D. d'Ambrosio

D. d'Ambrosio, J. Dingemanse, M. Hoch, 2014, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Effects of multiple-dose ponesimod, a selective S1P1 receptor modulator, on lymphocyte subsets in healthy humans

S. Jurcevic, D. d'Ambrosio, J. Dingemanse, 2016, Drug design, development and therapy.

Chemotactic profiling of lymphocyte subpopulations.

A. Iellem, D. d'Ambrosio, L. Colantonio, 2004, Methods in molecular biology.

Chemokine receptors in chronic obstructive pulmonary disease (COPD).

P. Panina, M. Mariani, D. d'Ambrosio, 2006, Current drug targets.

Inter-species differences in sensitivity to the calcemic activity of the novel 1,25-dihydroxyvitamin D3 analog BXL746.

B. Camisa, D. d'Ambrosio, Enrico Baroni, 2008, Regulatory toxicology and pharmacology : RTP.

Differential effects of ponesimod, a selective S1P1 receptor modulator, on blood-circulating human T cell subpopulations

D. d'Ambrosio, J. Dingemanse, J. Steinmann, 2015, Immunopharmacology and immunotoxicology.

The SHIP phosphatase becomes associated with Fc gammaRIIB1 and is tyrosine phosphorylated during 'negative' signaling.

J. Cambier, D. d'Ambrosio, D. Fong, 1996, Immunology letters.

Oral ponesimod in patients with chronic plaque psoriasis: a randomised, double-blind, placebo-controlled phase 2 trial

S. Chimenti, P. Sator, P. Holló, 2014, The Lancet.

Preferentially Expressed in Th 2 But Not Th 1 Cutting Edge : The Chemokine Receptor CCR 8 Is

M. Rocchi, D. Robinson, A. Santoni, 1998 .

Oral treatment with a vitamin D3 analogue (BXL628) has anti‐inflammatory effects in rodent model of interstitial cystitis

P. Zvára, T. Streng, K. Andersson, 2006, BJU international.

Biocomparison of Three Formulations of the S1P1 Receptor Modulator Ponesimod in Healthy Subjects

D. d'Ambrosio, J. Dingemanse, M. Hoch, 2015, Drugs in R&D.

Differential expression of granzyme A and granzyme B proteases and their secretion by fresh rat natural killer cells (NK) and lymphokine‐activated killer cells with NK phenotype (LAK‐NK)

L. Frati, A. Santoni, D. d'Ambrosio, 1992, European journal of immunology.

Inhibition by IL‐12 and IFN‐α of I‐309 and macrophage‐derived chemokine production upon TCR triggering of human Th1 cells

S. Sozzani, A. Iellem, F. Sinigaglia, 2000 .

Differential Expression of Chemokine Receptors and Chemotactic Responsiveness of Type 1 T Helper Cells (Th1s) and Th2s

P. Allavena, A. Mantovani, S. Sozzani, 1998, The Journal of experimental medicine.

Cell migration in inflammation and immunity

F. Sinigaglia, D. d'Ambrosio, 2003 .

Regulation of the IL‐12/IL‐12R axis: a critical step in T‐helper cell differentiation and effector function

L. Rogge, F. Sinigaglia, D. d'Ambrosio, 1999, Immunological reviews.

A phase II, multicenter, open-label study evaluating dosing and preliminary safety and efficacy of canakinumab in systemic juvenile idiopathic arthritis with active systemic features.

N. Wulffraat, P. Woo, A. Martini, 2012, Arthritis and rheumatism.

Robocasting of multicomponent sol-gel–derived silicate bioactive glass scaffolds for bone tissue engineering

E. Fiume, F. Baino, J. Massera, 2022, Ceramics International.

The viral chemokine macrophage inflammatory protein-II is a selective Th2 chemoattractant.

P. Allavena, A. Mantovani, G. Bernardini, 1998, Blood.

Chemokine receptors in inflammation: an overview.

F. Sinigaglia, P. Panina-Bordignon, D. d'Ambrosio, 2003, Journal of immunological methods.

The B-cell antigen receptor complex: structure and signal transduction.

J. Cambier, C. Pleiman, D. d'Ambrosio, 1994, Immunology today.

Chemokines Fail to Up-Regulate β1 Integrin-Dependent Adhesion in Human Th2 T Lymphocytes1

J. Downward, R. Pardi, N. Freshney, 2000, The Journal of Immunology.

Effects on bladder function of combining elocalcitol and tolterodine in rats with outflow obstruction

C. Gratzke, T. Streng, K. Andersson, 2012, BJU international.

Involvement of p21ras activation in T cell CD69 expression

R. Testi, L. Frati, D. Cantrell, 1994, European journal of immunology.

Helicobacter pylori-Induced Interleukin-12 p40 Expression

C. Sasakawa, T. Hirayama, C. Ishikawa, 2009, Infection and Immunity.

Differential regulation of chemokine production by Fcγ receptor engagement in human monocytes: association of CCL1 with a distinct form of M2 monocyte activation (M2b, Type 2)

A. Mantovani, S. Sozzani, A. Martini, 2006, Journal of leukocyte biology.

Quantitative Differences in Chemokine Receptor Engagement Generate Diversity in Integrin-Dependent Lymphocyte Adhesion1

Giampiero Girolomoni, Cristina Albanesi, Carlo Laudanna, 2002, The Journal of Immunology.

Integrin-Dependent Lymphocyte Adhesion Receptor Engagement Generate Diversity in Quantitative Differences in Chemokine

C. Albanesi, G. Girolomoni, C. Laudanna, 2002 .

Chemokines and their receptors in asthma and chronic obstructive pulmonary disease

P. Panina-Bordignon, D. d'Ambrosio, 2003, Current opinion in pulmonary medicine.

Transcriptional regulation of interleukin‐2 gene expression by CD69‐generated signals

R. Testi, L. Frati, A. Gulino, 1993, European journal of immunology.

Decreased IL‐12 production and Th1 cell development by acetyl salicylic acid‐mediated inhibition of NF‐κB

D. Mazzeo, F. Sinigaglia, P. Panina-Bordignon, 1998, European journal of immunology.

Upregulation of Integrin 6/β1 and Chemokine Receptor CCR1 by Interleukin-12 Promotes the Migration of Human Type 1 Helper T Cells

R. Pardi, L. Rogge, A. Iellem, 1999 .

Skewing of cytotoxic activity and chemokine production, but not of chemokine receptor expression, in human type-1/-2 gamma delta T lymphocytes.

M. Ferrarini, L. Dagna, A. Iellem, 2002, European journal of immunology.

Efficient Recruitment of Lymphocytes in Inflamed Brain Venules Requires Expression of Cutaneous Lymphocyte Antigen and Fucosyltransferase-VII1

L. Piccio, E. Scarpini, B. Rossi, 2005, The Journal of Immunology.

Ponesimod Compared With Teriflunomide in Patients With Relapsing Multiple Sclerosis in the Active-Comparator Phase 3 OPTIMUM Study

C. Pozzilli, X. Montalban, L. Kappos, 2021, JAMA neurology.

Population pharmacokinetics and pharmacodynamics of ponesimod, a selective S1P1 receptor modulator

D. d'Ambrosio, J. Dingemanse, A. Krause, 2014, Journal of Pharmacokinetics and Pharmacodynamics.

Modeling clinical efficacy of the S1P receptor modulator ponesimod in psoriasis.

D. d'Ambrosio, J. Dingemanse, A. Krause, 2017, Journal of dermatological science.

Oc015—Up-Titration Study With Ponesimod, A Selective S1p1 Receptor Modulator, To Assess Its Maximum Tolerated Dose In Healthy Subjects

D. d'Ambrosio, J. Dingemanse, M. Hoch, 2013 .

Three different up‐titration regimens of ponesimod, an S1P1 receptor modulator, in healthy subjects

D. d'Ambrosio, J. Dingemanse, M. Scherz, 2015, Journal of clinical pharmacology.

Skin-homing CLA+ T cells and regulatory CD25+ T cells represent major subsets of human peripheral blood memory T cells migrating in response to CCL1/I-309.

A. Iellem, F. Sinigaglia, D. d'Ambrosio, 2002, European journal of immunology.

Fucosyltransferase-VII of Cutaneous Lymphocyte Antigen and Inflamed Brain Venules Requires Expression Efficient Recruitment of Lymphocytes in

L. Piccio, E. Scarpini, B. Rossi, 2005 .

Concurrency in leukocyte vascular recognition: developing the tools for a predictive computer model.

Paola Lecca, Corrado Priami, Carlo Laudanna, 2004, Trends in immunology.

Efficacy and Safety of 2 Doses of Ponesimod (10 and 20 mg o.d.): Interim Analysis of a Phase II Extension Trial in Relapsing-remitting Multiple Sclerosis (P3.398)

C. Pozzilli, M. Freedman, A. Achiron, 2018 .

Long-Term Efficacy, Safety and Tolerability of Ponesimod in Patients with Relapsing–Remitting Multiple Sclerosis (P01.156)

C. Pozzilli, M. Freedman, T. Olsson, 2013 .

Helicobacter pylori-Induced Interleukin-12 p40 Expression

C. Sasakawa, T. Hirayama, C. Ishikawa, 2009, Infection and Immunity.

Inhibition of IL-12 production by 1,25-dihydroxyvitamin D3. Involvement of NF-kappaB downregulation in transcriptional repression of the p40 gene.

M. Cippitelli, D. D'Ambrosio, D. Mazzeo, 1998, The Journal of clinical investigation.

Selective up-regulation of chemokine receptors CCR4 and CCR8 upon activation of polarized human type 2 Th cells.

A. Mantovani, S. Sozzani, R. Bonecchi, 1998, Journal of immunology.

Beta2-agonists prevent Th1 development by selective inhibition of interleukin 12.

L. Fabbri, D. D'Ambrosio, D. Mazzeo, 1997, The Journal of clinical investigation.

Targeting chemoattractant receptors in allergic inflammation.

D. d'Ambrosio, 2005, Current drug targets. Inflammation and allergy.

Localization of Th-cell subsets in inflammation: differential thresholds for extravasation of Th1 and Th2 cells.

R. Pardi, D. D'Ambrosio, A. Iellem, 2000, Immunology today.

Differential Expression of Chemokine Receptors and Chemotactic Responsiveness of Type 1 T Helper Cells (Th1s) and Th2s

P. Allavena, A. Mantovani, S. Sozzani, 1998, The Journal of experimental medicine.

Ponesimod, a selective S1P1 receptor modulator: a potential treatment for multiple sclerosis and other immune-mediated diseases

M. Freedman, J. Prinz, D. d'Ambrosio, 2016, Therapeutic advances in chronic disease.

Differential effects of ponesimod, a selective S1P1 receptor modulator, on blood-circulating human T cell subpopulations

D. d'Ambrosio, J. Dingemanse, J. Steinmann, 2015, Immunopharmacology and immunotoxicology.

Helicobacter pylori-Induced Interleukin-12 p40 Expression

C. Sasakawa, T. Hirayama, C. Ishikawa, 2011, Infection and Immunity.