N. Morral

发表

Genomic DNA transfer with a high-capacity adenovirus vector results in improved in vivo gene expression and decreased toxicity

A. Beaudet, S. Kochanek, F. Graham, 1998, Nature Genetics.

Use of a liver-specific promoter reduces immune response to the transgene in adenoviral vectors.

A. Beaudet, S. Kochanek, H. Zhou, 1999, Human gene therapy.

Development of a complementing cell line and a system for construction of adenovirus vectors with E1 and E2a deleted

A. Beaudet, H. Zhou, N. Morral, 1996, Journal of virology.

Basal insulin gene expression significantly improves conventional insulin therapy in type 1 diabetic rats.

J. Altomonte, S. Thung, M. Meseck, 2002, Diabetes.

Lack of liver glycogen causes hepatic insulin resistance and steatosis in mice

A. Depaoli-Roach, P. Roach, N. Morral, 2017, The Journal of Biological Chemistry.

Delta F508 gene deletion in cystic fibrosis in southern Europe [letter]

X. Estivill, P. Pignatti, P. Gasparini, 1989 .

ΔF508 GENE DELETION IN CYSTIC FIBROSIS IN SOUTHERN EUROPE

X. Estivill, P. Pignatti, R. Williamson, 1989, The Lancet.

Immune responses to reporter proteins and high viral dose limit duration of expression with adenoviral vectors: comparison of E2a wild type and E2a deleted vectors.

A. Beaudet, H. Zhou, H. Zhou, 1997, Human gene therapy.

Novel targets and therapeutic strategies for type 2 diabetes

N. Morral, Núria Morral, 2003, Trends in Endocrinology & Metabolism.

Adenovirus-mediated expression of glucokinase in the liver as an adjuvant treatment for type 1 diabetes.

J. Altomonte, S. Thung, M. Meseck, 2002, Human gene therapy.

Sterol Regulatory Element-binding Protein-1 (SREBP-1) Is Required to Regulate Glycogen Synthesis and Gluconeogenic Gene Expression in Mouse Liver*

A. Depaoli-Roach, P. Roach, C. Hoppel, 2014, The Journal of Biological Chemistry.

Hepatic insulin expression improves glycemic control in type 1 diabetic rats.

S. Thung, M. Meseck, Hengjiang Dong, 2001, Diabetes research and clinical practice.

Lethal toxicity, severe endothelial injury, and a threshold effect with high doses of an adenoviral vector in baboons.

A. Beaudet, P. Piedra, C. Langston, 2002, Human gene therapy.

Insights from a high-fat diet fed mouse model with a humanized liver

Xiao-Ming Yin, N. Morral, M. Nassiri, 2022, PloS one.

Liver Gluconeogenic Gene Expression in Mouse Regulate Glycogen Synthesis and Protein-1 ( SREBP-1 ) Is Required to Sterol Regulatory Element-binding Gene Regulation :

A. Depaoli-Roach, P. Roach, C. Hoppel, 2014 .

CFTR haplotypic variability for normal and mutant genes in cystic fibrosis families from southern France

X. Estivill, M. Claustres, N. Morral, 1996, Human Genetics.

Dinucleotide (CA/GT) repeat polymorphism in intron 17B of the cystic fibrosis transmembrane conductance regulator (CFTR) gene

X. Estivill, J. Zieleński, L. Tsui, 2004, Human Genetics.

Toxicity Associated with Repeated Administration of First-Generation Adenovirus Vectors Does Not Occur with a Helper-Dependent Vector

A. Beaudet, S. Kochanek, F. Graham, 2000, Molecular medicine.

Analysis of the CFTR gene confirms the high genetic heterogeneity of the Spanish population: 43 mutations account for only 78% of CF chromosomes

X. Estivill, T. Casals, M. Chillón, 1994, Human Genetics.

Vector and helper genome rearrangements occur during production of helper-dependent adenoviral vectors.

S. Witting, S. Obici, N. Morral, 2013, Human gene therapy methods.

Reply to — Age of the ΔF508 cystic fibrosis mutation

X. Estivill, J. Bertranpetit, N. Morral, 1994, Nature Genetics.

Prenatal diagnosis of cystic fibrosis by multiplex PCR of mutation and microsatellite alleles

X. Estivill, T. Casals, V. Nunes, 1991, The Lancet.

Molecular cloning and analysis of a yeast protein phosphatase with an unusual amino-terminal region.

A. Casamayor, F. Posas, J. Ariño, 1992, The Journal of biological chemistry.

Enhancing hepatic mitochondrial fatty acid oxidation stimulates eating in food-deprived mice.

W. Langhans, Deepti Ramachandran, N. Morral, 2015, American journal of physiology. Regulatory, integrative and comparative physiology.

Accurate single-day titration of adenovirus vectors based on equivalence of protein VII nuclear dots and infectious particles.

D. A. Engel, N. Morral, Marcin P. Walkiewicz, 2009, Journal of virological methods.

Complete detection of mutations in cystic fibrosis patients of Native American origin

X. Estivill, P. Pignatti, C. Férec, 1994, Human Genetics.

Haplotype analysis of 94 cystic fibrosis mutations with seven polymorphic CFTR DNA markers

X. Estivill, L. Tsui, J. Zieleński, 1996, Human mutation.

The search for south European cystic fibrosis mutations: identification of two new mutations, four variants, and intronic sequences.

X. Estivill, P. Gasparini, B. Dallapiccola, 1991, Genomics.

Administration of helper-dependent adenoviral vectors and sequential delivery of different vector serotype for long-term liver-directed gene transfer in baboons.

A. Beaudet, S. Kochanek, H. Zhou, 1999, Proceedings of the National Academy of Sciences of the United States of America.

RNAi‐Mediated Therapeutics

S. Witting, N. Morral, 2011 .

The origin of the major cystic fibrosis mutation (ΔF508) in European populations

X. Estivill, J. Kere, J. Bertranpetit, 1994, Nature Genetics.

Gene targets of mouse miR-709: regulation of distinct pools

K. Dunn, Janaiah Kota, N. Morral, 2016, Scientific Reports.

Helper-dependent Adenovirus-mediated Short Hairpin RNA Expression in the Liver Activates the Interferon Response*

S. Witting, N. Morral, R. Saxena, 2008, Journal of Biological Chemistry.

Constitutive expression of short hairpin RNA in vivo triggers buildup of mature hairpin molecules.

S. Witting, N. Morral, R. Saxena, 2011, Human gene therapy.

shRNA-induced interferon-stimulated gene analysis.

S. Witting, N. Morral, 2012, Methods in molecular biology.

Transcription releases protein VII from adenovirus chromatin.

D. A. Engel, N. Morral, Jiangning Chen, 2007, Virology.

Comparative nucleic acid transfection efficacy in primary hepatocytes for gene silencing and functional studies

N. Morral, L. Kamendulis, Jae-seung Park, 2011, BMC Research Notes.

Toxicological comparison of E2a-deleted and first-generation adenoviral vectors expressing alpha1-antitrypsin after systemic delivery.

A. Beaudet, H. Zhou, B. Mull, 1998, Human gene therapy.

Aberrant gene expression induced by a high fat diet is linked to H3K9 acetylation in the promoter-proximal region.

Yunlong Liu, Yue Wang, J. Wan, 2021, Biochimica et biophysica acta. Gene regulatory mechanisms.

Microsatellite haplotypes for cystic fibrosis: mutation frameworks and evolutionary tracers.

X. Estivill, J. Bertranpetit, T. Casals, 1993, Human molecular genetics.

Independent origins of cystic fibrosis mutations R334W, R347P, R1162X, and 3849 + 10kbC-->T provide evidence of mutation recurrence in the CFTR gene.

X. Estivill, T. Dörk, P. Gasparini, 1994, American journal of human genetics.

Multiplex PCR amplification of three microsatellites within the CFTR gene.

X. Estivill, N. Morral, 1992, Genomics.

A tetranucleotide repeat polymorphism in the cystic fibrosis gene

X. Estivill, P. Pignatti, P. Gasparini, 1991, Human Genetics.

Uniparental inheritance of microsatellite alleles of the cystic fibrosis gene (CFTR): identification of a 50 kilobase deletion.

X. Estivill, T. Casals, Ó. Asensio, 1993, Human molecular genetics.

CA/GT microsatellite alleles within the cystic fibrosis transmembrane conductance regulator (CFTR) gene are not generated by unequal crossingover.

X. Estivill, T. Casals, V. Nunes, 1991, Genomics.

Caracterització molecular de la FQ a la població espanyola Cystic fibrosis in the basque country: high frequency of mutation F508 in patients of basque origin

X. Estivill, C. Lázaro, A. Gaona, 2005 .

Robust hepatic gene silencing for functional studies using helper-dependent adenoviral vectors.

S. Witting, N. Morral, R. Saxena, 2008, Human gene therapy.

Cystic fibrosis in Spain: high frequency of mutation G542X in the Mediterranean coastal area

X. Estivill, A. Gaona, T. Casals, 1993, Human Genetics.

Gene therapy for age-related macular degeneration

T. Ciulla, N. Morral, P. Bracha, 2017, Expert opinion on biological therapy.

Impact of silencing hepatic SREBP-1 on insulin signaling

Yongyong Hou, N. Morral, Sneha Surendran, 2018, PloS one.

The origin of the major cystic fibrosis mutation (delta F508) in European populations.

X. Estivill, J. Bertranpetit, L. Kalaydjieva, 1994, Nature genetics.

Effects of glucose metabolism on the regulation of genes of fatty acid synthesis and triglyceride secretion in the livers⃞ Published, JLR Papers in Press, April 21, 2007.

S. Witting, H. Edenberg, J. Altomonte, 2007, Journal of Lipid Research.

Role of non-coding RNAs on liver metabolism and NAFLD pathogenesis.

N. Morral, G. Qian, 2022, Human Molecular Genetics.

High doses of a helper-dependent adenoviral vector yield supraphysiological levels of alpha1-antitrypsin with negligible toxicity.

A. Beaudet, S. Kochanek, H. Zhou, 1998, Human gene therapy.

Gene therapy for inherited retinal and optic nerve degenerations

T. Ciulla, N. Morral, P. Bracha, 2018, Expert opinion on biological therapy.

Improved glycemia by hepatic insulin gene expression in insulin-dependent diabetes mellitus

M. Meseck, H. H. Dong, N. Morral, 2000 .

Analysis of microsatellites by direct blotting electrophoresis and chemiluminescence detection

T. Dörk, B. Tümmler, T. Deufel, 1995, Electrophoresis.

Cystic fibrosis in a low-incidence population: two major mutations in Finland

X. Estivill, A. Chapelle, J. Kere, 1994, Human Genetics.

Erratum: Haplotype analysis of 94 cystic fibrosis mutations with seven polymorphic CFTR DNA markers (Human Mutation (1996) 8 (149-159))

X. Estivill, L. Tsui, J. Zieleński, 1996 .

Lack of liver glycogen causes hepatic insulin resistance and steatosis in mice

A. Depaoli-Roach, P. Roach, N. Morral, 2017, The Journal of Biological Chemistry.