I. McMurtry

发表

Serotonin passes through myoendothelial gap junctions to promote pulmonary arterial smooth muscle cell differentiation.

Natalie N Bauer, S. Gairhe, S. Gebb, 2012, American journal of physiology. Lung cellular and molecular physiology.

Peptide-Coated Liposomal Fasudil Enhances Site Specific Vasodilation in Pulmonary Arterial Hypertension

E. Nozik-Grayck, K. Nahar, F. Ahsan, 2014, Molecular pharmaceutics.

Recombinant tumor necrosis factor/cachectin and interleukin 1 pretreatment decreases lung oxidized glutathione accumulation, lung injury, and mortality in rats exposed to hyperoxia.

P. Ghezzi, C. Dinarello, C. White, 1987, The Journal of clinical investigation.

Lidocaine Reduces Canine Infarct Size and Decreases Release of a Lipid Peroxidation Product

L. Horwitz, R. Johnston, E. Lesnefsky, 1989, Journal of cardiovascular pharmacology.

Cocktail of Superoxide Dismutase and Fasudil Encapsulated in Targeted Liposomes Slows PAH Progression at a Reduced Dosing Frequency.

E. Nozik-Grayck, K. Stenmark, F. Ahsan, 2017, Molecular pharmaceutics.

Inhaled PLGA particles of prostaglandin E₁ ameliorate symptoms and progression of pulmonary hypertension at a reduced dosing frequency.

E. Nozik-Grayck, F. Ahsan, Vivek Gupta, 2013, Molecular pharmaceutics.

Involvement of RhoA/Rho kinase signaling in pulmonary hypertension of the fawn-hooded rat.

K. Morris, M. Oka, V. Karoor, 2006, Journal of applied physiology.

NIP-121 is more effective than nifedipine in acutely reversing chronic pulmonary hypertension.

K. Morris, M. Oka, I. McMurtry, 1993, Journal of applied physiology.

Pulmonary Vascular Remodeling

P. Jones, S. Gebb, I. McMurtry, 2021, Encyclopedia of Molecular Pharmacology.

Cellular and molecular basis of pulmonary arterial hypertension.

N. Weissmann, P. Thistlethwaite, S. Archer, 2009, Journal of the American College of Cardiology.

Tyrosine kinase inhibitors are potent acute pulmonary vasodilators in rats.

W. Gerthoffer, A. Alzoubi, M. Oka, 2011, American journal of respiratory cell and molecular biology.

Myoendothelial gap junctional signaling induces differentiation of pulmonary arterial smooth muscle cells.

S. Gairhe, S. Gebb, I. McMurtry, 2011, American journal of physiology. Lung cellular and molecular physiology.

Inhibitors of Oxidative ATP Production Cause Transient Vasoconstriction and Block Subsequent Pressor Responses in Rat Lungs

I. McMurtry, S. Rounds, 1981, Circulation research.

Role of endothelium-derived relaxing factor during transition of pulmonary circulation at birth.

S. Abman, I. McMurtry, I. McMurtry, 1990, The American journal of physiology.

S1P4 receptor mediates S1P-induced vasoconstriction in normotensive and hypertensive rat lungs

M. Oka, K. Abe, I. McMurtry, 2011, Pulmonary circulation.

Maturational changes in endothelium-derived relaxing factor activity of ovine pulmonary arteries in vitro.

D. Rodman, S. Abman, I. McMurtry, 1991, The American journal of physiology.

Effects of birth-related stimuli on L-arginine-dependent pulmonary vasodilation in ovine fetus.

D. Cornfield, S. Abman, I. McMurtry, 1992, The American journal of physiology.

Hypoxic pulmonary hypertension is prevented in rats with common bile duct ligation.

M. Fallon, D. Ivy, M. Oka, 2005, Journal of applied physiology.

Down-Regulation of Replication Factor C-40 (RFC40) Causes Chromosomal Missegregation in Neonatal and Hypertrophic Adult Rat Cardiac Myocytes

J. Downey, H. Ata, M. Oka, 2012, PloS one.

Dimethylthiourea, but not dimethylsulfoxide, reduces canine myocardial infarct size.

L. Horwitz, J. Repine, E. Lesnefsky, 1989, Free radical biology & medicine.

Reperfusion after acute coronary occlusion in dogs impairs endothelium-dependent relaxation to acetylcholine and augments contractile reactivity in vitro.

L. Horwitz, I. McMurtry, K. Vanbenthuysen, 1987, The Journal of clinical investigation.

Repurposing rosiglitazone, a PPAR‐&ggr; agonist and oral antidiabetic, as an inhaled formulation, for the treatment of PAH

E. Nozik-Grayck, K. Stenmark, F. Ahsan, 2018, Journal of controlled release : official journal of the Controlled Release Society.

Influence of hypertension and hypoxemia on arterial biochemistry and morphology in swine.

D. H. Will, I. McMurtry, C. Frith, 1974, Atherosclerosis.

Effects of chronic hypoxia and altered hemodynamics on endothelial nitric oxide synthase expression in the adult rat lung.

R. Johns, R. Tuder, T. L. Le Cras, 1998, The Journal of clinical investigation.

Inhaled Rho kinase inhibitors are potent and selective vasodilators in rat pulmonary hypertension.

H. Shimokawa, Tsutomu Suzuki, K. Morris, 2005, American journal of respiratory and critical care medicine.

Exaggerated hypoxic pulmonary hypertension in endothelin B receptor-deficient rats.

M. Yanagisawa, C. Gariepy, D. Ivy, 2002, American journal of physiology. Lung cellular and molecular physiology.

Strategic plan for lung vascular research: An NHLBI-ORDR Workshop Report.

M. Gladwin, R. Weinshilboum, M. Humbert, 2010, American journal of respiratory and critical care medicine.

Rho/Rho-kinase Signaling in Hypoxic Pulmonary Hypertension

M. Oka, S. Gebb, I. McMurtry, 2004 .

Hypoxia-induced glucose-6-phosphate dehydrogenase overexpression and -activation in pulmonary artery smooth muscle cells: implication in pulmonary hypertension.

S. Gupte, S. Gebb, I. McMurtry, 2015, American journal of physiology. Lung cellular and molecular physiology.

Rho/Rho kinase signaling mediates increased basal pulmonary vascular tone in chronically hypoxic rats.

M. Oka, S. Gebb, I. McMurtry, 2004, American journal of physiology. Lung cellular and molecular physiology.

Inhibition of Hypoxic Pulmonary Vasoconstriction by Calcium Antagonists in Isolated Rat Lungs

A. Davidson, I. McMurtry, J. Reeves, 1976, Circulation research.

Deficient Rats : A New Model of Severe Pulmonary Arterial Hypertension − B Receptor Development of Occlusive Neointimal Lesions in Distal Pulmonary Arteries of Endothelin

D. Ivy, M. Oka, P. Jones, 2005 .

Development of Occlusive Neointimal Lesions in Distal Pulmonary Arteries of Endothelin B Receptor—Deficient Rats: A New Model of Severe Pulmonary Arterial Hypertension

D. Ivy, M. Oka, P. Jones, 2005, Circulation.

Lungs from chronically hypoxic rats have decreased pressor response to acute hypoxia.

I. McMurtry, J. Reeves, M. Petrun, 1978, The American journal of physiology.

Nitric oxide production in the hypoxic lung.

T. L. Le Cras, I. McMurtry, T. L. Cras, 2001, American journal of physiology. Lung cellular and molecular physiology.

Increased Reactive Oxygen Species, Metabolic Maladaptation, and Autophagy Contribute to Pulmonary Arterial Hypertension–Induced Ventricular Hypertrophy and Diastolic Heart Failure

S. Gupte, A. Alzoubi, I. McMurtry, 2014, Hypertension.

Nitric oxide synthase inhibition and acute renal ischemia: effect on systemic hemodynamics and mortality.

R. Schrier, I. McMurtry, T. Burke, 1995, Renal failure.

Hypoxia increases glutathione redox cycle and protects rat lungs against oxidants.

J. Jackson, C. White, J. Repine, 1988, Journal of applied physiology.

Inhaled combination of sildenafil and rosiglitazone improves pulmonary hemodynamics, cardiac function, and arterial remodeling.

E. Nozik-Grayck, K. Stenmark, F. Ahsan, 2019, American journal of physiology. Lung cellular and molecular physiology.

Pulmonary vasodilation to endothelin isopeptides in vivo is mediated by potassium channel activation.

H. Lippton, I. McMurtry, A. Hyman, 1991, Journal of applied physiology.

Peptide-directed highly selective targeting of pulmonary arterial hypertension.

E. Ruoslahti, N. Ambalavanan, T. Järvinen, 2011, The American journal of pathology.

Mechanism of hypoxic pulmonary vasoconstriction involves ET(A) receptor-mediated inhibition of K(ATP) channel.

K. Morris, D. Rodman, I. McMurtry, 2000, American journal of physiology. Lung cellular and molecular physiology.

Inhaled nitric oxide attenuates pulmonary hypertension and improves lung growth in infant rats after neonatal treatment with a VEGF receptor inhibitor.

S. Abman, I. McMurtry, J. Kinsella, 2004, American journal of physiology. Lung cellular and molecular physiology.

Granulocytes mediate acute edematous lung injury in rabbits and in isolated rabbit lungs perfused with phorbol myristate acetate: role of oxygen radicals.

J. Repine, I. McMurtry, D. Shasby, 2015, The American review of respiratory disease.

Rosiglitazone attenuates hypoxia-induced pulmonary arterial remodeling.

K. Stenmark, J. Reusch, D. Klemm, 2007, American journal of physiology. Lung cellular and molecular physiology.

Increased aortic cyclic guanosine monophosphate concentration in experimental cirrhosis in rats: Evidence for a role of nitric oxide in the pathogenesis of arterial vasodilation in cirrhosis

R. Schrier, P. Ginès, K. Morris, 1995, Hepatology.

Moderation of hypoxic vasoconstriction by infused arachidonic acid: role of PGI2.

N. Voelkel, J. Gerber, I. McMurtry, 1980, Journal of applied physiology: respiratory, environmental and exercise physiology.

Sphingosine-1-Phosphate is Involved in the Occlusive Arteriopathy of Pulmonary Arterial Hypertension

S. Joshi, M. Oka, S. Gairhe, 2016, Pulmonary circulation.

Dehydroepiandrosterone restores right ventricular structure and function in rats with severe pulmonary arterial hypertension.

A. Alzoubi, M. Oka, K. Abe, 2013, American journal of physiology. Heart and circulatory physiology.

Cardiac Output Is Decreased and Hypoxic Vasoconstriction Is Intact in Chronically Hypoxic Sheep 1

L. Moore, N. Voelkel, I. McMurtry, 1980, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

in Endothelin B Receptor Deficient Rats

M. Yanagisawa, C. Gariepy, D. Ivy, 2001 .

Pulmonary vascular dysfunction secondary to pulmonary arterial hypertension: insights gained through retrograde perfusion.

I. McMurtry, T. Stevens, Chun Zhou, 2018, American journal of physiology. Lung cellular and molecular physiology.

Haemodynamic unloading reverses occlusive vascular lesions in severe pulmonary hypertension.

K. Sunagawa, Y. Hirooka, M. Oka, 2016, Cardiovascular research.

Prevention and reversal of hypoxic pulmonary hypertension by calcium antagonists.

K. Morris, I. McMurtry, H. Stanbrook, 1984, The American review of respiratory disease.

Lung vascular smooth muscle as a determinant of pulmonary hypertension at high altitude.

D. H. Will, I. McMurtry, J. Reeves, 1975, The American journal of physiology.

Lipid nanoparticle delivery of a microRNA-145 inhibitor improves experimental pulmonary hypertension.

S. Joshi, W. Gerthoffer, J. Sparks, 2015, Journal of controlled release : official journal of the Controlled Release Society.

Animal Models of Human Severe PAH

I. McMurtry, 2008 .

Lung mast cell density and distribution in chronically hypoxic animals.

I. McMurtry, J. Reeves, A. Tucker, 1977, Journal of applied physiology: respiratory, environmental and exercise physiology.

Evidence for diminished sensitivity of the hamster pulmonary vasculature to hypoxia.

N. Voelkel, B. Walker, I. McMurtry, 1982, Journal of applied physiology: respiratory, environmental and exercise physiology.

Calcium augments hypoxic vasoconstriction in lungs from high-altitude rats.

N. Voelkel, K. Morris, I. McMurtry, 1980, Journal of applied physiology: respiratory, environmental and exercise physiology.

Angiotensin is not required for hypoxic constriction in salt solution-perfused rat lungs.

I. McMurtry, 1984, Journal of applied physiology: respiratory, environmental and exercise physiology.

BAY K 8644 potentiates and A23187 inhibits hypoxic vasoconstriction in rat lungs.

I. McMurtry, 1985, The American journal of physiology.

Aneurysm-type Plexiform Lesions Form in Supernumerary Arteries in Pulmonary Arterial Hypertension: Potential Therapeutic Implications.

S. Joshi, M. Oka, K. Abe, 2019, American journal of physiology. Lung cellular and molecular physiology.

Rho Kinase-Mediated Vasoconstriction Is Important in Severe Occlusive Pulmonary Arterial Hypertension in Rats

N. Voelkel, K. Morris, M. Oka, 2007, Circulation research.

Lung vessel leak precedes right ventricular hypertrophy in monocrotaline-treated rats.

I. Dauber, W. Wagner, I. McMurtry, 1983, Journal of applied physiology: respiratory, environmental and exercise physiology.

Cyp2c44 Gene Disruption Exacerbated Pulmonary Hypertension and Heart Failure in Female but Not Male Mice

S. Joshi, S. Gupte, J. Capdevila, 2016, Pulmonary circulation.

Mechanisms of hypoxic pulmonary vasoconstriction and their roles in pulmonary hypertension: new findings for an old problem.

J. Ward, I. McMurtry, J. Ward, 2009, Current opinion in pharmacology.

Thyroxine treatment increases the hypoxic pulmonary vasoconstriction in isolated lungs from thyroidectomized rats.

I. McMurtry, J. Herget, M. Frydrychová, 1987, Bulletin europeen de physiopathologie respiratoire.

Acetylcholine-induced pulmonary vasodilation in lung vascular injury.

N. Voelkel, P. Henson, I. McMurtry, 1986, The American review of respiratory disease.

Endotoxin (Etx) induced lung protein leak and loss of endothelial dependent relaxation

J. Weil, C. Welsh, I. McMurtry, 1986 .

Chronic propranolol treatment blunts right ventricular hypertrophy in rats at high altitude.

N. Voelkel, I. McMurtry, J. Reeves, 1980, Journal of applied physiology: respiratory, environmental and exercise physiology.

Hypoxia impairs vasodilation in the lung.

N. Voelkel, I. McMurtry, J. Reeves, 1981, The Journal of clinical investigation.

Release of Vasodilator Prostaglandin, PGI from Isolated Rat Lung during Vasoconstriction

N. Voelkel, J. Gerber, I. McMurtry, 1981, Circulation research.

Prostaglandin synthetase inhibitors do not decrease hypoxic pulmonary vasoconstriction.

E. K. Weir, I. McMurtry, J. Reeves, 1976, Journal of applied physiology.

Acetylcholine induces vasodilation and prostacyclin synthesis in rat lungs.

N. Voelkel, M. Mathias, I. McMurtry, 1986, Prostaglandins.

CAR, a homing peptide, prolongs pulmonary preferential vasodilation by increasing pulmonary retention and reducing systemic absorption of liposomal fasudil.

E. Nozik-Grayck, A. Keshavarz, K. Stenmark, 2019, Molecular pharmaceutics.

Fifty Years of Monocrotaline-Induced Pulmonary Hypertension: What Has It Meant to the Field?

M. Gillespie, N. Hill, I. McMurtry, 2017, Chest.

A novel vascular homing peptide strategy to selectively enhance pulmonary drug efficacy in pulmonary arterial hypertension.

E. Ruoslahti, T. Järvinen, T. Urakami, 2014, The American journal of pathology.

Rho kinase-mediated vasoconstriction in rat models of pulmonary hypertension.

M. Oka, I. McMurtry, N. Homma, 2008, Methods in enzymology.

Vascular hypertrophy in cattle susceptible to hypoxic pulmonary hypertension.

E. K. Weir, R. Looga, D. H. Will, 1979, Journal of applied physiology: respiratory, environmental and exercise physiology.

Protein kinase C-epsilon-null mice have decreased hypoxic pulmonary vasoconstriction.

K. Morris, E. Dempsey, R. Messing, 2003, American journal of physiology. Heart and circulatory physiology.

Involvement of RhoA/Rho kinase signaling in dehydroepiandrosterone's protection against monocrotaline-induced pulmonary hypertension in pneumonectomized rats

L. Walker, M. Oka, V. Karoor, 2008 .

Involvement of RhoA/Rho kinase signaling in protection against monocrotaline-induced pulmonary hypertension in pneumonectomized rats by dehydroepiandrosterone.

L. Walker, M. Oka, V. Karoor, 2008, American journal of physiology. Lung cellular and molecular physiology.

Chapter 206 – Endothelin-1

I. McMurtry, K. Fagan, N. Bauer, 2013 .

Upregulation of nitric oxide synthase in mice with severe hypoxia-induced pulmonary hypertension

B. Morrissey, J. Harral, K. Morris, 2001, Respiratory research.

Cardiopulmonary responses of male and female swine to simulated high altitude.

D. H. Will, I. McMurtry, C. Frith, 1973, Journal of applied physiology.

Red blood cells but not platelets prolong vascular reactivity of isolated rat lungs.

I. McMurtry, B. W. Hookway, S. Roos, 1978, The American journal of physiology.

with common bile duct ligation Hypoxic pulmonary hypertension is prevented in rats

D. Conrad, N. Voelkel, A. Abbate, 2015 .

Pulmonary Circulation and Hypoxia Hypoxic pulmonary hypertension is prevented in rats with common bile duct ligation

M. Fallon, D. Ivy, M. Oka, 2004 .

Inhibition of Glucose-6-Phosphate Dehydrogenase Activity Attenuates Right Ventricle Pressure and Hypertrophy Elicited by VEGFR Inhibitor + Hypoxia

S. Gupte, A. Jordan, I. Waddell, 2021, The Journal of Pharmacology and Experimental Therapeutics.

Glucose-6-phosphate dehydrogenase plays a critical role in hypoxia-induced CD133+ progenitor cells self-renewal and stimulates their accumulation in the lungs of pulmonary hypertensive rats.

S. Joshi, S. Gupte, A. Alzoubi, 2014, American journal of physiology. Lung cellular and molecular physiology.

Variable expression of endothelial NO synthase in three forms of rat pulmonary hypertension.

K. Bloch, D. Rodman, S. Abman, 1999, American journal of physiology. Lung cellular and molecular physiology.

Serotonin transporter protein in pulmonary hypertensive rats treated with atorvastatin.

U. Christians, V. Schmitz, S. Trump, 2007, American journal of physiology. Lung cellular and molecular physiology.

Jane Muscle Cells Signaling in Pulmonary Artery Smooth Phosphatidylinositol 3-Kinase / Akt Degradation of CREB via Nuclear Export and Proteasomal Platelet-Derived Growth Factor BB Induces

J. Reusch, D. Klemm, I. McMurtry, 2006 .

Platelet-activating factor causes pulmonary vasodilation in the rat.

K. Morris, I. McMurtry, 1986, The American review of respiratory disease.

Acetyl glyceryl ether phosphorylcholine-stimulated human platelets cause pulmonary hypertension and edema in isolated rabbit lungs. Role of thromboxane A2.

J. Heffner, J. Repine, I. McMurtry, 1983, The Journal of clinical investigation.

Effects of oxygen and exogenous L-arginine on EDRF activity in fetal pulmonary circulation.

D. Cornfield, S. Abman, I. McMurtry, 1993, The American journal of physiology.

Pulmonary-arterial-hypertension (PAH)-on-a-chip: fabrication, validation and application†

R. Kamm, E. Nozik-Grayck, A. Keshavarz, 2020, Lab on a chip.

Temporal hemodynamic and histological progression in Sugen5416/hypoxia/normoxia-exposed pulmonary arterial hypertensive rats.

A. Alzoubi, M. Oka, K. Abe, 2014, American journal of physiology. Heart and circulatory physiology.

Mechanisms of acute hypoxic and hyperpoxic changes in pulmonary vascular reactivity

S. Archer, E. K. Weir, I. McMurtry, 1989 .

Rho kinase-mediated vasoconstriction in pulmonary hypertension.

M. Oka, K. Abe, I. McMurtry, 2010, Advances in experimental medicine and biology.

Lung edema due to hydrogen peroxide is independent of cyclooxygenase products.

N. Voelkel, M. Mathias, I. McMurtry, 1984, Journal of applied physiology: respiratory, environmental and exercise physiology.

Possible role for membrane Lipids in the function of the normal and ab normal pulmonary circulation.

N. Voelkel, I. McMurtry, J. Reeves, 1987, The American review of respiratory disease.

Pulmonary artery catheterization in the rat.

N. Voelkel, K. Morris, I. McMurtry, 1988, The American journal of physiology.

PAF antagonists: different effects on platelets, neutrophils, guinea pig ileum and PAF-induced vasodilation in isolated rat lung.

N. Voelkel, K. Pfeffer, P. Henson, 1986, Prostaglandins.

Inhaled Nitric Oxide Pretreatment But Not Post‐treatment Attenuates Ischemia‐Reperfusion‐induced Pulmonary Microvascular Leak

J. Bridges, I. McMurtry, T. Stevens, 1997, Anesthesiology.

Inhibition of K(Ca) channels restores blunted hypoxic pulmonary vasoconstriction in rats with cirrhosis.

I. McMurtry, E. P. Carter, K. Sato, 2000, American journal of physiology. Lung cellular and molecular physiology.

Prostaglandin synthesis does not mediate the pulmonary vasodilatory effect of acetylcholine.

E. K. Weir, D. H. Will, I. McMurtry, 1976, Prostaglandins.

Endothelin B receptor deficiency potentiates ET-1 and hypoxic pulmonary vasoconstriction.

M. Yanagisawa, C. Gariepy, T. L. Le Cras, 2001, American journal of physiology. Lung cellular and molecular physiology.

Neonatal dexamethasone treatment increases the risk for pulmonary hypertension in adult rats.

T. L. Le Cras, K. Morris, S. Abman, 2000, American journal of physiology. Lung cellular and molecular physiology.

Pulmonary and systemic vascular responsiveness to TNF-alpha in conscious rats.

M. Zamora, K. Morris, I. McMurtry, 1993, Journal of applied physiology.

Endothelin-1 and Serotonin are Involved in Activation of RhoA/Rho Kinase Signaling in the Chronically Hypoxic Hypertensive Rat Pulmonary Circulation

M. Oka, V. Karoor, S. Gebb, 2007, Journal of cardiovascular pharmacology.

Activation of Glucose-6-phosphate Dehydrogenase Promotes Acute Hypoxic Pulmonary Artery Contraction*

W. Gerthoffer, S. Gupte, I. McMurtry, 2010, The Journal of Biological Chemistry.

Dehydroepiandrosterone upregulates soluble guanylate cyclase and inhibits hypoxic pulmonary hypertension.

M. Oka, V. Karoor, S. Gebb, 2007, Cardiovascular research.

Endothelium‐dependent vascular hyporesponsiveness without detection of nitric oxide synthase induction in aortas of cirrhotic rats

R. Schrier, P. Ginès, I. McMurtry, 1995, Hepatology.

Normalization of nitric oxide production corrects arterial vasodilation and hyperdynamic circulation in cirrhotic rats.

R. Schrier, Ding-li Xu, P. Ginès, 1995, Gastroenterology.

Platelet-induced pulmonary hypertension and edema. A mechanism involving acetyl glyceryl ether phosphorylcholine and thromboxane A2.

J. Heffner, J. Repine, I. McMurtry, 1983, Chest.

Mitochondria in hypoxic pulmonary vasoconstriction: potential importance of compartmentalized reactive oxygen species signaling.

A. Al-Mehdi, M. Gillespie, I. McMurtry, 2013, American journal of respiratory and critical care medicine.

How does pulmonary endarterectomy cure CTEPH: A clue to cure PAH?

M. Oka, I. McMurtry, K. Oshima, 2016, American journal of physiology. Lung cellular and molecular physiology.

Introduction: pre- and postnatal lung development, maturation, and plasticity.

I. McMurtry, 2002, American journal of physiology. Lung cellular and molecular physiology.

Variable expression of endothelial NO synthase in three forms of rat pulmonary hypertension.

K. Bloch, D. Rodman, S. Abman, 1999, The American journal of physiology.

Hypoxia inhibits increased ETB receptor-mediated NO synthesis in hypertensive rat lungs.

D. Rodman, I. McMurtry, Koichi Sato, 1999, American journal of physiology. Lung cellular and molecular physiology.

Role of endothelin-1 in lung disease

D. Rodman, I. McMurtry, K. Fagan, 2001, Respiratory research.

Oxygen-radical-mediated permeability edema and vasoconstriction in isolated perfused rabbit lungs.

J. Repine, I. McMurtry, D. Shasby, 2015, The American review of respiratory disease.

EDHF-mediated vasodilation involves different mechanisms in normotensive and hypertensive rat lungs.

M. Oka, I. McMurtry, E. P. Carter, 2003, American journal of physiology. Heart and circulatory physiology.

Expression and preferential inhibition of inducible nitric oxide synthase in aortas of endotoxemic rats.

R. Schrier, M. Raynolds, I. McMurtry, 1995, Journal of the American Society of Nephrology : JASN.

Physiological effects of high altitude on the pulmonary circulation.

W. Wagner, I. McMurtry, J. Reeves, 1979, International review of physiology.

Chronic pulmonary hypertension in utero impairs endothelium-dependent vasodilation.

D. Ivy, S. Abman, I. McMurtry, 1995, The American journal of physiology.

Hemodynamic effects of endothelin-1 on ovine fetal pulmonary circulation.

S. Abman, I. McMurtry, I. McMurtry, 1991, The American journal of physiology.

contractions in the rat main pulmonary artery Chronic hypoxia-induced spontaneous and rhythmic

R. Marthan, M. Oka, B. Walker, 2005 .

Pulmonary vascular reactivity in the spontaneously hypertensive rat.

I. McMurtry, J. Reeves, A. Tucker, 1979, Blood vessels.

Alterations in redox homeostasis and prostaglandins impair endothelial-dependent vasodilation in euglycemic autoimmune nonobese diabetic mice.

J. McCord, S. Flores, K. Haskins, 2005, Free radical biology & medicine.

Effects of Sex Hormones on Cardiovascular and Hematologic Responses to Chronic Hypoxia in Rats

L. Moore, I. McMurtry, J. Reeves, 1978, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

Oxygen Radical-Induced Pulmonary Edema

J. Repine, I. McMurtry, D. Shasby, 1982 .

Enhanced ETA-receptor-mediated inhibition of Kv channels in hypoxic hypertensive rat pulmonary artery myocytes.

D. Rodman, I. McMurtry, B. Fouty, 1999, American journal of physiology. Heart and circulatory physiology.

Chronic hypoxia does not cause wall thickening of intra‐acinar pulmonary supernumerary arteries

M. Oka, W. Wagner, I. McMurtry, 2016, Physiological reports.

Critical Role of Ca + Sensitization in Acute Hypoxic Pulmonary Vasoconstriction

I. McMurtry, T. Robertson, 2004 .

Potential Mechanisms of Hypoxic Pulmonary Vasoconstriction

I. McMurtry, 1987 .

Inhibitors of Arachidonic Acid Metabolism Prevent NeutrophilDependent Acute Lung Injury in Isolated Perfused Rabbit Lungs

J. Repine, I. McMurtry, D. Shasby, 1982 .

1 Inhaled PLGA Particles of Prostaglandin E 1 Ameliorate Symptoms 2 and Progression of Pulmonary Hypertension at a Reduced Dosing

E. Nozik-Grayck, F. Ahsan, Vivek Gupta, 2013 .

Ca(2+) release from ryanodine-sensitive store contributes to mechanism of hypoxic vasoconstriction in rat lungs.

I. McMurtry, Y. Morio, 2002, Journal of applied physiology.

mechanism of hypoxic vasoconstriction in rat lungs release from ryanodine-sensitive store contributes to 2 + Ca

I. McMurtry, 2001 .

Role of pentose phosphate pathway-derived NADPH in hypoxic pulmonary vasoconstriction.

S. Gupte, M. Oka, I. McMurtry, 2006, Pulmonary pharmacology & therapeutics.

Aggregating platelets increase intracellular calcium in endothelial cells through release of adenine nucleotides.

L. Horwitz, I. Dauber, I. McMurtry, 1990, Biochemical and biophysical research communications.

Inhibition of G6PD activity attenuates right ventricle pressure and hypertrophy elicited by VEGFR inhibitor + hypoxia

S. Gupte, A. Jordan, I. Waddell, 2021 .

Coronary endothelial dysfunction from ischemia and reperfusion: effect of reactive oxygen metabolite scavengers.

L. Horwitz, I. Dauber, E. Lesnefsky, 1990, Free radical biology & medicine.

Liposomal fasudil, a rho-kinase inhibitor, for prolonged pulmonary preferential vasodilation in pulmonary arterial hypertension.

E. Nozik-Grayck, F. Ahsan, Vivek Gupta, 2013, Journal of controlled release : official journal of the Controlled Release Society.

Genetic Transmission of Susceptibility to Hypoxic Pulmonary Hypertension

E. K. Weir, D. H. Will, I. McMurtry, 1975 .

Cold-induced pulmonary hypertension in cattle.

D. H. Will, I. McMurtry, J. Reeves, 1978, Journal of applied physiology: respiratory, environmental and exercise physiology.

Effects of intracellular pH on hypoxic vasoconstriction in rat lungs.

I. McMurtry, B. Raffestin, 1987, Journal of applied physiology.

Animal models of pulmonary arterial hypertension: the hope for etiological discovery and pharmacological cure.

Kurt R Stenmark, Barbara Meyrick, W. Mooi, 2009, American journal of physiology. Lung cellular and molecular physiology.

Formation of Plexiform Lesions in Experimental Severe Pulmonary Arterial Hypertension

N. Voelkel, C. Cool, A. Alzoubi, 2010, Circulation.

Endothelial cells in culture produce a vasoconstrictor substance

R. Robbins, I. McMurtry, Richard F. O'Brien, 1987, Journal of cellular physiology.

Inhaled sildenafil as an alternative to oral sildenafil in the treatment of pulmonary arterial hypertension (PAH)

E. Nozik-Grayck, K. Stenmark, F. Ahsan, 2017, Journal of controlled release : official journal of the Controlled Release Society.

MicroRNA-140 is elevated and mitofusin-1 is downregulated in the right ventricle of the Sugen5416/hypoxia/normoxia model of pulmonary arterial hypertension.

S. Joshi, S. Gupte, J. Edwards, 2016, American journal of physiology. Heart and circulatory physiology.

Regulation of heme oxygenase-1 by nitric oxide during hepatopulmonary syndrome.

K. Morris, I. McMurtry, E. P. Carter, 2002, American journal of physiology. Lung cellular and molecular physiology.

The Pulmonary Circulation Conferences

E. K. Weir, I. McMurtry, J. Reeves, 1985 .

Lung development versus hypoxic pulmonary hypertension

M. Oka, S. Gebb, I. McMurtry, 2003 .

Hypoxic Activation of G6PD Controls the Expression of Genes Involved in the Pathogenesis of Pulmonary Hypertension Through the Regulation of DNA Methylation.

A. D’Alessandro, S. Joshi, K. Stenmark, 2020, American journal of physiology. Lung cellular and molecular physiology.

Attenuation of acute hypoxic pulmonary vasoconstriction and hypoxic pulmonary hypertension in mice by inhibition of Rho-kinase.

K. Morris, D. Ivy, M. Oka, 2004, American journal of physiology. Lung cellular and molecular physiology.

Platelet-Derived Growth Factor BB Induces Nuclear Export and Proteasomal Degradation of CREB via Phosphatidylinositol 3-Kinase/Akt Signaling in Pulmonary Artery Smooth Muscle Cells

J. Reusch, D. Klemm, I. McMurtry, 2006, Molecular and Cellular Biology.

Cardioprotective and vasomotor effects of HO activity during acute and chronic hypoxia.

K. Morris, D. Ivy, D. Rodman, 2004, American journal of physiology. Heart and circulatory physiology.

TRPC4 inactivation confers a survival benefit in severe pulmonary arterial hypertension.

A. Alzoubi, M. Oka, I. McMurtry, 2013, The American journal of pathology.

Pluripotent HSCs Augment a-Adrenergic Receptor-Mediated Contraction of Pulmonary Artery and Contribute to the Pathogenesis of Pulmonary Hypertension.

S. Joshi, R. Tuder, K. Stenmark, 2020, American journal of physiology. Lung cellular and molecular physiology.

Inhibition of nitric oxide synthase unmasks vigorous vasoconstriction in established pulmonary arterial hypertension

K. Sunagawa, M. Oka, H. Tsutsui, 2017, Physiological reports.

Rodent models of PAH: are we there yet?

I. McMurtry, T. Moore, Natalie Bauer, 2007, American journal of physiology. Lung cellular and molecular physiology.

Relative contributions of endothelial , inducible , and neuronal NOS to tone in the murine pulmonary circulation

Paul L Huang, K. Morris, D. Rodman, 1999 .

Functional coronary microvascular injury evident as increased permeability due to brief ischemia and reperfusion.

L. Horwitz, J. Weil, I. Dauber, 1990, Circulation research.

Role of leukocytes in coronary vascular endothelial injury due to ischemia and reperfusion.

L. Horwitz, I. Dauber, E. Lesnefsky, 1991, Circulation research.

Brief Ischemia and Reperfusion

L. Horwitz, J. Weil, I. Dauber, 2005 .

Effects of hypertension and hypoxemia on arterial metabolism and structure.

D. H. Will, I. McMurtry, C. Frith, 1972, Advances in experimental medicine and biology.

Evidence for distinct endothelin receptors in the pulmonary vascular bed in vivo.

W. Summer, H. Lippton, I. McMurtry, 1991, Journal of Cardiovascular Pharmacology.

Attenuation of Hypoxic Pulmonary Vasoconstriction by Verapamil in Intact Dogs 1

I. McMurtry, J. Reeves, A. Tucker, 1976, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

Reduction of bovine pulmonary hypertension by normoxia, verapamil and hexaprenaline

D. H. Will, I. McMurtry, J. Reeves, 1977, Experientia.

Studies of the mechanism of hypoxic pulmonary vasoconstriction.

I. McMurtry, H. Stanbrook, S. Rounds, 1982, Advances in shock research.

Staphylococcus aureus and human platelets cause pulmonary hypertension and thromboxane generation in isolated saline-perfused rabbit lungs.

J. Heffner, J. Repine, I. McMurtry, 1984, The American review of respiratory disease.

Inhibition of glycolysis potentiates hypoxic vasoconstriction in rat lungs.

I. McMurtry, H. Stanbrook, 1983, Journal of applied physiology: respiratory, environmental and exercise physiology.

Capillary recruitment and transit time in the rat lung.

W W Wagner, T. Todoran, R. Presson, 1997, Journal of applied physiology.

Protein kinase C-ε-null mice have decreased hypoxic pulmonary vasoconstriction

K. Morris, E. Dempsey, R. Messing, 2003 .

Blunted hypoxic vasoconstriction in lungs from short-term high-altitude rats.

K. Morris, I. McMurtry, M. Petrun, 1980, The American journal of physiology.

Effects of ouabain, low K+, and aldosterone on hypoxic pressor reactivity of rat lungs.

I. McMurtry, J. Herget, 1985, The American journal of physiology.

Glucose metabolism accelerates the decline of hypoxic vasoconstriction in rat lungs.

I. McMurtry, J. Reeves, I. McMurtry, 1981, Respiration physiology.

Protein kinase C influences rat pulmonary vascular reactivity.

I. McMurtry, B. Raffestin, E. Orton, 1990, The American review of respiratory disease.

Vascular remodeling versus vasoconstriction in chronic hypoxic pulmonary hypertension: a time for reappraisal?

K. Stenmark, I. McMurtry, 2005, Circulation research.

Hypoxia and Rho/Rho-Kinase Signaling

M. Oka, S. Gebb, I. McMurtry, 2003 .

Red blood cells play a crucial role in maintaining vascular reactivity to hypoxia in isolated rat lungs.

I. McMurtry, I. McMurtry, B. W. Hookway, 1977, Chest.

Cyp2c44 gene disruption is associated with increased hematopoietic stem cells: implication in chronic hypoxia-induced pulmonary hypertension.

S. Joshi, S. Gupte, J. Capdevila, 2017, American journal of physiology. Heart and circulatory physiology.

Cyp 2 c 44 gene disruption is associated with increased hematopoietic stem cells : implication in chronic hypoxia-induced pulmonary hypertension

S. Joshi, S. Gupte, J. Capdevila, 2017 .

Protein kinase G is not essential to NO-cGMP modulation of basal tone in rat pulmonary circulation.

T. Lincoln, D. Rodman, P. Komalavilas, 1998, American journal of physiology. Heart and circulatory physiology.

Indispensable roles of OX40L-derived signal and epistatic genetic effect in immune-mediated pathogenesis of spontaneous pulmonary hypertension

K. Sugamura, H. Shimokawa, M. Ono, 2011, BMC Immunology.

Comparison of vascular nitric oxide production and systemic hemodynamics in cirrhosis versus prehepatic portal hypertension in rats

K. Morris, I. McMurtry, M. Niederberger, 1996, Hepatology.

Blunted pulmonary pressor responses to hypoxia in blood perfused, ventilated lungs isolated from oxygen toxic rats: possible role of prostaglandins.

J. Newman, I. McMurtry, J. Reeves, 1981, Prostaglandins.

Use of fat-fed rats to study the metabolic and vascular sequelae of obesity and beta-adrenergic antagonism.

I. McMurtry, K. Fagan, E. Orton, 2009, Comparative medicine.

Meclofenamate potentiates vasoreactivity to alpha-adrenergic stimulation in chronically hypoxic guinea pigs.

L. Moore, I. McMurtry, G. Harrison, 1986, The American journal of physiology.

Comparative sensitivities of isolated rat renal arterioles to endothelin.

B. Yuan, J. Conger, I. McMurtry, 1992, The American journal of physiology.

Effects of Meclofenamate on Pulmonary Vascular Resistance Correlate with Postnatal Age in Young Piglets

G. Redding, I. McMurtry, J. Reeves, 1984, Pediatric Research.

Therapeutic potential of RhoA/Rho kinase inhibitors in pulmonary hypertension

M. Oka, P. Jones, I. McMurtry, 2008, British journal of pharmacology.