Arif Khan

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Research design features and patient characteristics associated with the outcome of antidepressant clinical trials.

Russell L. Kolts, K. Krishnan, M. Thase, 2004, The American journal of psychiatry.

Does the increasing placebo response impact outcomes of adult and pediatric ADHD clinical trials? Data from the US Food and Drug Administration 2000-2009.

W. Brown, Arif Khan, Kaysee Fahl Mar, 2017, Journal of psychiatric research.

Has the rising placebo response impacted antidepressant clinical trial outcome? Data from the US Food and Drug Administration 1987‐2013

W. Brown, Arif Khan, Kaysee Fahl Mar, 2017, World psychiatry : official journal of the World Psychiatric Association.

Does the rising placebo response impact antihypertensive clinical trial outcomes? An analysis of data from the Food and Drug Administration 1990-2016

W. Brown, Arif Khan, Kaysee Fahl Mar, 2018, PloS one.

Magnitude and Pattern of Placebo Response in Clinical Trials of Oral Antihyperglycemic Agents: Data From the U.S. Food and Drug Administration, 1999–2015

W. Brown, Arif Khan, Kaysee Fahl Mar, 2018, Diabetes Care.

The efficacy and safety of aripiprazole as adjunctive therapy in major depressive disorder: a multicenter, randomized, double-blind, placebo-controlled study.

R. Berman, R. Mcquade, Arif Khan, 2007, The Journal of clinical psychiatry.

Mortality during US FDA clinical trials in patients with diabetes, hypertension, depression and schizophrenia

W. Brown, Arif Khan, Kaysee Fahl Mar, 2018, The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry.

Placebo Response and Antidepressant Clinical Trial Outcome

M. Detke, C. Mallinckrodt, Arif Khan, 2003, The Journal of nervous and mental disease.

Suicide risk in placebo vs active treatment in placebo-controlled trials for schizophrenia.

W. van den Brink, L. de Haan, T. Wohlfarth, 2003, Archives of general psychiatry.

Subject Numbers and Placebo Outcome Variability in Clinical Trials of New CNS Medications

C. Lineberry, Arif Khan, D. Ridgway, 2007 .

A double-blind, placebo-controlled study of selegiline transdermal system in depressed adolescents.

M. DelBello, A. Azzaro, G. Emslie, 2014, Journal of child and adolescent psychopharmacology.

Outcome measures and serious asthma exacerbation in clinical trials of asthma controller medications.

Arif Khan, J. Schilling, S. Khan, 2012, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.

Handbook of Contemporary Neuropharmacology

W. Brown, D. Solomon, Arif Khan, 2007 .

Magnitude and pattern of placebo response in clinical trials of antiepileptic medications: Data from the Food and Drug Administration 1996-2016.

W. Brown, Arif Khan, Kaysee Fahl Mar, 2018, Contemporary clinical trials.

The history and current state of antidepressant clinical trial design: a call to action for proof-of-concept studies.

H. Kraemer, R. Shelton, M. Fava, 2008, The Journal of clinical psychiatry.

Decreased suicide rates in recent antidepressant clinical trials

W. Brown, Arif Khan, Kaysee Fahl Mar, 2018, Psychopharmacology.

Adjunctive Lanicemine (AZD6765) in Patients with Major Depressive Disorder and History of Inadequate Response to Antidepressants: A Randomized, Placebo-Controlled Study

Michael R. Johnson, M. Quirk, J. Zajecka, 2016, Neuropsychopharmacology.

Placebo in mood disorders: the tail that wags the dog

Arif Khan, S. Khan, Shirin R F Khan, 2003 .

Mifepristone versus Placebo in the Treatment of Psychosis in Patients with Psychotic Major Depression

L. Carpenter, G. Alva, C. Blasey, 2006, Biological Psychiatry.

Efficacy of galcanezumab in patients with chronic migraine and a history of preventive treatment failure

S. Aurora, Shuu-Jiun Wang, E. Pearlman, 2019, Cephalalgia : an international journal of headache.

Dosing strategies for antidepressant clinical trials: a commentary.

Arif Khan, D. Robinson, 2004, Journal of clinical psychopharmacology.

Measures of suicidality in phase 3 clinical trials of levomilnacipran ER in adults with major depressive disorder

M. Thase, S. Durgam, C. Gommoll, 2017, CNS Spectrums.

Relationship Between Depression Severity Entry Criteria and Antidepressant Clinical Trial Outcomes

Russell L. Kolts, C. Lineberry, Arif Khan, 2007, Biological Psychiatry.

Effectiveness and gastrointestinal tolerability during conversion and titration with once-daily OROS® hydromorphone extended release in opioid-tolerant patients with chronic low back pain

Arif Khan, S. Nalamachu, M. Hale, 2013, Journal of pain research.

Seizure Incidence in Psychopharmacological Clinical Trials: An Analysis of Food and Drug Administration (FDA) Summary Basis of Approval Reports

Russell L. Kolts, Kenneth Alper, K. Alper, 2007, Biological Psychiatry.

Comparative mortality risk in adult patients with schizophrenia, depression, bipolar disorder, anxiety disorders, and attention-deficit/hyperactivity disorder participating in psychopharmacology clinical trials.

W. Brown, Arif Khan, James Faucett, 2013, JAMA psychiatry.

Differential pattern of response in mood symptoms and suicide risk measures in severely ill depressed patients assigned to citalopram with placebo or citalopram combined with lithium: role of lithium levels.

E. Giller, Arif Khan, James Faucett, 2011, Journal of psychiatric research.

The effect of a switch to ziprasidone in an adult population with autistic disorder: chart review of naturalistic, open-label treatment.

Arif Khan, Seth A Cohen, B. Fitzgerald, 2004, The Journal of clinical psychiatry.

Suicide risk in patients with anxiety disorders: a meta-analysis of the FDA database.

W. Brown, Arif Khan, S. Khan, 2002, Journal of affective disorders.

A Systematic Review of Comparative Efficacy of Treatments and Controls for Depression

I. Kirsch, W. Brown, P. Lichtenberg, 2012, PloS one.

Suicide rates in clinical trials of SSRIs, other antidepressants, and placebo: analysis of FDA reports.

W. Brown, Arif Khan, S. Khan, 2003, The American journal of psychiatry.

Antidepressants versus placebo in major depression: an overview

W. Brown, Arif Khan, 2015, World psychiatry : official journal of the World Psychiatric Association.

Are placebo controls necessary to test new antidepressants and anxiolytics?

W. Brown, Arif Khan, S. Khan, 2002, The international journal of neuropsychopharmacology.

Relative sensitivity of the Montgomery–Åsberg depression rating scale, the Hamilton depression rating scale and the Clinical Global Impressions rating scale in antidepressant clinical trials: a replication analysis

Arif Khan, Amy E Brodhead, Russell Kolts, 2004, International clinical psychopharmacology.

Maternal prenatal psychological distress and temperament in 1-4 month old infants - A study in a non-western population.

Arif Khan, K. Srinivasan, A. Bhat, 2015, Infant behavior & development.

Sex Differences in Antidepressant Response in Recent Antidepressant Clinical Trials

W. Brown, Arif Khan, Kelly A. Schwartz, 2005, Journal of clinical psychopharmacology.

An application of the revised CONSORT standards to FDA summary reports of recently approved antidepressants and antipsychotics

K. Krishnan, J. Gorman, Arif Khan, 2002, Biological Psychiatry.

BMI, sex, and antidepressant response.

W. Brown, Arif Khan, Kelly A. Schwartz, 2007, Journal of affective disorders.

Relapse prevention of panic disorder in adult outpatient responders to treatment with venlafaxine extended release.

Arif Khan, J. Ferguson, E. Tzanis, 2007, The Journal of clinical psychiatry.

Severity of Depression and Response to Antidepressants and Placebo: An Analysis of the Food and Drug Administration Database

Robyn M Leventhal, W. Brown, Arif Khan, 2002, Journal of clinical psychopharmacology.

Frequency of Positive Studies Among Fixed and Flexible Dose Antidepressant Clinical Trials: An Analysis of the Food and Drug Administraton Summary Basis of Approval Reports

E. Giller, Arif Khan, S. Khan, 2003, Neuropsychopharmacology.

Severity of depressive symptoms and response to antidepressants and placebo in antidepressant trials.

W. Brown, Arif Khan, Amy E Brodhead, 2005, Journal of psychiatric research.

Psychiatric Diagnosis and Clinical Trial Completion Rates: Analysis of the FDA SBA Reports

W. Brown, Arif Khan, Kelly A. Schwartz, 2007, Neuropsychopharmacology.

Magnitude of placebo response and drug–placebo differences across psychiatric disorders

K. Krishnan, M. Rapaport, Arif Khan, 2004, Psychological Medicine.

Aripiprazole Monotherapy in Nonpsychotic Bipolar I Depression: Results of 2 Randomized, Placebo-Controlled Studies

M. Thase, C. Bowden, R. Mcquade, 2008, Journal of clinical psychopharmacology.

Efficacy of aripiprazole adjunctive to lithium or valproate in the long‐term treatment of patients with bipolar I disorder with an inadequate response to lithium or valproate monotherapy: a multicenter, double‐blind, randomized study

L. Rollin, Arif Khan, W. Carson, 2011, Bipolar disorders.

Why Has the Antidepressant–Placebo Difference in Antidepressant Clinical Trials Diminished over the Past Three Decades?

M. Thase, W. Brown, Arif Khan, 2010, CNS neuroscience & therapeutics.

The persistence of the placebo response in antidepressant clinical trials.

W. Brown, Arif Khan, Nick Redding, 2008, Journal of psychiatric research.

Response to letter from Lipsitz et al.

W. Brown, Arif Khan, James Faucett, 2014, Journal of psychiatric research.

Reply to Millman and Opler.

W. Brown, Arif Khan, James Faucett, 2015, Journal of Psychiatric Research.

Magnitude of change with antidepressants and placebo in antidepressant clinical trials using structured, taped and appraised rater interviews (SIGMA-RAPS) compared to trials using traditional semi-structured interviews

W. Brown, Arif Khan, James Faucett, 2014, Psychopharmacology.

Magnitude of placebo response and response variance in antidepressant clinical trials using structured, taped and appraised rater interviews compared to traditional rating interviews.

W. Brown, Arif Khan, James Faucett, 2014, Journal of psychiatric research.

Are the colors and shapes of current psychotropics designed to maximize the placebo response?

W. Brown, Arif Khan, Arif Khan, 2010, Psychopharmacology.

Vilazodone, a novel dual-acting serotonergic antidepressant for managing major depression

Arif Khan, 2009, Expert opinion on investigational drugs.

A randomized, double-blind, placebo-controlled, 8-week study of vilazodone, a serotonergic agent for the treatment of major depressive disorder.

M. Athanasiou, C. Reed, D. Kajdasz, 2011, The Journal of clinical psychiatry.

Mortality risk in patients with schizophrenia participating in premarketing atypical antipsychotic clinical trials.

W. Brown, Arif Khan, D. Robinson, 2007, The Journal of clinical psychiatry.

Assessment of the Efficacy and Safety of BMS-820836 in Patients With Treatment-Resistant Major Depression: Results From 2 Randomized, Double-Blind Studies

R. Shelton, M. Thase, Z. Bhagwagar, 2015, Journal of clinical psychopharmacology.

Current evidence for aripiprazole as augmentation therapy in major depressive disorder

Arif Khan, 2008, Expert review of neurotherapeutics.

The conundrum of depression clinical trials: one size does not fit all

W. Brown, Arif Khan, Kaysee Fahl Mar, 2018, International clinical psychopharmacology.

W. Brown, Arif Khan, James Faucett, 2014, Psychopharmacology.

Antidepressant–placebo differences in 16 clinical trials over 10 years at a single site: role of baseline severity

W. Brown, Arif Khan, James Faucett, 2011, Psychopharmacology.

Suicide risk and symptom reduction in patients assigned to placebo in duloxetine and escitalopram clinical trials: analysis of the FDA summary basis of approval reports.

Arif Khan, Kelly A. Schwartz, K. Schwartz, 2007, Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists.

Abrupt Discontinuation Compared With a 1-Week Taper Regimen in Depressed Outpatients Treated for 24 Weeks With Desvenlafaxine 50 mg/d

P. Ninan, Arif Khan, T. Ramey, 2014, Journal of clinical psychopharmacology.

Weight, lipids, glucose, and behavioral measures with ziprasidone treatment in a population with mental retardation.

Arif Khan, Seth A Cohen, B. Fitzgerald, 2003, The Journal of clinical psychiatry.

Double-Blind Comparison of Escitalopram and Duloxetine in the Acute Treatment of Major Depressive Disorder

G. Alexopoulos, C. Gommoll, Arif Khan, 2007, Clinical drug investigation.

Are antidepressants effective? What's a clinician to think?

M. Thase, Arif Khan, J. Nelson, 2008, The Journal of clinical psychiatry.

Study designs and outcomes in antidepressant clinical trials.

Arif Khan, Arif Khan, Kelly A. Schwartz, 2005, Essential psychopharmacology.

Efficacy and safety of vilazodone 20 and 40 mg in major depressive disorder: a randomized, double-blind, placebo-controlled trial

C. Gommoll, R. Nunez, M. Mathews, 2015, International clinical psychopharmacology.

Symptom reduction and suicide risk in patients treated with placebo in antidepressant clinical trials: an analysis of the Food and Drug Administration database.

W. Brown, Arif Khan, A. Khan, 2000, Archives of general psychiatry.

Levomilnacipran ER 40 mg and 80 mg in patients with major depressive disorder: a phase III, randomized, double-blind, fixed-dose, placebo-controlled study.

M. Liebowitz, C. Gommoll, R. Nunez, 2014, Journal of psychiatry & neuroscience : JPN.

Aripiprazole Monotherapy in Nonpsychotic Bipolar I Depression: Results of 2 Randomized, Placebo-Controlled Studies

M. Thase, C. Bowden, R. Mcquade, 2008, Journal of clinical psychopharmacology.

Magnitude of placebo response and response variance in antidepressant clinical trials using structured, taped and appraised rater interviews compared to traditional rating interviews.

W. Brown, Arif Khan, James Faucett, 2014, Journal of psychiatric research.

Effectiveness and gastrointestinal tolerability during conversion and titration with once-daily OROS® hydromorphone extended release in opioid-tolerant patients with chronic low back pain

Arif Khan, S. Nalamachu, M. Hale, 2013, Journal of pain research.

Symptom reduction and suicide risk among patients treated with placebo in antipsychotic clinical trials: an analysis of the food and drug administration database.

W. Brown, Arif Khan, A. Khan, 2001, The American journal of psychiatry.

Why Has the Antidepressant–Placebo Difference in Antidepressant Clinical Trials Diminished over the Past Three Decades?

M. Thase, W. Brown, Arif Khan, 2010, CNS neuroscience & therapeutics.