Hugh Rosen

发表

Table 1, Assay Summaries

Yongjun Wang, Michael D. Cameron, Becky A. Mercer, 2013 .

The Scripps Molecular Screening Center and Translational Research Institute

Louis Scampavia, Timothy P. Spicer, Hugh Rosen, 2019, SLAS discovery : advancing life sciences R & D.

Probe Development Efforts to Identify Novel Inhibitors of ABHD10

Peter Hodder, Hugh Rosen, Jill Ferguson, 2013 .

[Table, SAR Tables].

Franck Madoux, Becky A. Mercer, Peter Hodder, 2011 .

[Table], Table of Assay Rationale and Description

Becky A. Mercer, Peter Hodder, Hugh Rosen, 2011 .

Table 2, Most promising leads from HTS Campaign for PAFAH2 inhibitor discovery

Peter Hodder, Hugh Rosen, Jill Ferguson, 2013 .

Table 6, Summary

Becky A. Mercer, Peter Hodder, Hugh Rosen, 2010 .

Figure 4, Flow chart describing Maybridge screening results

Michael D. Cameron, Hugh Rosen, Steven J Brown, 2014 .

Table 3, Comparison of Current and Prior ROR Probes

Naresh Kumar, Michael D. Cameron, Becky A. Mercer, 2013 .

Figure 5, Flow chart of HTS screening for NOX1 inhibitors

Peter Hodder, Hui Zhang, William R. Roush, 2011 .

Figure 9, Structures of existing LYPLA1-inhibitors

Peter Hodder, Hugh Rosen, Jill Ferguson, 2013 .

Table 3, Assay Rationale and Description

Dmitriy Minond, Becky A. Mercer, Peter Hodder, 2010 .

Figure 6, CRC overlay of muscarinic rM1 – rM5 selectivity profile for ML326 (VU0467903)

Peter Hodder, Thomas M. Bridges, Michael R. Wood, 2013 .

Table 3, Top HTS Hit from LYPLA1 Inhibitor Discovery Campaign

Peter Hodder, Hugh Rosen, Jill Ferguson, 2013 .

Table S5, SAR Analysis for Target: Ring-Constrained acetamides

Peter Hodder, Hugh Rosen, Jill Ferguson, 2011 .

Figure 5, CRC overlay for CID 2145491

Peter Hodder, Thomas M. Bridges, Michael R. Wood, 2013 .

Table 4, Target SAR Analysis

Peter Hodder, Hugh Rosen, Jill Ferguson, 2013 .

Table 5, Pan Labs profiling of ML326 and selected results for ML172

Peter Hodder, Thomas M. Bridges, Michael R. Wood, 2013 .

[Table, Scientific Rationale for Project].

Becky A. Mercer, Peter Hodder, Hugh Rosen, 2010 .

Table S2, SAR Analysis for Target: R2/R3 = cyclo

Peter Hodder, Hugh Rosen, Jill Ferguson, 2011 .

Table 1, Overview of PubChem assays for NOX1 inhibitor project

Hui Zhang, Peter Hodder, William R. Roush, 2011 .

Table 3.4-1, Target SAR Analysis

Peter Hodder, Hugh Rosen, Jill Ferguson, 2014 .

[Table], PMID List

Becky A. Mercer, Peter Hodder, Hugh Rosen, 2010 .

Table S1, Activity of cherry-picked HTS hits against pPAFAH as assessed by gel-based competitive ABPP (AID 588474)

Peter Hodder, Hugh Rosen, Benjamin F. Cravatt, 2014 .

Table 2, Top Inhibitors from 2ary Screen

Peter Hodder, Hugh Rosen, Jill Ferguson, 2013 .

Ligand-binding pocket shape differences between sphingosine 1-phosphate (S1P) receptors S1P1 and S1P3 determine efficiency of chemical probe identification by ultrahigh-throughput screening.

Peter Hodder, Peter Chase, Hugh Rosen, 2008, ACS chemical biology.

Endothelial Cells Are Central Orchestrators of Cytokine Amplification during Influenza Virus Infection

Robert Peach, Hugh Rosen, Edward Roberts, 2011, Cell.

Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo

Ian Parker, Hugh Rosen, Chi-Huey Wong, 2006, Nature chemical biology.

Lysophospholipid receptors as potential drug targets in tissue transplantation and autoimmune diseases.

Hugh Rosen, J. Chun, H. Rosen, 2006, Current pharmaceutical design.

Novel inhibitors for PRMT1 discovered by high-throughput screening using activity-based fluorescence polarization.

Hugh Rosen, Steven J Brown, B. Cravatt, 2012, ACS chemical biology.

Ranking the selectivity of PubChem screening hits by activity-based protein profiling: MMP13 as a case study.

Hugh Rosen, B. Cravatt, H. Rosen, 2009, Bioorganic & medicinal chemistry.

Crystal Structure of a Lipid G Protein–Coupled Receptor

Hugh Rosen, Peter Kuhn, Raymond C Stevens, 2012, Science.

Suppression of cytokine storm with a sphingosine analog provides protection against pathogenic influenza virus

Hugh Rosen, Yoshihiro Kawaoka, Michael B. A. Oldstone, 2011, Proceedings of the National Academy of Sciences.

The GPCR Network: a large-scale collaboration to determine human GPCR structure and function

Ruben Abagyan, Kurt Wüthrich, Hugh Rosen, 2012, Nature Reviews Drug Discovery.

Molecular characterization of the murine SIGNR1 gene encoding a C-type lectin homologous to human DC-SIGN and DC-SIGNR.

Christopher P Austin, Hugh Rosen, Theresa Zhang, 2002, Gene.