D. Northrop

发表

Kinetics of enzymes with iso-mechanisms: dead-end inhibition of fumarase and carbonic anhydrase II.

K. Rebholz, D. Northrop, 1994, Archives of biochemistry and biophysics.

Purification and properties of gentamicin nucleotidyltransferase from Escherichia coli: nucleotide specificity, pH optimum, and the separation of two electrophoretic variants.

D. Northrop, J. V. Van Pelt, 1984, Archives of biochemistry and biophysics.

Fitting enzyme-kinetic data to V/K.

D. Northrop, 1983, Analytical biochemistry.

On the Meaning of Km and V/K in Enzyme Kinetics

D. Northrop, 1998 .

Kinetic isotope effects in cytochrome P-450-catalyzed oxidation reactions. Intermolecular and intramolecular deuterium isotope effects during the N-demethylation of N,N-dimethylphentermine.

A. Y. Lu, G. Miwa, D. Northrop, 1980, The Journal of biological chemistry.

Unusual origins of isotope effects in enzyme-catalysed reactions

D. Northrop, 2006, Philosophical Transactions of the Royal Society B: Biological Sciences.

Quantitative analysis of absorption spectra and application to the characterization of ligand binding curves

R. Duggleby, D. Northrop, 1989, Experientia.

Enzyme kinetics: by Irwin H. Segel, published by Wiley and Sons, New York, £17.05 ($34.10) (xxii + 957 pages)

W. Cleland, D. Northrop, 1976 .

Effects of high pressure on solvent isotope effects of yeast alcohol dehydrogenase.

Y. Cho, D. Northrop, 2000, Biophysical journal.

Determination of Enzyme Mechanisms by Stopped-Flow ESI-MS

F. B. Simpson, D. Northrop, 2000 .

Beyond enzyme kinetics: direct determination of mechanisms by stopped-flow mass spectrometry.

F. B. Simpson, D. Northrop, 1997, Bioorganic & medicinal chemistry.

Transcarboxylase. VI. Kinetic analysis of the reaction mechanism.

D. Northrop, 1969, The Journal of biological chemistry.

Deuterium and tritium kinetic isotope effects on initial rates.

D. Northrop, 1982, Methods in enzymology.

Substrate specificity and structure-activity relationships of gentamicin acetyltransferase I. The dependence of antibiotic resistance upon substrate Vmax/Km values.

J. W. Williams, D. Northrop, 1978, The Journal of biological chemistry.

The kinetics of pig heart triphosphopyridine nucleotide-isocitrate dehydrogenase. II. Dead-end and multiple inhibition studies.

W. Cleland, D. Northrop, 1974, The Journal of biological chemistry.

Correlation of antibiotic resistance with Vmax/Km ratio of enzymatic modification of aminoglycosides by kanamycin acetyltransferase

K. Radika, D. Northrop, 1984, Antimicrobial Agents and Chemotherapy.

Kinetic mechanisms of gentamicin acetyltransferase I. Antibiotic-dependent shift from rapid to nonrapid equilibrium random mechanisms.

J. W. Williams, D. Northrop, J. W. Williams, 1978, The Journal of biological chemistry.

Kinetic distinction between rapid-equilibrium random and abortive ordered enzymatic mechanisms using alternative substrates or kinetic isotope effects.

D. Northrop, C. Gates, 1988, Biochemical and biophysical research communications.

Isotope effects on enzyme-catalyzed reactions : [proceedings of the Sixth Annual Harry Steenbock Symposium, held in Madison, Wisconsin, on June 4 and 5, 1976]

W. Cleland, M. O'Leary, D. Northrop, 1977 .

Uses of isotope effects in the study of enzymes.

D. Northrop, D B Northrop, 2001, Methods.

Purification and properties of gentamicin acetyltransferase I.

J. W. Williams, J W Williams, D. Northrop, 1976, Biochemistry.

Purification of reduced nicotinamide adenine dinucleotide by ion-exchange and high-performance liquid chromatography.

D. Northrop, C. Newton, S. Faynor, 1983, Methods in enzymology.

Purification of reduced nicotinamide adenine dinucleotide by ion-exchange and high-performance liquid chromatography.

D. Northrop, C. Newton, S. Faynor, 1983, Analytical biochemistry.

Transcarboxylase. V. The presence of bound zinc and cobalt.

D. Northrop, H. G. Wood, 1969, The Journal of biological chemistry.

Purification of two forms of kanamycin acetyltransferase from Escherichia coli.

K. Radika, D. Northrop, 1984, Archives of biochemistry and biophysics.

Steady-state analysis of kinetic isotope effects in enzymic reactions.

D. Northrop, D B Northrop, 1975, Biochemistry.

Transcarboxylase. VII. Exchange reactions and kinetics of oxalate inhibition.

D. Northrop, H. G. Wood, 1969, The Journal of biological chemistry.

[36] Oxaloacetate transcarboxylase from Propionibacterium

H. Wood, D. Northrop, B. Gerwin, 1969 .

Determination of the rate-limiting segment of aminoglycoside nucleotidyltransferase 2''-I by pH and viscosity-dependent kinetics.

D. Northrop, C. Gates, 1988, Biochemistry.

Energetics of substrate binding, catalysis, and product release.

W. Cleland, D. Northrop, 1999, Methods in enzymology.

Minimal kinetic mechanism and general equation for deuterium isotope effects on enzymic reactions: uncertainty in detecting a rate-limiting step.

D. Northrop, D B Northrop, 1981, Biochemistry.

Alternative substrate and inhibition kinetics of aminoglycoside nucleotidyltransferase 2''-I in support of a Theorell-Chance kinetic mechanism.

D. Northrop, C. Gates, 1988, Biochemistry.

Applications of Alternative Substrate Kinetics: In Vivo and In Vitro Data on Aminoglycoside Antibiotic Inactivating Enzymes

D. Northrop, 1988 .

Synthesis of a tight-binding, multisubstrate analog inhibitor of gentamicin acetyltransferase I.

D. Northrop, J. W. Williams, 1979, The Journal of antibiotics.

Preparation of stable gentamicin adenylyl transferase of high specific activity.

D. Northrop, P. Goldman, 1975, Biochemical and Biophysical Research Communications - BBRC.

A spectrophotometric assay for gentamicin.

D. Northrop, J. W. Williams, J. S. Langer, 1975, Journal of antibiotics (Tokyo. 1968).

Substrate specificities and structure-activity relationships for the nucleotidylation of antibiotics catalyzed by aminoglycoside nucleotidyltransferase 2''-I.

D. Northrop, C. Gates, 1988, Biochemistry.

Spectrophotometric Assay for Amikacin Using Purified Kanamycin Acetyltransferase

D. Northrop, J. W. Williams, E. Scarbrough, 1979, Antimicrobial Agents and Chemotherapy.

Purification and spectrophotometric assay of neomycin phosphotransferase II1;.

D. Northrop, P. Goldman, 1976, Biochemical and biophysical research communications.

Follow the protons: a low-barrier hydrogen bond unifies the mechanisms of the aspartic proteases.

D. Northrop, D B Northrop, 2001, Accounts of chemical research.

High-pressure effects in molecular biophysics and enzymology

J. Markley, C. Royer, D. Northrop, 1996 .

The expression of isotope effects on enzyme-catalyzed reactions.

D. Northrop, 1981, Annual review of biochemistry.

Effect of pressure on deuterium isotope effects of formate dehydrogenase.

D. Northrop, D. J. Quirk, 2001, Biochemistry.

Calculations of intrinsic isotope effects and the detection of tunneling in enzyme-catalyzed reactions

R. Duggleby, D. Northrop, 1990 .

Solvent isotope effects on the onset of inhibition of porcine pepsin by pepstatin.

Y. Cho, K. Rebholz, D. Northrop, 1994, Biochemistry.

Kinetics of enzymes with iso-mechanisms: analysis of product inhibition.

K. Rebholz, D. Northrop, 1993, The Biochemical journal.

Desalting of nucleotides by reverse-phase high-performance liquid chromatography.

D. Northrop, C. Newton, 1980, Methods in enzymology.

Kinetics of enzymes with iso-mechanisms: solvent isotope effects.

K. Rebholz, D. Northrop, 1997, Archives of biochemistry and biophysics.

Effects of high pressure on enzymatic activity.

D. Northrop, 2002, Biochimica et biophysica acta.

Rethinking fundamentals of enzyme action.

D. Northrop, Dexter B. Northrop, 1999, Advances in enzymology and related areas of molecular biology.

Kinetic mechanism of the GCN5-related chromosomal aminoglycoside acetyltransferase AAC(6')-Ii from Enterococcus faecium: evidence of dimer subunit cooperativity.

Gerard D. Wright, D. Northrop, Kari-ann Draker, 2003, Biochemistry.

Effects of High Pressure on Isotope Effects and Hydrogen Tunneling

D. Northrop, 1999 .

Slow step after bond-breaking by porcine pepsin identified using solvent deuterium isotope effects.

K. Rebholz, D. Northrop, 1991, Biochemical and biophysical research communications.

[9] Kinetics of iso mechanisms

K. Rebholz, D. Northrop, 1995 .

Research Funding

D. Northrop, 1991, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Kinetics of enzymes with isomechanisms: britton induced transport catalyzed by bovine carbonic anhydrase II, measured by rapid-flow mass spectrometry.

F. B. Simpson, D. Northrop, 1998, Archives of biochemistry and biophysics.

Effects of viscosity and solvent deuterium identify multiple partially rate-limiting steps in the kinetics of porcine pepsin.

K. Rebholz, D. Northrop, 1991, Advances in Experimental Medicine and Biology.

Transpeptidation by Porcine Pepsin Catalyzed by a Noncovalent Intermediate Unique to Its Iso-mechanism*

D. Northrop, Y. Cho, 1998, Journal of Biological Chemistry.

Substrate specificities and structure-activity relationships for acylation of antibiotics catalyzed by kanamycin acetyltransferase.

K. Radika, D. Northrop, 1984, Biochemistry.

The expression of kinetic isotope effects during the time course of enzyme-catalyzed reactions

R. Duggleby, D. Northrop, 1989 .