E. Dawson

发表

Discovery of 2‐(2‐Benzoxazoyl amino)‐4‐Aryl‐5‐Cyanopyrimidine as Negative Allosteric Modulators (NAMs) of Metabotropic Glutamate Receptor 5 (mGlu5): From an Artificial Neural Network Virtual Screen to an In Vivo Tool Compound

Jens Meiler, Andrew S. Felts, Brittney S. Bates, 2012, ChemMedChem.

Structural determinants of species‐selective substrate recognition in human and Drosophila serotonin transporters revealed through computational docking studies

R. Blakely, J. Meiler, J. Field, 2009, Proteins.

Optimized Translocator Protein Ligand for Optical Molecular Imaging and Screening.

J. Smith, A. Fu, Jarrod A. Smith, 2017, Bioconjugate chemistry.

Streptomyces coelicolor A3(2) CYP102 Protein, a Novel Fatty Acid Hydroxylase Encoded as a Heme Domain without an N-Terminal Redox Partner

S. Kelly, D. Lamb, M. Waterman, 2010, Applied and Environmental Microbiology.

Discovery of a new molecular probe ML228: an activator of the hypoxia inducible factor (HIF) pathway.

Julie L. Engers, Andrew S. Felts, Brittney S. Bates, 2012, Bioorganic & medicinal chemistry letters.

Inhibition of protein phosphatase 2A activity by selective electrophile alkylation damage.

D. Liebler, B. Wadzinski, S. Codreanu, 2006, Biochemistry.

Discovery and development of a second highly selective M1 Positive Allosteric Modulator (PAM)

C. Lindsley, C. Weaver, E. Dawson, 2010 .

Extended Probe Characterization: Development of an M4 PAM with Improved Activity and Brain Exposure, while Avoiding Species Bias

Julie L. Engers, Bruce J. Melancon, D. Sheffler, 2013 .

Development of a Selective Small-Molecule Inhibitor of Kir1.1, the Renal Outer Medullary Potassium Channel

Brian A. Chauder, J. Meiler, C. Lindsley, 2011, Molecular Pharmacology.

Novel benzodiazepine photoaffinity probe stereoselectively labels a site deep within the membrane-spanning domain of the cholecystokinin receptor.

T. Lybrand, L. Miller, E. Hadac, 2006, Journal of medicinal chemistry.

2-Substituted Nγ-glutamylanilides as novel probes of ASCT2 with improved potency.

E. Dawson, H. Manning, Michael L. Schulte, 2015, Bioorganic & medicinal chemistry letters.

Discovery and SAR of a novel series of non-MPEP site mGlu₅ PAMs based on an aryl glycine sulfonamide scaffold.

G. Macdonald, H. Lavreysen, C. Lindsley, 2012, Bioorganic & medicinal chemistry letters.

Iterative experimental and virtual high-throughput screening identifies metabotropic glutamate receptor subtype 4 positive allosteric modulators

Jens Meiler, Mariusz Butkiewicz, Ralf Mueller, 2012, Journal of Molecular Modeling.

Identification of Metabotropic Glutamate Receptor Subtype 5 Potentiators Using Virtual High-Throughput Screening

Jens Meiler, C. David Weaver, P. Jeffrey Conn, 2010, ACS chemical neuroscience.

Discovery of N-(benzo[1,2,3]triazol-1-yl)-N-(benzyl)acetamido)phenyl) carboxamides as severe acute respiratory syndrome coronavirus (SARS-CoV) 3CLpro inhibitors: Identification of ML300 and noncovalent nanomolar inhibitors with an induced-fit binding

C. Lindsley, A. Mesecar, P. Hodder, 2013, Bioorganic & Medicinal Chemistry Letters.

The Discovery and Characterization of ML218: A Novel, Centrally Active T-Type Calcium Channel Inhibitor with Robust Effects in STN Neurons and in a Rodent Model of Parkinson's Disease.

Bruce J. Melancon, Z. Xiang, O. McManus, 2011, ACS chemical neuroscience.

Evaluation of the biosynthetic proposal for the synthesis of marineosins A and B.

C. Lindsley, E. Dawson, L. Aldrich, 2010, Organic letters.

Moleular models for cholecystokinin-A receptor.

T. Lybrand, L. Miller, E. Dawson, 2002, Pharmacology & toxicology.

X-ray Structure of the Water Soluble [Adeninium]-[p-Sulfonatocalix[4]arene] which Displays Cationic and Anionic Bilayers

J. Atwood, L. Barbour, P. Junk, 1996 .

Application of machine learning approaches on quantitative structure activity relationships

Jens Meiler, Eric Dawson, Mariusz Butkiewicz, 2009, CIBCB.

SecA alone can Promote Protein Translocation and Ion-Channel Activity: SecYEG Increases Efficiency and Specificity

R. Farid, S. Noskov, G. Erdemli, 2012 .

A model for the solution structure of the rod arrestin tetramer.

J. Meiler, W. Hubbell, V. Gurevich, 2008, Structure.

Discovery, synthesis, and structure-based optimization of a series of N-(tert-butyl)-2-(N-arylamido)-2-(pyridin-3-yl) acetamides (ML188) as potent noncovalent small molecule inhibitors of the severe acute respiratory syndrome coronavirus (SARS-CoV) 3CL protease.

C. Lindsley, A. Mesecar, P. Hodder, 2013, Journal of medicinal chemistry.

Selective inhibition of the K(ir)2 family of inward rectifier potassium channels by a small molecule probe: the discovery, SAR, and pharmacological characterization of ML133.

O. McManus, C. Lindsley, Haibo Yu, 2011, ACS chemical biology.

Discovery and characterization of novel subtype-selective allosteric agonists for the investigation of M(1) receptor function in the central nervous system.

S. Jadhav, J. Meiler, Z. Xiang, 2010, ACS chemical neuroscience.

Discovery and characterization of novel subtype-selective allosteric agonists for the investigation of M(1) receptor function in the central nervous system.

S. Jadhav, J. Meiler, Z. Xiang, 2010, ACS chemical neuroscience.

An Overview of the Challenges in Designing, Integrating, and Delivering BARD

Tudor I. Oprea, Noel Southall, Stephan C Schürer, 2014, Journal of biomolecular screening.

A Peptide-Based Positron Emission Tomography Probe for In Vivo Detection of Caspase Activity in Apoptotic Cells

M. Washington, R. Coffey, Dewei Tang, 2014, Clinical Cancer Research.

Determination of amino acid residues that are accessible from the ligand binding crevice in the seventh transmembrane-spanning region of the human A(1) adenosine receptor.

E. Dawson, J. N. Wells, 2001, Molecular pharmacology.

A model for glutathione binding and activation in the fosfomycin resistance protein, FosA.

Rachel E Rigsby, T. Lybrand, R. Armstrong, 2007, Archives of biochemistry and biophysics.

Measurement of intermolecular distances for the natural agonist Peptide docked at the cholecystokinin receptor expressed in situ using fluorescence resonance energy transfer.

T. Lybrand, L. Miller, K. Harikumar, 2004, Molecular pharmacology.

Discovery of a Small Molecule Activator of the Hypoxia Inducible Factor Pathway

Julie L. Engers, Andrew S. Felts, Brittney S. Bates, 2013 .

Community-wide assessment of GPCR structure modelling and ligand docking: GPCR Dock 2008

Charles L. Brooks, Adrian W. R. Serohijos, John Moult, 2009, Nature Reviews Drug Discovery.

Discovery and development of the a highly selective M1 Positive Allosteric Modulator (PAM)

C. Lindsley, C. Weaver, E. Dawson, 2010 .

A potent and selective small molecule Kir2.1 inhibitor

O. McManus, C. Lindsley, Meng Wu, 2010 .

Development of the First Selective mGlu3 NAM from an mGlu5 PAM Hit

Julie L. Engers, Joshua A. Brunner, Anna L. Blobaum, 2013 .

A Conserved Asparagine Residue in Transmembrane Segment 1 (TM1) of Serotonin Transporter Dictates Chloride-coupled Neurotransmitter Transport*

R. Blakely, J. Meiler, L. DeFelice, 2011, The Journal of Biological Chemistry.