J. Epstein

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Live Attenuated Malaria Vaccine Designed to Protect Through Hepatic CD8+ T Cell Immunity

E. R. James, S. Hoffman, C. Loucq, 2011, Science.

Protection Against Malaria by Intravenous Immunization with a Nonreplicating Sporozoite Vaccine

Mario Roederer, Barney S. Graham, Sumana Chakravarty, 2013, Science.

Protection against malaria at 1 year and immune correlates following PfSPZ vaccination

Mario Roederer, Sumana Chakravarty, Martha C Nason, 2016, Nature Medicine.

Malaria vaccines: are we getting closer?

T. Richie, G. Mullen, B. Giersing, 2007, Current opinion in molecular therapeutics.

Lack of mannose-binding lectin-A enhances survival in a mouse model of acute septic peritonitis.

S. Thiel, J. Jensenius, M. Carroll, 2002, Microbes and infection.

Rheumatic fever: autoantibodies against a variety of cardiac, nuclear, and streptococcal antigens.

Q. Eichbaum, J. Epstein, D. Beatty, 1995, Annals of the rheumatic diseases.

Induction in Humans of CD8+ and CD4+ T Cell and Antibody Responses by Sequential Immunization with Malaria DNA and Recombinant Protein1

S. Hoffman, D. Carucci, P. de la Vega, 2004, The Journal of Immunology.

Safety, tolerability, and antibody responses in humans after sequential immunization with a PfCSP DNA vaccine followed by the recombinant protein vaccine RTS,S/AS02A.

S. Hoffman, D. Carucci, Joe D. Cohen, 2004, Vaccine.

Cardiovascular manifestations of HIV infection.

S. Lipshultz, Q. Eichbaum, J. Epstein, 1996, Comprehensive therapy.

Early Gamma Interferon and Interleukin-2 Responses to Vaccination Predict the Late Resting Memory in Malaria-Naïve and Malaria-Exposed Individuals

D. Carucci, K. Marsh, T. Lang, 2006, Infection and Immunity.

Recombinant Protein Immunization with Malaria DNA and Cell and Antibody Responses by Sequential T + and CD4 + Induction in Humans of CD8

Patricia De la Vega, S. Hoffman, D. Carucci, 2004 .

Safety and clinical outcome of experimental challenge of human volunteers with Plasmodium falciparum-infected mosquitoes: an update.

S. Hoffman, D. Freilich, J. Sacci, 2007, The Journal of infectious diseases.

Safety, tolerability, and lack of antibody responses after administration of a PfCSP DNA malaria vaccine via needle or needle-free jet injection, and comparison of intramuscular and combination intramuscular/intradermal routes.

S. Hoffman, E. Gorak, Sanjai Kumar, 2002, Human gene therapy.

Plasmodium falciparum 7G8 challenge provides conservative prediction of efficacy of PfNF54-based PfSPZ Vaccine in Africa

Joana C. Silva, S. Hoffman, B. Mordmüller, 2022, Nature Communications.

Adenovirus-5-Vectored P. falciparum Vaccine Expressing CSP and AMA1. Part B: Safety, Immunogenicity and Protective Efficacy of the CSP Component

D. Carucci, D. Doolan, J. Bruder, 2011, PloS one.

Protective Efficacy of Plasmodium vivax Radiation-Attenuated Sporozoites in Colombian Volunteers: A Randomized Controlled Trial

T. Richie, S. Herrera, M. Arévalo-Herrera, 2016, PLoS neglected tropical diseases.

Mosquito bite immunization with radiation-attenuated Plasmodium falciparum sporozoites: safety, tolerability, protective efficacy and humoral immunogenicity

S. Hoffman, D. Carucci, D. Freilich, 2016, Malaria Journal.

Correction: Corrigendum: Protection against malaria at 1 year and immune correlates following PfSPZ vaccination

Andrea A. Berry, S. Hoffman, S. Kappe, 2016, Nature Medicine.

Immune responses and protection of Aotus monkeys immunized with irradiated Plasmodium vivax sporozoites.

S. Hoffman, T. Richie, S. Herrera, 2011, The American journal of tropical medicine and hygiene.

Successful Induction of CD8 T Cell-Dependent Protection Against Malaria by Sequential Immunization with DNA and Recombinant Poxvirus of Neonatal Mice Born to Immune Mothers 1

S. Hoffman, D. Carucci, C. Siegrist, 2003, The Journal of Immunology.

Born to Immune Mothers Recombinant Poxvirus of Neonatal Mice by Sequential Immunization with DNA and Cell-Dependent Protection Against Malaria Successful Induction of CD 8 T

S. Hoffman, D. Carucci, C. Siegrist, 2003 .

IMRAS—Immunization with radiation-attenuated Plasmodium falciparum sporozoites by mosquito bite: Cellular immunity to sporozoites, CSP, AMA1, TRAP and CelTOS

T. Richie, M. Sedegah, H. Ganeshan, 2021, PloS one.

IMRAS—A clinical trial of mosquito-bite immunization with live, radiation-attenuated P. falciparum sporozoites: Impact of immunization parameters on protective efficacy and generation of a repository of immunologic reagents

S. Chaudhury, T. Richie, L. Garver, 2020, PloS one.

Controlled Human Malaria Infection (CHMI) differentially affects cell-mediated and antibody responses to CSP and AMA1 induced by adenovirus vaccines with and without DNA-priming

M. Sedegah, E. Abot, H. Ganeshan, 2015, Human vaccines & immunotherapeutics.

Progress with PfSPZ Vaccine, a radiation attenuated Plasmodium falciparum sporozoite vaccine

S. Hoffman, M. Tanner, B. Graham, 2014, Malaria Journal.

Sterile Immunity to Malaria after DNA Prime/Adenovirus Boost Immunization Is Associated with Effector Memory CD8+T Cells Targeting AMA1 Class I Epitopes

Bjoern Peters, A. Sette, Yohan Kim, 2014, PloS one.

The Effects of radiation on the safety and protective efficacy of an attenuated Plasmodium yoelii sporozoite malaria vaccine.

S. Hoffman, J. Epstein, E. James, 2009, Vaccine.

Increased levels of anti-PfCSP antibodies in post-pubertal females versus males immunized with PfSPZ Vaccine does not translate into increased protective efficacy

S. Hoffman, B. Mordmüller, P. Kremsner, 2022, Frontiers in Immunology.

Novel sporozoite-based ELISpot assay to assess frequency of parasite-specific B cells after vaccination with irradiated sporozoites

E. Bergmann-Leitner, S. Dutta, J. Epstein, 2019, Malaria journal.

A Phase IIa Controlled Human Malaria Infection and Immunogenicity Study of RTS,S/AS01E and RTS,S/AS01B Delayed Fractional Dose Regimens in Malaria-Naive Adults

Linda A. Murray, N. Waters, E. Jongert, 2020, The Journal of infectious diseases.

Measuring naturally acquired immune responses to candidate malaria vaccine antigens in Ghanaian adults

D. Doolan, J. Ocran, W. Rogers, 2011, Malaria Journal.

Taking a Bite out of Malaria: Controlled Human Malaria Infection by Needle and Syringe

J. Epstein, 2013, The American journal of tropical medicine and hygiene.

Vaccines against asexual stage malaria parasites.

Sanjai Kumar, T. Richie, J. Epstein, 2002, Chemical immunology.

Boosting of DNA Vaccine-Elicited Gamma Interferon Responses in Humans by Exposure to Malaria Parasites

S. Hoffman, D. Freilich, T. Richie, 2005, Infection and Immunity.

Ex vivo tetramer staining and cell surface phenotyping for early activation markers CD38 and HLA-DR to enumerate and characterize malaria antigen-specific CD8+ T-cells induced in human volunteers immunized with a Plasmodium falciparum adenovirus-vectored malaria vaccine expressing AMA1

Bjoern Peters, S. Buus, Yohan Kim, 2013, Malaria Journal.

Consistent safety and infectivity in sporozoite challenge model of Plasmodium vivax in malaria-naive human volunteers.

T. Richie, S. Herrera, M. Arévalo-Herrera, 2011, The American journal of tropical medicine and hygiene.

Successful sporozoite challenge model in human volunteers with Plasmodium vivax strain derived from human donors.

M. Chen-Mok, S. Herrera, M. Arévalo-Herrera, 2009, The American journal of tropical medicine and hygiene.

Progress with Plasmodium falciparum sporozoite (PfSPZ)-based malaria vaccines

Pedro Alonso, Ogobara K. Doumbo, Robert W. Sauerwein, 2015, Vaccine.

Induction of CD4+ T cell-dependent CD8+ type 1 responses in humans by a malaria DNA vaccine

S. Hoffman, D. Carucci, D. Doolan, 2001, Proceedings of the National Academy of Sciences of the United States of America.

antigens . variety of cardiac , nuclear , and streptococcal Rheumatic fever : autoantibodies against a

Q. Eichbaum, J. Epstein, D. Beatty, 2022 .

Development of a metabolically active, non-replicating sporozoite vaccine to prevent Plasmodium falciparum malaria

Sumana Chakravarty, Stephen L. Hoffman, S. Hoffman, 2010, Human vaccines.

Comparison of Clinical and Parasitological Data from Controlled Human Malaria Infection Trials

R. Sauerwein, A. Hill, A. J. van der Ven, 2012, PloS one.

A three-antigen Plasmodium falciparum DNA prime—Adenovirus boost malaria vaccine regimen is superior to a two-antigen regimen and protects against controlled human malaria infection in healthy malaria-naïve adults

S. Chaudhury, A. Lawrie, E. Bergmann-Leitner, 2021, PloS one.

Genome, proteome, and immunome data explain why 6 month controlled human malaria infection with sporozoites of the Pf7G8 clone of Plasmodium falciparum is a rigorous predictor of the efficacy of the PfNF54-based PfSPZ Vaccine in Africa

Joana C. Silva, S. Hoffman, B. Mordmüller, 2021, medRxiv.

Protection against Plasmodium falciparum malaria by PfSPZ Vaccine.

Sumana Chakravarty, Joana C. Silva, S. Hoffman, 2017, JCI insight.

Human adenovirus 5-vectored Plasmodium falciparum NMRC-M3V-Ad-PfCA vaccine encoding CSP and AMA1 is safe, well-tolerated and immunogenic but does not protect against controlled human malaria infection

Edward B. Miller, J. Bruder, T. Richie, 2013, Human vaccines & immunotherapeutics.

DNA Prime/Adenovirus Boost Malaria Vaccine Encoding P. falciparum CSP and AMA1 Induces Sterile Protection Associated with Cell-Mediated Immunity

D. Carucci, Awalludin Sutamihardja, A. J. McCoy, 2013, PloS one.

Clinical trial in healthy malaria-naïve adults to evaluate the safety, tolerability, immunogenicity and efficacy of MuStDO5, a five-gene, sporozoite/hepatic stage Plasmodium falciparum DNA vaccine combined with escalating dose human GM-CSF DNA

S. Hoffman, D. Freilich, J. Aguiar, 2012, Human vaccines & immunotherapeutics.

Adenovirus 5-Vectored P. falciparum Vaccine Expressing CSP and AMA1. Part A: Safety and Immunogenicity in Seronegative Adults

D. Carucci, D. Doolan, J. Bruder, 2011, PloS one.

A DNA Prime-Modified Vaccinia Virus Ankara Boost Vaccine Encoding Thrombospondin-Related Adhesion Protein but Not Circumsporozoite Protein Partially Protects Healthy Malaria-Naive Adults against Plasmodium falciparum Sporozoite Challenge

D. Webster, D. Carucci, R. Sinden, 2006, Infection and Immunity.

What will a partly protective malaria vaccine mean to mothers in Africa?

J. Epstein, 2007, The Lancet.

The whole parasite, pre-erythrocytic stage approach to malaria vaccine development: a review

T. Richie, J. Epstein, 2013, Current opinion in infectious diseases.

Decrease in circulating CD25(hi)Foxp3(+) regulatory T cells following vaccination with the candidate malaria vaccine RTS,S.

M. Sedegah, Eileen D. Villasante, J. Epstein, 2016, Vaccine.

Early whole blood transcriptional responses to radiation-attenuated Plasmodium falciparum sporozoite vaccination in malaria naïve and malaria pre-exposed adult volunteers

Fergal J. Duffy, S. Hoffman, J. Aitchison, 2021, Malaria journal.

More on partitioning and inactivation of AIDS virus in immune globulin preparations.

A. Wittek, J. Epstein, G. Quinnan,, 1986, The New England journal of medicine.

Bjoern Peters, S. Buus, Yohan Kim, 2013, Malaria Journal.

A multilateral effort to develop DNA vaccines against falciparum malaria.

S. Hoffman, D. Carucci, Sanjai Kumar, 2002, Trends in parasitology.

First-in-human evaluation of genetically attenuated Plasmodium falciparum sporozoites administered by bite of Anopheles mosquitoes to adult volunteers.

S. Kappe, A. Cowman, P. de la Vega, 2013, Vaccine.

Polymerase chain reaction evidence for human immunodeficiency virus 1 neutralization by passive immunization in patients with AIDS and AIDS-related complex.

B. Gazzard, I. Hewlett, A. Karpas, 1990, Proceedings of the National Academy of Sciences of the United States of America.

A consultation on the optimization of controlled human malaria infection by mosquito bite for evaluation of candidate malaria vaccines.

R. Sauerwein, A. Hill, C. Ockenhouse, 2012, Vaccine.

Progress with PfSPZ Vaccine, a radiation attenuated Plasmodium falciparum sporozoite vaccine

S. Hoffman, M. Tanner, B. Graham, 2014, Malaria Journal.

A systematic review of safety data reporting in clinical trials of vaccines against malaria, tuberculosis, and human immunodeficiency virus.

T. Richie, U. Heininger, J. Bonhoeffer, 2013, Vaccine.

Sporozoite immunization: innovative translational science to support the fight against malaria

Joana C. Silva, S. Hoffman, A. Dicko, 2023, Expert review of vaccines.

Multidose Priming and Delayed Boosting Improve PfSPZ Vaccine Efficacy against Heterologous P. falciparum Controlled Human Malaria Infection.

Andrea A. Berry, S. Hoffman, K. Lyke, 2020, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.