M. Leese

发表

STX140 and STX641 cause apoptosis via the intrinsic mitochondrial pathway and down-regulate survivin and XIAP expression in ovarian and prostate cancer cells.

B. Potter, A. Purohit, M. Reed, 2009, Anticancer research.

STX140 Is Efficacious In vitro and In vivo in Taxane-Resistant Breast Carcinoma Cells

B. Potter, J. Day, A. Purohit, 2008, Clinical Cancer Research.

STX140 Is Efficacious In vitro and In vivo in Taxane-Resistant Breast Carcinoma Cells

B. Potter, J. Day, A. Purohit, 2008, Clinical Cancer Research.

Class III β-tubulin expression and in vitro resistance to microtubule targeting agents

B. Potter, A. Purohit, M. Reed, 2009, British Journal of Cancer.

2-MeOE2bisMATE induces caspase-dependent apoptosis in CAL51 breast cancer cells and overcomes resistance to TRAIL via cooperative activation of caspases

B. Potter, G. Packham, A. Purohit, 2004, Apoptosis.

A-ring-substituted estrogen-3-O-sulfamates: potent multitargeted anticancer agents.

B. Potter, A. Purohit, M. Reed, 2005, Journal of medicinal chemistry.

The effects of 2-methoxy oestrogens and their sulphamoylated derivatives in conjunction with TNF-α on endothelial and fibroblast cell growth, morphology and apoptosis

A. Purohit, M. Reed, S. Newman, 2003, The Journal of Steroid Biochemistry and Molecular Biology.

In vivo inhibition of angiogenesis by sulphamoylated derivatives of 2-methoxyoestradiol

B. Potter, A. Purohit, M. Reed, 2007, British Journal of Cancer.

The therapeutic potential of a series of orally bioavailable anti-angiogenic microtubule disruptors as therapy for hormone-independent prostate and breast cancers

B. Potter, J. Day, A. Purohit, 2007, British Journal of Cancer.

BCRP expression does not result in resistance to STX140 in vivo, despite the increased expression of BCRP in A2780 cells in vitro after long-term STX140 exposure

H. Tutill, B. Potter, J. Day, 2009, British Journal of Cancer.

In vivo and in vitro properties of STX2484: a novel non-steroidal anti-cancer compound active in taxane-resistant breast cancer

B. Potter, J. Day, A. Purohit, 2014, British Journal of Cancer.

In vivo and in vitro properties of STX 2484 : a novel non-steroidal anti-cancer compound active in taxane-resistant breast cancer

B. Potter, J. Day, A. Purohit, 2014 .

Steroidomimetic Tetrahydroisoquinolines for the Design of New Microtubule Disruptors

Mark P Thomas, B. Potter, E. Hamel, 2011, ACS medicinal chemistry letters.

Chimeric microtubule disruptors.

B. Potter, K. Acharya, A. Purohit, 2010, Chemical communications.

2-MeOE2bisMATE and 2-EtE2bisMATE induce cell cycle arrest and apoptosis in breast cancer xenografts as shown by a novel ex vivo technique

B. Potter, A. Purohit, M. Reed, 2008, Breast Cancer Research and Treatment.

2-Methoxyoestradiol-3,17-O,O-bis-sulphamate and 2-deoxy-D-glucose in combination: a potential treatment for breast and prostate cancer

B. Potter, A. Purohit, M. Reed, 2008, British Journal of Cancer.

Optimisation of Tetrahydroisoquinoline‐Based Chimeric Microtubule Disruptors

B. Potter, E. Hamel, M. Leese, 2014, ChemMedChem.

A comparison of two orally bioavailable anti-cancer agents, IRC-110160 and STX140.

B. Potter, A. Purohit, M. Reed, 2008, Anticancer research.

Synthesis, Antitubulin, and Antiproliferative SAR of C3/C1‐Substituted Tetrahydroisoquinolines

B. Potter, B. Potter, A. Purohit, 2014, ChemMedChem.

Effects of C-17 heterocyclic substituents on the anticancer activity of 2-ethylestra-1,3,5(10)-triene-3-O-sulfamates: synthesis, in vitro evaluation and computational modelling.

B. Potter, A. Purohit, M. Reed, 2008, Organic & biomolecular chemistry.

Anti-cancer activities of novel D-ring modified 2-substituted estrogen-3-O-sulfamates

B. Potter, A. Purohit, M. Reed, 2005, The Journal of Steroid Biochemistry and Molecular Biology.

Targeted NF1 cancer therapeutics with multiple modes of action: small molecule hormone-like agents resembling the natural anticancer metabolite, 2-methoxyoestradiol

B. Potter, D. Jewett, K. Barald, 2015, British Journal of Cancer.

Transition metal catalysed reactions using glass bead technology

M. Leese, L. Tonks, M. Anson, 1998 .

2-substituted estradiol bis-sulfamates, multitargeted antitumor agents: synthesis, in vitro SAR, protein crystallography, and in vivo activity.

C. Supuran, B. Potter, A. Purohit, 2006, Journal of medicinal chemistry.

Inhibition of carbonic anhydrase II by steroidal and non-steroidal sulphamates.

B. Potter, A. Purohit, M. Reed, 2003, Biochemical and biophysical research communications.

Quinazolinone-Based Anticancer Agents: Synthesis, Antiproliferative SAR, Antitubulin Activity, and Tubulin Co-crystal Structure.

M. Steinmetz, B. Potter, A. Prota, 2018, Journal of medicinal chemistry.

ALLENE FORMATION BY THE REACTION OF OLEFINS WITH PROPARGYL SILYL ETHERS MEDIATED BY A ZIRCONOCENE COMPLEX

Tamotsu Takahashi, R. Hara, M. Leese, 1997 .

Accessing simply-substituted 4-hydroxytetrahydroisoquinolines via Pomeranz–Fritsch–Bobbitt reaction with non-activated and moderately-activated systems

B. Potter, M. Leese, Marco Mottinelli, 2017, Beilstein journal of organic chemistry.

Cover Picture: Tetrahydroisoquinolinone‐Based Steroidomimetic and Chimeric Microtubule Disruptors (ChemMedChem 1/2014)

B. Potter, E. Hamel, M. Leese, 2014 .

PALLADIUM CATALYSED COUPLING REACTIONS USING GUANIDINIUM PHOSPHINE COMPLEXES ON GLASS BEADS

M. Leese, Jonathan M. J. Williams, 1999 .

Pharmacokinetics and efficacy of 2-methoxyoestradiol and 2-methoxyoestradiol-bis-sulphamate in vivo in rodents

B. Potter, A. Purohit, M. Reed, 2004, British Journal of Cancer.

The Role of 17β-Hydroxysteroid Dehydrogenases in Modulating the Activity of 2-Methoxyestradiol in Breast Cancer Cells

H. Tutill, B. Potter, J. Day, 2006 .

The role of 17beta-hydroxysteroid dehydrogenases in modulating the activity of 2-methoxyestradiol in breast cancer cells.

H. Tutill, B. Potter, J. Day, 2006, Cancer research.

The Role of 17 B -Hydroxysteroid Dehydrogenases in Modulating the Activity of 2-Methoxyestradiol in Breast Cancer Cells

H. Tutill, B. Potter, J. Day, 2005 .

Steroid sulphatase inhibitors for breast cancer therapy

B. Potter, A. Purohit, M. Reed, 2003, The Journal of Steroid Biochemistry and Molecular Biology.

The effects of 2-methoxyoestrogen sulphamates on the in vitro and in vivo proliferation of breast cancer cells

A. Purohit, M. Reed, S. Newman, 2005, The Journal of Steroid Biochemistry and Molecular Biology.

Regulation of aromatase activity by cytokines, PGE2 and 2-methoxyoestrone-3-O-sulphamate in fibroblasts derived from normal and malignant breast tissues

B. Potter, A. Purohit, M. Reed, 2005, The Journal of Steroid Biochemistry and Molecular Biology.

A survey of suitable protecting groups for the synthesis of hydroxylamines by Mitsunobu reactions

D. Knight, M. Leese, 2001 .

Inhibition of in vitro angiogenesis by 2‐methoxy‐ and 2‐ethyl‐estrogen sulfamates

B. Potter, A. Purohit, M. Reed, 2004, International journal of cancer.

The In Vitro and In Vivo Activity of the Microtubule Disruptor STX140 Is Mediated by Hif-1 Alpha and CAIX Expression.

Mark P Thomas, B. Potter, A. Purohit, 2015, Anticancer research.

Tetrahydroisoquinolinone‐Based Steroidomimetic and Chimeric Microtubule Disruptors

B. Potter, E. Hamel, M. Leese, 2014, ChemMedChem.

3,17-disubstituted 2-alkylestra-1,3,5(10)-trien-3-ol derivatives: synthesis, in vitro and in vivo anticancer activity.

B. Potter, A. Purohit, M. Reed, 2007, Journal of medicinal chemistry.

Synthesis, antitubulin, and antiproliferative SAR of analogues of 2-methoxyestradiol-3,17-O,O-bis-sulfamate.

B. Potter, A. Purohit, M. Reed, 2010, Journal of medicinal chemistry.

The in vivo properties of STX243: a potent angiogenesis inhibitor in breast cancer

B. Potter, A. Purohit, M. Reed, 2008, British Journal of Cancer.

Growth inhibition of multi-drug-resistant breast cancer cells by 2-methoxyoestradiol-bis-sulphamate and 2-ethyloestradiol-bis-sulphamate

A. Purohit, M. Reed, S. Newman, 2003, The Journal of Steroid Biochemistry and Molecular Biology.

Inhibition of MCF-7 breast cancer cell proliferation and in vivo steroid sulphatase activity by 2-methoxyoestradiol-bis-sulphamate

B. Potter, A. Purohit, M. Reed, 2003, The Journal of Steroid Biochemistry and Molecular Biology.

2-difluoromethyloestrone 3-O-sulphamate, a highly potent steroid sulphatase inhibitor.

Julie E Reed, B. Potter, A. Purohit, 2004, Biochemical and biophysical research communications.

Inhibition of MDA‐MB‐231 cell cycle progression and cell proliferation by C‐2‐substituted oestradiol mono‐ and bis‐3‐O‐sulphamates

B. Potter, A. Purohit, M. Reed, 2005, International journal of cancer.

2-Alkylsulfanyl estrogen derivatives: synthesis of a novel class of multi-targeted anti-tumour agents.

B. Potter, A. Purohit, M. Reed, 2004, Bioorganic & medicinal chemistry letters.

N‐Phenyl‐1,2,3,4‐tetrahydroisoquinoline: An Alternative Scaffold for the Design of 17β‐Hydroxysteroid Dehydrogenase 1 Inhibitors

B. Potter, T. Rižner, M. Leese, 2020, ChemMedChem.

The synthesis of N-hydroxyisoindolines by reverse-Cope chemistry

D. Knight, M. Leese, N. Kimpe, 2001 .

The Synthesis of N-Hydroxyisoindolines by Reverse-Cope Chemistry.

D. Knight, M. Leese, N. Kimpe, 2001 .

A new, stereoselective approach to pyrrolidine-N-oxides by sequential condensation of sulfones with nitrones and reverse-cope elimination

D. Knight, M. Leese, A. Wheildon, 1997 .

Structure-activity relationships of C-17-substituted estratriene-3-O-sulfamates as anticancer agents.

B. Potter, A. Purohit, S. Newman, 2011, Journal of medicinal chemistry.

A new micronized formulation of 2-methoxyestradiol-bis-sulfamate (STX140) is therapeutically potent against breast cancer.

B. Potter, A. Purohit, M. Reed, 2008, Anticancer Research.

Structures of human carbonic anhydrase II/inhibitor complexes reveal a second binding site for steroidal and nonsteroidal inhibitors.

G. Cozier, N. Thiyagarajan, M. Baker, 2010, Biochemistry.

Quinazolinone-Based Anticancer Agents: Synthesis, Antiproliferative SAR, Antitubulin Activity, and Tubulin Co-crystal Structure.

M. Steinmetz, B. Potter, A. Prota, 2018, Journal of medicinal chemistry.