N. Kratochwil

发表

Mutational analysis and molecular modeling of the binding pocket of the metabotropic glutamate 5 receptor negative modulator 2-methyl-6-(phenylethynyl)-pyridine.

P. Malherbe, C. Kratzeisen, Pari Malherbe, 2003, Molecular pharmacology.

Pyrido pyrimidinones as selective agonists of the high affinity niacin receptor GPR109A: optimization of in vitro activity.

J. Peters, D. Hainzl, U. Grether, 2010, Bioorganic & medicinal chemistry letters.

Mutational Analysis and Molecular Modeling of the Allosteric Binding Site of a Novel, Selective, Noncompetitive Antagonist of the Metabotropic Glutamate 1 Receptor*

J. Kew, G. Adam, P. Malherbe, 2003, The Journal of Biological Chemistry.

Comparison of the binding pockets of two chemically unrelated allosteric antagonists of the mGlu5 receptor and identification of crucial residues involved in the inverse agonism of MPEP

Martin Stahl, Andreas Mühlemann, P. Gerber, 2006, Journal of neurochemistry.

G protein-coupled receptor transmembrane binding pockets and their applications in GPCR research and drug discovery: a survey.

Rainer E. Martin, W. Guba, J. Slack, 2011, Current topics in medicinal chemistry.

Model-based assessment of erlotinib effect in vitro measured by real-time cell analysis

A. Walz, T. Lavé, A. Iliadis, 2015, Journal of Pharmacokinetics and Pharmacodynamics.

Predicting plasma protein binding of drugs: a new approach.

Manfred Kansy, Walter Huber, Francis Müller, 2002, Biochemical pharmacology.

Partially fluorinated alkoxy groups − Conformational adaptors to changing environments

E. Carreira, B. Kuhn, Quentin A. Huchet, 2017 .

Nanotracing and cavity-ring down spectroscopy: A new ultrasensitive approach in large molecule drug disposition studies

S. Dueker, D. Muri, N. Kratochwil, 2018, PloS one.

Functional analysis and transcriptional output of the Göttingen minipig genome

B. Kuhn, U. Certa, Guido Steiner, 2015, BMC Genomics.

Effect of Partially Fluorinated N‐Alkyl‐Substituted Piperidine‐2‐carboxamides on Pharmacologically Relevant Properties

E. Carreira, M. Kansy, Björn Wagner, 2016, ChemMedChem.

Nucleotide Platination Induced by Visible Light.

P. Sadler, P. Bednarski, J. Parkinson, 1999, Angewandte Chemie.

Synthesis and X-ray crystal structure of trans,cis-[Pt(OAc)2I2(en)]: a novel type of cisplatin analog that can be photolyzed by visible light to DNA-binding and cytotoxic species in vitro.

P. Bednarski, N. Kratochwil, M. Zabel, 1996, Journal of medicinal chemistry.

Population pharmacokinetic analysis of RO5459072, a low water‐soluble drug exhibiting complex food–drug interactions

Cordula Stillhart, C. Diack, N. Frey, 2021, British journal of clinical pharmacology.

ELECTRON-TRANSFER-DRIVEN TRANS-LIGAND LABILIZATION : A NOVEL ACTIVATION MECHANISM FOR PT(IV) ANTICANCER COMPLEXES

P. Sadler, Zijian Guo, P. Bednarski, 1998 .

cis-[PtCl2(NH3){2-(2-hydroxyethyl)pyridine}] − an Analogue of the Anticancer Drug AMD473: Unusual Hydrolysis Rates and pKa Values for the Diaqua Adduct

P. Sadler, T. Hambley, J. Parkinson, 2002 .

Fluorination Patterning: A Study of Structural Motifs That Impact Physicochemical Properties of Relevance to Drug Discovery.

Manfred Kansy, Björn Wagner, Erick M Carreira, 2015, Journal of medicinal chemistry.

Nucleotide cross-linking induced by photoreactions of platinum(IV)-azide complexes.

Andrew Parkin, Simon Parsons, Peter J Sadler, 2003, Angewandte Chemie.

The binding site for neohesperidin dihydrochalcone at the human sweet taste receptor

Nicole A Kratochwil, J. Slack, W. Meyerhof, 2007, BMC Structural Biology.

Chemical stability, biological activity and cellular uptake of a cisplatin analogue having a 1,2-diarylethyleneamine ligand in cultures of human breast cancer cells

A. Otto, P. Bednarski, N. Kratochwil, 2005, Journal of Cancer Research and Clinical Oncology.

Reversible and irreversible interactions of a cisplatin analog bearing a 1,2-diphenylethylenediamine ligand with plasma and plasma proteins in vitro.

A. Otto, P. Bednarski, N. Kratochwil, 1994, Drug metabolism and disposition: the biological fate of chemicals.

Metabolic Profiling of Human Long-Term Liver Models and Hepatic Clearance Predictions from In Vitro Data Using Nonlinear Mixed-Effects Modeling

Thierry Lavé, Franz Schuler, Stephen Fowler, 2017, The AAPS Journal.

An Automated System for the Analysis of G Protein-Coupled Receptor Transmembrane Binding Pockets: Alignment, Receptor-Based Pharmacophores, and Their Application

Martin Ebeling, Martin Stahl, Paul R. Gerber, 2005, J. Chem. Inf. Model..

Photolysis of an iodoplatinum(IV) diamine complex to cytotoxic species by visible light.

A. Vogler, N. Kratochwil, J. Nagle, 1996, Anti-cancer drug design.

Relationships between Reduction Properties and Cancer Cell Growth Inhibitory Activities of cis‐Dichloro‐ and cis‐Diiodo‐Pt(IV)‐ethylenediamines

P. Bednarski, N. Kratochwil, 1999, Archiv der Pharmazie.

Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors.

Martin Ebeling, Nicole A Kratochwil, D. Grandy, 2005, Genomics.

Model-based assessment of erlotinib effect in vitro measured by real-time cell analysis

A. Walz, T. Lavé, A. Iliadis, 2015, Journal of Pharmacokinetics and Pharmacodynamics.

Addressing Today’s Absorption, Distribution, Metabolism, and Excretion (ADME) Challenges in the Translation of In Vitro ADME Characteristics to Humans: A Case Study of the SMN2 mRNA Splicing Modifier Risdiplam

Cordula Stillhart, A. Guenther, K. Heinig, 2021, Drug Metabolism and Disposition.

Characterization of Pharmacokinetics in the Göttingen Minipig with Reference Human Drugs: An In Vitro and In Vivo Approach

T. Singer, N. Parrott, N. Kratochwil, 2016, Pharmaceutical Research.

Population Pharmacokinetics and Novel Exposure-Response Analyses to Inform Optimal Biologic Dose Selection for CD20-TCB, a T-Cell-Engaging Bispecific Antibody, in Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma

P. N. Morcos, C. Ferlini, N. Kratochwil, 2019, Blood.

Predicting plasma protein binding of drugs--revisited.

Manfred Kansy, Walter Huber, Francis Müller, 2004, Current opinion in drug discovery & development.

Determination of key amino acids implicated in the actions of allosteric modulation by 3,3'-difluorobenzaldazine on rat mGlu5 receptors.

Andreas Mühlemann, P. Malherbe, N. Ward, 2006, European journal of pharmacology.

Effect of thiols exported by cancer cells on the stability and growth-inhibitory activity of Pt(IV) complexes

P. Bednarski, N. Kratochwil, 1999, Journal of Cancer Research and Clinical Oncology.

Characterization of Pharmacokinetics in the Göttingen Minipig with Reference Human Drugs: An In Vitro and In Vivo Approach

T. Singer, N. Parrott, N. Kratochwil, 2016, Pharmaceutical Research.

Discovery of the first nonpeptidic, small-molecule, highly selective somatostatin receptor subtype 5 antagonists: a chemogenomics approach.

Wolfgang Guba, Rainer E. Martin, Luke G Green, 2007, Journal of medicinal chemistry.

Bioanalytics and pharmacokinetics of the nociceptin/orphanin FQ peptide receptor agonist RO0646198 in Wistar rats and Cynomolgus monkeys.

K. Heinig, N. Kratochwil, F. Bucheli, 2010, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

The binding site for neohesperidin dihydrochalcone at the human sweet taste receptor

J. Slack, W. Meyerhof, B. Bufe, 2007, BMC Structural Biology.

Population Pharmacokinetics and Exposure-Response Analyses for Glofitamab in Relapsed/Refractory B-Cell Non-Hodgkin Lymphoma (R/R NHL): Confirmation of Efficacy and CRS Mitigation in Patients with Step-up Dosing

A. Kwan, P. N. Morcos, N. Kratochwil, 2020, Blood.

Mechanisms of release of nucleotides and integration of their action as P2X- and P2Y-receptor activating molecules.

T Kendall Harden, Richard C Boucher, T. K. Harden, 2003, Molecular pharmacology.

Simultaneous Assessment of Clearance, Metabolism, Induction, and Drug-Drug Interaction Potential Using a Long-Term In Vitro Liver Model for a Novel Hepatitis B Virus Inhibitor

Stephen Fowler, Nicole A. Kratochwil, Florian Klammers, 2018, The Journal of Pharmacology and Experimental Therapeutics.

Abstract CT096: Phase 1 study of RO7119929 (TLR7 agonist prodrug) in patients (pts) with advanced primary or metastatic liver cancers

B. Sangro, T. Yau, Chia‐Chi Lin, 2023, Cancer Research.

The In Vitro Biotransformation of the Fusion Protein Tetranectin-Apolipoprotein A1

N. Qiu, C. Funk, C. Husser, 2019, Scientific Reports.

The binding site for neohesperidin dihydrochalcone at the human sweet taste receptor

J. Slack, W. Meyerhof, B. Bufe, 2007, BMC Structural Biology.

CD20-TCB, a Novel T-Cell-Engaging Bispecific Antibody, Induces T-Cell-Mediated Killing in Relapsed or Refractory Non-Hodgkin Lymphoma: Biomarker Results From a Phase I Dose-Escalation Trial

M. Bacac, K. Korfi, P. N. Morcos, 2019, Blood.

Addressing Today ’ s Absorption, Distribution, Metabolism, and Excretion (ADME) Challenges in the Translation of In Vitro ADME Characteristics to Humans: A Case Study of the SMN2 mRNA Splicing Modifier Risdiplam S

Cordula Stillhart, D. Tuerck, A. Poirier, 2021 .

SURPRISING REACTIONS OF IODO PT(IV) AND PT(II) COMPLEXES WITH HUMAN ALBUMIN : DETECTION OF CYS34 SULFENIC ACID

P. Sadler, A. Ivanov, M. Patriarca, 1999 .

From astemizole to a novel hit series of small-molecule somatostatin 5 receptor antagonists via GPCR affinity profiling.

Wolfgang Guba, Harald Mauser, Martin Stahl, 2007, Journal of medicinal chemistry.