland, 2012, AIDS research and human retroviruses.

Doravirine Concentrations and HIV-1 RNA in the Genital Fluids of Virologically Suppressed Adults Switching to Doravirine plus Emtricitabine/Tenofovir Alafenamide.

D. Podzamczer, J. Niubó, A. Kashuba, 2022, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

High resolution spatio-temporal assessment of simian/human immunodeficiency virus (SHIV) evolution reveals a highly dynamic process within the host

D. Petrov, B. Keele, Shiu-Lok Hu, 2017, bioRxiv.

Analysis of Antiretrovirals in Single Hair Strands for Evaluation of Drug Adherence with Infrared-Matrix-Assisted Laser Desorption Electrospray Ionization Mass Spectrometry Imaging.

D. Muddiman, A. Kashuba, C. Sykes, 2016, Analytical chemistry.