J. Mokrosiński

发表

Palmitic Acid Hydroxystearic Acids Activate GPR40, Which Is Involved in Their Beneficial Effects on Glucose Homeostasis.

C. Donaldson, A. Saghatelian, D. Siegel, 2018, Cell metabolism.

Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes

M. McCarthy, A. Morris, D. Altshuler, 2012, Diabetologia.

Obesity-Associated GNAS Mutations and the Melanocortin Pathway.

I. Barroso, I. Farooqi, P. Clayton, 2021, The New England journal of medicine.

The Location of Missense Variants in the Human GIP Gene Is Indicative for Natural Selection

J. Holst, M. Rosenkilde, A. Hauser, 2022, Frontiers in Endocrinology.

Evaluation of a melanocortin-4 receptor (MC4R) agonist (Setmelanotide) in MC4R deficiency

K. Clément, S. O’Rahilly, R. Cone, 2017, Molecular metabolism.

Modulation of Constitutive Activity and Signaling Bias of the Ghrelin Receptor by Conformational Constraint in the Second Extracellular Loop*

T. Schwartz, T. Frimurer, B. Holst, 2012, The Journal of Biological Chemistry.

An aromatic region to induce a switch between agonism and inverse agonism at the ghrelin receptor.

T. Schwartz, T. Frimurer, B. Holst, 2012, Journal of medicinal chemistry.

A Novel Thyrotropin-Releasing Hormone Receptor Missense Mutation (P81R) in Central Congenital Hypothyroidism

I. Farooqi, O. Koulouri, M. Gurnell, 2016, The Journal of clinical endocrinology and metabolism.

Human loss-of-function variants in the serotonin 2C receptor associated with obesity and maladaptive behavior

Sean M. Hartig, I. Barroso, L. Liao, 2022, Nature Medicine.

Overlapping Binding Site for the Endogenous Agonist, Small-Molecule Agonists, and Ago-allosteric Modulators on the Ghrelin Receptor

Thomas M Frimurer, Birgitte Holst, T. Schwartz, 2009, Molecular Pharmacology.

Allosteric and Orthosteric Sites in CC Chemokine Receptor (CCR5), a Chimeric Receptor Approach*

T. Frimurer, M. Rosenkilde, J. Mokrosiński, 2011, The Journal of Biological Chemistry.

Expression of Endoglin in Primary Endometrial Cancer

A. Semczuk, W. Krajewska, J. Mokrosiński, 2011, Oncology.

Loss of function mutations in the melanocortin 4 receptor in a UK birth cohort

N. Timpson, S. O’Rahilly, Xiaomin Liu, 2021, Nature Medicine.

Prevalence and expressivity of loss of function mutations in the Melanocortin 4 Receptor (MC4R) in a UK birth cohort

S. O’Rahilly, I. Farooqi, A. Mörseburg, 2020, medRxiv.

MC4R agonism promotes durable weight loss in patients with leptin receptor deficiency

K. Clément, A. Grüters, H. Biebermann, 2018, Nature Medicine.

The orphan G protein-coupled receptor GPR139 is activated by the peptides: Adrenocorticotropic hormone (ACTH), α-, and β-melanocyte stimulating hormone (α-MSH, and β-MSH), and the conserved core motif HFRW

Kirsten B. Andersen, A. Hauser, D. Gloriam, 2017, Neurochemistry International.

Dysregulation of Betaglycan Expression in Primary Human Endometrial Carcinomas

A. Semczuk, W. Krajewska, J. Mokrosiński, 2011, Cancer investigation.

Human Gain-of-Function MC4R Variants Show Signaling Bias and Protect against Obesity

Chen Li, Stephen J. Sharp, Claudia Langenberg, 2019, Cell.

The E92K Melanocortin 1 Receptor Mutant Induces cAMP Production and Arrestin Recruitment but Not ERK Activity Indicating Biased Constitutive Signaling

M. Rosenkilde, J. Mokrosiński, T. Benned-Jensen, 2011, PloS one.

[TGF beta signalling accessory receptors].

W. Krajewska, J. Mokrosiński, 2008, Postepy biochemii.

Biased Gs Versus Gq Proteins and β-Arrestin Signaling in the NK1 Receptor Determined by Interactions in the Water Hydrogen Bond Network*

T. Schwartz, T. Frimurer, N. Holliday, 2015, The Journal of Biological Chemistry.

Conserved Water-mediated Hydrogen Bond Network between TM-I, -II, -VI, and -VII in 7TM Receptor Activation*

Thomas M. Frimurer, T. Schwartz, T. Frimurer, 2010, The Journal of Biological Chemistry.

Human MC4R variants affect endocytosis, trafficking and dimerization revealing multiple cellular mechanisms involved in weight regulation

M. Babu, I. Farooqi, M. Bouvier, 2021, Cell reports.

The aromatic amino acid sensor GPR142 controls metabolism through balanced regulation of pancreatic and gut hormones

Margaret S. Wu, J. Holst, J. Rehfeld, 2018, Molecular metabolism.

Modulation of the constitutive activity of the ghrelin receptor by use of pharmacological tools and mutagenesis.

B. Holst, J. Mokrosiński, 2010, Methods in enzymology.

Identification of an Efficacy Switch Region in the Ghrelin Receptor Responsible for Interchange between Agonism and Inverse Agonism*

T. Schwartz, T. Frimurer, B. Holst, 2007, Journal of Biological Chemistry.

Conformational Constraint in the Second Signaling Bias of the Ghrelin Receptor by Modulation of Constitutive Activity and

T. Schwartz, T. Frimurer, B. Holst, 2014 .

An aromatic region to induce a switch between agonism and inverse agonism at the ghrelin receptor.

T. Schwartz, T. Frimurer, B. Holst, 2012, Journal of medicinal chemistry.

Overlapping Binding Site for the Endogenous Agonist, Small-Molecule Agonists, and Ago-allosteric Modulators on the Ghrelin Receptor

T. Schwartz, T. Frimurer, B. Holst, 2009, Molecular Pharmacology.

A rare human variant that disrupts GPR10 signalling causes weight gain in mice

D. Bechtold, P. Froguel, I. Barroso, 2023, Nature Communications.