P. Krimpenfort

发表

Longevity of Antigen Presentation and Activation Status of APC Are Decisive Factors in the Balance Between CTL Immunity Versus Tolerance1

R. Offringa, C. Melief, R. Toes, 2001, The Journal of Immunology.

T-cell-specific deletion of T-cell receptor transgenes allows functional rearrangement of endogenous alpha- and beta-genes.

A. Berns, Y. Uematsu, M. Malissen, 1988, Nature.

The CD3γ chain is essential for development of both the TCRαβ and TCRγδ lineages

J. Borst, A. Kruisbeek, M. Haks, 1998 .

Insertional mutagenesis in mice deficient for p15Ink4b, p16Ink4a, p21Cip1, and p27Kip1 reveals cancer gene interactions and correlations with tumor phenotypes.

Jeroen de Ridder, Jos Jonkers, Konstantin Matentzoglu, 2010, Cancer research.

Insertional Mutagenesis in Mice Deficient for p 15 Ink 4 b , p 16 Ink 4 a , p 21 Cip 1 , and p 27 Kip 1 Reveals Cancer Gene Interactions and Correlations with Tumor Phenotypes

Miranda van Uitert, J. Rogers, M. V. Uitert, 2010 .

Combined deletion of Bap1, Nf2, and Cdkn2ab causes rapid onset of malignant mesothelioma in mice

A. Berns, O. Krijgsman, D. Peeper, 2020, The Journal of experimental medicine.

A conditional mouse model for malignant mesothelioma.

M. J. van de Vijver, A. Berns, M. Vooijs, 2008, Cancer cell.

Cancer Cell A Somatic Sporadic Murine Mesothelioma Model

A. Berns, M. Vijver, M. Vooijs, 2022 .

Targeted biallelic inactivation of Pten in the mouse prostate leads to prostate cancer accompanied by increased epithelial cell proliferation but not by reduced apoptosis.

T. H. van der Kwast, A. Berns, P. V. van Duijn, 2005, Cancer research.

Immunological defects in mice with a targeted disruption in Bcl-3.

I. Verma, E. Schwarz, A. Berns, 1997, Genes & development.

Mice with a targeted disruption of the Fanconi anemia homolog Fanca.

A. Berns, A. Berns, H. Joenje, 2000, Human molecular genetics.

Transgenic mice carrying the apolipoprotein E3-Leiden gene exhibit hyperlipoproteinemia.

R. Frants, L. Havekes, A. M. van den Maagdenberg, 1993, The Journal of biological chemistry.

In transgenic mice the introduced functional T cell receptor β gene prevents expression of endogenous β genes

S. Ryser, A. Berns, Y. Uematsu, 1988, Cell.

The CD3gamma chain is essential for development of both the TCRalphabeta and TCRgammadelta lineages.

J. Borst, A. Kruisbeek, M. Haks, 1998, The EMBO journal.

An inducible mouse model of melanoma expressing a defined tumor antigen.

I. Huijbers, P. Chomez, A. Berns, 2006, Cancer research.

VascularSMCproliferationisacrucialeventinocclusivecardiovasculardiseases.PPARαisanuclearrecep- torcontrollinglipidmetabolismandinflammation,butitsroleintheregulationofSMCgrowthremains tobeestablished.Here,weshowthatPPARα controlsSMCcell-cycleprogressionattheG 1 /Stransitionby

B. Staels, G. Torpier, O. Barbier, 2005 .

Pre-TCR signaling and inactivation of p53 induces crucial cell survival pathways in pre-T cells.

A. Kruisbeek, M. Haks, J. V. D. van den Brakel, 1999, Immunity.

Deleted in colorectal carcinoma suppresses metastasis in p53-deficient mammary tumours

A. Berns, J. Jonkers, N. Proost, 2012, Nature.

Virus-Specific CD 8 TCR Down-Regulation Controls

J. Christensen, C. Geisler, A. Thomsen, 2008 .

TCR Down-Regulation Controls Virus-Specific CD8+ T Cell Responses1

J. Christensen, C. Geisler, A. Thomsen, 2008, The Journal of Immunology.

Pim1 Reconstitutes Thymus Cellularity in Interleukin 7–And Common γ Chain–Mutant Mice and Permits Thymocyte Maturation in Rag- but Not Cd3γ-Deficient Mice

B. Blom, A. Berns, H. Spits, 1999, The Journal of experimental medicine.

Crosses of two independently derived transgenic mice demonstrate functional complementation of the genes encoding heavy (HLA‐B27) and light (beta 2‐microglobulin) chains of HLA class I antigens.

H. Ploegh, A. Berns, G. Rudenko, 1987, The EMBO journal.

HLA-restricted recognition of viral antigens in HLA transgenic mice

A. Berns, H. Ploegh, P. Krimpenfort, 1987, Nature.

Identification and Characterization of Collaborating Oneogenes in Compound Mutant Mice 1

A. Berns, J. Jonkers, B. Scheijen, 2007 .

Identification and characterization of collaborating oncogenes in compound mutant mice.

A. Berns, J. Jonkers, B. Scheijen, 1999, Cancer research.

PIM1 Reconstitutes Thymus Cellularity in Interleukin 7– and Common (cid:103) Chain–Mutant Mice and Permits Thymocyte Maturation in Rag- but Not CD3 (cid:103) -deﬁcient Mice

B. Blom, A. Berns, H. Spits, 1999 .

Lack of expression of HLA-B27 gene in transgenic mouse trophoblast. Conserved genetic pressures underlying extra-embryonic development

C. Meijer, H. Ploegh, C. Oudejans, 1989, The Journal of experimental medicine.

T-cell-specific deletion of T-cell receptor transgenes allows functional rearrangement of endogenous α- and β-genes

A. Berns, Y. Uematsu, M. Malissen, 1988, Nature.

The Loss of PTEN Allows TCR (cid:1)(cid:2) Lineage Thymocytes to Bypass IL-7 and Pre-TCR–mediated Signaling

Thijs J. Hagenbeek, J. Trapman, J. Nunès, 2004 .

In Vivo Triggering Through 4-1BB Enables Th-Independent Priming of CTL in the Presence of an Intact CD28 Costimulatory Pathway1

R. Offringa, C. Melief, R. Toes, 2002, The Journal of Immunology.

Pathway Presence of an Intact CD 28 Costimulatory Th-Independent Priming of CTL in the In Vivo Triggering Through 4-1 BB Enables Mittler

Boer, R. Offringa, C. Melief, 2002 .

Transgenic expression of the muscle-specific intermediate filament protein desmin in nonmuscle cells

A. Berns, F. Pieper, F. Ramaekers, 1989, The Journal of cell biology.

Actin maturation requires the ACTMAP/C19orf54 protease

M. Vermeulen, T. Brummelkamp, C. Ottenheijm, 2022, Science.

The Loss of PTEN Allows TCR αβ Lineage Thymocytes to Bypass IL-7 and Pre-TCR–mediated Signaling

Thijs J. Hagenbeek, J. Trapman, J. Nunès, 2004, The Journal of experimental medicine.

The Role of the Common Gamma Chain of the IL-2, IL-4, IL-7 and IL-15 Receptors in Development of Lymphocytes. Constitutive Expression of Bcl-2 does not Rescue the Developmental Defects in Gamma Common-Deficient Mice

B. Blom, H. Spits, P. Krimpenfort, 1997 .

United States Patent ( 19 ) Krimpenfort et al . 54 TRANSGENIC MICE DEPLETED IN MATURE T-CELLS AND METHODS FOR MAKING TRANSGENIC MICE

A. Berns, P. Krimpenfort, 2017 .

Efficient generation of functional transgenes by homologous recombination in murine zygotes.

F. Pieper, P. Krimpenfort, H. D. de Boer, 1992, Nucleic acids research.

of the T Cell Receptor–associated CD3 (cid:2) –ITAM to Thymocyte Selection

H. Kessels, A. Kruisbeek, M. Haks, 2002 .

Rejuvenation by Therapeutic Elimination of Senescent Cells

A. Berns, P. Krimpenfort, 2017, Cell.

Transcription of T cell receptor beta‐chain genes is controlled by a downstream regulatory element.

Uematsu, S. Ryser, A. Berns, 1988, The EMBO journal.

Human-mouse interspecies collagen I heterotrimer is functional during embryonic development of Mov13 mutant mouse embryos

A. Schnieke, A. Sharpe, A. Berns, 1990, Molecular and cellular biology.

In transgenic mice the introduced functional T cell receptor beta gene prevents expression of endogenous beta genes.

S. Ryser, A. Berns, Y. Uematsu, 1988, Cell.

Generation Of Transgenic Dairy Cattle Using ‘in vitro’ Embryo Production

F. Pieper, G. Platenburg, P. Krimpenfort, 1991, Bio/Technology.

Epithelial detachment due to absence of hemidesmosomes in integrin β4 null mice

A. Sonnenberg, J. Calafat, C. Niessen, 1996, Nature Genetics.

Somatic inactivation of E-cadherin and p53 in mice leads to metastatic lobular mammary carcinoma through induction of anoikis resistance and angiogenesis.

Jos Jonkers, Robert D Cardiff, Bastiaan Evers, 2006, Cancer cell.

Mammary-specific inactivation of E-cadherin and p53 impairs functional gland development and leads to pleomorphic invasive lobular carcinoma in mice

J. Wesseling, J. Jonkers, M. Hornsveld, 2011, Disease Models & Mechanisms.

PPAR alpha inhibits vascular smooth muscle cell proliferation underlying intimal hyperplasia by inducing the tumor suppressor p16INK4a.

B. Staels, G. Torpier, O. Barbier, 2005, The Journal of clinical investigation.

Loss of p16Ink4a confers susceptibility to metastatic melanoma in mice

A. Berns, W. Mooi, P. Krimpenfort, 2001, Nature.

p15Ink4b is a critical tumour suppressor in the absence of p16Ink4a

A. Berns, M. Nawijn, M. Valk, 2007, Nature.

A murine mesenchymal stem cell model for initiating events in osteosarcomagenesis points to CDK4/CDK6 inhibition as a therapeutic target

A. Cleton-Jansen, A. Kruisselbrink, J. Bovée, 2021, Laboratory Investigation.

A targeted mouse Brca1 mutation removing the last BRCT repeat results in apoptosis and embryonic lethality at the headfold stage

P. Devilee, C. Cornelisse, R. Fodde, 2001, Oncogene.

T cell depletion in transgenic mice carrying a mutant gene for TCR-β

A. Berns, C. Melief, J. Borst, 1989, Nature.

Predisposition to lymphomagenesis in pim-1 transgenic mice: Cooperation with c-myc and N-myc in murine leukemia virus-induced tumors

A. Berns, M. Lohuizen, J. Domen, 1989, Cell.

Senolytic treatment preserves biliary regenerative capacity lost through cellular senescence during cold storage

S. Forbes, R. Aird, G. Oniscu, 2022, Science Translational Medicine.

ARF functions as a melanoma tumor suppressor by inducing p53-independent senescence

R. DePinho, S. Lowe, N. Sharpless, 2007, Proceedings of the National Academy of Sciences.

Toxicity of ligand-dependent Cre recombinases and generation of a conditional Cre deleter mouse allowing mosaic recombination in peripheral tissues.

Jos Jonkers, Ernesto Bockamp, Steffen Schmitt, 2007, Physiological genomics.

Wnt Down, Tumors Wind Up?

A. Berns, P. Krimpenfort, 2015, Cell.

Rapid target gene validation in complex cancer mouse models using re-derived embryonic stem cells

I. Huijbers, A. Berns, M. Cozijnsen, 2014, EMBO molecular medicine.

Rapid validation of cancer genes in chimeras derived from established genetically engineered mouse models

I. Huijbers, A. Berns, J. Jonkers, 2011, BioEssays : news and reviews in molecular, cellular and developmental biology.

Cellular senescence inhibits renal regeneration after injury in mice, with senolytic treatment promoting repair

S. Forbes, J. Hughes, A. Melk, 2021, Science Translational Medicine.

Gene transfer into mammalian embryos.

A. Berns, P. Krimpenfort, 1987, Human reproduction.

The generation of a conditional reporter that enables bioluminescence imaging of Cre/loxP-dependent tumorigenesis in mice.

Anton Berns, A. Berns, S. Lyons, 2003, Cancer research.

PTEN is essential for cell migration but not for fate determination and tumourigenesis in the cerebellum.

A. Berns, S. Brandner, J. Trapman, 2002, Development.

SHP2 is required for growth of KRAS-mutant non-small-cell lung cancer in vivo

R. Bernards, A. Prahallad, A. Bardelli, 2018, Nature Medicine.

Increased sensitivity to anticancer drugs and decreased inflammatory response in mice lacking the multidrug resistance-associated protein

Jos H. Beijnen, Piet Borst, Jan Wijnholds, 1997, Nature Medicine.

Expression analysis of the individual bovine beta-, alpha s2- and kappa-casein genes in transgenic mice.

M. Rijnkels, F. Pieper, P. Krimpenfort, 1995, The Biochemical journal.

Expression of human lactoferrin in milk of transgenic mice

F. Pieper, G. Platenburg, S. L. Woloshuk, 1994, Transgenic Research.

Constitutive CD27/CD70 interaction induces expansion of effector-type T cells and results in IFNgamma-mediated B cell depletion.

R. V. van Lier, J. Borst, M. V. van Oers, 2001, Immunity.

Epithelial detachment due to absence of hemidesmosomes in integrin beta 4 null mice.

A. Sonnenberg, J. Calafat, C. Niessen, 1996, Nature genetics.

dcc orchestrates the development of the prefrontal cortex during adolescence and is altered in psychiatric patients

B. Kolb, B. Giros, E. Nestler, 2013, Translational Psychiatry.

A Redundant Role of the CD3γ-Immunoreceptor Tyrosine-Based Activation Motif in Mature T Cell Function1

J. Haanen, J. Borst, E. de Vries, 2001, The Journal of Immunology.

A Redundant Role of the CD3g-Immunoreceptor Tyrosine-Based Activation Motif in Mature T Cell Function

E. D. Vries, J. Borst, A. Kruisbeek, 2001 .

A doxycycline- and light-inducible Cre recombinase mouse model for optogenetic genome editing

R. Beijersbergen, J. van Rheenen, K. Jalink, 2022, Nature Communications.

Contributions of the T Cell Receptor–associated CD3γ–ITAM to Thymocyte Selection

H. Kessels, A. Kruisbeek, M. Haks, 2002, The Journal of experimental medicine.

SHP2 is required for growth of KRAS-mutant non-small-cell lung cancer in vivo

R. Bernards, A. Prahallad, A. Bardelli, 2018, Nature Medicine.

DCC expression by neurons regulates synaptic plasticity in the adult brain.

E. S. Ruthazer, C. Chapman, G. Doucet, 2013, Cell reports.

DCC Receptors Drive Prefrontal Cortex Maturation by Determining Dopamine Axon Targeting in Adolescence

B. Kolb, A. Torres-Berrío, C. Flores, 2018, Biological Psychiatry.

Improved pregnancy and birth rates with routine application of nonsurgical embryo transfer

I. Huijbers, A. Berns, C. Pritchard, 2014, Transgenic Research.

Progressive Disorganization of Paranodal Junctions and Compact Myelin Due to Loss of DCC Expression by Oligodendrocytes

A. Sadikot, T. Kennedy, A. Boutet, 2014, The Journal of Neuroscience.

L11.05 RAPID VALIDATION OF CANCER GENES AND DRUG TARGETS IN GENETICALLY ENGINEERED MOUSE MODELS OF CANCER

I. Huijbers, A. Berns, M. Cozijnsen, 2013 .

A natural WNT signaling variant potently synergizes with Cdkn2ab loss in skin carcinogenesis

A. Berns, D. Adams, Elzo de Wit, 2019, Nature Communications.

cGAS–STING drives ageing-related inflammation and neurodegeneration

Vivek V. Thacker, V. V. Thacker, L. Favre, 2023, Nature.

Identification of an alternative triglyceride biosynthesis pathway

T. Brummelkamp, H. Janssen, J. Jonker, 2023, Nature.

Tissue‐specific expression of a vimentin–desmin hybrid gene in transgenic mice.

A. Berns, F. Pieper, F. Ramaekers, 1988, The EMBO journal.

A natural WNT signaling variant potently synergizes with Cdkn2ab loss in skin carcinogenesis

A. Berns, D. Adams, Elzo de Wit, 2019, Nature Communications.

The Loss of PTEN Allows TCR αβ Lineage Thymocytes to Bypass IL-7 and Pre-TCR–mediated Signaling

Thijs J. Hagenbeek, J. Trapman, J. Nunès, 2004, The Journal of experimental medicine.