C. Li

发表

Discovery of MK-1439, an orally bioavailable non-nucleoside reverse transcriptase inhibitor potent against a wide range of resistant mutant HIV viruses.

Sébastien Gagné, Eric Langlois, Jean-François Truchon, 2014, Bioorganic & medicinal chemistry letters.

An efficient copper-catalyzed coupling reaction of pyridin-2-ones with aryl and heterocyclic halides based on Buchwald's protocol

Darryl D Dixon, C. Li, Darryl D. Dixon, 2004 .

The identification of potent, selective, and bioavailable cathepsin S inhibitors.

M. Percival, W. Cromlish, J. Gauthier, 2007, Bioorganic & medicinal chemistry letters.

Synthesis and SAR of 1,2-trans-(1-hydroxy-3-phenylprop-1-yl)cyclopentane carboxamide derivatives, a new class of sodium channel blockers.

M. Fisher, K. Lyons, M. Wyvratt, 2006, Bioorganic & medicinal chemistry letters.

Rapid measurement of deuterium-labeled long-chain fatty acids in plasma by HPLC-ESI-MS Published, JLR Papers in Press, October 4, 2006.

K. Bateman, S. Gagné, C. Li, 2007, Journal of Lipid Research.

Tryptophan-replacement and indole-modified apicidins: synthesis of potent and selective antiprotozoal agents

M. Fisher, M. Wyvratt, P. Meinke, 2000 .

Conversion of systemically-distributed triazole-based stearoyl-CoA desaturase (SCD) uHTS hits into liver-targeted SCD inhibitors.

J. Falgueyret, R. Oballa, J. Guay, 2011, Bioorganic & medicinal chemistry letters.

Synthesis and biological evaluation of 5,6-diarylimidazo[2.1-b]thiazole as selective COX-2 inhibitors

D. Riendeau, P. Prasit, C. Brideau, 1997 .

Thiazole analog as stearoyl-CoA desaturase 1 inhibitor.

J. Guay, C. Li, Yeeman K. Ramtohul, 2009, Bioorganic & medicinal chemistry letters.

Characterization of the in vitro oxidative metabolites of the COX-2 selective inhibitor L-766,112

J. Yergey, C. Li, L. Trimble, 1997 .

SAR and optimization of thiazole analogs as potent stearoyl-CoA desaturase inhibitors.

R. Oballa, J. Guay, Sébastien Guiral, 2010, Bioorganic & medicinal chemistry letters.

Synthesis and biological activity of a potent and orally bioavailable SCD inhibitor (MF-438).

J. Falgueyret, R. Oballa, J. Guay, 2010, Bioorganic & medicinal chemistry letters.

Plasma-based approach to measure target engagement for liver-targeting stearoyl-CoA desaturase 1 inhibitors

R. Oballa, K. Bateman, C. Li, 2011, Journal of Lipid Research.

Pyridazinones as selective cyclooxygenase-2 inhibitors.

D. Riendeau, P. Prasit, C. Brideau, 2003, Bioorganic & medicinal chemistry letters.

Structure based design of a series of potent and selective non peptidic PTP-1B inhibitors.

C. Bayly, E. Asante-Appiah, Y. Boie, 2004, Bioorganic & medicinal chemistry letters.

Synthesis of pyran-4-ones from isoxazoles

C. Li, E. Lacasse, Chunshi Li, 2002 .

An Efficient Copper‐Catalyzed Coupling Reaction of Pyridin‐2‐ones with Aryl and Heterocyclic Halides Based on Buchwald′s Protocol.

C. Li, Darryl D. Dixon, 2004 .

The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K.

J. Falgueyret, J. Palmer, M. Venuti, 2008, Bioorganic & medicinal chemistry letters.

Development of a liver-targeted stearoyl-CoA desaturase (SCD) inhibitor (MK-8245) to establish a therapeutic window for the treatment of diabetes and dyslipidemia.

David A. Powell, Lei Zhang, R. Oballa, 2011, Journal of medicinal chemistry.

The isoxazoline route to the hypocholesterolemic agent compactin: use of the isoxazoline as a 1,3-diene equivalent

A. Kozikowski, C. Li, 1987 .

The structural basis for the selectivity of benzotriazole inhibitors of PTP1B.

C. Bayly, C. Desponts, E. Asante-Appiah, 2003, Biochemistry.

Enhancement of mass spectrometric detection of LTC4, LTD4, and LTE4 by derivatization

J. Yergey, O. Mamer, G. Just, 1994, Journal of the American Society for Mass Spectrometry.

Side-chain homologation of nodulisporic acid: synthesis of potent new dienyl derivatives.

D. Schmatz, M. Fisher, M. Wyvratt, 2002, Bioorganic & medicinal chemistry letters.

Synthesis of a novel peptidic photoaffinity probe for the PTP-1B enzyme.

R. Zamboni, D. Waddleton, C. Ramachandran, 2004, Bioorganic & medicinal chemistry letters.

Identification of a potent and selective non-basic cathepsin K inhibitor.

J. Falgueyret, M. Mcgrath, M. Percival, 2006, Bioorganic & medicinal chemistry letters.

A nitrile oxide based entry to 2,3-dihydropyran-4-ones: synthesis of a protected version of compactin lactonë in racemic and optically active forms

A. Kozikowski, C. Li, 1985 .

Structure–activity relationship studies on ortho-substituted cinnamic acids, a new class of selective EP3 antagonists

D. Denis, R. Gordon, R. Zamboni, 2005 .

Difluoroethylamines as an amide isostere in inhibitors of cathepsin K.

J. Falgueyret, M. Percival, R. Young, 2005, Bioorganic & medicinal chemistry letters.

Trifluoroethylamines as amide isosteres in inhibitors of cathepsin K.

C. Bayly, J. Falgueyret, J. Palmer, 2006, Bioorganic & Medicinal Chemistry Letters.

Discovery of a potent and selective COX-2 inhibitor in the alkoxy lactone series with optimized metabolic profile.

D. Riendeau, P. Prasit, C. Brideau, 2002, Bioorganic & medicinal chemistry letters.

3,4-Diaryl-5-hydroxyfuranones: highly selective inhibitors of cyclooxygenase-2 with aqueous solubility.

D. Riendeau, P. Prasit, C. Brideau, 2003, Bioorganic & medicinal chemistry letters.

Evaluation of loxoprofen and its alcohol metabolites for potency and selectivity of inhibition of cyclooxygenase-2.

D. Riendeau, J. Mancini, M. Ouellet, 2004, Bioorganic & medicinal chemistry letters.

Bicyclic heteroaryl inhibitors of stearoyl-CoA desaturase: from systemic to liver-targeting inhibitors.

Lei Zhang, Serge Leger, Jean-Philippe Leclerc, 2011, Bioorganic & medicinal chemistry letters.

Continuous Flow Liquid Secondary Ion Mass Spectrometric Characterization of Phospholipid Molecular Species

J. Yergey, C. Li, 1997 .

The discovery of MK-0674, an orally bioavailable cathepsin K inhibitor.

J. Falgueyret, M. Percival, R. Oballa, 2010, Bioorganic & medicinal chemistry letters.