J. Malina

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Trifunctional dinuclear platinum complexes as DNA-protein cross-linking agents.

V. Brabec, N. Farrell, J. Kašpárková, 2004, Biochemistry.

Optically pure, water-stable metallo-helical 'flexicate' assemblies with antibiotic activity.

V. Brabec, G. Clarkson, A. Rodger, 2011, Nature chemistry.

Metallohelices with activity against cisplatin-resistant cancer cells; does the mechanism involve DNA binding?

Rebecca A. Kaner, V. Brabec, A. Rodger, 2013 .

Iron(II) supramolecular helicates condense plasmid DNA and inhibit vital DNA-related enzymatic activities.

V. Brabec, J. Malina, M. J. Hannon, 2015, Chemistry.

Conformation of DNA GG intrastrand cross-link of antitumor oxaliplatin and its enantiomeric analog.

V. Brabec, G. Natile, O. Novakova, 2007, Biophysical journal.

Replacement of a thiourea with an amidine group in a monofunctional platinum-acridine antitumor agent. Effect on DNA interactions, DNA adduct recognition and repair.

Amanda J. Pickard, V. Brabec, J. Kašpárková, 2011, Molecular pharmaceutics.

Thermodynamic and mechanistic insights into translesion DNA synthesis catalyzed by Y-family DNA polymerase across a bulky double-base lesion of an antitumor platinum drug.

N. Margiotta, V. Brabec, G. Natile, 2012, Chemistry.

The thermodynamics of translesion DNA synthesis past major adducts of enantiomeric analogues of antitumor cisplatin.

V. Brabec, G. Natile, O. Novakova, 2012, Chemistry, an Asian journal.

Increasing DNA reactivity and in vitro antitumor activity of trans diiodido Pt(II) complexes with UVA light.

O. Novakova, C. Garino, L. Salassa, 2015, Journal of inorganic biochemistry.

Metallohelix vectors for efficient gene delivery via cationic DNA nanoparticles

V. Brabec, H. Kostrhunova, J. Malina, 2022, Nucleic acids research.

Antimicrobial activity and DNA/HSA interaction of fluorinated 3,6,9-trisubstituted acridines

V. Brabec, L. Novotný, J. Kašpárková, 2020, Chemical Papers.

DNA condensing effects and sequence selectivity of DNA binding of antitumor noncovalent polynuclear platinum complexes.

V. Brabec, N. Farrell, J. Malina, 2014, Inorganic chemistry.

Studies of the mechanism of action of platinum(II) complexes with potent cytotoxicity in human cancer cells.

V. Brabec, J. Kašpárková, J. Aldrich-Wright, 2009, Journal of medicinal chemistry.

Recognition of major DNA adducts of enantiomeric cisplatin analogs by HMG box proteins and nucleotide excision repair of these adducts.

V. Brabec, G. Natile, J. Kašpárková, 2002, Chemistry & biology.

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J. Malina, 1983 .

Substitution-Inert Polynuclear Platinum Complexes That Inhibit the Activity of DNA Polymerase in Triplex-Forming Templates.

V. Brabec, N. Farrell, J. Malina, 2018, Angewandte Chemie.

Spontaneous translocation of antitumor oxaliplatin, its enantiomeric analogue, and Cisplatin from one strand to another in double-helical DNA.

V. Brabec, G. Natile, J. Malina, 2013, Chemistry.

DNA interstrand cross-links of an antitumor trinuclear platinum(II) complex: thermodynamic analysis and chemical probing.

V. Brabec, N. Farrell, J. Malina, 2011, Chemistry, an Asian journal.

Substitution-Inert Polynuclear Platinum Complexes with Dangling Amines: Condensation/Aggregation of Nucleic Acids and Inhibition of DNA-Related Enzymatic Activities.

V. Brabec, N. Farrell, J. Malina, 2019, Inorganic chemistry.

DNA interactions of antitumor cisplatin analogs containing enantiomeric amine ligands.

V. Brabec, G. Natile, C. Hofr, 2000, Biophysical journal.

DNA interactions of 2-pyrrolinodoxorubicin, a distinctively more potent daunosamine-modified analogue of doxorubicin.

K. Ulbrich, V. Brabec, J. Kašpárková, 2011, Biochemical pharmacology.

Cationic Fe(II)-Triplex Forming Metallohelices as DNA Bulge Binders.

V. Brabec, J. Malina, P. Scott, 2020, Chemistry.

Biophysical analysis of natural, double-helical DNA modified by anticancer heterocyclic complexes of ruthenium(III) in cell-free media

V. Brabec, O. Novakova, B. Keppler, 2001, JBIC Journal of Biological Inorganic Chemistry.

DNA adducts of the enantiomers of the Pt(II) complexes of the ahaz ligand (ahaz=3-aminohexahydroazepine) and recognition of these adducts by HMG domain proteins.

T. Hambley, V. Brabec, M. Vojtíṥková, 2005, Biochemical and biophysical research communications.

Effect of bridging ligand structure on the thermal stability and DNA binding properties of iron(II) triple helicates.

P. Lincoln, G. Clarkson, A. Rodger, 2009, Dalton transactions.

DNA-protein cross-linking by trans-[PtCl(2)(E-iminoether)(2)]. A concept for activation of the trans geometry in platinum antitumor complexes.

V. Brabec, G. Natile, J. Kašpárková, 2003, Nucleic acids research.

Design, Preparation, and Characterization of Zn and Cu Metallopeptides Based On Tetradentate Aminopyridine Ligands Showing Enhanced DNA Cleavage Activity.

V. Brabec, X. Ribas, M. Costas, 2015, Inorganic chemistry.

Influence of surface shape on DNA binding of bimetallo helicates.

S. Khalid, A. Rodger, J. Peberdy, 2007, Journal of inorganic biochemistry.

Energetics, conformation, and recognition of DNA duplexes modified by methylated analogues of [PtCl(dien)]+.

V. Brabec, G. Natile, J. Kašpárková, 2009, Chemistry.

Interaction of dinuclear ruthenium(II) supramolecular cylinders with DNA: sequence-specific binding, unwinding, and photocleavage.

V. Brabec, J. Malina, M. J. Hannon, 2008, Chemistry.

Shape-selective Targeting on RNA Bulges by Peptidomimetic Metallohelices.

V. Brabec, J. Malina, P. Scott, 2020, Chemistry.

Iron(II) supramolecular helicates interfere with the HIV-1 Tat–TAR RNA interaction critical for viral replication

V. Brabec, J. Malina, M. J. Hannon, 2016, Scientific Reports.

Recognition of DNA bulges by dinuclear iron(II) metallosupramolecular helicates

V. Brabec, J. Malina, M. J. Hannon, 2014, The FEBS journal.

DNA binding of dinuclear iron(II) metallosupramolecular cylinders. DNA unwinding and sequence preference

V. Brabec, J. Malina, M. J. Hannon, 2008, Nucleic acids research.

A DNA-binding copper(I) metallosupramolecular cylinder that acts as an artificial nuclease.

E. Sletten, V. Moreno, M. Prieto, 2006, Chemistry.

Design and DNA binding of an extended triple-stranded metallo-supramolecular cylinder.

V. Moreno, G. Clarkson, A. Rodger, 2005, Chemistry.

Mechanistic studies of the modulation of cleavage activity of topoisomerase I by DNA adducts of mono- and bi-functional PtII complexes

V. Brabec, J. Malina, O. Vrána, 2009, Nucleic acids research.

Tröger's base scaffold in racemic and chiral fashion as a spacer for bisdistamycin formation. Synthesis and DNA binding study

V. Brabec, V. Král, J. Malina, 2006 .

Substitution-inert trinuclear platinum complexes efficiently condense/aggregate nucleic acids and inhibit enzymatic activity.

V. Brabec, N. Farrell, J. Malina, 2014, Angewandte Chemie.

NMR analysis of duplex d(CGCGATCGCG)2 modified by Λ- and Δ-[Ru(bpy)2(m-GHK)]Cl2 and DNA photocleavage study

V. Brabec, J. Malina, A. Garoufis, 2007, JBIC Journal of Biological Inorganic Chemistry.

Antiproliferative Activity and Associated DNA Interactions of [Co2L3]6+ Cylinders Derived from Bis(bidentate) 2-Pyridyl-1,2,3-triazole Ligands

V. Brabec, J. Kašpárková, H. Kostrhunova, 2020 .

A Subset of New Platinum Antitumor Agents Kills Cells by a Multimodal Mechanism of Action Also Involving Changes in the Organization of the Microtubule Cytoskeleton.

V. Brabec, J. Kašpárková, J. Aldrich-Wright, 2019, Journal of medicinal chemistry.

Recognition of DNA three-way junctions by metallosupramolecular cylinders: gel electrophoresis studies.

V. Brabec, J. Malina, M. J. Hannon, 2007, Chemistry.

Stabilization of human telomeric RNA G-quadruplex by the water-compatible optically pure and biologically-active metallohelices

V. Brabec, J. Malina, P. Scott, 2020, Scientific Reports.

Optically Pure Metallohelices That Accumulate in Cell Nuclei, Condense/Aggregate DNA, and Inhibit Activities of DNA Processing Enzymes.

V. Brabec, H. Kostrhunova, J. Malina, 2020, Inorganic chemistry.

Energetics, conformation, and recognition of DNA duplexes containing a major adduct of an anticancer azolato-bridged dinuclear Pt(II) complex.

V. Brabec, J. Kašpárková, J. Malina, 2012, Biochimica et biophysica acta.

On the Biology of Werner's Complex.

V. Brabec, N. Farrell, S. Berners‐Price, 2021, Angewandte Chemie.

Antitumor substitution-inert polynuclear platinum complexes stabilize G-quadruplex DNA and suppress G-quadruplex-mediated gene expression

V. Brabec, N. Farrell, H. Kostrhunova, 2021 .

Substitution-Inert Polynuclear Platinum Complexes Inhibit Reverse Transcription Preferentially in RNA Triplex-Forming Templates.

V. Brabec, N. Farrell, J. Malina, 2020, Inorganic chemistry.

Recognition of DNA/RNA bulges by antimicrobial and antitumor metallohelices.

V. Brabec, J. Malina, P. Scott, 2015, Dalton transactions.

Shape-selective recognition of DNA abasic sites by metallohelices: inhibition of human AP endonuclease 1

V. Brabec, J. Malina, P. Scott, 2015, Nucleic acids research.

Archaeology Yesterday and Today: The Development of Archaeology in the Sciences and Humanities

M. Zvelebil, Z. Vasícek, J. Malina, 1990 .

Archaeology and experiment

J. Malina, 1983 .

Substitution-Inert Polynuclear Platinum Complexes Act as Potent Inducers of Condensation/Aggregation of Short Single- and Double-Stranded DNA and RNA Oligonucleotides.

V. Brabec, N. Farrell, J. Malina, 2019, Chemistry.

Thermodynamic impact of abasic sites on simulated translesion DNA synthesis.

V. Brabec, J. Malina, 2014, Chemistry.

Energetics, conformation, and recognition of DNA duplexes modified by monodentate Ru(II) complexes containing terphenyl arenes.

P. Sadler, V. Brabec, J. Kašpárková, 2010, Chemistry.

Chiral differentiation of DNA adducts formed by enantiomeric analogues of antitumor cisplatin is sequence-dependent.

V. Brabec, O. Delalande, J. Malina, 2005, Biophysical journal.

DNA binding selectivity of oligopyridine-ruthenium(II)-lysine conjugate.

O. Novakova, J. Malina, A. Garoufis, 2011, Dalton Transactions.

Oligopyridine-ruthenium(II)-amino acid conjugates: synthesis, characterization, DNA binding properties and interactions with the oligonucleotide duplex d(5'-CGCGCG-3')2.

J. Malina, A. Garoufis, K. Karidi, 2009, Dalton transactions.

Thermodynamic properties of damaged DNA and its recognition by xeroderma pigmentosum group A protein and replication protein A.

V. Brabec, J. Kašpárková, K. Stehlikova, 2006, Archives of biochemistry and biophysics.

Chiral discrimination in platinum anticancer drugs.

V. Brabec, G. Natile, J. Kašpárková, 2002, Environmental health perspectives.

Probing the Thermodynamics of Incorporation of N 6 ‐methyl‐dATP Opposite an Abasic Site, dCMP, and dTMP During Simulated DNA Synthesis by Differential Scanning Calorimetry

V. Brabec, J. Malina, 2018, ChemistrySelect.

Radiation in low doses reduces life span of Daphnia magna

J. Malina, E. Sarapultseva, A. Gorski, 2011 .

A Petro-Archaeological Study of a Deposit of Neolithic Stone Tools at Stará Břeclav, Czechoslovakia

J. Štelcl, F. Kalousek, J. Malina, 1970, Proceedings of the Prehistoric Society.

Walking of antitumor bifunctional trinuclear PtII complex on double-helical DNA

Jaroslav Malina, Jana Kasparkova, Nicholas P. Farrell, 2010, Nucleic Acids Res..

Multiply Intercalator-Substituted Cu(II) Cyclen Complexes as DNA Condensers and DNA/RNA Synthesis Inhibitors.

V. Brabec, B. Keller, S. Wedepohl, 2018, Inorganic chemistry.

Metallohelices stabilize DNA three-way junctions and induce DNA damage in cancer cells

V. Brabec, J. Malina, Peter Scott, 2023, Nucleic acids research.

Fe(II) metallohelices stabilize DNA G-quadruplexes and down-regulate expression of G-quadruplex regulated oncogenes.

V. Brabec, J. Malina, P. Scott, 2021, Chemistry.

Asymmetric triplex metallohelices stabilise DNA G-quadruplexes in promoter oncogene sequences and efficiently reduce their expression in cancer cells

V. Brabec, J. Malina, Hualong Song, 2023, Journal of enzyme inhibition and medicinal chemistry.

DNA interstrand cross-links of an antitumor trinuclear platinum(II) complex: thermodynamic analysis and chemical probing.

V. Brabec, N. Farrell, J. Malina, 2011, Chemistry - An Asian Journal.

Metallohelices that kill Gram-negative pathogens using intracellular antimicrobial peptide pathways

Alexia Hapeshi, J. Malina, D. H. Simpson, 2019, Chemical science.