M. Liebsch

发表

Animal testing and alternative approaches for the human health risk assessment under the proposed new European chemicals regulation

Horst Spielmann, Manfred Liebsch, Ursula Gundert-Remy, 2004, Archives of Toxicology.

The Advent of the Golden Era of Animal Alternatives

A. Luch, M. Oelgeschläger, A. Seiler, 2013 .

Wind of Change Challenges Toxicological Regulators

Andreas Luch, Manfred Liebsch, Christian Riebeling, 2012, Environmental health perspectives.

[Development of a new in vitro test for dermal phototoxicity using a model of reconstituted human epidermis]

H. Spielmann, M. Liebsch, C. Barrabas, 1997, ALTEX.

Validation study of alternatives to the Draize eye irritation test in Germany: Cytotoxicity testing and HET-CAM test with 136 industrial chemicals.

M Liebsch, I Gerner, H Spielmann, 1993, Toxicology in vitro : an international journal published in association with BIBRA.

3.3. Eye Irritation

A. Worth, T. Seidle, P. Vanparys, 2005 .

IRAG working group 2: CAM-based assays

H. Holzhütter, F. Moldenhauer, H. Spielmann, 1997 .

Modulation of 5-ALA-induced PpIX xenofluorescence intensities of a murine tumour and non-tumour tissue cultivated on the chorio-allantoic membrane

M. S. Ismail, C. Dressler, H. Weitzel, 1997, Lasers in Medical Science.

Regulatory assessment of in vitro skin corrosion and irritation data within the European framework: Workshop recommendations.

S. Hoffmann, P. Vanparys, N. Hopf, 2012, Regulatory toxicology and pharmacology : RTP.

Skin Irritation / Corrosion

P. Botham, V. Zuang, C. Eskes, 2004 .

Fetal Bovine Serum ( FBS ) : Past – Present – Future 1

Christiane D. Hohensee, J. Hickman, C. Buta, 2017 .

An Evaluation of the Proposed OECD Testing Strategy for Skin Corrosion

Andrew P. Worth, Michael Balls, Manfred Liebsch, 1998, Alternatives to laboratory animals : ATLA.

Implementation and enforcement of the 3Rs principle in the field of transgenic animals used for scientific purposes. Report and recommendations of the BfR expert workshop, May 18-20, 2009, Berlin, Germany.

A. Luch, K. Reifenberg, A. Seiler, 2010, ALTEX.

Report of the International Workshop on In Vitro Methods for Assessing Acute Systemic Toxicity

L. Gribaldo, M. Gómez-Lechón, E. Walum, 2000 .

Fetal Bovine Serum (FBS): Past - Present - Future.

Markus Schulz, Wilhelm G Dirks, Manfred Liebsch, 2018, ALTEX.

Eye irritation.

T. Seidle, P. Vanparys, L. Bruner, 2021, Alternatives to laboratory animals : ATLA.

29 Development of (Q)SARs for Dermal Irritation and Corrosion Assessment Using European Union New Chemicals Notification Data

Emiel Rorije, John D. Walker, Ingrid Gerner, 2007 .

Assessment of the human epidermis model skinethic RHE (TM) for in vitro skin corrosion testing according to OECD TG 431

H. Spielmann, B. Wever, E. Genschow, 2004 .

Statistical analysis of the hen's egg test for micronucleus induction (HET-MN assay).

L. Hothorn, A. Poth, R. Pirow, 2013, Mutation research.

Metabolically Competent Human Skin Models: Activation and Genotoxicity of Benzo[a]pyrene

T. Otter, A. Luch, U. Bock, 2012, Toxicological sciences : an official journal of the Society of Toxicology.

Alternative (non-animal) methods for chemicals testing: Current status and future prospects - Overview

Valérie Zuang, Silvia Casati, Andrew P. Worth, 2002 .

The Second ECVAM Workshop on Phototoxicity Testing

D. Averbeck, N. Gibbs, H. Spielmann, 2000, Alternatives to laboratory animals : ATLA.

[Permanent embryonic mouse germ cell-lines, an in vitro alternative to in vivo germ cell mutagenicity tests].

H. Spielmann, E. Genschow, M. Liebsch, 2001, ALTEX.

[Prediction of human lethal concentrations by cytotoxicity data from 50 MEIC chemicals].

H. Spielmann, M. Liebsch, W. Halle, 2000, ALTEX.

Development of an in vitro Modified Skin Absorption Test for the Investigation of the Follicular Penetration Pathway of Caffeine

J. Lademann, M. Linscheid, A. Patzelt, 2010, Skin Pharmacology and Physiology.

Permeation of topically applied caffeine through human skin--a comparison of in vivo and in vitro data.

J. Lademann, M. Linscheid, A. Patzelt, 2009, British journal of clinical pharmacology.

An improvement of blood sampling technique for Biomphalaria glabrata using anaesthesia and long-term relaxation and the role of this method in studies of the regulation of hemolymph glucose

M. Liebsch, W. Becker, Gerhard Gagelmann, 1978 .

Results of a Validation Study in Germany on Two in Vitro Alternatives to the Draize Eye Irritation Test, the HET-CAM Test and the 3T3 NRU Cytotoxicity Test

Reinhard Kreiling, Hermann-Georg Holzhütter, Horst Spielmann, 1996 .

Alternatives to the Animal Testing of Medical Devices

Horst Spielmann, Manfred Liebsch, J. C. Jensen, 1996 .

Acute Toxicity Testing in Vitro and the Classification and Labelling of Chemicals

Michael Balls, Manfred Liebsch, Julia H. Fentem, 1996 .

The 3T3 neutral red uptake phototoxicity test: practical experience and implications for phototoxicity testing--the report of an ECVAM-EFPIA workshop.

V. Rogiers, W. Muster, D. Bauer, 2012, Regulatory toxicology and pharmacology : RTP.

[First results of an EC/COLIPA validation project of in vitro phototoxicity testing methods]

F. Moldenhauer, H. Spielmann, M. Liebsch, 1994, ALTEX.

Skin phototoxicity of cosmetic formulations containing photounstable and photostable UV-filters and vitamin A palmitate.

L. R. Gaspar, M. Liebsch, P. M. Maia Campos, 2013, Toxicology in vitro : an international journal published in association with BIBRA.

Comparative glucose tolerance studies in the freshwater snail Biomphalaria glabrata: influence of starvation and infection with the trematode Schistosoma mansoni

M. Liebsch, W. Becker, 2004, Journal of Comparative Physiology B.

Allergic contact dermatitis: epidemiology, molecular mechanisms, in vitro methods and regulatory aspects

A. M. Api, T. L. Diepgen, D. A. Basketter, 2011, Cellular and Molecular Life Sciences.

The EpiDerm™ Phototoxicity Test (EpiDerm™ H3D-PT)

M. Liebsch, H. Kandárová, H. Kanďárová, 2017 .

Phototoxicity of bergamot oil assessed by in vitro techniques in combination with human patch tests.

M Liebsch, M. Liebsch, K Kejlová, 2007, Toxicology in vitro : an international journal published in association with BIBRA.

3.8. UV-induced Effects

Chantra Eskes, Horst Spielmann, Manfred Liebsch, 2005, Alternatives to laboratory animals : ATLA.

A Study on UV Filter Chemicals from Annex VII of European Union Directive 76/768/EEC, in the In Vitro 3T3 NRU Phototoxicity Test

Michael Balls, Horst Spielmann, Manfred Liebsch, 1998, Alternatives to laboratory animals : ATLA.

The International EU/COLIPA In Vitro Phototoxicity Validation Study: Results of Phase II (Blind Trial). Part 1: The 3T3 NRU Phototoxicity Test.

M Liebsch, H Spielmann, O de Silva, 1998, Toxicology in vitro : an international journal published in association with BIBRA.

application of the human dermal model skin(2) ZK 1350 to phototoxicity and skin corrosivity testing.

M Liebsch, H Spielmann, H. Spielmann, 1995, Toxicology in vitro : an international journal published in association with BIBRA.

EEC/COLIPA project on in vitro phototoxicity testing: First results obtained with a Balb/c 3T3 cell phototoxicity assay.

M Liebsch, H Spielmann, M Balls, 1994, Toxicology in vitro : an international journal published in association with BIBRA.

Reconstructed Human Epidermis for Skin Absorption Testing: Results of the German Prevalidation Study

Claus-Michael Lehr, Elisabeth Schmidt, Horst Spielmann, 2006, Alternatives to laboratory animals : ATLA.

In vitro skin absorption of butyl methoxydibenzoylmethane determined in human epidermis and in a reconstituted human epidermis model

C. Lehr, M. Liebsch, H. Kandárová, 2006 .

ECVAM feasibility study: Can the prevalidated in vitro skin model phototoxicity assay be upgraded to quantify phototoxic potency of topical phototoxins?

M. Liebsch, K. Kejlová, H. Kandárová, 2005 .

Comparison of human skin irritation and photo-irritation patch test data with cellular in vitro assays and animal in vivo data

D. Basketter, M. Liebsch, K. Kejlová, 2008 .

Reconstructed epidermis versus human and animal skin in skin absorption studies.

A. Haberland, H. Korting, U. Schäfer, 2005, Toxicology in vitro : an international journal published in association with BIBRA.

Quantitative in vitro assessment of phototoxicity using a human skin model, Skin2.

M Liebsch, H Spielmann, H. Spielmann, 1994, Photodermatology, photoimmunology & photomedicine.

The Use of Reconstructed Human Epidermis for Skin Absorption Testing: Results of the Validation Study

Claus-Michael Lehr, Elisabeth Schmidt, Horst Spielmann, 2008, Alternatives to laboratory animals : ATLA.

Eye Irritation Testing: The Way Forward. The Report and Recommendations of ECVAM Workshop 34.

M Liebsch, Y Ohno, H Spielmann, 1999, Alternatives to laboratory animals : ATLA.

Modern biostatistical methods for assessing in vitro/in vivo correlation of severely eye irritating chemicals in a validation study of in vitro alternatives to the Draize eye test.

M Liebsch, H Spielmann, O de Silva, 1995, Toxicology in vitro : an international journal published in association with BIBRA.

IRAG working group 2. CAM-based assays. Interagency Regulatory Alternatives Group.

H. Holzhütter, F. Moldenhauer, H. Spielmann, 1997, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

The ECVAM International Validation Study on in Vitro Tests for Acute Skin Irritation: Report on the Validity of the EPISKIN and EpiDerm Assays and on the Skin Integrity Function Test a

Valérie Zuang, Andrew Worth, Sebastian Hoffmann, 2007, Alternatives to laboratory animals : ATLA.

Validation of the hen’s egg test for micronucleus induction (HET-MN): detailed protocol including scoring atlas, historical control data and statistical analysis

A. Luch, A. Poth, M. Schulz, 2021, Mutagenesis.

The hen’s egg test for micronucleus induction (HET-MN): validation data set

A. Luch, A. Poth, M. Schulz, 2021, Mutagenesis.

Influence of massage and occlusion on the ex vivo skin penetration of rigid liposomes and invasomes.

A. Fahr, J. Lademann, J. Kuntsche, 2014, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

3.2. Skin Irritation and Corrosion

Valérie Zuang, Chantra Eskes, Manfred Liebsch, 2005, Alternatives to laboratory animals : ATLA.

The Role of Prevalidation in the Development, Validation and Acceptance of Alternative Methods

Michael Balls, Horst Spielmann, Manfred Liebsch, 1995 .

Developmental toxicity testing in the 21st century: the sword of Damocles shattered by embryonic stem cell assays?

Andreas Luch, Manfred Liebsch, Christian Riebeling, 2011, Archives of Toxicology.

Determination of the Starting dose for Acute Oral Toxicity (LD50) Testing in the up and down Procedure (UDP) from Cytotoxicity Data

Horst Spielmann, Manfred Liebsch, Elke Genschow, 1999, Alternatives to laboratory animals : ATLA.

Validation of the 3D Skin Comet assay using full thickness skin models: Transferability and reproducibility.

Markus Schulz, Andreas Luch, Sebastian Hoffmann, 2018, Mutation research. Genetic toxicology and environmental mutagenesis.

Assessment of the human epidermis model SkinEthic RHE for in vitro skin corrosion testing of chemicals according to new OECD TG 431.

Elisabeth Schmidt, Horst Spielmann, Manfred Liebsch, 2006, Toxicology in vitro : an international journal published in association with BIBRA.

Prevalidation of the ex-vivo model PCLS for prediction of respiratory toxicity.

M Liebsch, R Landsiedel, R Pirow, 2016, Toxicology in vitro : an international journal published in association with BIBRA.

The Use of Human Keratinocytes and Human Skin Models for Predicting Skin Irritation

N. Fusenig, J. J. van de Sandt, M. Ponec, 1999, Alternatives to laboratory animals : ATLA.

Successful validation of in vitro methods in toxicology by ZEBET, the National Centre for Alternatives in Germany at the BfR (Federal Institute for Risk Assessment).

H. Spielmann, A. Seiler, M. Liebsch, 2008, Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie.

Validation Successes: Chemicals

Horst Spielmann, Manfred Liebsch, H. Spielmann, 2002, Alternatives to laboratory animals : ATLA.

Lessons learned from validation of in vitro toxicity test: from failure to acceptance into regulatory practice.

M Liebsch, H Spielmann, H. Spielmann, 2001, Toxicology in vitro : an international journal published in association with BIBRA.

Permanent embryonic germ cell lines of BALB/cJ mice--an in vitro alternative for in vivo germ cell mutagenicity tests.

H. Spielmann, E. Genschow, M. Liebsch, 2001, Toxicology in vitro : an international journal published in association with BIBRA.

Comparison of human skin irritation patch test data with in vitro skin irritation assays and animal data

Manfred Liebsch, David Basketter, Helena Kandárová, 2010, Contact dermatitis.

In vitro models of inhalation toxicity and disease. The report of a FRAME workshop.

Robert Combes, Marianna Gaça, Manfred Liebsch, 2009, Alternatives to laboratory animals : ATLA.

The Current Scientific and Legal Status of Alternative Methods to the LD50 Test for Botulinum Neurotoxin Potency Testing

Andreas Luch, Barbara Grune, Horst Spielmann, 2010, Alternatives to laboratory animals : ATLA.

Allergic contact dermatitis: epidemiology, molecular mechanisms, in vitro methods and regulatory aspects

A. M. Api, H. Maibach, A. Schnuch, 2011, Cellular and Molecular Life Sciences.

The ECVAM International Validation Study on In Vitro Tests for Skin Corrosivity. 2. Results and Evaluation by the Management Team.

M Liebsch, M Balls, J H Fentem, 1998, Toxicology in vitro : an international journal published in association with BIBRA.

Points of Reference in the Validation Process

Thomas Hartung, Ian Gardner, Christoph Klein, 2008, Alternatives to laboratory animals : ATLA.

The Validation of Toxicological Prediction Models

Rodger Curren, Julia H. Fentem, Michael Balls, 1997 .

Alternatives to animal testing: current status and future perspectives

Andreas Luch, Barbara Grune, Manfred Liebsch, 2011, Archives of Toxicology.

Stratum corneum architecture of reconstructed human skin models monitored by fluorescent confocal laser scanning microscopy

J. Lademann, H. Richter, M. Liebsch, 2007 .

Currently available in vitro methods used in the regulatory toxicology.

Horst Spielmann, Manfred Liebsch, H. Spielmann, 2002, Toxicology letters.

The EpiDerm Test Protocol for the Upcoming ECVAM Validation Study on In Vitro Skin Irritation Tests — An Assessment of the Performance of the Optimised Test

Elisabeth Schmidt, Horst Spielmann, Manfred Liebsch, 2005, Alternatives to laboratory animals : ATLA.

Assessment of the Eye Irritating Properties of Chemicals by Applying Alternatives to the Draize Rabbit Eye Test: The Use of QSARs and In Vitro Tests for the Classification of Eye Irritation

Horst Spielmann, Manfred Liebsch, Ingrid Gerner, 2005, Alternatives to laboratory animals : ATLA.

Evaluation of in vitro embryotoxicity tests for Chinese herbal medicines.

Rongyun Wang, Qiu-hua Sun, Lu Li, 2019, Reproductive toxicology.

Catch-up validation study of an in vitro skin irritation test method based on an open source reconstructed epidermis (phase I).

M Liebsch, K R Mewes, A Fischer, 2016, Toxicology in vitro : an international journal published in association with BIBRA.

Bergamot oil intended for topical use - attempts for a risk assessment of phototoxicity

M. Liebsch, K. Kejlová, H. Bendová, 2005 .

A knowledge-based search engine to navigate the information thicket of nanotoxicology.

Carsten Kneuer, Barbara Grune, Thomas Wächter, 2011, Regulatory toxicology and pharmacology : RTP.

The Three-fold Strategy of ZEBET at the BfR to improve Dissemination of Information on Alternative Methods to Animal Experiments

Barbara Grune, Manfred Liebsch, Andreas Luch, 2010, CRIS.

Mission and accomplishments of ZEBET, the national centre for alternatives in Germany at the BfR (Federal Institute for Risk Assessment)

Horst Spielmann, Barbara Grune, Manfred Liebsch, 2008 .

EEC/COLIPA in vitro photoirritancy program: results of the first stage of validation.

H. Spielmann, M. Balls, T. Maurer, 1995, Current problems in dermatology.

Regulatory use of (Q)SARs in toxicological hazard assessment strategies

M Liebsch, I Gerner, H Spielmann, 2004, SAR and QSAR in environmental research.

Assessment of the predictive capacity of the 3T3 Neutral Red Uptake cytotoxicity test method to identify substances not classified for acute oral toxicity (LD50>2000 mg/kg): results of an ECVAM validation study.

Hans Raabe, Manfred Liebsch, Maurice Whelan, 2013, Regulatory toxicology and pharmacology : RTP.

Follow-up to the ECVAM Prevalidation Study on In Vitro Tests for Acute Skin Irritation

Valérie Zuang, Emanuela Corsini, Michael Balls, 2002, Alternatives to laboratory animals : ATLA.

Optimisation of the EpiDerm test protocol for the upcoming ECVAM validation study on in vitro skin irritation tests.

Horst Spielmann, Manfred Liebsch, Helena Kandárová, 2004, ALTEX.

ZEBET: Three Years of the National German Center for Documentation and Evaluation of Alternatives to Animal Experiments at the Federal Health Office (BGA) in Berlin

Horst Spielmann, Manfred Liebsch, Barbara Grune‐Wolff, 2008 .

[Reduction of the numbers of animals used for the classification of the acute oral toxicity of chemicals by taking into account cytotoxicity data from the Registry of Cytotoxicity]

Horst Spielmann, Manfred Liebsch, Dieter Traue, 1997, ALTEX.

The Principles of Good Laboratory Practice: Application to In Vitro Toxicology Studies

M Liebsch, M Balls, R Clothier, 1999, Alternatives to laboratory animals : ATLA.

Influence of massage and occlusion on the ex vivo skin penetration of rigid liposomes and invasomes.

A. Fahr, J. Lademann, J. Kuntsche, 2014, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Validation of the 3D Skin Comet assay using full thickness skin models: Transferability and reproducibility.

A. Luch, C. Krul, T. Downs, 2018, Mutation research. Genetic toxicology and environmental mutagenesis.

Mission and accomplishments of ZEBET, the national centre for alternatives in Germany at the BfR (Federal Institute for Risk Assessment)

H. Spielmann, A. Seiler, M. Liebsch, 2008 .

The ECVAM Prevalidation Study on the Use of EpiDerm for Skin Corrosivity Testing

M Liebsch, H Spielmann, H. Spielmann, 2000, Alternatives to laboratory animals : ATLA.

Assessment of the Skin Irritation Potential of Chemicals by Using the SkinEthic Reconstructed Human Epidermal Model and the Common Skin Irritation Protocol Evaluated in the ECVAM Skin Irritation Validation Study

Elisabeth Schmidt, Horst Spielmann, Manfred Liebsch, 2006, Alternatives to laboratory animals : ATLA.

A Prevalidation Study on In Vitro Skin Corrosivity Testing

Michael Balls, Manfred Liebsch, Philip A. Botham, 1995 .