L. Bugaj

发表

Interrogating cellular perception and decision making with optogenetic tools

Wendell A. Lim, Geoff P. O’Donoghue, W. Lim, 2017, The Journal of cell biology.

Optogenetic Rac1 engineered from membrane lipid-binding RGS-LOV for inducible lamellipodia formation

B. Chow, Erin E. Berlew, L. Bugaj, 2020, Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology.

Visual detection of submicroscopic protein clusters with a phase-separation-based fluorescent reporter

L. Bugaj, Lukasz J. Bugaj, T. Mumford, 2022, bioRxiv.

Upregulation of arginase-II contributes to decreased age-related myocardial contractile reserve

A. Shoukas, L. Santhanam, K. Schuleri, 2012, European Journal of Applied Physiology.

Arginase modulates myocardial contractility by a nitric oxide synthase 1-dependent mechanism.

A. Shoukas, L. Santhanam, J. Hare, 2006, Proceedings of the National Academy of Sciences of the United States of America.

Age‐Associated Increase in BMP Signaling Inhibits Hippocampal Neurogenesis

D. Schaffer, H. Yousef, I. Conboy, 2015, Stem cells.

Early changes in vasoreactivity after simulated microgravity are due to an upregulation of the endothelium-dependent nitric oxide/cGMP pathway

A. Shoukas, J. Hare, H. Champion, 2010, European Journal of Applied Physiology.

Decoding of YAP levels and dynamics by pluripotency factors

O. Weiner, Nicholas C. Lammers, L. Bugaj, 2022, bioRxiv.

Arginase inhibition restores NOS coupling and reverses endothelial dysfunction and vascular stiffness in old rats.

A. Shoukas, Y. Oh, D. Christianson, 2009, Journal of applied physiology.

Bringing next-generation therapeutics to the clinic through synthetic biology.

Lukasz J Bugaj, David V Schaffer, D. Schaffer, 2012, Current opinion in chemical biology.

Systemic attenuation of the TGF-β pathway by a single drug simultaneously rejuvenates hippocampal neurogenesis and myogenesis in the same old mammal

D. Schaffer, H. Yousef, I. Conboy, 2015, Oncotarget.

Regulation of endogenous transmembrane receptors through optogenetic Cry2 clustering

D. Schaffer, R. Kane, M. Varedi, 2015, Nature Communications.

Modular engineering of cellular signaling proteins and networks.

Russell M Gordley, Wendell A Lim, Lukasz J Bugaj, 2016, Current opinion in structural biology.

Erratum to: Upregulation of arginase-II contributes to decreased age-related myocardial contractile reserve

A. Shoukas, L. Santhanam, K. Schuleri, 2012 .

Reverse and Forward Engineering Multicellular Structures with Optogenetics.

Thomas R. Mumford, Lee Roth, Lukasz J. Bugaj, 2020, Current opinion in biomedical engineering.

High-throughput multicolor optogenetics in microwell plates

Wendell A. Lim, Lukasz J. Bugaj, W. Lim, 2019, Nature Protocols.

Optogenetic protein clustering and signaling activation in mammalian cells

Ravi S Kane, Lukasz J Bugaj, David V Schaffer, 2013, Nature Methods.

Oncogenic protein condensates modulate cell signal perception and drug tolerance

T. Bivona, L. Bugaj, Lukasz J. Bugaj, 2022, bioRxiv.

Cancer mutations and targeted drugs can disrupt dynamic signal encoding by the Ras-Erk pathway

Jared E. Toettcher, W. Lim, J. Toettcher, 2018, Science.

Optogenetic Control Reveals Differential Promoter Interpretation of Transcription Factor Nuclear Translocation Dynamics

Hana El-Samad, Andrew H. Ng, Taylor H. Nguyen, 2019, bioRxiv.

T cells selectively filter oscillatory signals on the minutes timescale

Geoff P. O’Donoghue, W. Lim, D. Rawlings, 2021, Proceedings of the National Academy of Sciences.

Temperature-responsive optogenetic probes of cell signaling

Arndt F. Siekmann, B. Chow, Bomyi Lim, 2021, Nature Chemical Biology.

Single-Component Optogenetic Tools for Inducible RhoA GTPase Signaling.

B. Chow, Keisuke Yamada, Erin E. Berlew, 2021, Advanced biology.

β-Catenin signaling dynamics regulate cell fate in differentiating neural stem cells

D. Schaffer, R. Kane, L. Bugaj, 2020, Proceedings of the National Academy of Sciences.

Vertebrate cells differentially interpret ciliary and extraciliary cAMP

Wan Li, J. Reiter, S. Choksi, 2021, Cell.

Single-component optogenetic tools for inducible RhoA GTPase signaling

B. Chow, Keisuke Yamada, Erin E. Berlew, 2021, bioRxiv.

High-throughput feedback-enabled optogenetic stimulation and spectroscopy in microwell plates

Michael S. Magaraci, Sevile G. Mannickarottu, B. Chow, 2022, bioRxiv.

Upregulation of arginase-II contributes to decreased age-related myocardial contractile reserve

A. Shoukas, L. Santhanam, K. Schuleri, 2012, European Journal of Applied Physiology.

Enhancing single-cell western blotting sensitivity using diffusive analyte blotting and antibody conjugate amplification

Alex J. Hughes, L. Bugaj, W. Benman, 2023, bioRxiv.

Age‐associated Increase in Bmp Signaling In‐ Hibits Hippocampal Neurogenesis * Key Words. Adult Stem Cells @bullet Aging @bullet Neural Stem Cell @bullet Proliferation @bullet Neu‐ Rogenesis @bullet Stem Cell‐microenvironment Interactions @bullet Bmp Signaling

David, D. Schaffer, H. Yousef, 2022 .

Optogenetic clustering and membrane translocation of the BcLOV4 photoreceptor

B. Chow, L. Bugaj, Lukasz J. Bugaj, 2022, bioRxiv.

Light-inducible activation of target mRNA translation in mammalian cells.

D. Schaffer, R. Kane, Jicong Cao, 2013, Chemical communications.

Dynamic Regulation of Mammalian Cell Signaling through Optical Protein Clustering

L. Bugaj, Lukasz J. Bugaj, 2014 .