K. Miller

发表

A novel cereblon modulator recruits GSPT1 to the CRL4CRBN ubiquitin ligase

Chin-Chun Lu, H. Handa, G. Lander, 2016, Nature.

Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomide

S. Karasawa, H. Handa, A. Lopez-Girona, 2012, Leukemia.

Structure of the human Cereblon–DDB1–lenalidomide complex reveals basis for responsiveness to thalidomide analogs

H. Handa, Y. Hirano, T. Hakoshima, 2014, Nature Structural &Molecular Biology.

Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomide

S. Karasawa, H. Handa, R. Chopra, 2012, Leukemia.

Pomalidomide in combination with dexamethasone results in synergistic anti‐tumour responses in pre‐clinical models of lenalidomide‐resistant multiple myeloma

R. Orlowski, R. Chopra, B. Cathers, 2016, British journal of haematology.

95 Inhibition of AKT signaling during expansion of TCR-engineered T-cells from patient leukocyte material generates SPEAR T-cells with enhanced functional potential in vitro

M. Dudley, J. Silk, K. Miller, 2020, Journal for ImmunoTherapy of Cancer.

Detection and Quantification of Cereblon Protein and mRNA in Multiple Myeloma Cell Lines and Primary CD138+multiple Myeloma Cells

H. Avet-Loiseau, R. Chopra, B. Cathers, 2012 .

379 Initial safety, efficacy, and product attributes from the SURPASS trial with ADP-A2M4CD8, a SPEAR T-cell therapy incorporating an affinity optimized TCR targeting MAGE-A4 and a CD8α co-receptor

D. Hong, P. Fracasso, S. Saibil, 2020 .

Measuring cereblon as a biomarker of response or resistance to lenalidomide and pomalidomide requires use of standardized reagents and understanding of gene complexity

R. Chopra, B. Cathers, P. Schafer, 2013, British journal of haematology.

A Dual Color Immunohistochemistry Assay for Measurement of Cereblon in Multiple Myeloma Patient Samples

D. Hansel, R. Chopra, C. Bjorklund, 2016, Applied immunohistochemistry & molecular morphology : AIMM.