Leifu Chang

发表

Atomic structure of the APC/C and its mechanism of protein ubiquitination

D. Barford, Ziguo Zhang, S. McLaughlin, 2015, Nature.

The potential of cryo-electron microscopy for structure-based drug design.

D. Barford, A. Boland, Leifu Chang, 2017, Essays in biochemistry.

Building a pseudo-atomic model of the anaphase-promoting complex

D. Barford, P. D. da Fonseca, Ziguo Zhang, 2013, Acta crystallographica. Section D, Biological crystallography.

Structural organization of an intact phycobilisome and its association with photosystem II

Jindong Zhao, Fan Yang, Leifu Chang, 2015, Cell Research.

WD40 domain of Apc1 is critical for the coactivator-induced allosteric transition that stimulates APC/C catalytic activity

D. Barford, Ziguo Zhang, Leifu Chang, 2016, Proceedings of the National Academy of Sciences.

Structural basis for inhibition of the type I-F CRISPR–Cas surveillance complex by AcrIF4, AcrIF7 and AcrIF14

Leifu Chang, Heng Zhang, C. Gabel, 2020, Nucleic acids research.

Atomic-Resolution Structures of the APC/C Subunits Apc4 and the Apc5 N-Terminal Domain

D. Barford, N. Cronin, Ziguo Zhang, 2015, Journal of molecular biology.

Mechanism for remodelling of the cell cycle checkpoint protein MAD2 by the ATPase TRIP13

D. Barford, Leifu Chang, C. Alfieri, 2018, Nature.

Molecular mechanism of APC/C activation by mitotic phosphorylation

D. Barford, Suyang Zhang, M. Skehel, 2016, Nature.

Methods for Preparing Cryo-EM Grids of Large Macromolecular Complexes.

D. Barford, Leifu Chang, 2018, Methods in molecular biology.

Molecular architecture of the augmin complex

Ziguo Zhang, Leifu Chang, Jing Yang, 2022, Nature Communications.

Cryo-Electron Microscopy Structures of Yeast Alcohol Dehydrogenase.

B. Plapp, Leifu Chang, R. Subramanian, 2021, Biochemistry.

Structural Basis for the Inhibition of CRISPR-Cas12a by Anti-CRISPR Proteins.

Heng Zhang, A. Mesecar, Andrew D Mesecar, 2019, Cell host & microbe.

Molecular basis of APC/C regulation by the spindle assembly checkpoint

D. Barford, M. Skehel, Ziguo Zhang, 2016, Nature.

Mechanisms for target recognition and cleavage by the Cas12i RNA-guided endonuclease

Leifu Chang, Heng Zhang, Zhuang Li, 2020, Nature Structural & Molecular Biology.

Mechanisms for target recognition and cleavage by the Cas12i RNA-guided endonuclease

Leifu Chang, Heng Zhang, Zhuang Li, 2020, Nature structural & molecular biology.

Cryo-EM structure of the RNA-guided ribonuclease Cas12g

Leifu Chang, Heng Zhang, Zhuang Li, 2021, Nature Chemical Biology.

Cryo-EM structure of a separase-securin complex at near-atomic resolution

T. G. Martin, D. Barford, S. Scheres, 2017, Nature Structural &Molecular Biology.

Molecular architecture and mechanism of the anaphase-promoting complex

D. Barford, Ziguo Zhang, S. McLaughlin, 2014, Nature.

Structural basis of target DNA recognition by CRISPR-Cas12k for RNA-guided DNA transposition.

Leifu Chang, I. Mukherjee, C. Gabel, 2021, Molecular cell.

Structural basis of target DNA recognition by CRISPR-Cas12k for RNA-guided DNA transposition

Leifu Chang, I. Mukherjee, C. Gabel, 2021, bioRxiv.

Structure of the inner kinetochore CCAN complex assembled onto a centromeric nucleosome

D. Barford, A. Heck, A. Ehrenhofer-Murray, 2019, Nature.

Structural basis for substrate recognition and cleavage by the dimerization-dependent CRISPR–Cas12f nuclease

Leifu Chang, Zhuang Li, Ruijie Han, 2021, Nucleic acids research.

Structural basis for the dimerization-dependent CRISPR-Cas12f nuclease

Leifu Chang, Zhuang Li, Ruijie Han, 2020, bioRxiv.

Cryo-EM structure of a type I-F CRISPR RNA guided surveillance complex bound to transposition protein TniQ

Leifu Chang, Heng Zhang, Zhuang Li, 2020, Cell Research.

Cryo-EM structure of a type I-F CRISPR RNA guided surveillance complex bound to transposition protein TniQ

Leifu Chang, Heng Zhang, Zhuang Li, 2020, Cell Research.

Insights into the anaphase-promoting complex: a molecular machine that regulates mitosis.

D. Barford, Leifu Chang, 2014, Current opinion in structural biology.

Structure of the DOCK2−ELMO1 complex provides insights into regulation of the auto-inhibited state

D. Barford, Matthew J. Smith, J. Côté, 2020, Nature Communications.

Structure of the DOCK2−ELMO1 complex provides insights into regulation of the auto-inhibited state

D. Barford, Matthew J. Smith, J. Côté, 2020, Nature Communications.

Structures of rhodopsin in complex with G-protein-coupled receptor kinase 1

P. Andrews, Xin-Qiu Yao, T. Klose, 2021, Nature.

Structure of the inner kinetochore CCAN complex assembled onto a centromeric nucleosome

A. Heck, A. Ehrenhofer-Murray, Ziguo Zhang, 2019, Nature.

Structural basis of AcrIF24 as an anti-CRISPR protein and transcriptional suppressor

J. Bondy-Denomy, N. Noinaj, Leifu Chang, 2022, Nature Chemical Biology.

Mechanism for remodelling of the cell cycle checkpoint protein MAD2 by the ATPase TRIP13

D. Barford, Leifu Chang, C. Alfieri, 2018, Nature.

The four canonical tpr subunits of human APC/C form related homo-dimeric structures and stack in parallel to form a TPR suprahelix.

D. Barford, Ziguo Zhang, K. Kulkarni, 2013 .

New structural features of the APC/C revealed by high resolution cryo-EM structures of apo-APC/C and the APC/CCDH1:EMI1 complex

Ziguo Zhang, Leifu Chang, Jing Yang, 2023, bioRxiv.

Molecular mechanism for Tn7-like transposon recruitment by a type I-B CRISPR effector

T. Klose, Leifu Chang, C. Gabel, 2023, Cell.

The Four Canonical TPR Subunits of Human APC/C Form Related Homo-Dimeric Structures and Stack in Parallel to Form a TPR Suprahelix☆

Ziguo Zhang, Leifu Chang, Jing Yang, 2013, Journal of molecular biology.