F. Gotch

发表

A. McMichael, G. Noble, P. Beare, 1983, The New England journal of medicine.

Adenovirus vector vaccination induces expansion of memory CD4 T cells with a mucosal homing phenotype that are readily susceptible to HIV-1

G. Dickson, K. Fisher, A. Lieber, 2009, Proceedings of the National Academy of Sciences.

Human immunodeficiency virus genetic variation that can escape cytotoxic T cell recognition

Charles R. M. Bangham, Sarah Rowland-Jones, Andrew J. McMichael, 1991, Nature.

8-Specific Cytotoxic T-Cell Responses Identification of Human Herpesvirus

C. Boshoff, R. Weiss, F. Neipel, 2013 .

Model-Based Inference of Recombination Hotspots in a Highly Variable Oncogene

D. Geiger, B. Gazzard, G. Greenspan, 2004, Journal of Molecular Evolution.

Model-Based Inference of Recombination Hotspots in a Highly, Variable Oncogene

D. Geiger, B. Gazzard, G. Greenspan, 2004, Journal of Molecular Evolution.

Identification of Human Herpesvirus 8-Specific Cytotoxic T-Cell Responses

C. Boshoff, R. Weiss, F. Neipel, 1999, Journal of Virology.

Loss of Discrete Memory B Cell Subsets Is Associated with Impaired Immunization Responses in HIV-1 Infection and May Be a Risk Factor for Invasive Pneumococcal Disease1

B. Gazzard, P. Kelleher, M. Nelson, 2007, The Journal of Immunology.

Ex vivo analysis of HIV‐1 co‐receptors at the endocervical mucosa of women using oral contraceptives

F. Gotch, S. Patterson, M. Kapembwa, 2004, BJOG : an international journal of obstetrics and gynaecology.

Loss of Th22 Cells Is Associated With Increased Immune Activation and IDO-1 Activity in HIV-1 Infection

B. Gazzard, D. Fuchs, A. Boasso, 2014, Journal of acquired immune deficiency syndromes.

Oral contraceptive use induces upregulation of the CCR5 chemokine receptor on CD4(+) T cells in the cervical epithelium of healthy women.

F. Gotch, S. Patterson, M. Kapembwa, 2002, Journal of reproductive immunology.

Higher levels of activation markers and chemokine receptors on T lymphocytes in the cervix than peripheral blood of normal healthy women.

F. Gotch, S. Patterson, M. Kapembwa, 2001, Journal of reproductive immunology.

Evidence of widespread binding of HLA class I molecules to peptides

J. Frelinger, A. McMichael, F. Gotch, 1990, The Journal of experimental medicine.

Langerhans cells are more efficiently transduced than dermal dendritic cells by adenovirus vectors expressing either group C or group B fibre protein: Implications for mucosal vaccines

G. Dickson, F. Gotch, S. Patterson, 2005, European journal of immunology.

Frequencies of Gag-restricted T-cell escape “footprints” differ across HIV-1 clades A1 and D chronically infected Ugandans irrespective of host HLA B alleles☆

P. Kaleebu, N. Ndembi, F. Gotch, 2015, Vaccine.

Nadir B cell counts are significantly correlated with the risk of Kaposi's sarcoma

B. Gazzard, M. Nelson, M. Bower, 2004, International journal of cancer.

Prospective Study of the Effects of Antiretroviral Therapy on Kaposi Sarcoma‐Associated Herpesvirus Infection in Patients With and Without Kaposi Sarcoma

B. Gazzard, C. Boshoff, V. Calvez, 2002, Journal of acquired immune deficiency syndromes.

Recruitment of CD4 T lymphocytes and macrophages into the cervical epithelium of women after coitus.

F. Gotch, S. Patterson, M. Kapembwa, 2003, American journal of obstetrics and gynecology.

Profile of T cell recognition of HIV type 1 consensus group M Gag and Nef peptides in a clade A1- and D-infected Ugandan population.

R. Nsubuga, P. Kaleebu, L. Heath, 2012, AIDS research and human retroviruses.

CD34‐derived human Langerhans cells stimulate a T helper type 2 response independently of extracellular‐signal‐regulated kinase phosphorylation

S. Duraisingham, F. Gotch, S. Patterson, 2010, Immunology.

Regulation of dendritic cell interleukin‐12 secretion by tumour cell necrosis

D. Williams, F. Gotch, V. Bachy, 2005, Clinical and experimental immunology.

Up-regulation of CD 69 , HLA-DR , Interferon Secretion and Cytotoxic Activity by Plasmacytoid Dendritic Cells is Regulated through Overlapping but Different Pathways

L. Klavinskis, F. Gotch, S. Patterson, 2017 .

Science, medicine and research in the developing world: a perspective

J. Gilmour, F. Gotch, 2007, Nature Immunology.

Induction of single and dual cytotoxic T‐lymphocyte responses to viral proteins in mice using recombinant hybrid Ty–virus‐like particles

A. Kingsman, S. Adams, S. Woodrow, 1996, Immunology.

Class I cross-restricted T cells reveal low responder allele due to processing of viral antigen

A. McMichael, F. Gotch, H. Bodmer, 1989, Nature.

Kaposi's sarcoma — an update

B. Gazzard, F. Gotch, J. Stebbing, 2003, International journal of STD & AIDS.

Anti-HLA-A2 antibody-enhancement of peptide association with HLA-A2 as detected by cytotoxic T lymphocytes

G. Ogg, A. McMichael, F. Gotch, 1989, Nature.

Recognition of Viral Antigens by Cytotoxic T Lymphocytes

A. McMichael, J. Rothbard, F. Gotch, 1989 .

Human immunodeficiency virus variants that escape cytotoxic T-cell recognition.

S. Rowland-Jones, D. Nixon, R. Phillips, 1992, AIDS research and human retroviruses.

Reduced T(H)1/T(H)17 CD4 T-cell numbers are associated with impaired purified protein derivative-specific cytokine responses in patients with HIV-1 infection.

B. Gazzard, Rebecca Metcalf, P. Kelleher, 2011, The Journal of allergy and clinical immunology.

CD38 expression on CD8 T cells has a weak association with CD4 T‐cell recovery and is a poor marker of viral replication in HIV‐1‐infected patients on antiretroviral therapy

B. Gazzard, P. Kelleher, M. Shamji, 2008, HIV medicine.

A point mutation in CD45 may be associated with an increased risk of HIV-1 infection.

E. Tchilian, P. Beverley, F. Gotch, 2001, AIDS.

Identification of a new HLA-A allele (A*2502) by PCR-SSP

P. Krausa, F. Gotch, D. Young, 1996, Immunogenetics.

Characterization of the HLA-A2.2 subtype: T cell evidence for further heterogeneity

A. McMichael, M. Crumpton, A. Rickinson, 2004, Immunogenetics.

Variant and Mutant HLA-A2 Molecules Affect Recognition of Influenza Matrix Peptide 56–68 by Cytotoxic T Lymphocytes

A. McMichael, J. Strominger, J. Rothbard, 1989 .

Loss of blood CD11c(+) myeloid and CD11c(-) plasmacytoid dendritic cells in patients with HIV-1 infection correlates with HIV-1 RNA virus load.

B. Gazzard, A. Pozniak, J. Gilmour, 2001, Blood.

HLA-A, -B, -C, -DRB1, DRB3, DRB4, DRB5 and DQB1 Polymorphism Detected by PCR-SSP in a Semi-Urban HIV-Positive Ugandan Population

N. French, M. Bunce, P. Krausa, 1999, Experimental and Clinical Immunogenetics.

The Exon A (C77G) Mutation Is a Common Cause of Abnormal CD45 Splicing in Humans1

H. Liao, B. Haynes, J. Martinson, 2001, The Journal of Immunology.

Humans Cause of Abnormal CD 45 Splicing in The Exon A ( C 77 G ) Mutation Is a Common

H. Liao, B. Haynes, E. Tchilian, 2001 .

NKG2C+ NK Cells Are Enriched in AIDS Patients with Advanced-Stage Kaposi's Sarcoma

B. Gazzard, M. Bower, F. Gotch, 2006, Journal of Virology.

NKG2C (cid:1) NK Cells Are Enriched in AIDS Patients with Advanced-Stage Kaposi’s Sarcoma (cid:1)

M. Bower, F. Gotch, B. Gazzard, 2006 .

The effects of prednisolone in leucocyte function in man. A double blind controlled study.

I. Maclennan, S. Truelove, R. Gagnon, 1977, Clinical and experimental immunology.

Recognition of influenza A virus nucleoprotein by human cytotoxic T lymphocytes.

B. Moss, A. McMichael, Geoffrey L. Smith, 1986, The Journal of general virology.

Lysis of allogeneic human lymphocytes by nonspecifically activated T‐like cells

A. McMichael, F. Gotch, J. Hildreth, 1982, European journal of immunology.

Future vaccines for HIV

S. Rowland-Jones, A. McMichael, Geoffrey L. Smith, 1996, The Lancet.

The Fine Specificity of Recognition of Influenza Virus Proteins by Human Cytotoxic T Cells

F. Gotch, 1990 .

Recognition of influenza A virus by human cytotoxic T lymphocytes.

A. McMichael, F. Gotch, Frances M. Gotch, 1989, Advances in experimental medicine and biology.

Comparative loss and maturation of peripheral blood dendritic cell subpopulations in African and non-African HIV-1-infected patients

P. Kaleebu, Jimmy Whitworth, J. Gilmour, 2001, AIDS.

Immunization of human HIV‐seronegative volunteers with recombinant p17/p24: Ty virus‐like particles elicits HIV‐1 p24‐specific cellular and humoral immune responses

Seamus J. Martin, A. Kingsman, J. Senior, 1993, AIDS.

The epitopes of influenza nucleoprotein recognized by cytotoxic T lymphocytes can be defined with short synthetic peptides. 1986.

A. McMichael, J. Rothbard, D. Wraith, 2006, Journal of immunology.

Cytotoxic T lymphocyte epitopes shared between HIV-1, HIV-2, and SIV.

D. Nixon, A. McMichael, F. Gotch, 1993, Journal of medical primatology.

The T-Cell Immune Response against Kaposi's Sarcoma-Associated Herpesvirus

F. Gotch, R. Robey, S. Mletzko, 2011, Advances in virology.

'Naïve' and 'memory' CD4+ T-cells and T-cell receptor (TCR) V beta repertoire dynamics are independent of the levels of viremia following HIV seroconversion.

C. Loveday, G. Janossy, P. Amjadi, 1999, Immunology letters.

The CD8 and CD4 T-Cell Response against Kaposi's Sarcoma-Associated Herpesvirus Is Skewed Towards Early and Late Lytic Antigens

S. Henderson, C. Boshoff, M. Bower, 2009, PloS one.

Immunogenicity of the yeast recombinant p17/p24:Ty virus-like particles (p24-VLP) in healthy volunteers.

A. Kingsman, J. Weber, S. Adams, 1995, Vaccine.

Plasmacytoid Dendritic Cells Are Highly Susceptible to Human Immunodeficiency Virus Type 1 Infection and Release Infectious Virus

J. Gilmour, F. Gotch, A. Rae, 2001, Journal of Virology.

Specificity of anti-human leukocyte antigen antibody responses after immunization with Remune, an inactivated HIV-1 vaccine

F. Gotch, N. Almond, Agatha S. E. Ojugo, 2007, AIDS.

Therapeutic immunisation plus cytokine and hormone therapy improves CD4 T-cell counts, restores anti-HIV-1 responses and reduces immune activation in treated chronic HIV-1 infection.

M. Adojaan, M. Nelson, G. Moyle, 2014, Vaccine.

HLA Immunogenotype Determines Persistent Human Papillomavirus Virus Infection in HIV-Infected Patients Receiving Antiretroviral Treatment.

C. Bunker, A. Little, K. Purdie, 2016, The Journal of infectious diseases.

A human lymphocyte‐associated antigen involved in cell‐mediated lympholysis

A. McMichael, F. Gotch, J. Hildreth, 1983, European journal of immunology.

Identification of conserved antigenic components for a cytotoxic T lymphocyte-inducing vaccine against malaria

A. Hill, M. Aidoo, H. Whittle, 1995, The Lancet.

Cytotoxic T lymphocytes recognize a fragment of influenza virus matrix protein in association with HLA-A2

A. McMichael, J. Rothbard, A. Townsend, 1987, Nature.

Recognition of the PB1, neuraminidase, and matrix proteins of influenza virus A/NT/60/68 by cytotoxic T lymphocytes.

A. McMichael, I. Jones, P. Reay, 1989, Virology.

FAILURE OF INTRAVENOUS IMMUNOGLOBULIN TO AFFECT CYTOTOXIC T LYMPHOCYTE RESPONSES

J. Kurtz, F. Gotch, 1988, The Lancet.

Lymphocyte proliferation and cytotoxic assays using flat-bed scintillation counting.

F. Gotch, C. Potter, G. T. Warner, 1987, Journal of immunological methods.

Presentation of viral antigen controlled by a gene in the major histocompatibility complex

P. Cresswell, A. McMichael, V. Cerundolo, 1990, Nature.

The stability between two HIV-1 RNA measurements one year apart and the relationship with HIV subtype in rural Uganda

P. Kaleebu, J. Whitworth, J. Gilmour, 2001, International journal of STD & AIDS.

Loss of the CD56hiCD16− NK cell subset and NK cell interferon‐γ production during antiretroviral therapy for HIV‐1: partial recovery by human growth hormone

B. Gazzard, G. Moyle, F. Gotch, 2003, Clinical and experimental immunology.

Cytotoxic T-cell response to simian immunodeficiency virus by cynomolgus macaque monkeys immunized with recombinant vaccinia virus.

A. McMichael, F. Gotch, P. Silvera, 1991, AIDS.

Limited specific T-cell mediated cytolysis in the absence of extracellular Ca2+.

I. Maclennan, P. Golstein, F. Gotch, 1980, Immunology.

A CD45 polymorphism associated with abnormal splicing is absent in African populations

N. Yuldasheva, N. French, C. Carrington, 2002, Immunogenetics.

Analysis of the T Cell-Specific Sets of Monoclonal Antibodies

A. McMichael, F. Gotch, P. McShane, 1984 .

Molecular correlates in AIDS patients following antiretroviral therapy: diversified T‐cell receptor repertoires and in vivo control of cytomegalovirus replication

B. Gazzard, P. Hayes, F. Gotch, 2001, HIV medicine.

Depletion of natural killer cells in the colonic lamina propria of viraemic HIV-1-infected individuals

B. Gazzard, F. Gotch, C. Mela, 2007, AIDS.

Dysregulated immunophenotypic attributes of plasmacytoid but not myeloid dendritic cells in HIV‐1 infected individuals in the absence of highly active anti‐retroviral therapy

P. Kelleher, F. Gotch, S. Patterson, 2012, Clinical and experimental immunology.

The epitopes of influenza nucleoprotein recognized by cytotoxic T lymphocytes can be defined with short synthetic peptides

A. McMichael, J. Rothbard, A. Townsend, 1986, Cell.

Elevated mucosal addressin cell adhesion molecule-1 expression in acquired immunodeficiency syndrome is maintained during antiretroviral therapy by intestinal pathogens and coincides with increased duodenal CD4 T cell densities.

B. Gazzard, P. Hayes, F. Gotch, 2002, The Journal of infectious diseases.

Lessons from IAVI-006, a phase I clinical trial to evaluate the safety and immunogenicity of the pTHr.HIVA DNA and MVA.HIVA vaccines in a prime-boost strategy to induce HIV-1 specific T-cell responses in healthy volunteers.

S. McCormack, A. McMichael, J. Weber, 2008, Vaccine.

T Lymphocytes: Cytotoxic

F. Gotch, 2001 .

Simplified one-step antibody-HLA directed expansion of HIV-specific cytotoxic T lymphocytes: a system suited for use in vivo.

B. Gazzard, G. Ogg, A. Epenetos, 2004, AIDS.

Recognition of Nucleoprotein by Influenza Specific CTL

J. Davey, A. Townsend, F. Gotch, 1986 .

HLA‐Cw⊛0602 and HIV‐associated psoriasis

C. Bunker, P. Easterbrook, R. Newson, 1998, The British journal of dermatology.

Human NK Cell Up-regulation of CD69, HLA-DR, Interferon γ Secretion and Cytotoxic Activity by Plasmacytoid Dendritic Cells is Regulated through Overlapping but Different Pathways

Steven Patterson, Adel Benlahrech, Heather Donaghy, 2009, Sensors.

Human Langerhans’ cells and dermal‐type dendritic cells generated from CD34 stem cells express different toll‐like receptors and secrete different cytokines in response to toll‐like receptor ligands

S. Duraisingham, F. Gotch, S. Patterson, 2008, Immunology.

Human BDCA-1-Positive Blood Dendritic Cells Differentiate into Phenotypically Distinct Immature and Mature Populations in the Absence of Exogenous Maturational Stimuli: Differentiation Failure in HIV Infection1

B. Gazzard, P. Amjadi, P. Kelleher, 2005, The Journal of Immunology.

InfectionStimuli: Differentiation Failure in HIV the Absence of Exogenous Maturational Distinct Immature and Mature Populations in Cells Differentiate into Phenotypically Human BDCA-1-Positive Blood Dendritic

B. Gazzard, P. Amjadi, P. Kelleher, 2005 .

Dysfunction and infection of freshly isolated blood myeloid and plasmacytoid dendritic cells in patients infected with HIV-1.

B. Gazzard, F. Gotch, S. Patterson, 2003, Blood.

HLA‐C and guttate psoriasis

C. Bunker, R. Newson, M. Bunce, 2000, The British journal of dermatology.

Reversible granulocyte killing defect in anorexia nervosa.

I. Maclennan, P. Beeson, F. Gotch, 1975, Clinical and experimental immunology.

Cytotoxic lymphocytes from rats depleted of thymus processed cells.

I. Maclennan, F. Gotch, D. Pudifin, 1971, Nature: New biology.

The prevalence of human leucocyte antigen and human papillomavirus DNA in penile intraepithelial neoplasia in England 2011–2012

C. Bunker, W. Quint, A. Freeman, 2021, International journal of STD & AIDS.

Immunogenetics and human papillomavirus (HPV) in male genital lichen sclerosus (MGLSc)

C. Bunker, W. Quint, A. Freeman, 2020, International journal of STD & AIDS.

Evaluation of sperm washing as a potential method of reducing HIV transmission in HIV-discordant couples wishing to have children.

J. Gilmour, F. Gotch, S. Barton, 1999, AIDS.

Molecular analysis of the association of HLA-B53 and resistance to severe malaria

M. Aidoo, H. Whittle, A. McMichael, 1992, Nature.

A pilot study of the safety and efficacy of thymosin α1 in augmenting immune reconstitution in HIV‐infected patients with low CD4 counts taking highly active antiretroviral therapy

S. Ravindran, N. Paton, J. Villacian, 2003, Clinical and experimental immunology.

DECLINING T-CELL IMMUNITY TO INFLUENZA, 1977-82

A. McMichael, F. Gotch, C. Potter, 1983, The Lancet.

Amplified antigen-specific immune responses in HIV-1 infected individuals in a double blind DNA immunization and therapy interruption trial.

J. Lisziewicz, F. Lori, E. Sandström, 2011, Vaccine.

T‐cell re‐population in HIV‐infected children on highly active anti‐retroviral therapy (HAART)

F. Gotch, D. King, E. Larsson‐sciard, 2001, Clinical and experimental immunology.

Identification of Kaposi's Sarcoma-Associated Herpesvirus (KSHV)-Specific Cytotoxic T-Lymphocyte Epitopes and Evaluation of Reconstitution of KSHV-Specific Responses in Human Immunodeficiency Virus Type 1-Infected Patients Receiving Highly Active Antiretroviral Therapy

B. Gazzard, C. Boshoff, V. Calvez, 2002, Journal of Virology.

HIV-specific cytotoxic T-cells in HIV-exposed but uninfected Gambian women

S. Rowland-Jones, H. Whittle, A. McMichael, 1995, Nature Medicine.

The MHC E locus in macaques is polymorphic and is conserved between macaques and humans

A. Hughes, D. Watkins, T. Golos, 2004, Immunogenetics.

miR-132 regulates antiviral innate immunity through suppression of the p300 transcriptional co-activator

Frances Gotch, Dimitrios Lagos, Stephen Henderson, 2010, Nature Cell Biology.

Disease-associated dendritic cells respond to disease-specific antigens through the common heat shock protein receptor.

B. Gazzard, P. Srivastava, M. Bower, 2003, Blood.

TLR-Stimulated CD34 Stem Cell-Derived Human Skin-Like and Monocyte-Derived Dendritic Cells Fail to Induce Th17 Polarization of Naive T Cells but Do Stimulate Th1 and Th17 Memory Responses1

S. Duraisingham, F. Gotch, S. Patterson, 2009, The Journal of Immunology.

Monocyte-derived dendritic cells from HIV type 1-infected individuals show reduced ability to stimulate T cells and have altered production of interleukin (IL)-12 and IL-10.

B. Gazzard, P. Kelleher, F. Gotch, 2009, The Journal of infectious diseases.

Polarization of Naive T Cells but Do Dendritic Cells Fail to Induce Th 17 Human Skin-Like and Monocyte-Derived TLR-Stimulated CD 34 Stem Cell-Derived

S. Duraisingham, F. Gotch, S. Patterson, 2009 .

Activity of different vaccine-associated promoter elements in human dendritic cells.

G. Dickson, F. Gotch, S. Patterson, 2008, Immunology letters.

Gene expression profiling in male genital lichen sclerosus

C. Bunker, L. Game, G. Barton, 2011, International journal of experimental pathology.

Kaposi's Sarcoma-Associated Herpesvirus Cytotoxic T Lymphocytes Recognize and Target Darwinian Positively Selected Autologous K1 Epitopes

S. Henderson, C. Boshoff, M. Youle, 2003, Journal of Virology.

Evasion of Cytotoxic T Lymphocyte (CTL) Responses by Nef-dependent Induction of Fas Ligand (CD95L) Expression on Simian Immunodeficiency Virus–infected Cells

A. McMichael, G. Screaton, S. Nagata, 1997, The Journal of experimental medicine.

T‐cell telomere length maintained in HIV‐infected long‐term survivors

P. Easterbrook, J. Gilmour, F. Gotch, 2000, HIV medicine.

Cytotoxic T cells recognize fragments of the influenza nucleoprotein

J. Davey, A. Townsend, F. Gotch, 1985, Cell.

Enhanced T-Cell Maturation, Differentiation and Function in HIV-1-Infected Individuals after Growth Hormone and Highly Active Antiretroviral Therapy

B. Gazzard, G. Moyle, F. Gotch, 2004, Antiviral therapy.

Toll-like receptor 4 mediates innate immunity to Kaposi sarcoma herpesvirus.

Frances Gotch, Dimitrios Lagos, Rebecca Robey, 2008, Cell host & microbe.

Host HLA B*Allele-Associated Multi-Clade Gag T-Cell Recognition Correlates with Slow HIV-1 Disease Progression in Antiretroviral Therapy-Naïve Ugandans

P. Kaleebu, L. Shafer, J. Whitworth, 2009, PloS one.

Assessment of type 1 and type 2 cytokines in HIV type 1-infected individuals: impact of highly active antiretroviral therapy.

B. Gazzard, F. Gotch, N. Imami, 1999, AIDS research and human retroviruses.

HIV-1 RNA levels in an African population-based cohort and their relation to CD4 lymphocyte counts and World Health Organization clinical staging.

P. Kaleebu, J. Whitworth, F. Gotch, 1999, Journal of acquired immune deficiency syndromes.

The Cytotoxic T Lymphocyte Response to the Immunodeficiency Viruses

F. Gotch, S. McAdam, 1999 .

A sequence pattern for peptides presented to cytotoxic T lymphocytes by HLA B8 revealed by analysis of epitopes and eluted peptides

S. Rowland-Jones, D. Nixon, A. McMichael, 1993, European journal of immunology.

Identification of viral molecules recognized by influenza-specific human cytotoxic T lymphocytes

B. Moss, A. McMichael, Geoffrey L. Smith, 1987, The Journal of experimental medicine.

HLA B37 determines an influenza A virus nucleoprotein epitope recognized by cytotoxic T lymphocytes

A. McMichael, J. Rothbard, F. Gotch, 1986, The Journal of experimental medicine.

Autologous K 1 Epitopes Target Darwinian Positively Selected Cytotoxic T Lymphocytes Recognize and Kaposi ' s Sarcoma-Associated Herpesvirus

S. Henderson, C. Boshoff, M. Youle, 2003 .

HIV-1 Viral Replication below 50 Copies/ml in Patients on Antiretroviral Therapy is not associated with CD8+ T-cell Activation

B. Gazzard, P. Kelleher, M. Shamji, 2007, Antiviral therapy.

Early suppression of SIV replication by CD8+ nef-specific cytotoxic T cells in vaccinated macaques

A. McMichael, J. Bootman, F. Gotch, 1995, Nature Genetics.

Reconstitution of CD4+ T cell responses in HIV‐1 infected individuals initiating highly active antiretroviral therapy (HAART) is associated with renewed interleukin‐2 production and responsiveness

F. Gotch, N. Imami, A. Sullivan, 2003, Clinical and experimental immunology.

Development of immunotherapeutic strategies for HIV-1

F. Gotch, N. Imami, G. Hardy, 2001, Expert opinion on biological therapy.

Detection and quantification of HIV‐1 specific CD4 helper and CD8 cytotoxic cells: their role in HIV‐1‐infected individuals and vaccine recipients

F. Gotch, N. Imami, G. Hardy, 2001, HIV medicine.

The immune system: our best antiretroviral.

F. Gotch, G. Hardy, 2000, Current opinion in infectious diseases.

Therapeutic vaccines in HIV. 1 infection

F. Gotch, N. Imami, G. Hardy, 1999, Immunological reviews.

The human cytotoxic T cell response to influenza A vaccination.

R. Webster, A. McMichael, F. Gotch, 1981, Clinical and experimental immunology.

HIV-specific cytotoxic T-cell activity in an HIV-exposed but uninfected infant

S. Rowland-Jones, D. Nixon, A. McMichael, 1993, The Lancet.

Transient Nature of Long-Term Nonprogression and Broad Virus-Specific Proliferative T-Cell Responses with Sustained Thymic Output in HIV-1 Controllers

B. Gazzard, M. Nelson, F. Gotch, 2009, PloS one.

Rapid qualitative and quantitative analysis of T-cell responses in HIV-1-infected individuals receiving successful HAART and HIV-1 sero-negative controls: concomitant assessment of perforin, IFN-gamma and IL-4 secretion.

F. Gotch, N. Imami, C. Burton, 2006, Journal of immunological methods.

Tetanus vaccination with IL-2 during highly active antiretroviral therapy induces sustained and pronounced specific CD4 T-cell responses

B. Gazzard, A. Sullivan, M. Nelson, 2004, AIDS.

Distinct patterns of peripheral HIV-1-specific interferon- gamma responses in exposed HIV-1-seronegative individuals.

P. Kaleebu, J. Whitworth, F. Gotch, 2004, The Journal of infectious diseases.

New insights into the immunology and evolution of HIV

F. Gotch, S. Patterson, J. Stebbing, 2003, Cell Research.

Immunogenic HIV variant peptides that bind to HLA-B8 can fail to stimulate cytotoxic T lymphocyte responses.

P. Klenerman, A. Edwards, P. Giangrande, 1995, Journal of immunology.

Viral inhibition assay: a CD8 T cell neutralization assay for use in clinical trials of HIV-1 vaccine candidates.

B. Walker, E. Karita, O. Anzala, 2010, The Journal of infectious diseases.

HIV type 1-specific inter- and intrasubtype cellular immune responses in HIV type 1-infected Ugandans.

P. Kaleebu, J. Whitworth, J. Gilmour, 2004, AIDS research and human retroviruses.

CD8+/CD161++ mucosal-associated invariant T-cell levels in the colon are restored on lsong-term antiretroviral therapy and correlate with CD8+ T-cell immune activation

B. Gazzard, Rebecca Metcalf, L. Greathead, 2014, AIDS.

Cross-clade T cell recognition of HIV.1.

F. Gotch, 1998, Current opinion in immunology.

Single-nucleotide polymorphism-defined class I and class III major histocompatibility complex genetic subregions contribute to natural long-term nonprogression in HIV infection.

B. Autran, P. Debré, F. Macciardi, 2012, The Journal of infectious diseases.

Loss of CD4+ T cell proliferative ability but not loss of human immunodeficiency virus type 1 specificity equates with progression to disease.

J. Wilson, B. Gazzard, M. Westby, 2000, The Journal of infectious diseases.

Programmed death (PD)‐1 molecule and its ligand PD‐L1 distribution among memory CD4 and CD8 T cell subsets in human immunodeficiency virus‐1‐infected individuals

M. Bower, F. Gotch, G. Rosignoli, 2009, Clinical and experimental immunology.

Antibody-targeted MHC complex-directed expansion of HIV-1- and KSHV-specific CD8+ lymphocytes: a new approach to therapeutic vaccination.

B. Gazzard, G. Ogg, A. McMichael, 2004, Blood.

Mycobacterial immune reconstitution inflammatory syndrome in HIV-1 infection after antiretroviral therapy is associated with deregulated specific T-cell responses: Beneficial effect of IL-2 and GM-CSF immunotherapy

B. Gazzard, M. Nelson, F. Gotch, 2005, Journal of immune based therapies and vaccines.

Killing of Kaposi's sarcoma-associated herpesvirus-infected fibroblasts during latent infection by activated natural killer cells

M. Bower, F. Gotch, M. Goodier, 2011, European journal of immunology.

Switch from inhibitory to activating NKG2 receptor expression in HIV-1 infection: lack of reversion with highly active antiretroviral therapy

B. Gazzard, M. Nelson, F. Gotch, 2005, AIDS.

The importance of standardisation of laboratory evaluations in HIV vaccine trials.

F. Gotch, H. Holmes, N. Imami, 2005, Microbes and infection.

Combined use of cytokines, hormones and therapeutic vaccines during effective antiretroviral therapy

F. Gotch, N. Imami, S. Westrop, 2007 .

High frequency of memory and effector gag specific cytotoxic T lymphocytes in HIV seropositive individuals.

D. Nixon, A. McMichael, N. Alp, 1990, International immunology.

CCR2/64I mutation detection in a HIV-1-positive patient with slow CD4 T-cell decline and delay in disease progression

F. Gotch, N. Imami, C. Burton, 2005, International journal of STD & AIDS.

Elevated plasma lipopolysaccharide is not sufficient to drive natural killer cell activation in HIV-1-infected individuals

B. Gazzard, M. Bower, F. Gotch, 2009, AIDS.

Mechanisms of protection induced by attenuated simian immunodeficiency virus. II. Lymphocyte depletion does not abrogate protection.

S. Cobbold, R. Stebbings, F. Gotch, 1998, AIDS research and human retroviruses.

Kaposi sarcoma herpesvirus-encoded vFLIP and vIRF1 regulate antigen presentation in lymphatic endothelial cells.

C. Boshoff, M. Trotter, Hsei-Wei Wang, 2007, Blood.

Thymic activity in late‐stage HIV‐1 infected individuals receiving highly active antiretroviral therapy: potential effect of steroid therapy

B. Gazzard, F. Gotch, R. Aspinall, 2002, HIV medicine.

A phase I, randomized study of combined IL-2 and therapeutic immunisation with antiretroviral therapy

B. Gazzard, R. Moss, A. Sullivan, 2007, Journal of immune based therapies and vaccines.

Association between a defective CCR-5 gene and progression to disease in HIV infection.

P. Easterbrook, J. McKeating, R. Daniels, 1998, AIDS research and human retroviruses.

A phase I trial in HIV negative healthy volunteers evaluating the effect of potent adjuvants on immunogenicity of a recombinant gp120W61D derived from dual tropic R5X4 HIV-1ACH320.

S. McCormack, J. Weber, A. Carmichael, 2000, Vaccine.

A Balanced Type 1/Type 2 Response Is Associated with Long-Term Nonprogressive Human Immunodeficiency Virus Type 1 Infection

B. Gazzard, F. Gotch, N. Imami, 2002, Journal of Virology.

Interleukin-2-associated viral breakthroughs induce HIV-1-specific CD4 T cell responses in patients on fully suppressive highly active antiretroviral therapy.

B. Gazzard, A. Sullivan, M. Nelson, 2003, AIDS.

Cross‐clade recognition of p55 by cytotoxic T lymphocytes in HIV‐1 infection

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Inhibition of Virus-Specific, HLA-Restricted, T Cell-Mediated Lysis by Monoclonal Anti-T Cell Antibodies

A. McMichael, F. Gotch, P. Hildreth, 1984 .

An antigen processing polymorphism revealed by HLA‐B8‐restricted cytotoxic T lymphocytes which does not correlate with TAP gene polymorphism

S. Rowland-Jones, J. Trowsdale, A. McMichael, 1993, European Journal of Immunology.

Recognition of influenza virus proteins by cytotoxic T lymphocytes.

J. Rothbard, J. Davey, I. Jones, 1989, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

Cytotoxic T cells in HIV2 seropositive Gambians. Identification of a virus-specific MHC-restricted peptide epitope.

A. Hill, H. Whittle, A. McMichael, 1993, Journal of immunology.

New observations on cellular immune responses to HIV and T-cell epitopes.

J. Safrit, R. Koup, F. Gotch, 1997, AIDS.

Effect of mutations and variations of HLA-A2 on recognition of a virus peptide epitope by cytotoxic T lymphocytes.

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Immune responses and reconstitution in HIV-1 infected individuals: impact of anti-retroviral therapy, cytokines and therapeutic vaccination.

R. Moss, B. Gazzard, F. Gotch, 2001, Immunology letters.

Chemokine receptor expression on mucosal dendritic cells from the endocervix of healthy women.

F. Gotch, S. Patterson, M. Kapembwa, 2004, The Journal of infectious diseases.

Rational design of HIV vaccines and microbicides: report of the EUROPRISE annual conference 2011

R. Shattock, B. Wahrén, G. Scarlatti, 2012, Journal of Translational Medicine.

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Three-Year Immune Reconstitution in PI-Sparing and PI-Containing Antiretroviral Regimens in Advanced HIV-1 Disease

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Paclitaxel for anthracycline-resistant AIDS-related Kaposi's sarcoma: clinical and angiogenic correlations.

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Loss of NK Stimulatory Capacity by Plasmacytoid and Monocyte-Derived DC but Not Myeloid DC in HIV-1 Infected Patients

P. Kelleher, F. Gotch, S. Patterson, 2011, PloS one.

Ex-vivo recognition of late-lytic CD8 epitopes specific for Kaposi's sarcoma-associated herpesvirus (KSHV) by HIV/KSHV-coinfected individuals.

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Restoration of Human Immunodeficiency Virus‐1‐Specific Responses in Patients Changing from Protease to Non‐Nucleoside Reverse Transcriptase Inhibitor‐Based Antiretroviral Therapy

B. Gazzard, A. Sullivan, G. Moyle, 2003, Scandinavian journal of immunology.

Expression of the common heat‐shock protein receptor CD91 is increased on monocytes of exposed yet HIV‐1‐seronegative subjects

P. Kaleebu, F. Gotch, S. Patterson, 2005, Journal of leukocyte biology.

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B. Gazzard, P. Srivastava, S. Shaunak, 2003, Blood.

CD8+ T-Cell Responses before and after Structured Treatment Interruption in Ugandan Adults Who Initiated ART with CD4+ T Cells <200 Cell/μL: The DART Trial STI Substudy

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Immune reconstitution in HIV-1-infected patients.

F. Gotch, C. Mela, N. Imami, 2002, Current opinion in investigational drugs.

European Union and EDCTP strategy in the global context: recommendations for preventive HIV/AIDS vaccines research.

Q. Sattentau, J. H. van de Wijgert, T. Lehner, 2005, Vaccine.

Studies on the allostimulatory function of dendritic cells from HCV-HIV-1 co-infected patients

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Thymic output during initial highly active antiretroviral therapy (HAART) and during HAART supplementation with interleukin 2 and/or with HIV type 1 immunogen (Remune).

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Analysis of synergy between cyclophosphamide Therapy and Immunity Against a Mouse Tumour

I. Maclennan, F. Gotch, D. Chassoux, 1978, British Journal of Cancer.

Recent HIV-1 infection in a high-risk Ugandan cohort: implications for Phase IIB test-of-concept HIV vaccine trials.

P. Kaleebu, F. Gotch, H. Grosskurth, 2007, Pharmacogenomics.

Long-term increase of CD4+ central memory cells in HIV-1-infected individuals by therapeutic HIV-1 rgp160 immunization.

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AIDS vaccine 2001.

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Measuring human T cell responses in blood and gut samples using qualified methods suitable for evaluation of HIV vaccine candidates in clinical trials.

Frances Gotch, Peter Kelleher, Ambreen Ashraf, 2011, Journal of immunological methods.

Rapid progression to human immunodeficiency virus infection / acquired immunodeficiency syndrome (HIV/AIDS) correlates with variation in viral tat sequences

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Support for the RV144 HIV Vaccine Trial

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Immune interventions The changing face of HIV and AIDS

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Initiation of Antiretroviral Therapy During Recent HIV-1 Infection Results in Lower Residual Viral Reservoirs

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P43 Immune responses in patients changing from PI to NNRTI-based HAART

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T-cell signalling in antiretroviral-treated, aviraemic HIV-1-positive individuals is present in a raised state of basal activation that contributes to T-cell hyporesponsiveness

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The role of cytotoxic T-cells in HIV infection.

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Priming with a Simplified Intradermal HIV-1 DNA Vaccine Regimen followed by Boosting with Recombinant HIV-1 MVA Vaccine Is Safe and Immunogenic: A Phase IIa Randomized Clinical Trial

B. Moss, S. McCormack, M. Hoelscher, 2015, PloS one.

Role of the thymus in T lymphocyte reconstitution.

F. Gotch, R. Aspinall, N. Imami, 2000, Transplantation.

Treatment of primary HIV‐1 infection with nonnucleoside reverse transcriptase inhibitor‐based therapy is effective and well tolerated

B. Gazzard, F. Gotch, M. Nelson, 2004, HIV medicine.

New insights and approaches regarding B- and T-cell epitopes in HIV vaccine design.

K. Cease, J. Berzofsky, F. Gotch, 1999, AIDS.

Making smarter immunotherapies

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Binding and Functional Analysis of the Workshop T Cell Specific Set of Monoclonal Antibodies

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Expression of PD-L1, a marker of disease status, is not reduced by HAART in aviraemic patients

B. Gazzard, M. Nelson, F. Gotch, 2007, AIDS.

Human papillomavirus in the era of highly active antiretroviral therapy for human immunodeficiency virus: an immune reconstitution‐associated disease?

C. Bunker, F. Gotch, R. Meys, 2010, The British journal of dermatology.

Immune correlates of protection from HIV and AIDS - more answers but yet more questions.

J. Strominger, J. Heeney, G. Shearer, 1999, Immunology today.

HIV‐specific cytotoxic T‐cell activity in an HIV‐exposed but uninfected infants

S. Rowland-Jones, D. Nixon, A. McMichael, 1993 .

Effects of monoclonal antibodies to the a and β chains of the human lymphocyte function‐associated (H‐LFA‐1) antigen on T lymphocyte functions

A. McMichael, F. Gotch, J. Hildreth, 1985, European journal of immunology.

Natural killer cells are not infected by Kaposi's sarcoma-associated herpesvirus in vivo, and natural killer cell counts do not correlate with the risk of developing Kaposi's sarcoma

B. Gazzard, M. Bower, S. Mandalia, 2003, AIDS.

Cytotoxic T cells--protection from disease progression--protection from infection.

A. McMichael, F. Gotch, A. Gallimore, 1996, Immunology letters.

Immunodominance of a single CTL epitope in a primate species with limited MHC class I polymorphism.

Todd M. Allen, A. Hughes, D. Watkins, 1997, Journal of immunology.

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R. Shattock, G. Scarlatti, F. Fiorino, 2012, Journal of Translational Medicine.

Errata

S. Rowland-Jones, H. Whittle, A. McMichael, 1995, Nature Medicine.

Journal of Immune Based Therapies and Vaccines Mycobacterial Immune Reconstitution Inflammatory Syndrome in Hiv-1 Infection after Antiretroviral Therapy Is Associated with Deregulated Specific T-cell Responses: Beneficial Effect of Il-2 and Gm-csf Immunotherapy Immune Reconstitutiont Cellshiv-1mycob

B. Gazzard, F. Gotch, N. Imami, 2022 .

ACTIVATORS OF NEUTROPHILS AND K CELLS

P. Roberts-Thomson, F. Gotch, J. Clarke, 1976 .

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B. Gazzard, F. Gotch, N. Imami, 2002, Clinical and experimental immunology.

HLA B37 determines an influenza A virus nucleoprotein epitope recognized by cytotoxic T lymphocytes

A. McMichael, J. Rothbard, F. Gotch, 1986, The Journal of experimental medicine.

Monocyte-derived dendritic cells from HIV type 1-infected individuals show reduced ability to stimulate T cells and have altered production of interleukin (IL)-12 and IL-10.

B. Gazzard, P. Kelleher, F. Gotch, 2009, The Journal of infectious diseases.

Plasma membranes from influenza virus-infected cells induce in vitro human secondary virus-specific cytotoxic T lymphocyte responses.

A. McMichael, F. Gotch, J. Hildreth, 1983, Molecular biology & medicine.