D. Wright

发表

Towards the Ideal Synthesis

S. Handy, P. Wender, D. Wright, 1998 .

Antifolates as effective antimicrobial agents: new generations of trimethoprim analogs

A. Anderson, D. Wright, Wangda Zhou, 2013 .

Oxabicyclo[3.2.1]octane derivatives as highly reactive dienophiles: synthesis of bicyclo[5.n.0] systems.

R. Butcher, D. Wright, J. Jasinski, 2005, Organic letters.

Synthesis of versatile bicyclo[5.4.0]undecane systems from tetrachlorocyclopropene

K. Abboud, D. Wright, W. A. Batson, 2004 .

Chiral evasion and stereospecific antifolate resistance in Staphylococcus aureus

Marcel S. Frenkel, Graham T. Holt, B. Donald, 2020, bioRxiv.

Furans, thiophenes and related heterocycles in drug discovery.

Jeffrey B. Sperry, D. Wright, 2005, Current opinion in drug discovery & development.

MRSA Isolates from United States Hospitals Carry dfrG and dfrK Resistance Genes and Succumb to Propargyl-Linked Antifolates.

Amy C Anderson, A. Anderson, J. Aeschlimann, 2016, Cell chemical biology.

Toward Broad Spectrum DHFR inhibitors Targeting Trimethoprim Resistant Enzymes Identified in Clinical Isolates of Methicillin-Resistant Staphylococcus aureus

Marcel S. Frenkel, Graham T. Holt, B. Donald, 2019, bioRxiv.

Toward Broad Spectrum DHFR inhibitors Targeting Trimethoprim Resistant Enzymes Identified in Clinical Isolates of Methicillin-Resistant Staphylococcus aureus.

Marcel S. Frenkel, Graham T. Holt, B. Donald, 2019, ACS infectious diseases.

Structural and Biochemical Studies of Dihydrofolate Reductase from Streptococcus pyogenes as a Target for Antifolate Antibiotics

D. Wright, J. Krucinska, B. Hajian, 2018, bioRxiv.

Charged Nonclassical Antifolates with Activity Against Gram-Positive and Gram-Negative Pathogens.

N. Priestley, J. Alverson, A. Anderson, 2016, ACS medicinal chemistry letters.

A multi-component reaction (MCR) approach to the synthesis of highly diverse polymers with polypeptide-like features

K. Abboud, D. Wright, C. Robotham, 2004, Molecular Diversity.

Studies on the antiproliferative effects of tropolone derivatives in Jurkat T-lymphocyte cells.

A. Anderson, C. Giardina, D. Wright, 2014, Bioorganic & medicinal chemistry.

Drugging the Folate Pathway in Mycobacterium tuberculosis: The Role of Multi-targeting Agents.

H. Erlandsen, Jana Korduláková, Carolyn Shoen, 2019, Cell chemical biology.

Structure-guided development of efficacious antifungal agents targeting Candida glabrata dihydrofolate reductase.

N. Priestley, A. Anderson, D. Wright, 2008, Chemistry & biology.

High‐mobility‐group protein 2 regulated by microRNA‐127 and small heterodimer partner modulates pluripotency of mouse embryonic stem cells and liver tumor initiating cells

Yulan Zhao, Jianguo Wu, Raymond P. Wu, 2017, Hepatology communications.

Functional and structural basis of E. coli enolase inhibition by SF2312: a mimic of the carbanion intermediate

Eric R. May, V. Robinson, H. Erlandsen, 2019, Scientific Reports.

Elucidating features that drive the design of selective antifolates using crystal structures of human dihydrofolate reductase.

A. Anderson, D. Wright, K. Lamb, 2013, Biochemistry.

Antifolate agents: a patent review (2006 – 2010)

A. Anderson, D. Wright, 2011, Expert opinion on therapeutic patents.

Ring-opening metathesis polymerization with [2+2]-crosslinking to create new materials

D. Wright, E. Enholm, A. Joshi, 2004 .

Annulated heterocycles through a radical-cation cyclization: synthetic and mechanistic studies

Jeffrey B. Sperry, D. Wright, 2006 .

RECENT PROGRESS ON THE SYNTHESIS OF CYATHANE TYPE DITERPENES. A REVIEW

D. Wright, C. R. Whitehead, Christopher R. Whitehead, 2000 .

Structural and Functional Studies of Bacterial Enolase, a Potential Target against Gram-Negative Pathogens.

A. Anderson, V. Robinson, H. Erlandsen, 2019, Biochemistry.

The cycloaddition strategy for the synthesis of natural products containing carbocyclic seven-membered rings.

D. Wright, Phillip M. Pelphrey, M. Battiste, 2006, Chemistry.

Structure-Guided In Vitro to In Vivo Pharmacokinetic Optimization of Propargyl-Linked Antifolates

N. Priestley, J. Alverson, J. Hoody, 2019, Drug Metabolism and Disposition.

Photocurable hard and porous biomaterials from ROMP precursors cross-linked with diyl radicals.

D. Wright, E. Enholm, A. Joshi, 2005, Bioorganic & medicinal chemistry letters.

Cyclopropene cycloadditions with annulated furans: total synthesis of (+)- and (-)-frondosin B and (+)-frondosin A.

D. Wright, A. Wiemer, Michael D VanHeyst, 2014, Journal of the American Chemical Society.

Studies on the reactivity of CDDO, a promising new chemopreventive and chemotherapeutic agent: implications for a molecular mechanism of action.

M. Sporn, A. Anderson, T. Honda, 2005, Bioorganic & medicinal chemistry letters.

Tropolones as lead-like natural products: the development of potent and selective histone deacetylase inhibitors.

A. Anderson, D. Wright, Wangda Zhou, 2013, ACS medicinal chemistry letters.

Viral Nucleases from Herpesviruses and Coronavirus in Recombination and Proofreading: Potential Targets for Antiviral Drug Discovery

S. Weller, D. Wright, L. Wright, 2022, Viruses.

Oxabicyclic Building Blocks as Key Intermediates in the Synthesis of the Natural Products (−)-Platensimycin and (+)-Frondosin A

D. Wright, E. Z. Oblak, Michael D. Van Heyst, 2014 .

Highly substituted oxabicyclic derivatives from furan: synthesis of (±)-platensimycin.

D. Wright, E. Z. Oblak, E. Oblak, 2011, Organic letters.

Nonpeptidic lysosomal modulators derived from z-phe-ala-diazomethylketone for treating protein accumulation diseases.

B. Bahr, D. Wright, Kishore Viswanathan, 2012, ACS medicinal chemistry letters.

Toward isozyme-selective inhibitors of histone deacetylase as therapeutic agents for the treatment of cancer.

A. Anderson, D. Wright, S. Ononye, 2012, Pharmaceutical patent analyst.

Studies on the sequential multi-component coupling/Diels–Alder cycloaddition reaction

D. Wright, C. Robotham, Khalil Aboud, 2002 .

Tandem metathesis reactions of oxabicyclo[2.2.1]heptenes: studies on the spirocyclic core of cyclopamine.

D. Wright, N. G-Dayanandan, E. Z. Oblak, 2011, Organic letters.

Structure-guided functional studies of plasmid-encoded dihydrofolate reductases reveal a common mechanism of trimethoprim resistance in Gram-negative pathogens

H. Erlandsen, D. Wright, Debjani Si, 2022, Communications Biology.

Tropolone-induced effects on the unfolded protein response pathway and apoptosis in multiple myeloma cells are dependent on iron.

S. Holstein, D. Murry, D. Wright, 2019, Leukemia research.

Novel tropolones induce the unfolded protein response pathway and apoptosis in multiple myeloma cells

Cheryl L. Allen, Q. Hu, S. Holstein, 2017, Oncotarget.

Acetylenic Linkers in Lead Compounds: A Study of the Stability of the Propargyl-Linked Antifolates

A. Anderson, D. Hill, D. Wright, 2012, Drug Metabolism and Disposition.

Alternative oxidation on pyrimidinyl substructure / M 8 ‐ 3

A. Anderson, D. Hill, D. Wright, 2012 .

Post-Glycosylation Diversification (PGD): An Approach for Assembling Collections of Glycosylated Small Molecules.

V. Robinson, M. Peczuh, D. Wright, 2018, ACS combinatorial science.

Resolution of methyl nonactate by Rhodococcus erythropolis under aerobic and anaerobic conditions.

N. Priestley, D. Wright, S. Bergmeier, 2006, Organic letters.

Unusual influence of substituents on ring-opening metathesis reactions.

D. Wright, M. Estrella-Jimenez, L. C. Usher, 2001, Organic letters.

Antibacterial Antifolates: From Development through Resistance to the Next Generation.

A. Anderson, D. Wright, Alexavier Estrada, 2016, Cold Spring Harbor perspectives in medicine.

Crystal Structures of Trimethoprim-Resistant DfrA1 Rationalize Potent Inhibition by Propargyl-Linked Antifolates.

A. Anderson, D. Wright, M. N. Lombardo, 2016, ACS infectious diseases.

Crystal Structures of Klebsiella pneumoniae Dihydrofolate Reductase Bound to Propargyl-Linked Antifolates Reveal Features for Potency and Selectivity

N. Priestley, J. Alverson, A. Anderson, 2014, Antimicrobial Agents and Chemotherapy.

Nonracemic Antifolates Stereoselectively Recruit Alternate Cofactors and Overcome Resistance in S. aureus.

A. Anderson, D. Wright, S. Reeve, 2015, Journal of the American Chemical Society.

Prospective Screening of Novel Antibacterial Inhibitors of Dihydrofolate Reductase for Mutational Resistance

A. Anderson, K. Frey, D. Wright, 2012, Antimicrobial Agents and Chemotherapy.

Towards the understanding of resistance mechanisms in clinically isolated trimethoprim-resistant, methicillin-resistant Staphylococcus aureus dihydrofolate reductase.

A. Anderson, K. Frey, D. Wright, 2010, Journal of structural biology.

Crystal structures of wild-type and mutant methicillin-resistant Staphylococcus aureus dihydrofolate reductase reveal an alternate conformation of NADPH that may be linked to trimethoprim resistance.

A. Anderson, K. Frey, D. Wright, 2009, Journal of molecular biology.

Stereodivergent resolution of oxabicyclic ketones: preparation of key intermediates for platensimycin and other natural products.

D. Wright, Michael D VanHeyst, E. Z. Oblak, 2013, The Journal of organic chemistry.

The application of cathodic reductions and anodic oxidations in the synthesis of complex molecules.

Jeffrey B. Sperry, D. Wright, Jeffrey B Sperry, 2006, Chemical Society reviews.

The Frondosins: An Unusual Synthetic and Stereochemical Journey

D. Wright, Michael D VanHeyst, 2015 .

Studies on inducers of nerve growth factor: synthesis of the cyathin core.

I. Ghiviriga, D. Wright, D. Frey, 1999, Organic letters.

Furan as a Versatile Synthon.

D. Wright, 2002 .

A METALLOCARBENOID APPROACH TO THE FORMATION OF SPIROCYCLIC AMMONIUM YLIDES LEADING TO THE PREPARATION OF MEDIUM-SIZED AZACANE RINGS

D. Wright, M. McMills, R. Weekly, 1996 .

Electrooxidative coupling of furans and silyl enol ethers: application to the synthesis of annulated furans.

Jeffrey B. Sperry, I. Ghiviriga, R. M. Walczak, 2004, The Journal of organic chemistry.

Chapter 1 – Furans as versatile synthons for target-oriented and diversity-oriented synthesis

D. Wright, 2005 .

1‐Methoxy‐1‐(trimethylsilyloxy)propene

P. Wipf, D. Wright, M. McMills, 2001 .

Towards New Antifolates Targeting Eukaryotic Opportunistic Infections

Erin S. Bolstad, A. Anderson, D. Wright, 2009, Eukaryotic Cell.

Dihydrofolate reductase inhibitors: developments in antiparasitic chemotherapy

Erin S. Bolstad, A. Anderson, D. Wright, 2008, Expert opinion on therapeutic patents.

Highly efficient ligands for dihydrofolate reductase from Cryptosporidium hominis and Toxoplasma gondii inspired by structural analysis.

Erin S. Bolstad, A. Anderson, J. Beierlein, 2007, Journal of medicinal chemistry.

A CARBONYL-YLIDE APPROACH TO THE TIGLIANE DITERPENES

W. Watt, D. Wright, L. Zhuang, 1994 .

Direct Substitution of Arylalkynyl Carbinols Provides Access to Diverse Terminal Acetylene Building Blocks.

A. Anderson, D. Wright, Eric Scocchera, 2017, Organic letters.

Facile generation of aziridines from the reaction of α-diazoamides with tethered oximino-ethers

D. Wright, E. Valente, J. Zubkowski, 1996 .

Selective inhibitor of proteasome's caspase-like sites sensitizes cells to specific inhibition of chymotrypsin-like sites.

Matthew Britton, Martijn Verdoes, H. Overkleeft, 2009, Chemistry & biology.

Intramolecular Aziridination: Decomposition of Diazoamides with Tethered Imino Bonds

D. Wright, M. McMills, 1999 .

An imine addition/ring-closing metathesis approach to the spirocyclic core of halichlorine and pinnaic acid.

D. Wright, J. P. Schulte II, M. Page, 2000, Organic letters.

Halogenated Oxabicyclo[3.2.1]octadiene Building Blocks: Elaboration of the Dibromoenone

D. Wright, Richard J. Helmich, Phillip M. Pelphrey, 2005 .

New chiral building blocks from tetrabromocyclopropene and furan.

K. Abboud, D. Wright, Phillip M. Pelphrey, 2004, The Journal of organic chemistry.

Bridged synthons from tetrabromocyclopropene: studies on the rearrangement of the primary Diels-Alder adduct with 2,5-dimethylfuran.

K. Abboud, I. Ghiviriga, D. Wright, 2004, The Journal of organic chemistry.

Silver-promoted reactions of bicyclo[3.2.1]octadiene derivatives.

K. Abboud, D. Wright, M. Battiste, 2002, Organic letters.

An imine addition/ring-closing metathesis approach to the spirocyclic core of halichlorine and pinnaic acid.

D. Wright, J. P. Schulte II, M. Page, 2000, Organic letters.

Silver(I) Oxide

D. Wright, A. Demchenko, Phillip M. Pelphrey, 2015 .

Analysis of complexes of inhibitors with Cryptosporidium hominis DHFR leads to a new trimethoprim derivative.

A. Anderson, D. Wright, Y. Fillingham, 2006, Bioorganic & medicinal chemistry letters.

The Application of Cathodic Reductions and Anodic Oxidations in the Synthesis of Complex Molecules

Jeffrey B. Sperry, D. Wright, 2006 .

Electrochemical annulation of five-membered rings through dearomatization of furans and thiophenes.

Jeffrey B. Sperry, I. Ghiviriga, D. Wright, 2006, Chemical communications.

Studies on the Diels-Alder reaction of annulated furans : application to the synthesis of substituted phenanthrenes

Jeffrey B. Sperry, R. Butcher, D. Wright, 2005 .

Two-step electrochemical annulation for the assembly of polycyclic systems.

I. Ghiviriga, D. Wright, C. R. Whitehead, 2002, Organic letters.

Bicyclo[3.2.1]octane synthons from cyclopropenes: functionalization of cycloadducts by nucleophilic additions.

K. Abboud, D. Wright, Richard J. Helmich, 2004, The Journal of organic chemistry.

The Tandem Ring Opening/Ring Closing Metathesis Route to Oxaspirocycles: An Approach to Phelligridin G

D. Wright, Harold D. Cooper, 2013, Molecules.

Measuring propargyl-linked drug populations inside bacterial cells, and their interaction with a dihydrofolate reductase target, by Raman microscopy.

A. Anderson, T. Che, P. Carey, 2015, Biochemistry.

Targeting the pregnane X receptor using microbial metabolite mimicry

S. Vishveshwara, S. Kortagere, M. Redinbo, 2019, bioRxiv.

Antifolate agents: a patent review (2010 – 2013)

A. Anderson, D. Wright, 2014, Expert opinion on therapeutic patents.

Viridin analogs derived from steroidal building blocks.

A. Anderson, D. Wright, Kishore Viswanathan, 2012, Bioorganic & medicinal chemistry letters.

The gem‐Dialkyl Effect in Electron Transfer Reactions: Rapid Synthesis of Seven‐Membered Rings Through an Electrochemical Annulation.

Jeffrey B. Sperry, D. Wright, 2005 .

The gem-dialkyl effect in electron transfer reactions: rapid synthesis of seven-membered rings through an electrochemical annulation.

Jeffrey B. Sperry, D. Wright, 2005, Journal of the American Chemical Society.

Novel guanidine compounds inhibit platelet‐derived growth factor receptor alpha transcription and oligodendrocyte precursor cell proliferation

A. Nishiyama, W. Wood, D. Wright, 2020, Glia.

Synthetic and computational studies on liphagal: a natural product inhibitor of PI-3K

Erin S. Bolstad, A. Anderson, R. Butcher, 2010 .

Inhibitors of phosphoinositide-3-kinase: a structure-based approach to understanding potency and selectivity.

Amy C Anderson, A. Anderson, D. Wright, 2009, Organic & biomolecular chemistry.

The furan route to tropolones: probing the antiproliferative effects of β-thujaplicin analogs.

Erin S. Bolstad, N. Priestley, D. Wright, 2012, Organic & biomolecular chemistry.

The Exonuclease Activity of Herpes Simplex Virus 1 UL12 Is Required for Production of Viral DNA That Can Be Packaged To Produce Infectious Virus

R. Szczepaniak, S. L. Le Grice, S. Weller, 2017, Journal of Virology.

Structural analysis of the active sites of dihydrofolate reductase from two species of Candida uncovers ligand-induced conformational changes shared among species.

A. Anderson, D. Wright, J. Paulsen, 2013, Bioorganic & medicinal chemistry letters.

Probing the Active Site of Candida glabrata Dihydrofolate Reductase with High Resolution Crystal Structures and the Synthesis of New Inhibitors

N. Priestley, A. Anderson, D. Wright, 2009, Chemical biology & drug design.

Natural products in parallel synthesis: triazole libraries of nonactic acid.

N. Priestley, Sarah Luesse, D. Wright, 2008, Bioorganic & medicinal chemistry letters.

Oxabicyclo[3.2.1]octane derivatives as highly reactive dienophiles: synthesis of bicyclo[5.n.0] systems.

R. Butcher, D. Wright, J. Jasinski, 2005, Organic letters.

Identification of novel compounds that enhance colon cancer cell sensitivity to inflammatory apoptotic ligands

C. Giardina, A. Chopra, D. Wright, 2013, Cancer biology & therapy.

Two-Metal Ion-Dependent Enzymes as Potential Antiviral Targets in Human Herpesviruses

R. Szczepaniak, S. Weller, D. Wright, 2022, mBio.

Spindle Assembly Disruption and Cancer Cell Apoptosis with a CLTC-Binding Compound

C. Giardina, D. Rosenberg, M. Nakanishi, 2018, Molecular Cancer Research.

Toward New Therapeutics for Skin and Soft Tissue Infections: Propargyl-Linked Antifolates Are Potent Inhibitors of MRSA and Streptococcus pyogenes

N. Priestley, J. Alverson, A. Anderson, 2012, PloS one.

USP7-Specific Inhibitors Target and Modify the Enzyme's Active Site via Distinct Chemical Mechanisms.

D. Sterner, K. G. S. Kumar, P. Nguyen, 2017, Cell chemical biology.

Effect of temperature on linolenic acid loss and 18:3 Δ9-cis, Δ12-cis, Δ15-trans formation in soybean oil

S. O'keefe, V. Wiley, D. Wright, 1993 .

Synthetic and crystallographic studies of a new inhibitor series targeting Bacillus anthracis dihydrofolate reductase.

N. Priestley, A. Anderson, J. Beierlein, 2008, Journal of medicinal chemistry.

Development of intestinal organoids as tissue surrogates: Cell composition and the Epigenetic control of differentiation

Charles Giardina, C. Giardina, C. Nelson, 2015, Molecular carcinogenesis.

Altered specificity of Hint-W123Q supports a role for Hint inhibition by ASW in avian sex determination.

Jeffrey B. Sperry, C. Brenner, K. Howitz, 2004, Physiological genomics.

Hint inhibition by ASW in avian sex determination Altered specificity of Hint-W 123 Q supports a role for

Jeffrey B. Sperry, C. Brenner, K. Howitz, 2004 .

Charged Propargyl-Linked Antifolates Reveal Mechanisms of Antifolate Resistance and Inhibit Trimethoprim-Resistant MRSA Strains Possessing Clinically Relevant Mutations.

A. Anderson, D. Wright, Eric Scocchera, 2016, Journal of medicinal chemistry.

Incorporation of 53BP1 into phase-separated bodies in cancer cells during aberrant mitosis.

C. Giardina, D. Wright, Marina Bleiler, 2023, Journal of cell science.

Propargyl-Linked Antifolates are Dual Inhibitors of Candida albicans and Candida glabrata

N. Priestley, J. Alverson, A. Anderson, 2014, Journal of medicinal chemistry.

In vitro biological activity and structural analysis of 2,4-diamino-5-(2'-arylpropargyl)pyrimidine inhibitors of Candida albicans.

N. Priestley, A. Anderson, D. Wright, 2009, Bioorganic & medicinal chemistry.

Lithium Chloride–Hexamethylphosphoric Triamide

D. Wright, M. McMills, 2001 .

Propargyl-Linked Antifolates Are Potent Inhibitors of Drug-Sensitive and Drug-Resistant Mycobacterium tuberculosis

A. Anderson, Carolyn Shoen, M. Cynamon, 2016, PloS one.

Novel α-substituted tropolones promote potent and selective caspase-dependent leukemia cell apoptosis.

A. Anderson, S. Holstein, D. Wright, 2016, Pharmacological research.

Structure-based approach to the development of potent and selective inhibitors of dihydrofolate reductase from cryptosporidium.

Erin S. Bolstad, A. Anderson, K. Frey, 2008, Journal of medicinal chemistry.

The Role of Organic Synthesis in the Generation of Molecular Diversity

D. Wright, C. Robotham, Ravi S. Orugunty, 2003 .

Mapping Phorbol Ester Binding Domains of Protein Kinase C (PKC): The Design, Synthesis and Biological Activity of Novel Phorbol Ester Dimers

K. Irie, P. Wender, M. Koehler, 1999 .

SYNTHESIS OF HIGHLY FUNCTIONALIZED ARENE SYSTEMS. NOVEL SELECTIVITIES OF INTRA- AND INTERMOLECULAR FRIEDEL–CRAFTS REACTIONS

D. Wright, M. McMills, R. Matt Weekly, 2002 .

Z-Phe-Ala-diazomethylketone (PADK) Disrupts and Remodels Early Oligomer States of the Alzheimer Disease Aβ42 Protein*

B. Bahr, M. Bowers, Xueyun Zheng, 2012, The Journal of Biological Chemistry.

Pharmaceutical analysis of a novel propargyl-linked antifolate antibiotic in the mouse.

N. Priestley, J. Alverson, J. Hoody, 2017, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

In vitro biological activity and structural analysis of 2,4-diamino-5-(2'-arylpropargyl)pyrimidine inhibitors of Candida albicans.

N. Priestley, A. Anderson, D. Wright, 2009, Bioorganic & medicinal chemistry.

Towards New Antifolates Targeting Eukaryotic Opportunistic Infections

Erin S. Bolstad, A. Anderson, D. Wright, 2009, Eukaryotic Cell.

Structure‐based approach to pharmacophore identification, in silico screening, and three‐dimensional quantitative structure–activity relationship studies for inhibitors of Trypanosoma cruzi dihydrofolate reductase function

A. Anderson, N. Schormann, D. Chattopadhyay, 2008, Proteins.

Synthesis of functionalized pyrans by domino metathesis reaction of oxabicyclo derivatives: dramatic effect of remote substituents on reactivity and selectivity.

I. Ghiviriga, D. Wright, M. Estrella-Jimenez, 2002, Angewandte Chemie.

Studies on the Sequential Multi-Component Coupling/ Diels—Alder Cycloaddition Reaction.

D. Wright, C. Robotham, Khalil Aboud, 2002 .