N. Sakaguchi

发表

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.

M. Toda, S. Sakaguchi, M. Toda, 1995, Journal of immunology.

Regulatory T Cells in Immunologic Self-Tolerance and Autoimmune Disease

S. Sakaguchi, N. Sakaguchi, 2005, International reviews of immunology.

Organ-specific autoimmune disease induced in mice by elimination of T cell subsets. V. Neonatal administration of cyclosporin A causes autoimmune disease.

S. Sakaguchi, N. Sakaguchi, 1989, Journal of immunology.

A role for fungal β-glucans and their receptor Dectin-1 in the induction of autoimmune arthritis in genetically susceptible mice

S. Akira, S. Gordon, T. Nomura, 2005, The Journal of experimental medicine.

Increased T Cell Autoreactivity in the Absence of CD40-CD40 Ligand Interactions: A Role of CD40 in Regulatory T Cell Development1

H. Kikutani, W. Shi, S. Sakaguchi, 2001, The Journal of Immunology.

Development A Role of CD 40 in Regulatory T Cell Absence of CD 40-CD 40 Ligand Interactions : Increased T Cell Autoreactivity in the Sakaguchi

H. Kikutani, W. Shi, S. Sakaguchi, 2000 .

Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice

T. Nomura, S. Yamazaki, S. Sakaguchi, 2003, Nature.

Occult Thyroid Papillary Thyroid Carcinoma in Hashimoto ' s itis Presenting as a Metastatic Bone Tumor

M. Nishikawa, N. Yoshikawa, N. Sakaguchi, 2006 .

Variant angina in isolated adrenocorticotropin deficiency, inappropriate vasopressin secretion and Hashimoto's thyroiditis.

N. Sakaguchi, M. Miyaji, T. Iwasaka, 1998, Internal medicine.

autoimmune diseases self-tolerance causes various Breakdown of a single mechanism of receptor alpha-chains (CD25). by activated T cells expressing IL-2 Immunologic self-tolerance maintained

M. Toda, S. Sakaguchi, N. Sakaguchi, 2010 .

Virus and autoimmunity: induction of autoimmune disease in mice by mouse T lymphotropic virus (MTLV) destroying CD4+ T cells.

S. Morse, S. Sakaguchi, N. Sakaguchi, 1999, Journal of immunology.

Lymphotropic Virus ( MTLV ) Destroying CD 4 Autoimmune Disease in Mice by Mouse T Virus and Autoimmunity : Induction of

S. Morse, S. Sakaguchi, N. Sakaguchi, 1999 .

Causes and mechanism of autoimmune disease: cyclosporin A as a probe for the investigation.

S. Sakaguchi, N. Sakaguchi, 1992, The Journal of investigative dermatology.

History of CD25 + CD4 + regulatory T cells

S. Sakaguchi, N. Sakaguchi, 2005 .

Immunologic self tolerance maintained by T-cell-mediated control of self-reactive T cells: implications for autoimmunity and tumor immunity.

J. Shimizu, S. Yamazaki, S. Sakaguchi, 2001, Microbes and infection.

Thymus and autoimmunity. Transplantation of the thymus from cyclosporin A-treated mice causes organ-specific autoimmune disease in athymic nude mice

S. Sakaguchi, N. Sakaguchi, Shimon Sakaguchi, 1988, The Journal of experimental medicine.

Ionizing radiation and autoimmunity. Induction of autoimmune disease in mice by high dose fractionated total lymphoid irradiation and its prevention by inoculating normal T cells.

S. Sakaguchi, N. Sakaguchi, K. Miyai, 1992, Journal of immunology.

T cell-mediated maintenance of natural self-tolerance: its breakdown as a possible cause of various autoimmune diseases.

S. Morse, M. Toda, S. Sakaguchi, 1996, Journal of autoimmunity.

Induction of autoimmune disease in mice by germline alteration of the T cell receptor gene expression.

P. A. Peterson, M. Davis, M. Toda, 1994, Journal of immunology.

Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation

S. Sakaguchi, M. Toda, N. Sakaguchi, 1996, The Journal of experimental medicine.

Cell Function Thymic T Cell Selection and Regulatory T Distinct Autoimmune Diseases by Altering Graded Attenuation of TCR Signaling Elicits

T. Nomura, M. Hashimoto, S. Sakaguchi, 2010 .

Disease as a Consequence o f Deve lopmenta l Abnormal

M. Toda, S. Sakaguchi, N. Sakaguchi, 2003 .

Strain-Specific Manifestation of Lupus-like Systemic Autoimmunity Caused by Zap70 Mutation

K. Ohmura, T. Mimori, Hiromu Ito, 2019, The Journal of Immunology.

Cytokine production profile of splenocytes derived from zymosan A-treated SKG mice developing arthritis

T. Suda, I. Miki, S. Sakaguchi, 2006, Inflammation Research.

Role of genetic factors in organ-specific autoimmune diseases induced by manipulating the thymus or T cells, and not self-antigens.

S. Sakaguchi, N. Sakaguchi, 2000, Reviews in immunogenetics.

Thymic generation and selection of CD25+CD4+ regulatory T cells: implications of their broad repertoire and high self-reactivity for the maintenance of immunological self-tolerance.

T. Sasazuki, S. Hori, S. Sakaguchi, 2003, Novartis Foundation symposium.

Identification of Novel and Noninvasive Biomarkers of Acute Cellular Rejection After Liver Transplantation by Protein Microarray

H. Eguchi, Y. Doki, M. Mori, 2016, Transplantation direct.

Occult papillary thyroid carcinoma in Hashimoto's thyroiditis presenting as a metastatic bone tumor.

M. Nishikawa, N. Yoshikawa, N. Sakaguchi, 1998, Endocrine journal.

Gamma/delta T cells are the predominant source of interleukin-17 in affected joints in collagen-induced arthritis, but not in rheumatoid arthritis.

K. Ohmura, T. Mimori, M. Hashimoto, 2009, Arthritis and rheumatism.

Thymus and autoimmunity: production of CD25+CD4+ naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance.

F. Otsuka, J. Shimizu, S. Sakaguchi, 1999, Journal of immunology.

Paracrine effect of human chorionic gonadotropin ectopically produced from papillary thyroid cancer cells on growth and function of FRTL-5 rat thyroid cells.

J. Hershman, N. Sakaguchi, M. Inada, 1997, Thyroid : official journal of the American Thyroid Association.

Immunologic tolerance maintained by CD25+ CD4+ regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance

Sayuri Yamazaki, Masaaki Toda, Shimon Sakaguchi, 2001, Immunological reviews.

Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state.

M. Toda, J. Shimizu, S. Sakaguchi, 1998, International immunology.

Maternal thyroid function in multiple pregnancy: the variable thyrotropic activity of human chorionic gonadotropin.

N. Yoshikawa, N. Sakaguchi, T. Tokoro, 1998, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

Immunologic Self-Tolerance Maintained by Cd25+Cd4+Regulatory T Cells Constitutively Expressing Cytotoxic T Lymphocyte–Associated Antigen 4

T. Mak, J. Shimizu, S. Yamazaki, 2000, The Journal of experimental medicine.

Graded Attenuation of TCR Signaling Elicits Distinct Autoimmune Diseases by Altering Thymic T Cell Selection and Regulatory T Cell Function

T. Nomura, M. Hashimoto, S. Sakaguchi, 2010, The Journal of Immunology.

T cell self-reactivity forms a cytokine milieu for spontaneous development of IL-17+ Th cells that cause autoimmune arthritis

Satoshi Tanaka, Shimon Sakaguchi, Hiroyuki Yoshitomi, 2007, The Journal of experimental medicine.

Thymus and autoimmunity: capacity of the normal thymus to produce pathogenic self-reactive T cells and conditions required for their induction of autoimmune disease

S. Sakaguchi, N. Sakaguchi, Shimon Sakaguchi, 1990, The Journal of experimental medicine.

Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model

Hiromu Ito, Shimon Sakaguchi, Hiroyuki Yoshitomi, 2007, The Journal of experimental medicine.

Dysbiosis Contributes to Arthritis Development via Activation of Autoreactive T Cells in the Intestine

Y. Saeki, K. Takeda, D. Motooka, 2016, Arthritis & rheumatology.

Quantitative measurements for type 1 deiodinase messenger ribonucleic acid in human peripheral blood mononuclear cells: mechanism of the preferential increase of T3 in hyperthyroid Graves' disease.

M. Nishikawa, N. Sakaguchi, T. Tokoro, 1998, Biochemical and biophysical research communications.

Pillars article: immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J. Immunol. 1995.

Masaaki Toda, Shimon Sakaguchi, Masanao Asano, 2011, Journal of immunology.

Thymus, innate immunity and autoimmune arthritis: Interplay of gene and environment

M. Hashimoto, S. Sakaguchi, Yoshinaga Ito, 2011, FEBS letters.

Spontaneous development of autoimmune arthritis due to genetic anomaly of T cell signal transduction: Part 1.

T. Nomura, S. Sakaguchi, Takeshi Takahashi, 2006, Seminars in immunology.

Distinct contribution of IL-6, TNF-alpha, IL-1, and IL-10 to T cell-mediated spontaneous autoimmune arthritis in mice.

T. Nomura, Y. Azuma, Y. Iwakura, 2004, The Journal of clinical investigation.

Effect of nicotine on type 2 deiodinase activity in cultured rat glial cells.

N. Sakaguchi, T. Tokoro, M. Inada, 1999, Endocrine journal.

Effect of streptozotocin-induced diabetes mellitus on type 1 deiodinase (D1) in inherited D1-deficient mice.

N. Sakaguchi, Y. Imai, T. Tokoro, 1999, Endocrine journal.

Autoantibodies to NMDA receptor in patients with chronic forms of epilepsia partialis continua

M. Mishina, Y. Takahashi, Y. Takahashi, 2003, Neurology.

Construction of a T cell receptor signaling range for spontaneous development of autoimmune disease

T. Nomura, D. Standley, R. Ueda, 2022, The Journal of experimental medicine.

Complement drives Th17 cell differentiation and triggers autoimmune arthritis

T. Nomura, T. Mimori, T. Fujita, 2010, The Journal of experimental medicine.

Chronic Renal Fai iting Activity in Serum of lure on Hemodialysis

Yonemoto, Toshiko, M. Nishikawa, 2006 .

Thyroid cell proliferation-inhibiting activity in serum of patients with chronic renal failure on hemodialysis.

N. Yoshikawa, N. Sakaguchi, A. Shouzu, 1996, Endocrine journal.

SKG mice, a monogenic model of autoimmune arthritis due to altered signal transduction in T-cells

T. Nomura, S. Sakaguchi, Takeshi Takahashi, 2006 .

Animal models of arthritis caused by systemic alteration of the immune system.

S. Sakaguchi, N. Sakaguchi, 2005, Current opinion in immunology.

Autoimmune Th17 Cells Induced Synovial Stromal and Innate Lymphoid Cell Secretion of the Cytokine GM-CSF to Initiate and Augment Autoimmune Arthritis

B. Stockinger, M. Hashimoto, Masao Tanaka, 2018, Immunity.

Differentiation and elimination of uterine natural killer cells in delayed implantation and parturition mice.

N. Sakaguchi, Y. Kiso, E. Hondo, 2005, The Journal of reproduction and development.

Arthritis and pneumonitis produced by the same T cell clones from mice with spontaneous autoimmune arthritis.

M. Hashimoto, Y. Tsuruta, R. Suzuki, 2008, International immunology.

Coexistence of an autonomously functioning thyroid nodule in a patient with Graves' disease: an unusual presentation of Marine-Lenhart syndrome.

N. Yoshikawa, N. Sakaguchi, T. Tokoro, 1997, Endocrine journal.

Detection of T cell responses to a ubiquitous cellular protein in autoimmune disease

T. Nomura, T. Mimori, S. Matsuda, 2014, Science.

Induction of type 2 deiodinase activity by cyclic guanosine 3',5'-monophosphate in cultured rat glial cells.

N. Sakaguchi, T. Tokoro, M. Inada, 1998, Thyroid : official journal of the American Thyroid Association.

SKG mice, a new genetic model of rheumatoid arthritis

T. Nomura, S. Sakaguchi, N. Sakaguchi, 2003 .

Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model

T. Nomura, M. Hashimoto, S. Sakaguchi, 2007, The Journal of experimental medicine.

Dispensable roles of Gsdmd and Ripk3 in sustaining IL-1β production and chronic inflammation in Th17-mediated autoimmune arthritis

T. Mimori, S. Sakaguchi, A. Morinobu, 2021, Scientific Reports.

Construction of a T cell receptor signaling range for spontaneous development of autoimmune disease

T. Nomura, D. Standley, R. Ueda, 2022, The Journal of experimental medicine.