P. James

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The procoagulant effects of extracellular vesicles derived from hypoxic endothelial cells can be selectively inhibited by inorganic nitrite.

Cass Whelan, Nicholas Burnley-Hall, K. Morris, 2022, Nitric oxide : biology and chemistry.

Simultaneous detection of pO2 and NO by electron paramagnetic resonance.

H. Swartz, P. James, 2002, Methods in enzymology.

Determining the anatomic position and histological effects in murine tumors of gloxy, an oxygen-sensitive paramagnetic material.

J. Dunn, J. O’Hara, H. Swartz, 1997, Advances in experimental medicine and biology.

The effects of endotoxin on oxygen consumption of various cell types in vitro: an EPR oximetry study.

S. Jackson, H. Swartz, P. James, 1995, Free radical biology & medicine.

Nitrate pharmacokinetics: Taking note of the difference.

Jason D. Allen, Andrew M. Jones, P. Winyard, 2015, Nitric oxide : biology and chemistry.

Low-dose sodium nitrite vasodilates hypoxic human pulmonary vasculature by a means that is not dependent on a simultaneous elevation in plasma nitrite.

A. Fraser, D. Bailey, P. James, 2010, American journal of physiology. Heart and circulatory physiology.

Young women with polycystic ovary syndrome have raised levels of circulating annexin V-positive platelet microparticles.

K. Ladell, A. Clayton, I. Guschina, 2014, Human reproduction.

Detection of angiotensin II mediated nitric oxide release within the nucleus of the solitary tract using electron-paramagnetic resonance (EPR) spectroscopy

J. Deuchars, J. Paton, S. Kasparov, 2006, Autonomic Neuroscience.

Antibacterial peptide PR-39 affects local nitric oxide and preserves tissue oxygenation in the liver during septic shock.

S. Jackson, C. Ross, H. Swartz, 2002, Biochimica et biophysica acta.

Sport-Specific Physiological Adaptations in Highly Trained Endurance Athletes.

T. Karlsen, Ø. Sandbakk, A. Tjønna, 2015, Medicine and science in sports and exercise.

Inflammatory adipocyte-derived extracellular vesicles promote leukocyte attachment to vascular endothelial cells.

D. Rees, P. James, D. Mathew, 2019, Atherosclerosis.

Nitrite-derived nitric oxide reduces hypoxia-inducible factor 1α-mediated extracellular vesicle production by endothelial cells.

G. Willis, Nicholas Burnley-Hall, D. Rees, 2017, Nitric oxide : biology and chemistry.

Pollen generates nitric oxide and nitrite: a possible link to pollen-induced allergic responses.

J. Hancock, S. Hiscock, P. James, 2009, Plant physiology and biochemistry : PPB.

Nitric oxide and nitrite are likely mediators of pollen interactions

J. Hancock, I. Wilson, S. Hiscock, 2009, Plant signaling & behavior.

Lipoprotein-apheresis reduces circulating microparticles in individuals with familial hypercholesterolemia[S]

K. Ladell, I. Guschina, G. Willis, 2014, Journal of Lipid Research.

Hypoxic Modulation of Exogenous Nitrite-Induced Vasodilation in Humans

Rebekah A. Weaver, M. Frenneaux, P. James, 2008, Circulation.

The effects of dietary nitrate supplementation on the adaptations to sprint interval training in previously untrained males.

N. Sculthorpe, C. Easton, P. James, 2017, Journal of science and medicine in sport.

Direct formation of thienopyridine-derived nitrosothiols--just add nitrite!

Richard A Anderson, P. James, Nurudeen Hassan, 2011, European journal of pharmacology.

Evidence for Adipocyte-Derived Extracellular Vesicles in the Human Circulation

D. Rees, P. James, Errin Johnson, 2018, Endocrinology.

Intrarenal pO2 measured by EPR oximetry and the effects of bacterial endotoxin.

H. Swartz, P. James, O. Grinberg, 1997, Advances in experimental medicine and biology.

Detailed characterisation of circulatory nitric oxide and free radical indices—is there evidence for abnormal cardiovascular homeostasis in young women with polycystic ovary syndrome?

M. Udiawar, G. Willis, D. Rees, 2014, BJOG : an international journal of obstetrics and gynaecology.

Changes in platelet function independent of pharmacotherapy following coronary intervention in non-ST-elevation myocardial infarction patients.

V. O’Donnell, T. Kinnaird, Richard A Anderson, 2015, Atherosclerosis.

A new mechanism of action of thienopyridine antiplatelet drugs - a role for gastric nitrosthiol metabolism?

R. A. Anderson, P. James, S. Bundhoo, 2014, Atherosclerosis.

womenand endurance exercise-trained men and receptors mediate postexercise hyperemia in

M. Ely, Dylan C. Sieck, S. Romero, 2015 .

The effects of a single dose of concentrated beetroot juice on performance in trained flatwater kayakers.

C. Pedlar, C. Easton, P. James, 2013, International journal of sport nutrition and exercise metabolism.

High‐altitude pulmonary hypertension is associated with a free radical‐mediated reduction in pulmonary nitric oxide bioavailability

I. Young, D. Bailey, E. Swenson, 2010, The Journal of physiology.

Ras-induced reactive oxygen species promote growth factor-independent proliferation in human CD34+ hematopoietic progenitor cells.

A. Burnett, P. James, R. Darley, 2010, Blood.

A single dose of beetroot juice enhances cycling performance in simulated altitude.

C. Pedlar, C. Easton, P. James, 2014, Medicine and science in sports and exercise.

Bariatric Surgery Is Accompanied by Changes in Extracellular Vesicle-Associated and Plasma Fatty Acid Binding Protein 4

J. Stephens, P. James, J. Witczak, 2018, Obesity Surgery.

Clopidogrel results in favourable changes in nitric oxide metabolism in patients undergoing percutaneous coronary intervention.

Richard A Anderson, P. James, S. Bundhoo, 2013, Thrombosis and haemostasis.

Blood vessel specific vaso-activity to nitrite under normoxic and hypoxic conditions.

P. James, Dewi E. Thomas, A. Milsom, 2009, Advances in experimental medicine and biology.

Dietary nitrate improved exercise capacity in COPD but not blood pressure or pulmonary function: a 2 week, double-blind randomised, placebo-controlled crossover trial

J. Faul, P. James, C. Kerley, 2018, International journal of food sciences and nutrition.

Direct Vasoactive Properties of Thienopyridine-Derived Nitrosothiols

Richard A Anderson, J. Halcox, P. James, 2011, Journal of cardiovascular pharmacology.

Oxygen indirectly regulates nitric oxide availability.

S. Jackson, M. Frenneaux, J. Parton, 2003, Advances in experimental medicine and biology.

Dietary nitrate increases exercise tolerance in patients with non-ischemic, dilated cardiomyopathy-a double-blind, randomized, placebo-controlled, crossover trial.

P. James, C. Kerley, L. Cormican, 2016, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

CoVaccine HT™ adjuvant is superior to Freund's in eliciting ovine polyclonal antibodies against human tumor necrosis factor-alpha.

P. James, J. Landon, R. Morris, 2022, Advances in protein chemistry and structural biology.

Exercise‐induced oxidative–nitrosative stress is associated with impaired dynamic cerebral autoregulation and blood–brain barrier leakage

S. Ogoh, P. Ainslie, I. Young, 2011, Experimental physiology.

Characterisation of adipocyte-derived extracellular vesicles released pre- and post-adipogenesis

A. Clayton, I. Guschina, M. Ludgate, 2015, Journal of extracellular vesicles.

Superoxide production by phagocytosing macrophages in relation to the intracellular distribution of oxygen

H. Swartz, P. James, O. Grinberg, 1998, Journal of leukocyte biology.

Effect of lipopolysaccharide on intra-phagosomal oxygen concentration as measured by EPR oximetry.

S. Jackson, H. Swartz, P. James, 1997, Advances in experimental medicine and biology.

In vivo EPR spectroscopy: biomedical and potential diagnostic applications.

S. Jackson, P. James, M. Madhani, 2004, Faraday discussions.

Simultaneous measurement of NO(*) and PO(2) from tissue by in vivo EPR.

H. Swartz, P. James, M. Miyake, 1999, Nitric oxide : biology and chemistry.

Intraphagosomal oxygen in stimulated macrophages

H. Swartz, P. James, O. Grinberg, 1995, Journal of cellular physiology.

Dietary Nitrate Supplementation Reduces Circulating Platelet-Derived Extracellular Vesicles in Coronary Artery Disease Patients on Clopidogrel Therapy: A Randomised, Double-Blind, Placebo-Controlled Study

F. Abdul, N. Ossei-Gerning, Richard A Anderson, 2018, Thrombosis and Haemostasis.

Dietary nitrate does not enhance running performance in elite cross-country skiers.

C. Cook, U. Wisløff, O. Peacock, 2012, Medicine and science in sports and exercise.

Low-dose sodium nitrite attenuates myocardial ischemia and vascular ischemia-reperfusion injury in human models.

A. Fraser, J. Halcox, P. James, 2013, Journal of the American College of Cardiology.

Tissue hypoxia during bacterial sepsis is attenuated by PR-39, an antibacterial peptide.

C. Ross, H. Swartz, A. Barchowsky, 2003, Advances in experimental medicine and biology.

Red blood cell-mediated hypoxic vasodilatation: a balanced physiological viewpoint.

M. Frenneaux, P. James, A. Milsom, 2004, Circulation research.

Variation in blood oxygenation and cerebral pO2 in a mouse model measured by EPR spectrometry.

S. Jackson, P. James, M. Thomas, 2003, Advances in experimental medicine and biology.

Muggeridge, David J. and Sculthorpe, Nicholas and Grace, Fergal M. and Willis, Gareth and Thornhill, Laurence and Weller, Richard B. and James, Philip E. and Easton, Chris (2015) Acute whole body UVA irradiation

R. Weller, F. Grace, N. Sculthorpe, 2018 .

Electron paramagnetic spectroscopic evidence of exercise-induced free radical accumulation in human skeletal muscle

S. Jackson, R. Henry, I. Young, 2007, Free radical research.

Red Blood Cell Nitric Oxide as an Endocrine Vasoregulator

M. Frenneaux, I. Beeton, Christopher J. H. Jones, 2004 .

Impact of chronic congestive heart failure on pharmacokinetics and vasomotor effects of infused nitrite

A. Christopoulos, M. Frenneaux, J. Horowitz, 2013, British journal of pharmacology.

Dietary nitrate lowers ambulatory blood pressure in treated, uncontrolled hypertension: a 7-d, double-blind, randomised, placebo-controlled, cross-over trial.

E. Dolan, P. James, C. Kerley, 2018, The British journal of nutrition.

Acute whole body UVA irradiation combined with nitrate ingestion enhances time trial performance in trained cyclists.

R. Weller, F. Grace, N. Sculthorpe, 2015, Nitric oxide : biology and chemistry.

Low levels of arsenic trioxide stimulate proliferative signals in primary vascular cells without activating stress effector pathways.

A. Barchowsky, K. Smith, P. James, 1999, Toxicology and applied pharmacology.

Stimulation of reactive oxygen, but not reactive nitrogen species, in vascular endothelial cells exposed to low levels of arsenite.

H. Swartz, A. Barchowsky, P. James, 1999, Free radical biology & medicine.

Vasorelaxation by Red Blood Cells and Impairment in Diabetes: Reduced Nitric Oxide and Oxygen Delivery by Glycated Hemoglobin

M. Frenneaux, P. James, A. Milsom, 2004, Circulation research.

Biological free radicals and biomedical applications of EPR spectroscopy

J. Hancock, S. Jackson, P. James, 2006 .

Tissue oxygenation in sepsis; new insights from in vivo EPR

S. Jackson, P. James, Matthew P. Thomas, 2004, NMR in biomedicine.

Binding of spin-labelled analogues of endotoxin to serum proteins

S. Jackson, C. Rowlands, B. Mile, 1992 .

Endotoxin-induced liver hypoxia: defective oxygen delivery versus oxygen consumption.

S. Jackson, H. Swartz, P. James, 2002, Nitric oxide : biology and chemistry.

Inflammatory bowel disease and targeted oral anti-TNFα therapy.

R. Coxon, R. Adams, P. James, 2020, Advances in protein chemistry and structural biology.

Role of adipocyte-derived extracellular vesicles in vascular inflammation.

D. Rees, P. James, K. Connolly, 2021, Free radical biology & medicine.

Binding of endotoxin to macrophages; interactions of spin-labelled saccharide residues.

S. Jackson, C. Rowlands, B. Mile, 1992, Biochimica et biophysica acta.

Molecular interactions between bacterial endotoxins and mammalian cells. A spin-label study

S. Jackson, C. Rowlands, B. Mile, 1992 .

Endotoxin-induced changes in intrarenal pO2, measured by in vivo electron paramagnetic resonance oximetry and magnetic resonance imaging.

J. Dunn, S. Jackson, H. Swartz, 1996, Free radical biology & medicine.

Increased cerebral output of free radicals during hypoxia: implications for acute mountain sickness?

C. Lundby, B. Pedersen, I. Young, 2009, American journal of physiology. Regulatory, integrative and comparative physiology.

Somatomedin-C binding to cultured human fibroblasts is dependent on donor age and culture density.

D. Clemmons, P. James, R. Elgin, 1986, The Journal of clinical endocrinology and metabolism.

HIIT'ing or MISS'ing the Optimal Management of Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis of High- Versus Moderate-Intensity Exercise Prescription

V. Meah, D. Rees, P. James, 2021, Frontiers in Physiology.

In Silico and In Vitro Analyses Reveal Promising Antimicrobial Peptides from Myxobacteria

D. Whitworth, P. James, P. Livingstone, 2022, Probiotics and Antimicrobial Proteins.

Free Nitric Oxide in Spent Capd Fluid: A Leap of Faith?

P. James, D. Lang, 2009, Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis.

Transcerebral Exchange Kinetics of Nitrite and Calcitonin Gene-Related Peptide in Acute Mountain Sickness: Evidence Against Trigeminovascular Activation?

C. Lundby, B. Pedersen, D. Bailey, 2009, Stroke.

Effects of E. coli 0111.B4 lipopolysaccharide on spin-labelled murine macrophage and hepatocyte membranes.

J. Evans, S. Jackson, C. Rowlands, 1989, Free radical research communications.

Sedentary aging increases resting and exercise-induced intramuscular free radical formation.

R. Henry, I. Young, D. Bailey, 2010, Journal of applied physiology.

Low-intensity exercise enhances expression of markers of alternative activation in circulating leukocytes: roles of PPARγ and Th2 cytokines.

K. Backx, P. James, S. Isa, 2010, Atherosclerosis.

Effects of acute supplementation of L-arginine and nitrate on endurance and sprint performance in elite athletes.

O. Peacock, Ø. Sandbakk, S. B. Sandbakk, 2015, Nitric oxide : biology and chemistry.

Abnormal metabolic fate of nitric oxide in Type I diabetes mellitus

C. Jones, M. Frenneaux, J. Peters, 2002, Diabetologia.

Free radical-mediated lipid peroxidation and systemic nitric oxide bioavailability: implications for postexercise hemodynamics.

D. Bailey, J. Hooper, P. James, 2013, American journal of hypertension.

Altered free radical metabolism in acute mountain sickness: implications for dynamic cerebral autoregulation and blood–brain barrier function

P. Ainslie, I. Young, D. Bailey, 2009, The Journal of physiology.

Impact of the antimetastatic drug Batimastat on tumor growth and PO2 measured by EPR oximetry in a murine mammary adenocarcinoma.

J. O’Hara, H. Swartz, P. James, 1999, Advances in experimental medicine and biology.

Gloxy: An oxygen‐sensitive coal for accurate measurement of low oxygen tensions in biological systems

J. O’Hara, H. Swartz, P. James, 1997, Magnetic resonance in medicine.

Applications of in vivo electron paramagnetic resonance (EPR) spectroscopy: measurements of pO2 and NO in endotoxin shock.

S. Jackson, P. James, G. Timmins, 2001, Toxicology letters.

Separation and enrichment of the active component of carbon based paramagnetic materials for use in EPR oximetry.

H. Swartz, P. James, M. Miyake, 1998, Journal of magnetic resonance.

The measurement of nitric oxide and its metabolites in biological samples by ozone-based chemiluminescence.

Andrew G Pinder, Stephen C Rogers, Afshin Khalatbari, 2008, Methods in molecular biology.

Detection of Human Red Blood Cell-bound Nitric Oxide*

M. Frenneaux, P. James, S. Rogers, 2005, Journal of Biological Chemistry.

Are there significant gradients of pO2 in cells?

H. Swartz, P. James, O. Grinberg, 1998, Advances in experimental medicine and biology.

Systemic oxidative–nitrosative–inflammatory stress during acute exercise in hypoxia; implications for microvascular oxygenation and aerobic capacity

S. Ogoh, I. Young, D. Bailey, 2014, Experimental physiology.

Influence of neuronally derived nitric oxide on blood oxygenation and cerebral pO2 in a mouse model measured by EPR spectrometry.

S. Jackson, P. James, Matthew P Thomas, 2003, Advances in experimental medicine and biology.

Red Blood Cell Nitric Oxide as an Endocrine Vasoregulator: A Potential Role in Congestive Heart Failure

M. Frenneaux, I. Beeton, Christopher J. H. Jones, 2004, Circulation.

Haemoglobin saturation controls the red blood cell mediated hypoxic vasorelaxation.

P. James, K. Morris, A. Pinder, 2009, Advances in experimental medicine and biology.

Oxygen Mediates Vascular Smooth Muscle Relaxation in Hypoxia

P. James, D. Lang, A. Pinder, 2013, PloS one.

Direct detection of tissue nitric oxide in septic mice.

H. Swartz, P. James, K. J. Liu, 1998, Advances in experimental medicine and biology.

NO metabolite flux across the human coronary circulation.

M. Frenneaux, P. James, V. Paul, 2007, Cardiovascular research.

Characterisation of adipocyte-derived extracellular vesicles released pre- and post-adipogenesis

A. Clayton, I. Guschina, M. Ludgate, 2015, Journal of extracellular vesicles.

Quantitative increases of extracellular vesicles in prolonged cold storage of platelets increases the potential to enhance fibrin clot formation.

P. James, A. Davies, C. George, 2023, Transfusion medicine.

Intratumoral pO2 measured using a new oxygen sensitive paramagnetic material, gloxy.

J. O’Hara, H. Swartz, P. James, 1997, Advances in experimental medicine and biology.

In vivo EPR spectroscopy

Jinjie Jiang, J. O’Hara, K. Mäder, 1995 .

Ras-induced reactive oxygen species promote growth factor-independent proliferation in human CD34+ hematopoietic progenitor cells.

A. Burnett, P. James, R. Darley, 2010, Blood.

When does low oxygen become hypoxia? Implications for nitrite reduction.

P. James, Andrew G. Pinder, 2009, Circulation research.

Evidence for Adipocyte-Derived Extracellular Vesicles in the Human Circulation

D. Rees, P. James, Errin Johnson, 2018, Endocrinology.