J. Laird

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Wind-up of spinal cord neurones and pain sensation: much ado about something?

J. Lopez-Garcia, J. F. Herrero, J. Laird, 2000, Progress in Neurobiology.

Mechanisms of touch-evoked pain (allodynia): a new model

F. Cerveró, Fernando Cervero, J. Laird, 1996, Pain.

Understanding the signaling and transmission of visceral nociceptive events.

F. Cerveró, J. Laird, 2004, Journal of neurobiology.

Viscero-Sensory Functions: Capsaicin

J. Laird, 2009 .

Acidic fibroblast growth factor stimulates motor and sensory axon regeneration after sciatic nerve crush in the rat

R. Hargreaves, K. Thomas, J. Laird, 1995, Neuroscience.

Responses of rat spinal neurones to natural and electrical stimulation of colonic afferents: effect of inflammation

F. Cerveró, J. Laird, T. Olivar, 2000, Brain Research.

Spinal mechanisms underlying persistent pain and referred hyperalgesia in rats with an experimental ureteric stone.

F. Cerveró, J. Laird, C. Roza, 1998, Journal of neurophysiology.

Voltage-gated sodium channels and visceral pain

F. Cerveró, J. Laird, 2005 .

Role of ion channels in mechanisms controlling gastrointestinal pain pathways.

F. Cerveró, J. Laird, 2003, Current opinion in pharmacology.

Analgesic activity of a novel use‐dependent sodium channel blocker, crobenetine, in mono‐arthritic rats

A. J. Carter, F. Cerveró, J. Laird, 2001, British journal of pharmacology.

Tailoring chronic pain treatments for the elderly: are we prepared for the challenge?

S. Arneric, J. Laird, A. Chappell, 2014, Drug discovery today.

Modality of hyperalgesia tested, not type of nerve damage, predicts pharmacological sensitivity in rat models of neuropathic pain

Xiao Hong Yu, A. Pradhan, J. Laird, 2010, European journal of pain.

Vasodilatation in hyperalgesic rat skin evoked by stimulation of afferent Aβ-fibers: further evidence for a role of dorsal root reflexes in allodynia

E. García-Nicas, F. Cerveró, J. Laird, 2001, Pain.

Absence of evidence is not evidence of absence (again)

F. Cerveró, J. Laird, 2000, Pain.

Time-course of spinal sensitization following carrageenan-induced inflammation in the young rat: a comparative electrophysiological and behavioural study in vitro and in vivo

J. Lopez-Garcia, J. Laird, G. Hedo, 1999, Neuroscience.

Mechanisms of allodynia: interactions between sensitive mechanoreceptors and nociceptors

F. Cerveró, J. Laird, Fernando Cervero, 1996, Neuroreport.

Selective changes of receptive field properties of spinal nociceptive neurones induced by noxious visceral stimulation in the cat

M. A. Pozo, F. Cerveró, J. Laird, 1992, Pain.

Role of central and peripheral tachykinin NK1 receptors in capsaicin-induced pain and hyperalgesia in mice

S. Hunt, F. Cerveró, J. Laird, 2001, Pain.

A new model of visceral pain and referred hyperalgesia in the mouse

E. García-Nicas, F. Cerveró, J. Laird, 2001, PAIN®.

Neurotrophic Factors in Peripheral Nerve Injury and Regeneration

S. Boyce, J. Laird, R. Hill, 1999 .

Cyclophosphamide cystitis in mice: Behavioural characterisation and correlation with bladder inflammation

J. Laird, T. Olivar, 1999, European journal of pain.

A peripherally restricted cannabinoid receptor agonist produces robust anti-nociceptive effects in rodent models of inflammatory and neuropathic pain

Xiao Hong Yu, J. Laird, É. Lessard, 2010, PAIN®.

Neuromedin U Receptor 2 does not play a role in the development of neuropathic pain following nerve injury in mice

J. Laird, A. Gilbert, X. Xu, 2013, European journal of pain.

Capsaicin‐Sensitive Vagal Afferent Fibers and Gastric Motility: Evidence for an “Axon Reflex” Mechanism

F. Cerveró, J. Laird, B. Chang, 1991 .

Extracellular signaling-regulated kinase-1 and -2 (ERK 1/2) mediate referred hyperalgesia in a murine model of visceral pain.

F. Cerveró, J. Laird, A. Galan, 2003, Brain research. Molecular brain research.

Effects of artificial calculosis on rat ureter motility: peripheral contribution to the pain of ureteric colic.

F. Cerveró, J. Laird, C. Roza, 1997, The American journal of physiology.

Dorsal root potentials and afferent input to the spinal cord in rats with an experimental peripheral neuropathy

G. Bennett, J. Laird, 1992, Brain Research.

From Acute to Chronic Pain Peripheral and Central Mechanisms

F. Cerveró, J. Laird, 2003 .

Effect of RP 67580, a non‐peptide neurokinin1 receptor antagonist, on facilitation of a nociceptive spinal flexion reflex in the rat

R. Hargreaves, J. Laird, R. Hargreaves, 1993, British journal of pharmacology.

Analgesic activity of the novel COX-2 preferring NSAID, meloxicam in mono-arthritic rats: Central and peripheral components

F. Cerveró, J. F. Herrero, J. Laird, 1997, Inflammation Research.

Altered nociception, analgesia and aggression in mice lacking the receptor for substance P

Stephen P. Hunt, S. Hunt, C. Belmonte, 1998, Nature.

Deficits in visceral pain and hyperalgesia of mice with a disruption of the tachykinin NK1 receptor gene

C. Roza, S. P. Hunt, S. Hunt, 2000, Neuroscience.

From acute to chronic pain: mechanisms and hypotheses.

F. Cerveró, J. Laird, 1996, Progress in brain research.

An electrophysiological study of dorsal horn neurons in the spinal cord of rats with an experimental peripheral neuropathy.

G. Bennett, J. Laird, 1993, Journal of neurophysiology.

Differential effects of N-Methyl-d-aspartate receptor blockade on nociceptive somatic and visceral reflexes

J. Laird, T. Olivar, 1999, Pain.

Excitability changes of somatic and viscero‐somatic nociceptive reflexes in the decerebrate‐spinal rabbit: role of NMDA receptors.

F. Cerveró, J. Laird, J. Laird, 1995, The Journal of physiology.

Allodynia and hyperalgesia evoked by sciatic mononeuropathy in NK1 receptor knockout mice

J. Laird, L. Martínez-Caro, Leticia Martinez-Caro, 2000, Neuroreport.

Deficits in Visceral Pain and Referred Hyperalgesia in Nav1.8 (SNS/PN3)-Null Mice

J. Wood, F. Cerveró, J. Laird, 2002, The Journal of Neuroscience.

Antinociceptive activity of metamizol in rats with experimental ureteric calculosis: Central and peripheral components

J. Laird, T. Olivar, C. Roza, 1998, Inflammation Research.

Effects of a partial agonist and a full antagonist acting at the glycine site of the NMDA receptor on inflammation‐induced mechanical hyperalgesia in rats

R. Hargreaves, J. Laird, R. Hargreaves, 1996, British journal of pharmacology.

Broad analgesic activity of a novel, selective M1 agonist

P. Schroeder, J. Laird, J. Sandin, 2017, Neuropharmacology.

In vivo recruitment by painful stimuli of AMPA receptor subunits to the plasma membrane of spinal cord neurons

F. Cerveró, J. Laird, A. Galan, 2004, Pain.

Activation of spinal extracellular signaling-regulated kinase-1 and -2 by intraplantar carrageenan in rodents

F. Cerveró, J. Laird, A. Galan, 2002, Neuroscience Letters.

Sensory neuron-specific receptor activation elicits central and peripheral nociceptive effects in rats.

Xiao Hong Yu, E. Grazzini, J. Laird, 2004, Proceedings of the National Academy of Sciences of the United States of America.

GABAA receptor blockade inhibits Aβ fibre evoked wind‐up in the arthritic rat

J. Schouenborg, H. Weng, F. Cerveró, 1998 .

Role of rat sensory neuron-specific receptor (rSNSR1) in inflammatory pain: Contribution of TRPV1 to SNSR signaling in the pain pathway

C. Ndong, A. Pradhan, J. Laird, 2009, Pain.

The M1/M4 preferring agonist xanomeline is analgesic in rodent models of chronic inflammatory and neuropathic pain via central site of action

Xiao Hong Yu, J. Laird, N. Markoglou, 2011, PAIN.

Visceral pain

F. Cerveró, J. Laird, 1987, PAIN.

The Tetrodotoxin‐Resistant Na+ Channel Nav1.8 is Essential for the Expression of Spontaneous Activity in Damaged Sensory Axons of Mice

J. Wood, F. Cerveró, J. Laird, 2003, The Journal of physiology.

Discovery and Pharmacological Characterization of a Small-Molecule Antagonist at Neuromedin U Receptor NMUR2

S. Trivedi, Jian Huang, Jay Liu, 2009, Journal of Pharmacology and Experimental Therapeutics.

Functional genomics of the rat neuromedin U receptor 1 reveals a naturally occurring deleterious allele.

Paul A. Cassar, J. Laird, T. Groblewski, 2013, Physiological genomics.

Presynaptic inhibition and spinal pain processing in mice: a possible role of the NKCC1 cation-chloride co-transporter in hyperalgesia

E. Delpire, E. García-Nicas, F. Cerveró, 2004, Neuroscience Letters.

GABAA-Receptor blockade reverses the injury-induced sensitization of nociceptor-specific (NS) neurons in the spinal dorsal horn of the rat.

E. García-Nicas, F. Cerveró, J. Laird, 2006, Journal of neurophysiology.

Responses of rat spinal neurons to distension of inflamed colon: role of tachykinin NK2 receptors

J. Lopez-Garcia, C. Maggi, F. Cerveró, 2001, Neuropharmacology.

Evaluation of an Innovative Population Pharmacokinetic-Based Design for Behavioral Pharmacodynamic Endpoints

J. Laird, É. Lessard, Anders Viberg, 2012, The AAPS Journal.

TRPV1 as a Polymodal Sensor: Potential to Discover TRPV1 Antagonists Selective for Specific Activating Modalities

J. Laird, W. Brown, S. Zicha, 2012 .

Gut feelings about tachykinin NK1 receptor antagonists.

J. Laird, 2001, Trends in pharmacological sciences.

Secondary hyperalgesia and presynaptic inhibition: an update

E. García-Nicas, F. Cerveró, J. Laird, 2003, European journal of pain.

Pressor responses to distension of the ureter in anaesthetised rats: characterisation of a model of acute visceral pain

J. Laird, C. Roza, 1995, Neuroscience Letters.

Spinal Mechanisms of Visceral Pain and Hyperalgesia

F. Cerveró, J. Laird, 2009 .

A comparative study of the changes in receptive-field properties of multireceptive and nocireceptive rat dorsal horn neurons following noxious mechanical stimulation.

F. Cerveró, J. Laird, 1989, Journal of neurophysiology.

Tachykinins in Visceral Pain and Hyperalgesia

F. Cerveró, J. Laird, 2000 .

Tonic descending influences on receptive-field properties of nociceptive dorsal horn neurons in sacral spinal cord of rat.

F. Cerveró, J. Laird, 1990, Journal of neurophysiology.

Potent and orally efficacious benzothiazole amides as TRPV1 antagonists.

D. Labrecque, M. Maudet, M. Svensson, 2012, Bioorganic & medicinal chemistry letters.