P. Erbel

发表

19F NMR chemical shift prediction with fluorine fingerprint descriptor

Anna Vulpetti, Gregory A. Landrum, Claudio Dalvit, 2010 .

Discovery of Potent, Highly Selective, and In Vivo Efficacious, Allosteric MALT1 Inhibitors by Iterative Scaffold Morphing.

A. Schuffenhauer, E. Altmann, G. Bold, 2020, Journal of medicinal chemistry.

Fragment-Based Screening by Biochemical Assays

Pascal Rigollier, U. Hassiepen, D. Vinzenz, 2010, Journal of biomolecular screening.

Structure elucidation of glycoprotein glycans and of polysaccharides by NMR spectroscopy.

J. Vliegenthart, B. R. Leeflang, P. Erbel, 2000, Journal of biotechnology.

Azaindoles as Zinc-Binding Small-Molecule Inhibitors of the JAMM Protease CSN5.

E. Altmann, U. Hassiepen, M. Renatus, 2017, Angewandte Chemie.

Structure-Based Library Design and Fragment Screening for the Identification of Reversible Complement Factor D Protease Inhibitors.

N. Ostermann, A. Vulpetti, B. Gerhartz, 2017, Journal of medicinal chemistry.

An allosteric MALT1 inhibitor is a molecular corrector rescuing function in an immunodeficient patient

R. Hersperger, C. Overall, M. Renatus, 2019, Nature Chemical Biology.

Discovery and Design of First Benzylamine-Based Ligands Binding to an Unlocked Conformation of the Complement Factor D.

N. Ostermann, A. Vulpetti, A. Mac Sweeney, 2018, ACS medicinal chemistry letters.

Solution structure of the a-subunit of human chorionic gonadotropin

R. Boelens, J. Kamerling, J. Vliegenthart, 1999 .

Optimization of the In Vivo Potency of Pyrazolopyrimidine MALT1 Protease Inhibitors by Reducing Metabolism and Increasing Potency in Whole Blood.

M. Renatus, M. Wartmann, S. Melkko, 2020, Journal of medicinal chemistry.

Stabilizing Inactive Conformations of MALT1 as an Effective Approach to Inhibit Its Protease Activity

M. Renatus, C. Wiesmann, F. Villard, 2020 .

Structure-based design and optimization of potent inhibitors of the adenoviral protease.

E. Altmann, A. Bernardi, F. Sirockin, 2015, Bioorganic & medicinal chemistry letters.

Small-molecule factor D inhibitors targeting the alternative complement pathway.

N. Ostermann, C. Durand, A. Vulpetti, 2016, Nature chemical biology.

Pharmacological inhibition of IKKβ dampens NLRP3 inflammasome activation after priming in the human myeloid cell line THP-1.

J. Eder, P. Erbel, A. Schlapbach, 2021, Biochemical and biophysical research communications.

Possible role of a short extra loop of the long-chain flavodoxin from Azotobacter chroococcum in electron transfer to nitrogenase: Complete 1H, 15N and 13C backbone assignments and secondary solution structure of the flavodoxin

S. Wijmenga, J. Vervoort, R. Robson, 1996, Journal of biomolecular NMR.

Discovery and structure-based optimization of adenain inhibitors.

E. Altmann, A. Bernardi, F. Sirockin, 2014, ACS medicinal chemistry letters.

Studies on the relevance of the glycan at Asn-52 of the α-subunit of human chorionic gonadotropin in the αβ dimer

J. Kamerling, J. Vliegenthart, P. Erbel, 2002 .

Effects of the N-linked glycans on the 3D structure of the free alpha-subunit of human chorionic gonadotropin.

J F Vliegenthart, J A van Kuik, R. Boelens, 2000, Biochemistry.

Solution structure of the alpha-subunit of human chorionic gonadotropin.

R. Boelens, J. Kamerling, J. Vliegenthart, 2000, European journal of biochemistry.

Structural basis for the activation of flaviviral NS3 proteases from dengue and West Nile virus

Zheng Yin, Ulrich Hommel, A. D'arcy, 2006, Nature Structural &Molecular Biology.

Structural determinants of MALT1 protease activity.

A. D'arcy, A. Bernardi, M. Renatus, 2012, Journal of molecular biology.

Structural basis of ARNT PAS-B dimerization: use of a common beta-sheet interface for hetero- and homodimerization.

K. Gardner, Kevin H Gardner, P. Erbel, 2005, Journal of molecular biology.

Mechanism of substrate specificity in Bacillus subtilis ResA, a thioredoxin-like protein involved in cytochrome c maturation.

J. Deisenhofer, K. Gardner, P. Erbel, 2006, Proceedings of the National Academy of Sciences of the United States of America.

Discovery of 4-((2S,4S)-4-Ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl)benzoic Acid (LNP023), a Factor B Inhibitor Specifically Designed To Be Applicable to Treating a Diverse Array of Complement Mediated Diseases.

Thomas M. Smith, N. Gradoux, Jian Ding, 2020, Journal of medicinal chemistry.

Crystal structure of NLRP3 NACHT domain with an inhibitor defines mechanism of inflammasome inhibition.

N. Stiefl, C. Dekker, J. Eder, 2021, Journal of molecular biology.

Functions of the Per/ARNT/Sim Domains of the Hypoxia-inducible Factor*

Lei Zhang, Kan Ding, K. Gardner, 2005, Journal of Biological Chemistry.

N-aryl-piperidine-4-carboxamides as a novel class of potent inhibitors of MALT1 proteolytic activity.

A. Schuffenhauer, M. Renatus, M. Wartmann, 2018, Bioorganic & medicinal chemistry letters.

Small-molecule factor B inhibitor for the treatment of complement-mediated diseases

Thomas M. Smith, F. Sirockin, B. Gerhartz, 2019, Proceedings of the National Academy of Sciences.

Structural basis for PAS domain heterodimerization in the basic helix–loop–helix-PAS transcription factor hypoxia-inducible factor

K. Gardner, R. Bruick, Kevin H Gardner, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Conformational analysis of the Sda determinant-containing tetrasaccharide and two mimics in aqueous solution by using 1H NMR ROESY spectroscopy in combination with MD simulations

J. Blanco, J. Vliegenthart, J. Kamerling, 2000, Journal of biomolecular NMR.

Identification and Biosynthesis of Cyclic Enterobacterial Common Antigen in Escherichia coli

K. Gardner, G. Gerwig, K. Barr, 2003, Journal of bacteriology.

Purification and crystallization of dengue and West Nile virus NS2B-NS3 complexes.

A. D'arcy, S. Lim, F. Villard, 2006, Acta crystallographica. Section F, Structural biology and crystallization communications.

Structural basis for the substrate specificity of bone morphogenetic protein 1/tolloid-like metalloproteases.

A. Bernardi, B. Gerhartz, D. Vinzenz, 2008, Journal of molecular biology.