P. Hartman

发表

Potent inhibitors of mammalian 2,3-oxidosqualene lanosterol cyclase are orally active cholesterol lowering agents

O. Morand, H. Lengsfeld, J. Himber, 1994 .

Antifungal chemotherapy--are we winning?

A. Polak, P. Hartman, 1991, Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques.

Mast cell chymase inhibition reduces atherosclerotic plaque progression and improves plaque stability in ApoE-/- mice.

T. V. van Berkel, I. Bot, H. Hilpert, 2011, Cardiovascular research.

Studies on the role and mode of operation of the very-lysine-rich histone H1 (F1) in eukaryote chromatin. The properties of the N-terminal and C-terminal halves of histone H1.

E. Bradbury, P. Hartman, P. Riches, 1975, European journal of biochemistry.

Synthesis of inhibitors of 2,3-oxidosqualene-lanosterol cyclase. 2. Cyclocondensation of .gamma.,.delta.-unsaturated-.beta.-keto esters with imines

N. Georgopapadakou, A. Polak, P. Hartman, 1992 .

A single amino acid substitution in Staphylococcus aureus dihydrofolate reductase determines trimethoprim resistance.

M. Page, A. D'arcy, C. Oefner, 1997, Journal of molecular biology.

Characterization of the gene for the chromosomal dihydrofolate reductase (DHFR) of Staphylococcus epidermidis ATCC 14990: the origin of the trimethoprim-resistant S1 DHFR from Staphylococcus aureus?

M. Page, G. Dale, C. Broger, 1995, Journal of bacteriology.

Optimization of a novel class of benzimidazole-based farnesoid X receptor (FXR) agonists to improve physicochemical and ADME properties.

B. Kuhn, M. Rudolph, K. Bleicher, 2011, Bioorganic & medicinal chemistry letters.

Synthesis of (6E)-8-thia, and (14E)-13-thia-2,3-oxidosqualene : inhibitors of 2,3-oxidosqualene-lanosterol cyclase

P. Hartman, A. Oehlschlager, Y. F. Zheng, 1994 .

The structure of histone H1 and its location in chromatin

P. G. Hartman, James Allan, F. X. Avilés, 1980, Nature.

A pilot study on the efficacy of epiroprim against developmental stages ofToxoplasma gondii andPneumocystis carinii in animal models

H. Mehlhorn, P. Hartman, R. Then, 2004, Parasitology Research.

Antibacterial activities of epiroprim, a new dihydrofolate reductase inhibitor, alone and in combination with dapsone

P. Hartman, R L Then, H H Locher, 1996, Antimicrobial agents and chemotherapy.

Inhibitors of 2,3-Oxidosqualene-Lanosterol Cyclase as Antifungal Agents

P. Hartman, S. Jolidon, P. Guerry, 1992 .

The role of reductants in the tyrosine hydroxylase reaction.

W. Lovenberg, M. Ames, P. Lerner, 1977, Archives of biochemistry and biophysics.

Effect of polydispersity on the n.m.r. spectra of poly(γ-benzyl-l-glutamate) through the helix → coil transition

C. Crane-Robinson, E. Bradbury, P. Hartman, 1973 .

Synthesis of vinyl sulfide analogs of 2,3-oxidosqualene and their inhibition of 2,3-oxidosqualene lanosterol-cyclases☆

Y. Zheng, P. Hartman, A. Oehlschlager, 1995 .

Discovery of tetrahydro-cyclopenta[b]indole as selective LXRs modulator.

M. Wright, Hassen Ratni, P. Hartman, 2009, Bioorganic & medicinal chemistry letters.

Studies on the role and mode of operation of the very-lysine-rich histone H1 in eukaryote chromatin. The three structural regions of the histone H1 molecule.

E. Bradbury, P. Hartman, T. Moss, 1977, European journal of biochemistry.

Comparative Molecular Profiling of the PPARα/γ Activator Aleglitazar: PPAR Selectivity, Activity and Interaction with Cofactors

Armin Ruf, Jörg Benz, Bernd Kuhn, 2012, ChemMedChem.

Studies in mice, hamsters, and rats demonstrate that repression of hepatic apoA-I expression by taurocholic acid in mice is not mediated by the farnesoid-X-receptor

Hans Richter, Martin Ebeling, Konrad Bleicher, 2011, Journal of Lipid Research.

Molecular aspects and mechanism of action of dihydrofolate reductase inhibitors.

P. Hartman, 1993, Journal of chemotherapy.

Studies on the role and mode of operation of the very-lysine-rich histone H1 in eukaryote chromatin. The isolation of the globular and non-globular regions of the histone H1 molecule.

E. Bradbury, P. Hartman, G. E. Chapman, 1976, European journal of biochemistry.

Synthesis and inhibition studies of sulfur-substituted squalene oxide analogues as mechanism-based inhibitors of 2,3-oxidosqualene-lanosterol cyclase.

G. Prestwich, I. Abe, P. Hartman, 1997, Journal of medicinal chemistry.

Synthesis of Sulfur- and Sulfoxide-Substituted 2,3-Oxidosqualenes and Their Evaluation as Inhibitors of 2,3-Oxidosqualene-Lanosterol Cyclase

N. Georgopapadakou, Y. Zheng, P. Hartman, 1995 .

Inhibitors of 2,3-oxidosqualene lanosterol-cyclase as potential antifungal agents.

A. Polak, P. Hartman, S. Jolidon, 1990, Biochemical Society Transactions.

Oxidosqualene cyclase (OSC) inhibitors for the treatment of dyslipidemia

T. Schulz-Gasch, M. Kansy, R. Thoma, 2005 .

Does high-mobility-group non-histone protein HMG 1 interact specifically with histone H1 subfractions?

P. Cary, G. Goodwin, E. Bradbury, 1979, The Biochemical journal.

Synthesis and evaluation of anilinohexafluoroisopropanols as activators/modulators of LXRα and β

Jörg Benz, Bernd Kuhn, B. Kuhn, 2006 .

N‐terminal amino acid sequence of the chromosomal dihydrofolate reductase purified from trimethoprim‐resistant Staphylococcus aureus

P. Hartman, H. Kocher, R. Then, 1988, FEBS letters.

Nuclear magnetic resonance of synthetic polypeptides

P. Cary, C. Crane-Robinson, E. Bradbury, 1973 .

Novel dihydrofolate reductase inhibitors. Structure-based versus diversity-based library design and high-throughput synthesis and screening.

Martin Stahl, P. Gerber, M. Stahl, 2003, Journal of medicinal chemistry.

Inhibitors of Ergosterol Biosynthesis as Antifungal Agents

D. Sanglard, P. Hartman, 1997, Current Pharmaceutical Design.

Discovery of novel and orally active FXR agonists for the potential treatment of dyslipidemia & diabetes.

Franz Schuler, Rainer E. Martin, Rainer E Martin, 2011, Bioorganic & medicinal chemistry letters.

A nuclear-magnetic-resonance study of the globular structure of the H1 histone.

P. Cary, E. Bradbury, P. Hartman, 1978, European journal of biochemistry.

STRUCTURAL DOMAINS IN HISTONES

P. Cary, L. Böhm, C. Crane-Robinson, 1980 .