C. Alfaro

发表

Cyclophosphamide for Metastatic Cancer Combined with GM-CSF, Pegylated IFN, and Loaded with Autologous Tumor Lysates Pilot Clinical Trial of Type 1 Dendritic Cells

B. Sangro, I. Melero, S. Martín-Algarra, 2011 .

Pilot Clinical Trial of Type 1 Dendritic Cells Loaded with Autologous Tumor Lysates Combined with GM-CSF, Pegylated IFN, and Cyclophosphamide for Metastatic Cancer Patients

B. Sangro, I. Melero, S. Martín-Algarra, 2011, The Journal of Immunology.

Treatment with anti-CD137 mAbs causes intense accumulations of liver T cells without selective antitumor immunotherapeutic effects in this organ

Lieping Chen, J. Prieto, I. Melero, 2010, Cancer Immunology, Immunotherapy.

Clinical implications of antigen transfer mechanisms from malignant to dendritic cells. exploiting cross-priming.

I. Melero, I. Tirapu, A. Arina, 2002, Experimental hematology.

Synergistic effects of CTLA‐4 blockade with tremelimumab and elimination of regulatory T lymphocytes in vitro and in vivo

B. Sangro, I. Melero, S. Martín-Algarra, 2011, International journal of cancer.

Improving efficacy of interleukin‐12‐transfected dendritic cells injected into murine colon cancer with anti‐CD137 monoclonal antibodies and alloantigens

Lieping Chen, J. Prieto, C. Qian, 2004, International journal of cancer.

Serum Interleukin-8 Reflects Tumor Burden and Treatment Response across Malignancies of Multiple Tissue Origins

B. Sangro, I. Melero, M. Rodriguez-Ruiz, 2014, Clinical Cancer Research.

Personalized Medicine and Imaging Serum Interleukin-8 Re fl ects Tumor Burden and Treatment Response across Malignancies of Multiple Tissue Origins

B. Sangro, I. Melero, M. Rodriguez-Ruiz, 2014 .

Dendritic cells delivered inside human carcinomas are sequestered by interleukin‐8

J. Prieto, B. Sangro, I. Melero, 2005, International journal of cancer.

Intratumoral injection of dendritic cells engineered to secrete interleukin-12 by recombinant adenovirus in patients with metastatic gastrointestinal carcinomas.

J. Prieto, C. Qian, B. Sangro, 2005, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Immunotherapy and immunoescape in colorectal cancer.

I. Melero, J. Pérez-Gracia, I. Tirapu, 2007, World journal of gastroenterology.

Nivolumab and urelumab enhance antitumor activity of human T lymphocytes engrafted in Rag2IL2R

M. Hidalgo, K. Schalper, I. Melero, 2015 .

CXCR1 and CXCR2 Chemokine Receptor Agonists Produced by Tumors Induce Neutrophil Extracellular Traps that Interfere with Immune Cytotoxicity.

M. Carleton, K. Schalper, I. Melero, 2020, Immunity.

Influence of Interleukin-8 and Neutrophil Extracellular Trap (NET) Formation in the Tumor Microenvironment: Is There a Pathogenic Role?

C. Alfaro, M. Gonzalez-Aparicio, 2019, Journal of immunology research.

Clinical development of combination strategies in immunotherapy: are we ready for more than one investigational product in an early clinical trial?

B. Sangro, I. Melero, J. Pérez-Gracia, 2009, Immunotherapy.

Combined immunotherapy encompassing intratumoral poly-ICLC, dendritic-cell vaccination and radiotherapy in advanced cancer patients

I. Melero, M. Rodriguez-Ruiz, J. Pérez-Gracia, 2017, Annals of oncology : official journal of the European Society for Medical Oncology.

Cellular liaisons of natural killer lymphocytes in immunology and immunotherapy of cancer

I. Melero, J. Pérez-Gracia, A. Arina, 2007, Expert opinion on biological therapy.

Interleukin-15 liver gene transfer increases the number and function of IKDCs and NK cells

J. Prieto, I. Melero, S. Ferrini, 2008, Gene Therapy.

Intensive pharmacological immunosuppression allows for repetitive liver gene transfer with recombinant adenovirus in nonhuman primates.

J. Prieto, I. Melero, S. Hervás-Stubbs, 2010, Molecular therapy : the journal of the American Society of Gene Therapy.

Nivolumab and Urelumab Enhance Antitumor Activity of Human T Lymphocytes Engrafted in Rag2 (cid:1) / (cid:1) IL2R g null Immunode ﬁ cient Mice

M. Hidalgo, K. Schalper, I. Melero, 2015 .

Recombinant adenoviral vectors turn on the type I interferon system without inhibition of transgene expression and viral replication.

J. Prieto, I. Melero, J. Pérez-Gracia, 2006, Molecular therapy : the journal of the American Society of Gene Therapy.

MAGE antigens: therapeutic targets in hepatocellular carcinoma?

I. Melero, G. Mazzolini, P. Sarobe, 2004, Journal of hepatology.

Liver Gene Transfer of Interkeukin-15 Constructs That Become Part of Circulating High Density Lipoproteins for Immunotherapy

J. Prieto, I. Melero, P. Berraondo, 2012, PloS one.

The combined actions of NK and T lymphocytes are necessary to reject an EGFP+ mesenchymal tumor through mechanisms dependent on NKG2D and IFNγ

J. Prieto, I. Melero, J. Pérez-Gracia, 2007, International journal of cancer.

Transient and intensive pharmacological immunosuppression fails to improve AAV-based liver gene transfer in non-human primates

J. Prieto, I. Melero, H. Petry, 2012, Journal of Translational Medicine.

Therapeutic Antitumor Efficacy of Anti-CD137 Agonistic Monoclonal Antibody in Mouse Models of Myeloma

I. Melero, J. Pérez-Gracia, A. Arina, 2008, Clinical Cancer Research.

Immunogenic Cell Death and Cross-Priming Are Reaching the Clinical Immunotherapy Arena

I. Melero, J. Pérez-Gracia, A. Arina, 2006, Clinical Cancer Research.

Immunogenic Cell Death and Cross-Priming Are Reaching the Clinical ImmunotherapyArena 55 Commentary on Saji

A. Arina, C. Alfaro, J. Dubrot, 2006 .

RETRACTED ARTICLE: Significance of the IL-8 pathway for immunotherapy

C. Alfaro, M. Gonzalez-Aparicio, 2019, Human vaccines & immunotherapeutics.

Intratumoral injection of interferon‐α and systemic delivery of agonist anti‐CD137 monoclonal antibodies synergize for immunotherapy

I. Melero, P. Berraondo, S. Hervás-Stubbs, 2011, International journal of cancer.

In vivo depletion of DC impairs the anti‐tumor effect of agonistic anti‐CD137 mAb

I. Melero, P. Berraondo, A. Arina, 2009, European journal of immunology.

Absence of surface expression of CD137 (4-1BB) on Myeloid-derived suppressor cells

I. Melero, P. Berraondo, A. Arina, 2007 .

Nivolumab and Urelumab Enhance Antitumor Activity of Human T Lymphocytes Engrafted in Rag2-/-IL2Rγnull Immunodeficient Mice.

M. Hidalgo, K. Schalper, I. Melero, 2015, Cancer research.

Interleukin-8 in cancer pathogenesis, treatment and follow-up.

K. Schalper, I. Melero, M. Rodriguez-Ruiz, 2017, Cancer treatment reviews.

Tumor-Produced Interleukin-8 Attracts Human Myeloid-Derived Suppressor Cells and Elicits Extrusion of Neutrophil Extracellular Traps (NETs)

I. Melero, J. Pérez-Gracia, P. Berraondo, 2016, Clinical Cancer Research.

[Specialized dendritic cells in cross-presentation of exogenous antigens to cytotoxic T lymphocytes].

I. Melero, J. Pérez-Gracia, C. Alfaro, 2013, Anales del sistema sanitario de Navarra.

Changes in serum interleukin-8 (IL-8) levels reflect and predict response to anti-PD-1 treatment in melanoma and non-small-cell lung cancer patients

R. Halaban, K. Schalper, M. Sznol, 2017, Annals of oncology : official journal of the European Society for Medical Oncology.

Potentiation of therapeutic immune responses against malignancies with monoclonal antibodies.

J. Prieto, I. Melero, I. Tirapu, 2003, Clinical cancer research : an official journal of the American Association for Cancer Research.

A Phase I Pharmacologic Study of Necitumumab (imc-11f8), a Fully Human Igg1 Monoclonal Antibody the Hif-1␣ Hypoxia Response in Tumor-infi Ltrating T Lymphocytes Induces Functional Cd137 (4-1bb) for Immunotherapy

I. Melero, J. Aragonés, J. Pérez-Gracia, 2022 .

[The immunotherapy potential of agonistic anti-CD137 (4-1BB) monoclonal antibodies for malignancies and chronic viral diseases].

J. Prieto, I. Melero, J. Pérez-Gracia, 2006, Anales del sistema sanitario de Navarra.

The role of IL-8 in the immune response associated to cancer development

C. Alfaro, M. Gonzalez-Aparicio, 2018 .

A clinical trial of CTLA-4 blockade with tremelimumab in patients with hepatocellular carcinoma and chronic hepatitis C.

J. Prieto, B. Sangro, I. Melero, 2013, Journal of hepatology.

REVISIONES Nuevos tratamientos para el carcinoma renal New treatments for renal carcinoma

I. Melero, C. Alfaro, C. Olier, 2007 .

Clinical grade adjuvants to mature CD141+ DCs for immunotherapy.

C. Alfaro, Blanca Alegría, 2022, Frontiers in bioscience.

Intratumoural administration of dendritic cells: hostile environment and help by gene therapy

I. Melero, I. Tirapu, E. Huarte, 2005, Expert opinion on biological therapy.

Critical appraisal of the current status of dendritic cell based therapy

I. Melero, I. Tirapu, E. Huarte, 2005 .

Malignancies with Monoclonal Antibodies Potentiation of Therapeutic Immune Responses against Updated

J. Prieto, I. Melero, I. Tirapu, 2003 .

Cardiotrophin-1 determines liver engraftment of syngenic colon carcinoma cells through an immune system-mediated mechanism

C. Ortiz de Solórzano, I. Melero, J. Pérez-Gracia, 2012, Oncoimmunology.

Carcinoma-Derived Interleukin-8 Disorients Dendritic Cell Migration Without Impairing T-Cell Stimulation

I. Melero, J. Pérez-Gracia, Álvaro González, 2011, PloS one.

A randomized phase II clinical trial of dendritic cell vaccination following complete resection of colon cancer liver metastasis

I. Melero, M. Rodriguez-Ruiz, F. Rotellar, 2018, Journal of Immunotherapy for Cancer.

Dendritic cells adhere to and transmigrate across lymphatic endothelium in response to IFN‐α

I. Melero, S. Hervás-Stubbs, I. Martinez-Forero, 2010, European journal of immunology.

Lymphatic endothelium forms integrin-engaging 3D structures during DC transit across inflamed lymphatic vessels.

I. Melero, S. Valitutti, Á. Teijeira, 2013, The Journal of investigative dermatology.

CD8 T Cell Priming in the Presence of IFN-α Renders CTLs with Improved Responsiveness to Homeostatic Cytokines and Recall Antigens: Important Traits for Adoptive T Cell Therapy

H. Pircher, J. Prieto, I. Melero, 2012, The Journal of Immunology.

Influence of bevacizumab, sunitinib and sorafenib as single agents or in combination on the inhibitory effects of VEGF on human dendritic cell differentiation from monocytes

I. Melero, J. Pérez-Gracia, S. Hervás-Stubbs, 2009, British Journal of Cancer.

Anti-ICAM-2 monoclonal antibody synergizes with intratumor gene transfer of interleukin-12 inhibiting activation-induced T-cell death.

J. Prieto, C. Qian, I. Melero, 2003, Clinical cancer research : an official journal of the American Association for Cancer Research.

Activation-induced T-Cell Death Intratumor Gene Transfer of Interleukin-12 Inhibiting Anti-ICAM-2 Monoclonal Antibody Synergizes with

J. Prieto, C. Qian, I. Melero, 2003 .

Adoptive T Cell Therapy and Recall Antigens: Important Traits for Responsiveness to Homeostatic Cytokines Renders CTLs with Improved a CD8 T Cell Priming in the Presence of IFN-Ignacio

H. Pircher, J. Prieto, I. Melero, 2012 .

Interferon producing killer dendritic cells (IKDC): A matter of controversy

I. Melero, S. Hervás-Stubbs, Ivan Martinez Forero, 2010 .

Changes in serum IL8 levels reflect and predict response to anti-PD-1 treatment in melanoma and non-small cell lung cancer patients

R. Halaban, M. Sznol, I. Melero, 2016 .

Dendritic Cells Take up and Present Antigens from Viable and Apoptotic Polymorphonuclear Leukocytes

I. Melero, J. Pérez-Gracia, Álvaro González, 2011, PloS one.

Functional expression of CD137 (4-1BB) on T helper follicular cells

I. Melero, M. Rodriguez-Ruiz, J. Pérez-Gracia, 2015, Oncoimmunology.