C. Alper

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Complotypes in individuals of African origin: frequencies and possible extended MHC haplotypes

E. Yunis, P. Fraser, Barbara Moore, 2004, Immunogenetics.

A genetic explanation for the rising incidence of type 1 diabetes, a polygenic disease.

C. Larsen, A. Pugliese, E. Yunis, 2006, Journal of autoimmunity.

HLA-Cw alleles associated with HLA extended haplotypes and C2 deficiency.

L. Truedsson, E. Yunis, J. Delgado, 1998, Tissue antigens.

Alpha-1-antitrypsin deficiency and disease.

A. Johnson, C. Alper, 1970, Pediatrics.

The cellular basis for lack of antibody response to hepatitis B vaccine in humans

C. Morimoto, E. Yunis, M. Salazar, 1991, The Journal of experimental medicine.

The haplotype structure of the human major histocompatibility complex.

C. Larsen, E. Yunis, C. Alper, 2006, Human immunology.

Frequent occurrence of conserved extended haplotypes (CEHs) in two Caucasian populations.

Á. Szilágyi, G. Füst, C. Larsen, 2010, Molecular immunology.

EXTENDED MHC HAPLOTYPES IN 21-HYDROXYLASE-DEFICIENCY CONGENITAL ADRENAL HYPERPLASIA: SHARED GENOTYPES IN UNRELATED PATIENTS

J. Granados, E. Yunis, S. Alosco, 1983, The Lancet.

Serum Complement ‘Supergenes' of the Major Histocompatibility Complex in Man (Complotypes)

E. Yunis, C. Alper, Z. Awdeh, 1983, Vox sanguinis.

Extended HLA/complement allele haplotypes: evidence for T/t-like complex in man.

E. Yunis, C. Alper, Z. Awdeh, 1983, Proceedings of the National Academy of Sciences of the United States of America.

Extended major histocompatibility complex haplotypes in patients with gluten-sensitive enteropathy.

E. Yunis, C. Alper, Z. Awdeh, 1987, The Journal of clinical investigation.

Extended major histocompatibility complex haplotypes in patients with multiple sclerosis

H. Weiner, S. Hauser, E. Yunis, 1989, Neurology.

Genetic prediction of nonresponse to hepatitis B vaccine.

A. Katz, D. Craven, S. Brink, 1989, The New England journal of medicine.

Major histocompatibility complex haplotype studies in Ashkenazi Jewish patients with pemphigus vulgaris.

A. Ahmed, E. Yunis, C. Alper, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Major histocompatibility complex haplotypes and class II genes in non-Jewish patients with pemphigus vulgaris.

A. Ahmed, E. Yunis, C. Alper, 1991, Proceedings of the National Academy of Sciences of the United States of America.

HLA-DR2, [HLA-B7, SC31, DR2], and [HLA-B8, SC01, DR3] haplotypes distinguish subjects with asthma from those with rhinitis only in ragweed pollen allergy.

B. Johnson, E. Yunis, D. Marcus-Bagley, 1992, Journal of immunology.

Predictability of alloreactivity among unrelated individuals.

E. Yunis, C. Alper, Z. Awdeh, 1992, Tissue antigens.

Major histocompatibility complex susceptibility genes for dermatitis herpetiformis compared with those for gluten-sensitive enteropathy

A. Ahmed, E. Yunis, J. Yunis, 1993, The Journal of experimental medicine.

Gametic association of HSP70-1 promoter region alleles and their inclusion in extended HLA haplotypes.

A. Pugliese, I. Cascino, S. D'alfonso, 1993, Tissue antigens.

Tumor necrosis factor (TNF) microsatellite haplotypes in relation to extended haplotypes, susceptibility to diseases associated with the major histocompatibility complex and TNF secretion.

S. Hauser, R. Lincoln, G. Eisenbarth, 1996, Human immunology.

Relationship between protein complotypes and DNA variant haplotypes: complotype-RFLP constellations (CRC).

L. Truedsson, G. Eisenbarth, S. Brink, 1997, Human immunology.

Incomplete penetrance of MHC susceptibility genes: prospective analysis of polygenic MHC-determined traits.

C. Alper, Z. Awdeh, C A Alper, 2000, Tissue antigens.

Prospective analysis suggests susceptibility genes for deficiencies of IgA and several other immunoglobulins on the [HLA-B8, SC01, DR3] conserved extended haplotype.

P. Schur, G. Eisenbarth, S. Brink, 2000, Tissue antigens.

Association of polymorphisms in the HLA-B region with extended haplotypes

J. Strominger, T. Spies, E. Yunis, 2004, Immunogenetics.

HLA-Cw*0409N is associated with HLA-A*2301 and HLA-B*4403-carrying haplotypes.

J. Hansen, C. Larsen, A. Smith, 2004, Human immunology.

HLA-DQB1*0602 Is Associated With Dominant Protection From Diabetes Even Among Islet Cell Antibody–Positive First-Degree Relatives of Patients with IDDM

H. Erlich, G. Eisenbarth, A. Pugliese, 1995, Diabetes.

Association of DQw7 (DQB1*0301) with ocular cicatricial pemphigoid.

A. Ahmed, E. Yunis, C. Alper, 1991, Proceedings of the National Academy of Sciences of the United States of America.

MHC class II alleles and haplotypes in patients with pemphigus vulgaris from India.

N. Mehra, A. Ahmed, E. Yunis, 1996, Tissue antigens.

Linkage of pemphigus vulgaris antibody to the major histocompatibility complex in healthy relatives of patients

E. Beutner, A. Ahmed, E. Yunis, 1993, The Journal of experimental medicine.

Major histocompatibility complex genes and susceptibility to systemic lupus erythematosus.

H. Mcdevitt, K. Kalunian, B. Peterlin, 1990, Arthritis and rheumatism.

Abstracts of Papers Presented at the Third International Complement Workshop, Harvard Medical School, Boston, Massachusetts, June 3–5, 1968 Genetic Aspects of Human C′3

F. Rosen, R. Johnston, C. Alper, 1968 .

Complex expression of natural killer receptor genes in single natural killer cells

Z. Husain, E. Yunis, C. Alper, 2002, Immunology.

Two subsets of HLA-DQA1 alleles mark phenotypic variation in levels of insulin autoantibodies in first degree relatives at risk for insulin-dependent diabetes.

H. Erlich, G. Eisenbarth, T. Bugawan, 1994, The Journal of clinical investigation.

Interaction between immunoglobulin allotypes and NK receptor genes in diabetes post-hepatitis C virus infection.

D. Middleton, C. Larsen, E. Yunis, 2011, Immunobiology.

BF types and the mode of inheritance of insulin-dependent diabetes mellitus (IDDM)

C. Alper, Z. Awdeh, D. Raum, 2005, Immunogenetics.

Conserved extended haplotypes discriminate HLA-DR3-homozygous Basque patients with type 1 diabetes mellitus and celiac disease

P. Fain, S. Gaztambide, J. Bilbao, 2006, Genes and Immunity.

Statement on the nomenclature of human C4 allotypes.

B. Olaisen, C. Nerl, P. Demant, 1983, Immunobiology.

Inherited structural polymorphism of the fourth component of human complement.

C. Alper, Z. Awdeh, 1980, Proceedings of the National Academy of Sciences of the United States of America.

GENETIC P OLYMORPHISM IN HUMAN G LYCINE-RICH BETA-GLYCOPROTEI N*, {

C. Alper, T. Boenisch, L. Watson, 1972 .

Inherited structural polymorphism in human C2: evidence for genetic linkage between C2 and Bf

C. Alper, 1976, The Journal of experimental medicine.

Major histocompatibility complex associations with systemic lupus erythematosus.

H. Mcdevitt, K. Kalunian, B. Peterlin, 1988, The American journal of medicine.

Genetics of the complement system.

C. Alper, K. Crawford, F. Rosen, 2000, Reviews in immunogenetics.

Hemolytic efficiencies of genetic variants of human C3.

H. Colten, C. Alper, 1972, Journal of immunology.

Mapping of the structural gene for the second component of complement with respect to the human major histocompatibility complex.

P. Schur, C. Carpenter, C. Alper, 1979, American journal of human genetics.

Monoclonal and oligoclonal gammopathy after bone marrow transplantation.

H. Weinstein, C. Alper, J. Antin, 1989, Blood.

Human factor D of the alternative complement pathway. Physicochemical characteristics and N-terminal amino acid sequence.

F. Rosen, A. Davis, C. Alper, 1979, Biochemistry.

The effect of ethnicity on major histocompatibility complex complement allotypes and extended haplotypes in patients with systemic lupus erythematosus.

P. Schur, E. Yunis, D. Marcus-Bagley, 1990, Arthritis and rheumatism.

Increased Apoptosis of CD 20 + IgA + B Cells is the Basis for IgA Deficiency : The Molecular Mechanism for Correction In Vitro by IL-10 and CD 40 L

Z. Husain, C. Alper, I. Szymanski, 2009 .

Increased Apoptosis of CD20+ IgA+ B Cells is the Basis for IgA Deficiency: The Molecular Mechanism for Correction In Vitro by IL-10 and CD40L

Z. Husain, C. Alper, I. Szymanski, 2006, Journal of Clinical Immunology.

Immunofixation Electrophoresis: A Technique for the Study of Protein Polymorphism

A. Johnson, C. Alper, 1993, Vox sanguinis.

Plasma protein measurements as a diagnostic aid.

C. Alper, 1974, The New England journal of medicine.

Progressive Autoimmune Beta Cell Insufficiency: Occurrence in the Absence of High-Risk HLA Alleles DR3, DR4

G. Eisenbarth, O. Ganda, S. Brink, 1985, Diabetes Care.

The immunoglobulin heavy chain and disease association: application to pemphigus vulgaris

M. Walter, D. Cox, A. Ahmed, 1994, Human Genetics.

Specific Association of HLA-DR4 With Increased Prevalence and Level of Insulin Autoantibodies in First-Degree Relatives of Patients With Type I Diabetes

G. Eisenbarth, S. Brink, L. Castano, 1991, Diabetes.

International system for human gene nomenclature (1979) ISGN (1979).

N E Morton, T H Roderick, P J McAlpine, 1979, Cytogenetics and cell genetics.

Complotype genetic loci segregate more frequently with HLA-DR than with HLA-B

R. Hartzman, E. Yunis, N. Suciu-Foca, 2004, Immunogenetics.

The distribution of human C4 DNA variants in relation to major histocompatibility complex alleles and extended haplotypes.

L. Truedsson, P. Schneider, A. Whitehead, 1988, Human immunology.

Metabolism of C4 and linkage analysis in a kindred with hereditary incomplete C4 deficiency.

A. Davis, C. Alper, M. Nathanson, 1987, Arthritis and rheumatism.

DNA polymorphism of the C4 genes. A new marker for analysis of the major histocompatibility complex.

H. Colten, A. Whitehead, D. Woods, 1984, The New England journal of medicine.

Genetic analysis of C4 deficiency.

H. Ochs, C. Alper, Z. Awdeh, 1981, The Journal of clinical investigation.

C4 polymorphism and HLA linkage: studies in a family with hereditary C4 deficiency.

E. Yunis, C. Alper, Z. Awdeh, 1981, Clinical immunology and immunopathology.

International System for Human Gene Nomenclature (1979) ISGN (1979).

N E Morton, T H Roderick, P J McAlpine, 1980, Birth defects original article series.

The location ofC2, C4, andBF relative toHLA-B andHLA-D

D. Glass, E. Yunis, C. Alper, 1981, Immunogenetics.

A Simple Estimate of the General Population Frequency of the MHC Susceptibility Gene for Autoimmune Polygenic Disease

E. Yunis, C. Alper, Z. Awdeh, 2000, Experimental and Clinical Immunogenetics.

HLA-Cw 7 Zygosity Affects the Size of a Subset of CD 158 b ! Natural Killer Cells

Z. Husain, C. Larsen, E. Yunis, 2009 .

Identification of HLA-B44 subtypes associated with extended MHC haplotypes

E. Yunis, C. Alper, Z. Awdeh, 2004, Immunogenetics.

Two variants of DRw52, DR3, and DQw2 specificities distinguish two different DR3-bearing extended haplotypes.

E. Yunis, C. Alper, Z. Awdeh, 1988, Human immunology.

Major histocompatibility complex markers and red cell antibodies to the Rh (D) antigen. Absence of association

E. Yunis, C. Alper, Z. Awdeh, 1990, Transfusion.

203 RA5 immune resposses, HLA antigens and complotypes

E. Yunis, M. Blumenthal, C. Alper, 1985 .

CD2 engagement induces dendritic cell activation: implications for immune surveillance and T-cell activation.

E. Reinherz, C. Larsen, C. Alper, 2003, Blood.

Association of HLA-DQB1*0201 with stiff-man syndrome.

P. De Camilli, H. Erlich, M. Solimena, 1993, The Journal of clinical endocrinology and metabolism.

Mendelian inheritance of polygenic diseases: a hypothetical basis for increasing incidence.

C. Alper, Z. Awdeh, 2005, Medical hypotheses.

Quantitative variation of C4 variant proteins associated with many MHC haplotypes

L. Truedsson, E. Yunis, Barbara Moore, 2006, Immunogenetics.

Restriction fragment length polymorphisms in BF , C 2 , C 4 A , and C 4 B Enzyme Probe Variants

L. Truedsson, G. Eisenbarth, S. Brink, 1997 .

Conserved, extended MHC haplotypes.

E. Yunis, C. Alper, Z. Awdeh, 1992, Experimental and clinical immunogenetics.

C4B gene polymorphisms among African and African-American HLA-Bw42-DRw18 haplotypes

E. Yunis, P. Fraser, Barbara Moore, 2004, Immunogenetics.

Complement-human histocompatibility antigen haplotypes in C2 deficiency.

P. Schur, E. Gelfand, R. Johnston, 1981, The Journal of clinical investigation.

Cryoglobulinuria: studies of a cryo-Bence Jones protein.

C. Alper, 2009, Acta medica Scandinavica. Supplementum.

A New Genetic Determinant of γG3 1

P. Schur, C. Alper, H. Borel, 1976 .

Selective gamma-g globulin deficiencies in patients with recurrent pyogenic infections.

P. Schur, E. Gelfand, F. Rosen, 1970, The New England journal of medicine.

Linkage between the gene (or genes) controlling synthesis of the fourth component of complement and the major histocompatibility complex.

H. Ochs, J. Hansen, B. Dupont, 1977, The New England journal of medicine.

Changes in serum proteinase inhibitor levels following bone surgery.

C. Alper, I. Dickson, 1974, Clinica chimica acta; international journal of clinical chemistry.

Deficiency of alpha-1 antitrypsin.

C. Alper, 1973, Annals of internal medicine.

Circulating CD 2 ! Monocytes Are Dendritic Cells 1

E. Reinherz, C. Alper, K. Crawford, 2009 .

No Independent Association Between HSP70 Gene Polymorphism and IDDM

G. Eisenbarth, A. Galluzzo, A. Pugliese, 1992, Diabetes.

Normal HBsAg presentation and T-cell defect in the immune response of nonresponders

M. Salazar, D. Marcus-Bagley, C. Alper, 2004, Immunogenetics.

agranulocytosis in two different ethnic groups HSP70- 2 variants is associated with clozapine-induced The major histocompatibility complex region marked by HSP70-1 and

J. Yunis, E. Yunis, D. Corzo, 2011 .

Genetically determined polymorphism of the circulating human breast cancer-associated DF3 antigen.

D. Hayes, D. Kufe, C. Alper, 1988, Blood.

HLA-DQ RFLP variants of five HLA-DQw2-bearing major histocompatability complex extended haplotypes

E. Yunis, J. Yunis, S. Alosco, 2004, Immunogenetics.

Evidence for a silent or null gene in hereditary C2 deficiency.

C. Alper, D. Raum, E. Berkman, 1978, Journal of immunology.

Prognostically Significant Heterogeneity of Cytoplasmic Islet Cell Antibodies in Relatives of Patients with Type I Diabetes

S. Bonner-Weir, G. Eisenbarth, A. Pugliese, 1992, Diabetes.

Variants of the group-specific component system as demonstrated by immunofixation electrophoresis. Report of a new variant, Gc Boston (Ge B).

A. Johnson, C. Alper, H. Cleve, 1975, American journal of human genetics.

Measurement of serum enzyme turnover rates.

D. Dawson, C. Alper, J. Seidman, 1969, Annals of internal medicine.

The MHC in human bone marrow allotransplantation.

C. Alper, Z. Awdeh, E. Yunis, 1983, Clinics in haematology.

Polymorphism of the human complement C4 and steroid 21-hydroxylase genes. Restriction fragment length polymorphisms revealing structural deletions, homoduplications, and size variants.

H. Colten, P. Schneider, A. Whitehead, 1986, The Journal of clinical investigation.

Amniotic fluid proteins: maternal and fetal contributions.

A. Johnson, C. Alper, C. Everett, 1974, The Journal of pediatrics.

Defect in Th1-like cells of nonresponders to hepatitis B vaccine.

E. Yunis, M. Salazar, C. Alper, 1997, Human immunology.

Inherited incomplete deficiency of the fourth component of complement (C4) determined by a gene not linked to human histocompatibility leukocyte antigens.

S. Hedrick, C. Alper, W. Muir, 1984, The Journal of clinical investigation.

Biosynthesis of the third component of complement (C3) in vitro by monocytes from both normal and homozygous C3-deficient humans.

H. Colten, F. Rosen, A. Davis, 1977, The Journal of clinical investigation.

Genetic aspects of the complement system.

F. Rosen, C. Alper, 1971, Advances in immunology.

Genetic polymorphism of human complement C4 and detection of heterozygotes

C. Alper, Z. Awdeh, D. Raum, 1979, Nature.

Studies of a hypomorphic variant of human C3.

F. Rosen, C. Alper, 1971, The Journal of clinical investigation.

Inherited deficiencies of complement proteins in man

F. Rosen, C. Alper, 2005, Springer Seminars in Immunopathology.

A History of Complement Genetics

C. Alper, 1999, Experimental and Clinical Immunogenetics.

Genetic Deficiencies of the Complement System

F. Rosen, C. Alper, 1985, Clinics in Immunology and Allergy.

Biosynthetic defect in monocytes from human beings with genetic deficiency of the second component of complement.

H. Colten, F. Rosen, J. David, 1975, The New England journal of medicine.

Pre-Type 1 (insulin-dependent) diabetes: common endocrinological course despite immunological and immunogenetic heterogeneity

O. Ganda, S. Brink, R. Jackson, 1984, Diabetologia.

Complotypes in pemphigus vulgaris: differences between Jewish and non-Jewish patients.

A. Ahmed, E. Yunis, C. Alper, 1990, Human immunology.

Behavior in vivo of normal and dysfunctional C1 inhibitor in normal subjects and patients with hereditary angioneurotic edema.

F. Rosen, M. Cicardi, R. Harrison, 1983, The Journal of clinical investigation.

ACUTE PHASE REACTANTS CERULOPLASMIN AND HAPTOGLOBIN AND THEIR RELATIONSHIP TO PLASMA PROSTAGLANDINS IN RABBITS BEARING THE VX~ CARCINOMA*

A. Tashjian, E. F. Voelkel, C. Alper, 2003 .

Acute phase reactants ceruloplasmin and haptoglobin and their relationship to plasma prostaglandins in rabbits bearing the VS2 carcinoma

A. Tashjian, E. F. Voelkel, C. Alper, 1978, The Journal of experimental medicine.

Human C4 haplotypes with duplicated C4A or C4B.

L. Strong, J. Granados, E. Yunis, 1984, American journal of human genetics.

Haptoglobin synthesis. II. Cellular localization studies.

C. Alper, J. Peters, 1966, The Journal of clinical investigation.

HAPTOGLOBIN SYNTHESIS. I. IN VIVO STUDIES OF THE PRODUCTION OF HAPTOGLOBIN, FIBRINOGEN, AND GAMMA-GLOBULIN BY THE CANINE LIVER.

F. Gardner, C. Alper, J. Peters, 1965, The Journal of clinical investigation.

Inherited deficiencies of complement components in man.

C. Alper, 1987, Immunology letters.

558 Immune response genes of ragweed sensitive individuals

N. Mendell, B. Johnson, E. Yunis, 1988 .

Genetic Polymorphism of Human C3

C. Alper, 1970 .

Synthesis of human plasminogen by the liver.

T. Starzl, C. Alper, D. Raum, 1980, Science.

Genetics and biosynthesis of complement proteins.

H. Colten, F. Rosen, C. Alper, 1981, The New England journal of medicine.

Studies of hepatic synthesis in vivo of plasma proteins, including orosomucoid, transferrin, α-antitrypsin, C8, and factor B

B. H. Petersen, T. Starzl, C. Alper, 1980 .

Complotypes, extended haplotypes, male segregation distortion, and disease markers.

E. Yunis, C. Alper, Z. Awdeh, 1986, Human immunology.

C4 nomenclature statement (1990).

P. Schneider, C. Rittner, C. Alper, 1990, Complement and inflammation.

THE ENHANCEMENT OF BACTERIAL PHAGOCYTOSIS BY SERUM THE ROLE OF COMPLEMENT COMPONENTS AND TWO COFACTORS

F. Rosen, R. Johnston, C. Alper, 1969 .

transplantation Monoclonal and oligoclonal gammopathy after bone marrow

B. Smith, H. Weinstein, C. Alper, 2011 .

Complotypes and extended haplotypes in laboratory medicine.

E. Yunis, C. Alper, Z. Awdeh, 1989, Complement and inflammation.

Inherited deficiency of the sixth component of complement: a silent or null gene.

P. Schur, E. Kagan, C. Alper, 1978, Journal of immunology.

Genetic polymorphism of human plasminogen.

C. Alper, D. Raum, D. Marcus, 1980, American journal of human genetics.

The metabolism of C1 inhibitor and C1q in patients with acquired C1-inhibitor deficiency.

F. Rosen, M. Cicardi, C. Alper, 1986, The Journal of allergy and clinical immunology.

Requirement for complement components and fibrinogen in the zymosan-induced release reaction of human blood platelets.

R. Grant, C. Alper, M. B. Zucker, 1974, Journal of immunology.

The chromosomal order of genes controlling the major histocompatibility complex, properdin factor B, and deficiency of the second component of complement.

P. Schur, C. Carpenter, C. Alper, 1976, The Journal of clinical investigation.

Properdin factor B and histocompatibility loci linked in the rhesus monkey

J. Ziegler, C. Alper, JOHN B. ZIEGLER, 1975, Nature.

A common major histocompatibility complex class II allele HLA-DQB1* 0301 is present in clinical variants of pemphigoid.

R. Good, E. Yunis, J. Delgado, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Common major histocompatibility complex class II markers in clinical variants of cicatricial pemphigoid.

C. Foster, R. Good, A. Ahmed, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Increased susceptibility to infection associated with abnormalities of complement-mediated functions and of the third component of complement (C3).

F. Rosen, R. Johnston, J. H. Jandl, 1970, The New England journal of medicine.

Circulating CD2+ monocytes are dendritic cells.

E. Reinherz, C. Alper, K. Crawford, 1999, Journal of immunology.

Efl ' ect of Divalent Cations on the Ingestion of Lipopolysaccharide Particles by Guinea Pig Granulocytes

T. Stossel, C. Alper, S. Rosén, 2003 .

The opsonic fragment of the third component of human complement (C3)

T. Stossel, F. Rosen, J. Gitlin, 1975, The Journal of experimental medicine.

THE ENHANCEMENT OF BACTERIAL PHAGOCYTOSIS BY SERUM THE ROLE OF COMPLEMENT COMPONENTS AND TWO COFACTORS

F. Rosen, R. Johnston, C. Alper, 2003 .

Liver in α1-Antitrypsin Deficiency: Morphologic Observations and in Vitro Synthesis of α1-Antitrypsin

H. Colten, A. Bhan, C. Alper, 1976, Pediatric Research.

GENETIC POLYMORPHISM IN HUMAN GLYCINE-RICH BETA-GLYCOPROTEIN

C. Alper, T. Boenisch, L. Watson, 1972, The Journal of experimental medicine.

Genetics and the C3 Molecule 1

C. Alper, Chester A. Alper, 1973, Vox sanguinis.

Immunofixation Electrophoresis: A Technique for the Study of Protein Polymorphism 1

C. Alper, A. M. Johnson, 1969, Vox sanguinis.

Study of four new kindreds with inherited thyroxine-binding globulin abnormalities. Possible mutations of a single gene locus.

S. Refetoff, C. Alper, N. I. Robin, 1972, The Journal of clinical investigation.

Isolation and properties of a glycine-rich β-glycoprotein of human serum

C. Alper, T. Boenisch, 1970 .

Inheritance of human alpha-1-acid glycoprotein (orosomucoid) variants.

A. Johnson, C. Alper, K. Schmid, 1969, The Journal of clinical investigation.

GENETIC PREDICTION OF NON-RESPONSE TO HEPATITIS B VACCINE

C. Alper, 1990 .

Cellular recognition and HLA restriction of a midsequence HBsAg peptide in hepatitis B vaccinated individuals.

J. Yunis, D. Bing, E. Yunis, 1993, Molecular immunology.

The immune response to hepatitis B vaccine in humans: inheritance patterns in families

E. Yunis, D. Marcus-Bagley, C. Alper, 1992, The Journal of experimental medicine.

Single Nucleotide Polymorphism Blocks and Haplotypes: Human MHC Block Diversity

J. Granados, C. Larsen, E. Yunis, 2006 .

The human immune response to hepatitis B surface antigen.

C. Alper, 1995, Experimental and clinical immunogenetics.

Implication of Specific DQB1 Alleles in Genetic Susceptibility and Resistance by Identification of IDDM Siblings With Novel HLA-DQB1 Allele and Unusual DR2 and DR1 Haplotypes

H. Erlich, G. Eisenbarth, T. Bugawan, 1991, Diabetes.

Genetic polymorphism of the third component of human complement (C'3).

C. Alper, R. Propp, 1968, The Journal of clinical investigation.

Extended major histocompatibility complex haplotypes in man: role of alleles analogous to murine t mutants.

E. Yunis, C. Alper, Z. Awdeh, 1982, Clinical immunology and immunopathology.

Pemphigus vulgaris autoantibody response is linked to HLA-DQB1*0503 in Pakistani patients.

A. Ahmed, E. Yunis, J. Delgado, 1997, Human immunology.

The Path to Conserved Extended Haplotypes: Megabase-Length Haplotypes at High Population Frequency

C. Alper, 2021, Frontiers in Genetics.

Pedigree-Defined Haplotypes and Their Applications to Genetic Studies.

C. Larsen, C. Alper, 2017, Methods in molecular biology.

Dominant Sequences of Human Major Histocompatibility Complex Conserved Extended Haplotypes from HLA-DQA2 to DAXX

C. Larsen, E. Yunis, C. Alper, 2014, PLoS genetics.

The genetics of HLA-associated disease.

C. Larsen, C. Alper, 2004, Current opinion in immunology.

Protective KIR-HLA interactions for HCV infection in intravenous drug users.

Z. Husain, R. Chung, E. Yunis, 2009, Molecular immunology.

Editorial: Population genomic architecture: Conserved polymorphic sequences (CPSs), not linkage disequilibrium

J. Kulski, C. Larsen, C. Alper, 2023, Frontiers in Genetics.

A New Pedigree-Based SNP Haplotype Method for Genomic Polymorphism and Genetic Studies

C. Larsen, C. Alper, Dennis R. Alford, 2019, Cells.

Inheritable variable sizes of DNA stretches in the human MHC: conserved extended haplotypes and their fragments or blocks.

J. Hansen, C. Larsen, E. Yunis, 2003, Tissue antigens.

Genetic fixity in the human major histocompatibility complex and block size diversity in the class I region including HLA-E

Z. Husain, E. Fox, C. Larsen, 2007, BMC Genetics.

Opsonic activity in the newborn: role of properdin.

T. Stossel, F. Rosen, C. Alper, 1973, Pediatrics.

C'3 Synthesis in the Human Fetus and Lack of Transplacental Passage

C. Alper, R. Propp, Richard P. Propp, 1968, Science.

Homozygous deficiency of C3 in a patient with repeated infections.

H. Colten, F. Rosen, J. Gear, 1972, Lancet.

Heterogeneity of nephritic factor and its identification as an immunoglobulin.

J. Ziegler, E. Gelfand, F. Rosen, 1977, Proceedings of the National Academy of Sciences of the United States of America.

Transfer of C3 nephritic factor from mother to fetus. Is C3 nephritic factor IgG?

M. Arnaout, F. Rosen, A. Davis, 1977, The New England journal of medicine.

Evidence That Cobra Venom Factor (CoF) Is Cobra C3

C. Alper, D. Balavitch, 1976, The Journal of Immunology.

Increased susceptibility to infection in a patient with type II essential hypercatabolism of C3.

K J Bloch, F. Rosen, C. Alper, 1973, The New England journal of medicine.

Genetically determined heterogeneity of the C1 esterase inhibitor in patients with hereditary angioneurotic edema.

F. Rosen, C. Alper, J. Pensky, 1971, The Journal of clinical investigation.

Deficiency of C3 inactivator in man.

F. Rosen, P. Lachmann, J. H. Jandl, 1971, Journal of immunology.

SERUM-DEPENDENT PHAGOCYTOSIS OF PARAFFIN OIL EMULSIFIED WITH BACTERIAL LIPOPOLYSACCHARIDE

T. Stossel, F. Rosen, C. Alper, 1973, The Journal of experimental medicine.

Enzymatic treatment transforms trypomastigotes of Trypanosoma cruzi into activators of alternative complement pathway and potentiates their uptake by macrophages.

A. Sher, J. David, T. Kipnis, 1981, Proceedings of the National Academy of Sciences of the United States of America.

Genetics of the Complement System a

C. Alper, 1986, Advances in human genetics.

C1 Inhibitor: Evidence for Decreased Hepatic Synthesis in Hereditary Angioneurotic Edema

A. Johnson, J. Craig, C. Alper, 1971, Science.

A stochastic epigenetic Mendelian oligogenic disease model for type 1 diabetes.

C. Larsen, C. Alper, Dennis R. Alford, 2019, Journal of autoimmunity.

Major Histocompatibility Complex: Disease Associations

C. Alper, 2015 .

Incomplete penetrance of susceptibility genes for MHC-determined immunoglobulin deficiencies in monozygotic twins discordant for type 1 diabetes.

Alissa C. Baker, Z. Husain, C. Larsen, 2006, Journal of autoimmunity.

ESTIMATION OF THE SERUM BETA-1C GLOBULIN CONCENTRATION: ITS RELATION TO THE SERUM HEMOLYTIC COMPLEMENT TITER.

F. Rosen, C. Alper, S. Gotoff, 1965, Pediatrics.

THE METABOLISM OF GAMMA GLOBULINS IN MYELOMA AND ALLIED CONDITIONS.

C. Alper, T. Freeman, J. Waldenstroem, 1963, The Journal of clinical investigation.

Studies in vivo and in vitro on an abnormality in the metabolism of C3 in a patient with increased susceptibility to infection.

F. Rosen, R. Johnston, J. H. Jandl, 1970, The Journal of clinical investigation.

Alper CA, Rosen FS: Studies of the in vivo behavior of human C'3 in normal subjects and patients.

F. Rosen, C. Alper, 1967, The Journal of clinical investigation.

Disorders of the complement and properdin systems.

F. Rosen, C. Alper, 1972, Ciba Foundation symposium.

Component of Human Complement (C'3)

F. Rosen, C. Alper, R. Propp, 1969 .

Tumor necrosis factor constellation polymorphism and clozapine-induced agranulocytosis in two different ethnic groups.

J. Lieberman, J. Yunis, J. Delgado, 1997, Blood.

Polymorphism and molecular genetics of human C4.

C. Alper, M. Carroll, 1987, British medical bulletin.

Polymorphic Hh genes in the HLA-B(C) region control natural killer cell frequency and activity

E. Yunis, C. Alper, Z. Awdeh, 1994, The Journal of experimental medicine.

Characterization of non-expressed C4 genes in a case of complete C4 deficiency: identification of a novel point mutation leading to a premature stop codon.

L. Truedsson, A. Sjöholm, P. Schneider, 1998, Human immunology.

Homozygous human C3 deficiency. The role of C3 in antibody production, C-1s-induced vasopermeability, and cobra venom-induced passive hemolysis.

H. Colten, F. Rosen, J. Gear, 1976, The Journal of clinical investigation.

A restriction fragment of the C2 gene is a unique marker for C2 deficiency and the uncommon C2 allele C2*B (a marker for type 1 diabetes).

P Ronco, R. Campbell, G. Eisenbarth, 1991, The Journal of clinical investigation.

Workshop Report of RFLP in C4, C2, BF, and 21OH Genes

J. Partanen, A. Arnaiz-Villena, J. R. Regueiro, 1989 .

Implication of Specific DQB 1 Alleles in Genetic Susceptibility and Resistance by Identification of IDDM Siblings With Novel HLA-DQB 1 Allele and Unusual DR 2 and DR 1 Haplotypes

H. Erlich, G. Eisenbarth, T. Bugawan, 2010 .

Identical MHC markers in non-Jewish Iranian and Ashkenazi Jewish patients with pemphigus vulgaris: possible common central Asian ancestral origin.

P. Gregersen, K. Bahar, A. Firooz, 1997, Human immunology.

The major histocompatibility complex region marked by HSP70-1 and HSP70-2 variants is associated with clozapine-induced agranulocytosis in two different ethnic groups.

J. Lieberman, J. Yunis, E. Yunis, 1995, Blood.

Extended major histocompatibility complex haplotypes in type I diabetes mellitus.

K. Gabbay, E. Yunis, C. Alper, 1984, The Journal of clinical investigation.

E. Yunis, R. Stein, S. Alosco, 1985, The Lancet.

Characterization of HLA-Bw73 by serology and one-dimensional isoelectric focusing patterns.

S. Y. Yang, E. Yunis, S. Alosco, 1986, Human Immunology.

HLA-DQA1, DQB1 and DPB1 alleles on HLA-DQ2- and DQ9-carrying extended haplotypes.

J. Yunis, D. Bing, M. Salazar, 1993, Tissue antigens.

Major Histocompatibility Complex : Disease Associations

C. Alper, 2014 .

Molecular analysis distinguishes two HLA-DR3-bearing major histocompatibility complex extended haplotypes

E. Yunis, C. Alper, Z. Awdeh, 2004, Immunogenetics.

GENETIC MARKER FOR INSULIN-DEPENDENT DIABETES MELLITUS

K. Gabbay, R. Stein, C. Alper, 1979, The Lancet.

Extended MHC Haplotypes in Salt‐Losing 21‐Hydroxylase Deficiency a

E. Yunis, C. Alper, Z. Awdeh, 1985, Annals of the New York Academy of Sciences.

Complement genes of the human major histocompatibility complex: implications for linkage disequilibrium and disease associations

E. Yunis, C. Alper, Z. Awdeh, 1984 .

Immunoglobulin Deficiencies and Susceptibility to Infection Among Homozygotes and Heterozygotes for C2 Deficiency

P. Densen, L. Truedsson, G. Sturfelt, 2003, Journal of Clinical Immunology.

Characterization of type I complement C2 deficiency MHC haplotypes. Strong conservation of the complotype/HLA-B-region and absence of disease association due to linked class II genes.

L. Truedsson, A. Sjöholm, G. Sturfelt, 1993, Journal of immunology.

Predictability of alloreactivity among unrelated individuals: role for HLA-DPB1.

E. Yunis, C. Alper, Z. Awdeh, 1995, Tissue antigens.

The [HLA-B18, F1C30, DR3] Conserved Extended Haplotype Carries a Susceptibility Gene for IgD Deficiency

D. Marcus-Bagley, C. Alper, L. Castaño, 2000, Journal of Clinical Immunology.

An unusual "morphologic" variant of BF S.

E. Yunis, C. Alper, Z. Awdeh, 1984, American journal of human genetics.

There are two C4 genetic loci and a null allele in the chimpanzee

J. Granados, E. Yunis, C. Alper, 2004, Immunogenetics.

Editorial overviewImmunogenetics: Human immunogenetics

C. Larsen, C. Alper, 2004 .

Immunogenetics Human immunogenetics Editorial overview

C. Larsen, C. Alper, 2004 .

Linkage disequilibrium of HLA-SB1 with the HLA-A1, B8, DR3, SCO1 and of HLA-SB4 with the HLA-A26, Bw38, Dw10, DR4, SC21 extended haplotypes

R. Hartzman, E. Yunis, S. Alosco, 2004, Immunogenetics.

The location of C2, C4, and BF relative to HLA-B and HLA-D.

D. Glass, E. Yunis, C. Alper, 1981, Immunogenetics.

Inheritance of human α1-acid glycoprotein (orosomucoid) variants

A. Johnson, C. Alper, K. Schmid, 1969 .

The MHC type 1 diabetes susceptibility gene is centromeric to HLA-DQB1.

Z. Husain, M. A. Kelly, G. Eisenbarth, 2008, Journal of autoimmunity.

The paternally inherited insulin gene B allele (1,428 FokI site) confers protection from insulin-dependent diabetes in families.

G. Eisenbarth, A. Pugliese, R. Jackson, 1994, Journal of autoimmunity.

Sharing of MHC haplotypes among apparently unrelated patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency

Z. Layrisse, E. Yunis, C. Alper, 2004, Immunogenetics.

Excess admixture proportion of extended major histocompatability complex haplotypes of Caucasian origin among rheumatoid arthritis associated haplotypes in African Americans and Afro-Caribbeans.

E. Yunis, P. Fraser, C. Alper, 1996, Ethnicity & health.

MHC-Extended haplotypes in IDDM

G. Eisenbarth, S. Brink, E. Yunis, 1988 .

An Immunoblotting Technique for Direct Visualization of Chido and Rodgers Reactivity on C4 Variants after Electrophoresis

C. Alper, Peter M. Sklarin, Zuheir L. Awdeh, 1988, Vox sanguinis.

Statement on the nomenclature of human C6 polymorphism.

P. Kühnl, C. Rittner, C. Alper, 1980, Immunobiology.

Genetic control of the eighth component of complement.

B. H. Petersen, M. Spence, N. Day, 1979, The Journal of clinical investigation.

Inactivator of the third component of complement as an inhibitor in the properdin pathway.

F. Rosen, P. Lachmann, C. Alper, 1972, Proceedings of the National Academy of Sciences of the United States of America.

Linkage Disequilibrium, Interlocus Association and Ancestral Haplotypes

J. Partanen, A. Arnaiz-Villena, J. Vicario, 1989 .

Possible human analogs of the murine T/t complex.

E. Yunis, C. Alper, Z. Awdeh, 1985, Experimental and clinical immunogenetics.

HLA: The Major Histocompatibility Complex of Man

R. Hartzman, C. Hurley, E. Yunis, 1991 .

Discordance between IgA switching at the DNA level and IgA expression at the mRNA level in IgA-deficient patients.

F. Alt, A. Bottaro, C. Alper, 1999, Clinical immunology.

HLA extended haplotypes in childhood and adult onset HLA-DR4-associated arthropathies.

D. Glass, M. Larson, P. Fraser, 1990, Tissue antigens.

HLA-Cw7 Zygosity Affects the Size of a Subset of CD158b+ Natural Killer Cells

Z. Husain, C. Larsen, E. Yunis, 2004, Journal of Clinical Immunology.

Inherited polymorphism of human C4 as revealed by desialyzation.

C. Alper, Z. Awdeh, 1980, Immunobiology.

Human C'3: Evidence for the Liver as the Primary Site of Synthesis

A. Johnson, C. Alper, Francis D. Moore, 1969, Science.

Genetic polymorphism of properdin factor B in the rhesus: evidence for single subunit structure in primates.

J. Ziegler, C. Alper, L. Watson, 1975, Journal of immunology.

25 – REGULATION AND METABOLISM OF THE THIRD COMPONENT OF COMPLEMENT (C3)

C. Alper, 1970 .

Genetic polymorphism of serum complement components in the chimpanzee

B. H. Petersen, C. Alper, D. Raum, 2005, Immunogenetics.

Inherited deficiency of the third component of human complement (C'3).

F. Rosen, C. Alper, R. Propp, 1969, The Journal of clinical investigation.

The third component of complement: covalent attachment of a radioactive sugar to the labile binding site of C3 via the alternative pathway.

F. Rosen, R. O'Brien, B. Babior, 1981, Journal of Immunology.

Cobra venom factor: evidence for its being altered cobra C3 (the third component of complement).

C. Alper, D. Balavitch, 1976, Science.

Abstracts of meeting presentations (Part 3 of 11)

A. Chapelle, J. Opitz, N. Morton, 1979 .

Major Histocompatibility Markers in Disease

E. Yunis, C. Alper, Z. Awdeh, 1981, Clinics in Immunology and Allergy.

Complement activation in semisolid media: insolubilization of alternative pathway convertases in agar gels with C3 nephritic factor-containing sera.

M. Arnaout, A. Davis, C. Alper, 1977, Journal of immunology.

Complement activation in semi-solid medium: Insolubilization of properdin and the third component of complement (C3) in agar gels.

J. Ziegler, C. Alper, I. Lepow, 1976, Journal of immunology.

THE RELATIONSHIP OF GLYCINE-RICH β-GLYCOPROTEIN TO FACTOR B IN THE PROPERDIN SYSTEM AND TO THE COBRA FACTOR-BINDING PROTEIN OF HUMAN SERUM

C. Alper, I. Lepow, I. Goodkofsky, 1973, The Journal of experimental medicine.

Genetic Polymorphism in C 8 fl-Chains EVIDENCE FOR TWOUNLINKED GENETIC LOCI FOR THE EIGHTH COMPONENT OF HUMANCOMPLEMENT ( C 8 )

Thomas, J., C. Alper, 2013 .

Genetic polymorphism in C8 beta-chains. Evidence for two unlinked genetic loci for the eighth component of human complement (C8).

B. H. Petersen, T. Spira, C. Alper, 1983, The Journal of clinical investigation.

Genetic Control ofthe Eighth Component ofComplement

B. H. Petersen, M. Spence, C. Alper, 1979 .

Normal and variant isoenzymes of human blood cell hexokinase and the isoenzyme patterns in hemolytic anemia.

D. Nathan, C. Alper, Ç. Altay, 1970, Blood.

Metabolism of properdin in normal subjects and patients with renal disease.

J. Ziegler, F. Rosen, C. Alper, 1975, The Journal of clinical investigation.

Genetically determined polymorphism of the circulating human breast cancer-associated DF3 antigen

D. Hayes, D. Kufe, C. Alper, 1988 .

Genetic Polymorphism of Complement Components as a Probe of Structure and Function

C. Alper, 1971 .

Genetic polymorphism of the sixth component of complement (C6) in the rhesus monkey.

C. Alper, J. Hall, 1977, Journal of immunology.

Clinical applications of complement assays.

F. Rosen, C. Alper, 1975, Advances in internal medicine.

Linkage of familial dysalbuminemic hyperthyroxinemia to the albumin gene in a large Amish kindred.

R. Weiss, S. Refetoff, P. Angkeow, 1995, The Journal of clinical endocrinology and metabolism.

Homozygous C3 deficiency: detection of C3 by radioimmunoassay.

H. Colten, F. Rosen, A. Davis, 1977, Clinical immunology and immunopathology.

Genetic polymorphism of rhesus thyroxine-binding prealbumin: evidence for tetrameric structure in primates.

S. Refetoff, C. Alper, N. I. Robin, 1969, Proceedings of the National Academy of Sciences of the United States of America.

The human T-cell receptor β-chain repertoire: longitudinal fluctuations and assessment in MHC matched populations

D. Schoenfeld, S. Hauser, C. Alper, 1993, Immunogenetics.

IgG subclass studies of C3 nephritic factor.

P. Schur, E. Gelfand, F. Rosen, 1978, Clinical immunology and immunopathology.

Decreased inhibition of immune precipitation by sera with the C2 B allotype.

G. Füst, C. Alper, Z. Zam, 1991, Clinical immunology and immunopathology.

Agarose Gel Electrophoresis Thxi

J. Jeppsson, C. Laurell, C. Alper, 2004 .

AgaroseGel Electrophoresis Thxi

O. Jeppsson, E. Tucker, C. Alper, 1979 .

Abstracts of meeting presentations (Part 5 of 11)

A. Chapelle, J. Opitz, N. Morton, 1979 .

Genetic Analysis of C 4 Deficiency

H. Ochs, C. Alper, Z. Awdeh, 2022 .

Metabolism of radiolabelled complement proteins in health and disease

F. Rosen, C. Alper, 1984 .

Beta-1C-Globulin: Metabolism in Glomerulonephritis

F. Rosen, C. Alper, A. Levin, 1966, Science.

Isolation and properties of a glycine-rich beta-glycoprotein of human serum.

C. Alper, T. Boenisch, 1970, Biochimica et biophysica acta.

Snakes and the Complement System

C. Alper, 1979 .

Solubilization of C3 fragments deposited on cross-linked dextran gel beads.

T. Stossel, M. Arnaout, F. Rosen, 1979, Clinical immunology and immunopathology.

Attachment of [35S]cysteine to the labile site of the third component of complement via the alternative pathway.

F. Rosen, B. Babior, C. Alper, 1983, Clinical immunology and immunopathology.

Studies of hepatic synthesis in vivo of plasma proteins, including orosomucoid, transferrin, alpha 1-antitrypsin, C8, and factor B.

B. H. Petersen, T. Starzl, C. Alper, 1980, Clinical immunology and immunopathology.

Congenital deficiency of C2 and factor B.

P. Schur, C. Alper, D. Raum, 1978, The New England journal of medicine.

Acute phase reactants ceruloplasmin and haptoglobin and their relationship to plasma prostaglandins in rabbits bearing the VX2 carcinoma

A. Tashjian, E. F. Voelkel, C. Alper, 1978 .

Nonresponsiveness to hepatitis B vaccine in health care workers. Results of revaccination and genetic typings.

C. Crumpacker, R. Platt, D. Snydman, 1986, Annals of internal medicine.

Host-pathogen interactions in emerging and re-emerging infectious diseases: a genomic perspective of tuberculosis, malaria, human immunodeficiency virus infection, hepatitis B, and cholera.

D. Swerdlow, J. Mcnicholl, C. Alper, 2000, Annual review of public health.

Immunogenetics

C. Larsen, C. Alper, K. Bender, 2005, Genes and Immunity.

Restoration by purified C3b inactivator of complement-mediated function in vivo in a patient with C3b inactivator deficiency.

J. Ziegler, C. Alper, P. Lachmann, 1975, The Journal of clinical investigation.

A restriction fragment of the C2 gene is a unique marker for C2 deficiency and the uncommon C2 allele C2*B (a marker for type 1 diabetes).

George, Stuart, Chester, 1991, The Journal of clinical investigation.

Extended haplotypes of chromosome 6 in adult rheumatoid arthritis.

L. Strong, M. Weinblatt, R. Rossen, 1984, Arthritis and rheumatism.

Major histocompatibility complex markers and red cell antibodies to the Rh, D antigen: use of an inappropriate control group

E. Yunis, C. Alper, Z. Awdeh, 1990, Transfusion.

Complex cytokine responses to hepatitis B surface antigen and tetanus toxoid in responders, nonresponders and subjects naive to hepatitis B surface antigen.

C. Larsen, E. Yunis, C. Alper, 2000, Vaccine.

THE ENHANCEMENT OF BACTERIAL PHAGOCYTOSIS BY SERUM

F. Rosen, R. Johnston, C. Alper, 1969, The Journal of experimental medicine.

CONCISE PUBLICATION Restoration byPurified C3bInactivator ofComplement-Mediated Function InVivoinaPatient withC3bInactivator Deficiency

C. Alper, 1975 .

Restoration by Purified C 3 b Inactivator of Complement-Mediated Function In Vivo in a Patient with C 3 b Inactivator Deficiency

J. Ziegler, F. Rosen, P. Lachmann, 2022 .

Genetic Defects Affecting C3 Associated with Increased Susceptibility to Infections

F. Rosen, C. Alper, 1973, The Journal of Immunology.

B-lymphocyte malignancy.

C. Alper, 1973, The New England journal of medicine.

Deficiency of α1-Antitrypsin in Childhood Liver Disease

A. Johnson, C. Alper, 1970, Pediatrics.