C. P. Whitman

发表

4-Oxalocrotonate tautomerase, an enzyme composed of 62 amino acid residues per monomer.

G. L. Kenyon, Christian, M. Bembenek, 1992, The Journal of biological chemistry.

Crystal structures of native and inactivated cis-3-chloroacrylic acid dehalogenase: Implications for the catalytic and inactivation mechanisms.

Youzhong Guo, W. Johnson, C. P. Whitman, 2011, Bioorganic chemistry.

Secretory leukocyte protease inhibitor: inhibition of human immunodeficiency virus-1 infection of monocytic THP-1 cells by a newly cloned protein.

N. Düzgüneş, K. Konopka, C. P. Whitman, 2002, Bioorganic chemistry.

Enzymatically inactive macrophage migration inhibitory factor inhibits monocyte chemotaxis and random migration.

W. Hanlon, S. Wright, C. P. Whitman, 1999, Biochemistry.

Identification and characterization of new family members in the tautomerase superfamily: analysis and implications.

C. P. Whitman, E. Burks, Jamison P. Huddleston, 2014, Archives of biochemistry and biophysics.

Kinetic, stereochemical, and structural effects of mutations of the active site arginine residues in 4-oxalocrotonate tautomerase.

T. Harris, M. Massiah, A. Mildvan, 1999, Biochemistry.

Chemical and enzymic ketonization of 2-hydroxymuconate, a conjugated enol

C. P. Whitman, N. Stolowich, W. Gillespie, 1991 .

Stereospecific ketonization of 2-hydroxymuconate by 4-oxalocrotonate tautomerase and 5-(carboxymethyl)-2-hydroxymuconate isomerase

M. Bembenek, W. Johnson, G. Hajipour, 1992 .

Ketonization of 2-hydroxy-2,4-pentadienoate by 4-oxalocrotonate tautomerase : implications for the stereochemical course and the mechanism

C. P. Whitman, Huiling Lian, 1993 .

4-Oxalocrotonate tautomerase: pH dependence of catalysis and pKa values of active site residues.

A. Mildvan, J. Stivers, G. Hajipour, 1996, Biochemistry.

Catalytic role of the amino-terminal proline in 4-oxalocrotonate tautomerase: affinity labeling and heteronuclear NMR studies.

L. H. Chen, A. Mildvan, J. Stivers, 1996, Biochemistry.

Inactivation of 4-oxalocrotonate tautomerase by 2-oxo-3-pentynoate.

M. Fitzgerald, W. Johnson, C. P. Whitman, 1997, Biochemistry.

Characterization of the role of the amino-terminal proline in the enzymatic activity catalyzed by macrophage migration inhibitory factor.

M. Fitzgerald, C. P. Whitman, S. L. Stamps, 1998, Biochemistry.

Crystal structure of 4-oxalocrotonate tautomerase inactivated by 2-oxo-3-pentynoate at 2.4 A resolution: analysis and implications for the mechanism of inactivation and catalysis.

Alexander B. Taylor, W. Johnson, C. P. Whitman, 1998, Biochemistry.

Characterization of two polyketide synthase genes in Exophiala lecanii-corni, a melanized fungus with bioremediation potential.

K. Kinney, P. J. Szaniszlo, Q. Cheng, 2004, Bioorganic chemistry.

Effects of mutations of the active site arginine residues in 4-oxalocrotonate tautomerase on the pKa values of active site residues and on the pH dependence of catalysis.

T. Harris, A. Mildvan, J. Stivers, 1999, Biochemistry.

The bacterial catabolism of polycyclic aromatic hydrocarbons: Characterization of three hydratase-aldolase-catalyzed reactions☆

W. Johnson, Wenzong Li, C. P. Whitman, 2016 .

Kinetic, mutational, and structural analysis of malonate semialdehyde decarboxylase from Coryneform bacterium strain FG41: mechanistic implications for the decarboxylase and hydratase activities.

Youzhong Guo, W. Johnson, C. P. Whitman, 2013, Biochemistry.

Stereochemical Consequences of Vinylpyruvate Hydratase-Catalyzed Reactions.

W. Johnson, C. P. Whitman, Stephanie M. Taylor, 2016, Biochemistry.

Symmetry and asymmetry in mandelate racemase catalysis.

G. L. Kenyon, W. Cleland, G. Hegeman, 1985, Biochemistry.

Pre-steady-state kinetic analysis of cis-3-chloroacrylic acid dehalogenase: analysis and implications.

Kenneth A. Johnson, Zhinan Jin, C. P. Whitman, 2009, Biochemistry.

A mutational analysis of the active site loop residues in cis-3-Chloroacrylic acid dehalogenase.

W. Johnson, C. P. Whitman, Jamison P. Huddleston, 2013, Biochemistry.

Inactivation of 4-Oxalocrotonate Tautomerase by 5-Halo-2-hydroxy-2,4-pentadienoates.

W. Johnson, Wenzong Li, C. P. Whitman, 2018, Biochemistry.

Crystal Structures of Apo and Liganded 4-Oxalocrotonate Decarboxylase Uncover a Structural Basis for the Metal-Assisted Decarboxylation of a Vinylogous β-Keto Acid.

J. Coitinho, R. Nagem, C. P. Whitman, 2016, Biochemistry.

Differential toxicities of cyclophosphamide and its glutathione metabolites to A549 cells.

C. P. Whitman, J. Kehrer, X. Liu, 1995, Toxicology in vitro : an international journal published in association with BIBRA.

Evidence for the generation of alpha carboxy alpha hydroxy p xylylene from p bromomethyl mandelate by mandelate racemase

G. L. Kenyon, J. Kozarich, C. P. Whitman, 1988 .

Phenylpyruvate tautomerase activity of trans-3-chloroacrylic acid dehalogenase: evidence for an enol intermediate in the dehalogenase reaction?

W. Johnson, C. P. Whitman, Héctor Serrano, 2007, Biochemistry.

Symmetry of 4-Oxalocrotonate Tautomerase Trimers Influences Unfolding and Fragmentation in the Gas Phase.

J. Brodbelt, Sarah N. Sipe, C. P. Whitman, 2022, Journal of the American Chemical Society.

Inactivation of Cg10062, a cis-3-Chloroacrylic Acid Dehalogenase Homologue in Corynebacterium glutamicum, by (R)- and (S)-Oxirane-2-carboxylate: Analysis and Implications†

W. Johnson, C. P. Whitman, H. Lo, 2008, Biochemistry.

Kinetic and stereochemical analysis of YwhB, a 4-oxalocrotonate tautomerase homologue in Bacillus subtilis: mechanistic implications for the YwhB- and 4-oxalocrotonate tautomerase-catalyzed reactions.

W. Johnson, C. P. Whitman, Susan C Wang, 2007, Biochemistry.

Evolution of enzymatic activity in the tautomerase superfamily: mechanistic and structural consequences of the L8R mutation in 4-oxalocrotonate tautomerase.

W. Johnson, C. P. Whitman, Héctor Serrano, 2006, Biochemistry.

Evolution of enzymatic activity in the tautomerase superfamily: mechanistic and structural studies of the 1,3-dichloropropene catabolic enzymes.

C. P. Whitman, G. Poelarends, 2004, Bioorganic chemistry.

Kinetic, Inhibition, and Structural Characterization of a Malonate Semialdehyde Decarboxylase-like Protein from Calothrix sp. PCC 6303: A Gateway to the non-Pro1 Tautomerase Superfamily Members.

C. P. Whitman, Y. Zhang, Emily B Lancaster, 2022, Biochemistry.

A kinetic and stereochemical investigation of the role of lysine-32 in the phenylpyruvate tautomerase activity catalyzed by macrophage migration inhibitory factor.

W. Johnson, C. P. Whitman, R. Czerwinski, 1999, Biochemistry.

Reactions of trans-3-chloroacrylic acid dehalogenase with acetylene substrates: consequences of and evidence for a hydration reaction.

M. Person, W. Johnson, C. P. Whitman, 2003, Biochemistry.

Synthesis and enzymatic ketonization of the 5-(halo)-2-hydroxymuconates and 5-(halo)-2-hydroxy-2,4-pentadienoates

C. P. Whitman, T. Stack, William H Johnson Jr., 2017, Beilstein journal of organic chemistry.

Total Chemical Synthesis and Catalytic Properties of the Enzyme Enantiomers L- and D-4-Oxalocrotonate Tautomerase

I. Chernushevich, K. Standing, S. Kent, 1995 .

Probing the oligomeric structure of an enzyme by electrospray ionization time-of-flight mass spectrometry.

I. Chernushevich, K. Standing, S. Kent, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Synthesis, chiroptical properties and absolute configuration of α-phenylglycidic acid

G. L. Kenyon, J. Craig, C. P. Whitman, 1985 .

Oral administration of naturally occurring coumarins leads to altered phase I and II enzyme activities and reduced DNA adduct formation by polycyclic aromatic hydrocarbons in various tissues of SENCAR mice.

H. Kleiner, J. DiGiovanni, W. Johnson, 2001, Carcinogenesis.

Reaction of cis-3-chloroacrylic acid dehalogenase with an allene substrate, 2,3-butadienoate: hydration via an enamine.

Kenneth A. Johnson, W. Johnson, C. P. Whitman, 2012, Journal of the American Chemical Society.

5.03 – Keto–Enol Tautomerism in Enzymatic Reactions

C. P. Whitman, 1999 .

Absolute Stereochemical Course of Muconolactone Δ-Isomerase and of 4-carboxymuconolactone Decarboxylase: A H NMR “Ricochet” Analysis

J. Kozarich, L. N. Ornston, R. Chari, 1987 .

4‐Oxalocrotonate tautomerase, a 41‐kDa homohexamer: Backbone and side‐chain resonance assignments, solution secondary structure, and location of active site residues by heteronuclear NMR spectroscopy

A. Mildvan, J. Stivers, C. P. Whitman, 1996, Protein science : a publication of the Protein Society.

A global view of structure–function relationships in the tautomerase superfamily

Eyal Akiva, Gemma L. Holliday, Patricia C Babbitt, 2017, The Journal of Biological Chemistry.

Inactivation of the phenylpyruvate tautomerase activity of macrophage migration inhibitory factor by 2-oxo-4-phenyl-3-butynoate.

P. A. Golubkov, M. Person, W. Johnson, 2006, Bioorganic chemistry.

Kinetic, crystallographic, and mechanistic characterization of TomN: elucidation of a function for a 4-oxalocrotonate tautomerase homologue in the tomaymycin biosynthetic pathway.

B. Gerratana, W. Johnson, Wenzong Li, 2011, Biochemistry.

A pre-steady state kinetic analysis of the αY60W mutant of trans-3-chloroacrylic acid dehalogenase: implications for the mechanism of the wild-type enzyme.

Kenneth A Johnson, C. P. Whitman, Gottfried K Schroeder, 2012, Biochemistry.

Reactions of trans-3-chloroacrylic acid dehalogenase with acetylene substrates: Consequences of and evidence for a hydration reaction

M. Person, W. Johnson, C. P. Whitman, 2003 .

The structural basis for the perturbed pKa of the catalytic base in 4-oxalocrotonate tautomerase: kinetic and structural effects of mutations of Phe-50.

T. Harris, M. Massiah, A. Mildvan, 2001, Biochemistry.

A mutagenic analysis of NahE, a hydratase-aldolase in the naphthalene degradative pathway.

Yan Zhang, C. P. Whitman, Jake Levieux, 2022, Archives of biochemistry and biophysics.

Preparation of dihydroxy polycyclic aromatic hydrocarbons and activities of two dioxygenases in the phenanthrene degradative pathway.

W. Johnson, C. P. Whitman, Andrew J. Meichan, 2019, Archives of biochemistry and biophysics.

Structural Characterization of the Hydratase-Aldolases, NahE and PhdJ: Implications for the Specificity, Catalysis, and N-Acetylneuraminate Lyase Subgroup of the Aldolase Superfamily.

B. Medellin, W. Johnson, Wenzong Li, 2018, Biochemistry.

Identification of a homogentisate-1,2-dioxygenase gene in the fungus Exophiala lecanii-corni: analysis and implications

K. Kinney, C. Gunsch, P. J. Szaniszlo, 2005, Applied Microbiology and Biotechnology.

Relative gene expression quantification in a fungal gas‐phase biofilter

K. Kinney, C. Gunsch, P. J. Szaniszlo, 2007, Biotechnology and bioengineering.

Quantification of homogentisate-1,2-dioxygenase expression in a fungus degrading ethylbenzene.

K. Kinney, C. Gunsch, P. J. Szaniszlo, 2006, Journal of microbiological methods.

Mechanistic Characterization of a Bacterial Malonate Semialdehyde Decarboxylase

A. Murzin, W. Johnson, C. P. Whitman, 2003, Journal of Biological Chemistry.

The 4-oxalocrotonate tautomerase- and YwhB-catalyzed hydration of 3E-haloacrylates: implications for the evolution of new enzymatic activities.

W. Johnson, C. P. Whitman, Susan C Wang, 2003, Journal of the American Chemical Society.

Mechanistic and structural studies of microbial dehalogenases: How Nature cleaves a carbon-halogen bond.

C. P. Whitman, G. Poelarends, 2010 .

The structure of the proline utilization a proline dehydrogenase domain inactivated by N-propargylglycine provides insight into conformational changes induced by substrate binding and flavin reduction.

J. Tanner, D. Srivastava, D. Becker, 2010, Biochemistry.

Structural basis for the inactivation of Thermus thermophilus proline dehydrogenase by N-propargylglycine.

J. Tanner, T. White, W. Johnson, 2008, Biochemistry.

Crystal structure of macrophage migration inhibitory factor complexed with (E)-2-fluoro-p-hydroxycinnamate at 1.8 A resolution: implications for enzymatic catalysis and inhibition.

W. Johnson, C. P. Whitman, M. Hackert, 1999, Biochemistry.

The chemical versatility of the β–α–β fold: Catalytic promiscuity and divergent evolution in the tautomerase superfamily

C. P. Whitman, G. Poelarends, V. P. Veetil, 2008, Cellular and Molecular Life Sciences.

Evolution of enzymatic activity in the tautomerase superfamily: mechanistic and structural consequences of the L8R mutation in 4-oxalocrotonate tautomerase.

W. Johnson, C. P. Whitman, Héctor Serrano, 2006, Biochemistry.

Kinetic and Structural Analysis of Two Linkers in the Tautomerase Superfamily: Analysis and Implications.

P. Babbitt, T. Kaoud, B. Medellin, 2021, Biochemistry.

Kinetic and structural characterization of a heterohexamer 4-oxalocrotonate tautomerase from Chloroflexus aurantiacus J-10-fl: implications for functional and structural diversity in the tautomerase superfamily .

A. Mesecar, S. Pegan, C. P. Whitman, 2010, Biochemistry.

Reaction mechanism of cis-3-chloroacrylic acid dehalogenase: a theoretical study.

Fahmi Himo, F. Himo, C. P. Whitman, 2009, Biochemistry.

Functional (Mis)Assignment in the Tomaymycin Biosynthetic Pathway

C. P. Whitman, 2013 .

Crystal structures of the wild-type, P1A mutant, and inactivated malonate semialdehyde decarboxylase: a structural basis for the decarboxylase and hydratase activities.

W. Johnson, C. P. Whitman, Héctor Serrano, 2005, Biochemistry.

The hydratase activity of malonate semialdehyde decarboxylase: mechanistic and evolutionary implications.

D. Hoffman, C. P. Whitman, Héctor Serrano, 2004, Journal of the American Chemical Society.

The roles of active-site residues in the catalytic mechanism of trans-3-chloroacrylic acid dehalogenase: a kinetic, NMR, and mutational analysis.

M. Massiah, A. Mildvan, H. Azurmendi, 2004, Biochemistry.

The X-ray Structure of trans-3-Chloroacrylic Acid Dehalogenase Reveals a Novel Hydration Mechanism in the Tautomerase Superfamily*

B. Dijkstra, W. Brugman, C. P. Whitman, 2004, Journal of Biological Chemistry.

Cloning, expression, and characterization of a cis-3-chloroacrylic acid dehalogenase: insights into the mechanistic, structural, and evolutionary relationship between isomer-specific 3-chloroacrylic acid dehalogenases.

A. Murzin, M. Person, W. Johnson, 2004, Biochemistry.

The crystal structure of YdcE, a 4-oxalocrotonate tautomerase homologue from Escherichia coli, confirms the structural basis for oligomer diversity.

A. Murzin, A. Kern, W. Johnson, 2002, Biochemistry.

The 4-oxalocrotonate tautomerase family of enzymes: How nature makes new enzymes using a β-α-β structural motif

C. P. Whitman, 2002 .

Structural Basis for the Asymmetry of a 4-Oxalocrotonate Tautomerase Trimer.

Shoshana D. Brown, P. Babbitt, B. Medellin, 2020, Biochemistry.

Structural, Kinetic, and Mechanistic Analysis of an Asymmetric 4-Oxalocrotonate Tautomerase Trimer.

Shoshana D. Brown, P. Babbitt, E. Akiva, 2019, Biochemistry.

Kinetic and structural characterization of a cis-3-Chloroacrylic acid dehalogenase homologue in Pseudomonas sp. UW4: A potential step between subgroups in the tautomerase superfamily.

P. Babbitt, T. Kaoud, C. P. Whitman, 2017, Archives of biochemistry and biophysics.

Kinetic and structural characterization of DmpI from Helicobacter pylori and Archaeoglobus fulgidus, two 4-oxalocrotonate tautomerase family members.

A. Kern, R. Dasgupta, C. P. Whitman, 2010, Bioorganic chemistry.

Characterization of Cg10062 from Corynebacterium glutamicum: Implications for the Evolution of cis-3-Chloroacrylic Acid Dehalogenase Activity in the Tautomerase Superfamily

M. Person, W. Johnson, C. P. Whitman, 2008, Biochemistry.

Crystal Structures of Native and Inactivated cis-3-Chloroacrylic Acid Dehalogenase

B. Dijkstra, A. Thunnissen, W. Johnson, 2007, Journal of Biological Chemistry.

Stereospecific alkylation of cis-3-chloroacrylic acid dehalogenase by (R)-oxirane-2-carboxylate: analysis and mechanistic implications.

W. Johnson, C. P. Whitman, Héctor Serrano, 2004, Biochemistry.

Mechanism of the phenylpyruvate tautomerase activity of macrophage migration inhibitory factor: properties of the P1G, P1A, Y95F, and N97A mutants.

C. P. Whitman, M. Hackert, A. Taylor, 2000, Biochemistry.

The 4-oxalocrotonate tautomerase family of enzymes: how nature makes new enzymes using a beta-alpha-beta structural motif.

C. P. Whitman, 2002, Archives of biochemistry and biophysics.

Structural and kinetic characterization of two 4-oxalocrotonate tautomerases in Methylibium petroleiphilum strain PM1.

D. Hoffman, C. Terrell, C. P. Whitman, 2013, Archives of biochemistry and biophysics.

THE CONTRIBUTION OF THE SUBSTRATE'S CARBOXYLATE GROUP TO THE MECHANISM OF 4-OXALOCROTONATE TAUTOMERASE

W. Johnson, C. P. Whitman, R. Czerwinski, 1998 .

Reactions of Cg10062, a cis-3-Chloroacrylic Acid Dehalogenase Homologue, with Acetylene and Allene Substrates: Evidence for a Hydration-Dependent Decarboxylation.

W. Johnson, C. P. Whitman, Jamison P. Huddleston, 2015, Biochemistry.

Absolute stereochemical course of the 3-carboxymuconate cycloisomerases from Pseudomonas putida and Acinetobacter calcoaceticus: analysis and implications

J. Kozarich, L. N. Ornston, R. Chari, 1987 .

Laccase removal of 2‐chlorophenol and sulfamethoxazole in municipal wastewater

K. Kinney, D. Lawler, C. P. Whitman, 2019, Water environment research : a research publication of the Water Environment Federation.

Structural and kinetic characterization of recombinant 2-hydroxymuconate semialdehyde dehydrogenase from Pseudomonas putida G7.

R. Aparício, R. Nagem, W. Johnson, 2015, Archives of biochemistry and biophysics.

Stereochemical and isotopic labeling studies of 2-oxo-hept-4-ene-1,7- dioate hydratase: Evidence for an enzyme-catalyzed ketonization step in the hydration reaction

W. Johnson, C. P. Whitman, E. Burks, 1998 .

Comprehensive Natural Products II: Chemistry and Biology

C. P. Whitman, G. Poelarends, 2010 .

Preliminary analysis of crystals of 4-oxalocrotonate tautomerase, an enzyme composed of unusually small monomers.

C. P. Whitman, R. C. Davenport, 1993, Journal of molecular biology.

Chemical and Enzymatic Ketonization of 2-Hydroxymuconate, a Conjugated Enol.

C. P. Whitman, N. Stolowich, W. Gillespie, 1991 .

The accidental assignment of function in the tautomerase superfamily

W. Johnson, C. P. Whitman, Jamison P. Huddleston, 2015 .

Inactivation of malonate semialdehyde decarboxylase by 3-halopropiolates: evidence for hydratase activity.

W. Johnson, C. P. Whitman, Héctor Serrano, 2005, Biochemistry.

A century of Michaelis--Menten kinetics. Introduction.

A. Cornish-Bowden, C. P. Whitman, 2013, FEBS letters.

A mutational analysis of active site residues in trans‐3‐chloroacrylic acid dehalogenase

C. P. Whitman, Héctor Serrano, G. Poelarends, 2013, FEBS letters.

Crystal Structures of Native and Inactivated cis-3-Chloroacrylic Acid Dehalogenase

B. Dijkstra, A. Thunnissen, W. Johnson, 2007, Journal of Biological Chemistry.

Characterization of Cg10062 from Corynebacterium glutamicum: Implications for the Evolution of cis-3-Chloroacrylic Acid Dehalogenase Activity in the Tautomerase Superfamily

C. P. Whitman, Héctor Serrano, G. Poelarends, 2008, Biochemistry.

Resolution of the uncertainty in the kinetic mechanism for the trans-3-Chloroacrylic acid dehalogenase-catalyzed reaction.

C. P. Whitman, Susan C Wang, Jamison P. Huddleston, 2017, Archives of biochemistry and biophysics.

Pre-steady-state kinetic analysis of cis-3-chloroacrylic acid dehalogenase: analysis and implications.

Zhinan Jin, C. P. Whitman, B. A. Robertson, 2009, Biochemistry.

Kinetic and structural effects of mutations of the catalytic amino-terminal proline in 4-oxalocrotonate tautomerase.

T. Harris, A. Mildvan, C. P. Whitman, 1997, Biochemistry.

15N NMR relaxation studies of free and inhibitor-bound 4-oxalocrotonate tautomerase: backbone dynamics and entropy changes of an enzyme upon inhibitor binding.

A. Mildvan, J. Stivers, C. P. Whitman, 1996, Biochemistry.