Sophie Roy

发表

Caspase Cleavage of Gene Products Associated with Triplet Expansion Disorders Generates Truncated Fragments Containing the Polyglutamine Tract*

Dale E. Bredesen, Christopher A. Ross, Michael R. Hayden, 1998, The Journal of Biological Chemistry.

Caspase Cleavage of Mutant Huntingtin Precedes Neurodegeneration in Huntington's Disease

Blair R. Leavitt, Claire-Anne Gutekunst, Michael R. Hayden, 2002, The Journal of Neuroscience.

A Combinatorial Approach Defines Specificities of Members of the Caspase Family and Granzyme B

N. Thornberry, M. Garcia-Calvo, E. Peterson, 1997, The Journal of Biological Chemistry.

Mek2 Is Dispensable for Mouse Growth and Development

M. Tremblay, J. Charron, R. Erikson, 2003, Molecular and Cellular Biology.

Caspase 3 Deficiency Rescues Peripheral Nervous System Defect in Retinoblastoma Nullizygous Mice

David S. Park, G. Robertson, J. Maclaurin, 2001, The Journal of Neuroscience.

Discovery of a potent and selective small molecule hGPR91 antagonist.

A. Chugh, J. Vacca, D. Cully, 2011, Bioorganic & medicinal chemistry letters.

The Renal Outer Medullary Potassium Channel Inhibitor, MK-7145, Lowers Blood Pressure, and Manifests Features of Bartter’s Syndrome Type II Phenotype

J. Metzger, G. Kaczorowski, B. Priest, 2016, The Journal of Pharmacology and Experimental Therapeutics.

Disintegration and Esophageal Irritation Profiles of Alendronate Formulations:Implications for Clinical Safety and Efficacy

P. Geusens, G. Rodan, S. Prahalada, 2005 .

Caspase-3 cleaves the formin-homology-domain-containing protein FHOD1 during apoptosis to generate a C-terminal fragment that is targeted to the nucleolus

D. Nicholson, Sophie Roy, F. Gervais, 2006, Apoptosis.

Involvement of Caspases in Proteolytic Cleavage of Alzheimer’s Amyloid-β Precursor Protein and Amyloidogenic Aβ Peptide Formation

David Smith, G. Robertson, Daigen Xu, 1999, Cell.

Caspase Inhibitors Attenuate 1-Methyl-4-Phenylpyridinium Toxicity in Primary Cultures of Mesencephalic Dopaminergic Neurons

J. Bilsland, Yongxin Han, S. Harper, 2002, The Journal of Neuroscience.

Acute hemodynamic and renal effects of glucagon-like peptide 1 analog and dipeptidyl peptidase-4 inhibitor in rats

A. Pocai, M. Forrest, D. Kelley, 2015, Cardiovascular Diabetology.

Effects of the renin inhibitor MK-8141 (ACT-077825) in patients with hypertension.

P. Feig, Yabing Mai, C. Jones-Burton, 2010, Journal of the American Society of Hypertension : JASH.

Hippi is essential for node cilia assembly and Sonic hedgehog signaling.

E. Simpson, M. Hayden, Rebecca Cullum, 2006, Developmental biology.

Cooperative Action of Multiple cis-Acting Elements Is Required for N-myc Expression in Branchial Arches: Specific Contribution of GATA3

Laurent Beuret, M. Tremblay, J. Charron, 2009, Mechanisms of Development.

Confinement of caspase-12 proteolytic activity to autoprocessing

W. Shao, J. Sharom, M. Saleh, 2008, Proceedings of the National Academy of Sciences.

Phosphorylation of Phospholemman (FXYD1) by Protein Kinases A and C Modulates Distinct Na,K-ATPase Isozymes*

K. Geering, Sophie Roy, J. Horisberger, 2008, Journal of Biological Chemistry.

Molecular determinants of desensitization in an ENaC/degenerin channel

S. Bernèche, S. Kellenberger, Sophie Roy, 2013, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Synthesis, structure and catalytic activity of low-spin dicyano iron(III) complexes of N , N ′ -bis(quinolyl)malonamide derivatives

Sophie Roy, I. Artaud, K. Barkigia, 2004 .

NF-kappa B and I kappa B alpha are found in the mitochondria. Evidence for regulation of mitochondrial gene expression by NF-kappa B.

David F. Kashatus, A. Baldwin, J. Reuther, 2003, Journal of Biological Chemistry.

A strategy of employing aminoheterocycles as amide mimics to identify novel, potent and bioavailable soluble epoxide hydrolase inhibitors.

J. Berger, Gaochao Zhou, Bei B. Zhang, 2009, Bioorganic & medicinal chemistry letters.

Discovery of 3,3-disubstituted piperidine-derived trisubstituted ureas as highly potent soluble epoxide hydrolase inhibitors.

J. Berger, Gaochao Zhou, Bei B. Zhang, 2009, Bioorganic & medicinal chemistry letters.

Improvement of hERG-ROMK index of spirocyclic ROMK inhibitors through scaffold optimization and incorporation of novel pharmacophores.

S. Xu, B. Priest, P. Morissette, 2017, Bioorganic & medicinal chemistry letters.

Discovery of a potent and selective ROMK inhibitor with improved pharmacokinetic properties based on an octahydropyrazino[2,1-c][1,4]oxazine scaffold.

A. Swensen, G. Kaczorowski, B. Priest, 2016, Bioorganic & medicinal chemistry letters.

Differentiation of ROMK potency from hERG potency in the phenacetyl piperazine series through heterocycle incorporation.

A. Swensen, G. Kaczorowski, B. Priest, 2016, Bioorganic & medicinal chemistry letters.

Discovery of MK-7145, an Oral Small Molecule ROMK Inhibitor for the Treatment of Hypertension and Heart Failure.

J. Metzger, A. Swensen, M. Forrest, 2016, ACS medicinal chemistry letters.

Discovery of a Potent and Selective ROMK Inhibitor with Pharmacokinetic Properties Suitable for Preclinical Evaluation.

J. Chen, R. Bentley, J. Metzger, 2015, ACS medicinal chemistry letters.

A Caspase Active Site Probe Reveals High Fractional Inhibition Needed to Block DNA Fragmentation*

N. Méthot, Yongxin Han, R. Zamboni, 2004, Journal of Biological Chemistry.

Caspase‐3 is activated following axotomy of neonatal facial motoneurons and caspase‐3 gene deletion delays axotomy‐induced cell death in rodents

G. Robertson, C. McBride, L. T. McPhail, 2000, The European journal of neuroscience.

Discovery of novel aspartyl ketone dipeptides as potent and selective caspase-3 inhibitors.

C. Bayly, Yongxin Han, R. Zamboni, 2004, Bioorganic & medicinal chemistry letters.

Pharmacologic Inhibition of the Renal Outer Medullary Potassium Channel Causes Diuresis and Natriuresis in the Absence of Kaliuresis

A. Swensen, K. Hoagland, G. Kaczorowski, 2014, Journal of Pharmacology and Experimental Therapeutics.

Discovery of Selective Small Molecule ROMK Inhibitors as Potential New Mechanism Diuretics.

G. Kaczorowski, B. Priest, Haifeng Tang, 2012, ACS medicinal chemistry letters.

Selective, Reversible Caspase-3 Inhibitor Is Neuroprotective and Reveals Distinct Pathways of Cell Death after Neonatal Hypoxic-ischemic Brain Injury*

D. Holtzman, G. Robertson, Yongxin Han, 2002, The Journal of Biological Chemistry.

Novel pyrazinone mono-amides as potent and reversible caspase-3 inhibitors.

C. Bayly, Yongxin Han, R. Zamboni, 2005, Bioorganic & medicinal chemistry letters.

Caspase-7 Expanded Function and Intrinsic Expression Level Underlies Strain-Specific Brain Phenotype of Caspase-3-Null Mice

E. Simpson, D. Nicholson, N. Coulombe, 2004, The Journal of Neuroscience.

Solid phase synthesis of selective caspase-3 peptide inhibitors.

C. Bayly, R. Zamboni, P. Tawa, 2004, Bioorganic & medicinal chemistry.

Discovery of pyrazole carboxylic acids as potent inhibitors of rat long chain L-2-hydroxy acid oxidase.

A. Chugh, J. Vacca, D. Barawkar, 2012, Bioorganic & medicinal chemistry letters.

Mek 2 Is Dispensable for Mouse Growth and Development

M. Tremblay, J. Charron, R. Erikson, 2003 .

Solid-phase analogue synthesis of caspase-3 inhibitors via palladium-catalyzed amination of 3-bromopyrazinones.

Yongxin Han, R. Zamboni, P. Tawa, 2007, Bioorganic & medicinal chemistry letters.

Lipophilic versus hydrogen-bonding effect in P3 on potency and selectivity of valine aspartyl ketones as caspase 3 inhibitors.

C. Bayly, Yongxin Han, R. Zamboni, 2005, Bioorganic & medicinal chemistry letters.

Nicotinyl aspartyl ketones as inhibitors of caspase-3.

C. Bayly, R. Zamboni, N. Thornberry, 2000, Bioorganic & medicinal chemistry letters.

Targeting native and apo-sGC

M. Struthers, Sophie Roy, C. Sinz, 2013, BMC Pharmacology and Toxicology.

Discovery of a highly potent, selective, and bioavailable soluble epoxide hydrolase inhibitor with excellent ex vivo target engagement.

J. Berger, Gaochao Zhou, Sanjeev Kumar, 2009, Journal of medicinal chemistry.

FXYD6 Is a Novel Regulator of Na,K-ATPase Expressed in the Inner Ear*

Jean-Luc Puel, K. Geering, B. Delprat, 2007, Journal of Biological Chemistry.

Cell death attenuation by `Usurpin', a mammalian DED-caspase homologue that precludes caspase-8 recruitment and activation by the CD-95 (Fas, APO-1) receptor complex

M. Hayden, S. Hadano, B. Koop, 1998, Cell Death and Differentiation.

Reducing the peptidyl features of caspase-3 inhibitors: a structural analysis.

C. Bayly, Yongxin Han, R. Zamboni, 2004, Journal of medicinal chemistry.

Discovery of a novel sub-class of ROMK channel inhibitors typified by 5-(2-(4-(2-(4-(1H-Tetrazol-1-yl)phenyl)acetyl)piperazin-1-yl)ethyl)isobenzofuran-1(3H)-one.

A. Swensen, G. Kaczorowski, B. Priest, 2013, Bioorganic & medicinal chemistry letters.

Heterozygous Disruption of Renal Outer Medullary Potassium Channel in Rats Is Associated With Reduced Blood Pressure

J. Wade, P. Welling, J. Levorse, 2013, Hypertension.

Mutations in the palm domain disrupt modulation of acid-sensing ion channel 1a currents by neuropeptides

V. Zoete, Benoîte Bargeton, S. Kellenberger, 2019, Scientific Reports.

Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms

S. Srinivasula, E. Alnemri, R. Hotchkiss, 2004, Nature.

Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi

A. Hackam, M. Hayden, B. Leavitt, 2002, Nature Cell Biology.

Maintenance of caspase-3 proenzyme dormancy by an intrinsic “safety catch” regulatory tripeptide

Christopher I. Bayly, C. Bayly, S. Kargman, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Caspase-2 Is Localized at the Golgi Complex and Cleaves Golgin-160 during Apoptosis

N. Thornberry, D. Nicholson, C. Machamer, 2000, The Journal of cell biology.

The Caspase-3 Precursor Has a Cytosolic and Mitochondrial Distribution: Implications for Apoptotic Signaling

N. Thornberry, E. Peterson, D. Nicholson, 1998, The Journal of cell biology.

Differential Efficacy of Caspase Inhibitors on Apoptosis Markers during Sepsis in Rats and Implication for Fractional Inhibition Requirements for Therapeutics

N. Méthot, Yongxin Han, R. Zamboni, 2004, The Journal of experimental medicine.

The Cell Adhesion Molecule CEACAM1-L Is a Substrate of Caspase-3-mediated Cleavage in Apoptotic Mouse Intestinal Cells*

N. Beauchemin, D. Nicholson, Sophie Roy, 2003, The Journal of Biological Chemistry.

NF-κB and IκBα Are Found in the Mitochondria

David F. Kashatus, A. Baldwin, J. Reuther, 2003, The Journal of Biological Chemistry.

The Neuronal Apoptosis Inhibitory Protein Is a Direct Inhibitor of Caspases 3 and 7

Raouf Fetni, R. Slack, A. MacKenzie, 2002, The Journal of Neuroscience.

Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome

Keisuke Kuida, Liam O'Connor, David L. Vaux, 2002, Nature.

Evolution of Na,K-ATPase βm-subunit into a coregulator of transcription in placental mammals

K. Geering, Sophie Roy, N. Modyanov, 2007, Proceedings of the National Academy of Sciences.

Transcriptome profiling and network analysis of genetically hypertensive mice identifies potential pharmacological targets of hypertension.

I-Ming Wang, Mette Peters, Yair Benita, 2010, Physiological genomics.

Cleavage at the Caspase-6 Site Is Required for Neuronal Dysfunction and Degeneration Due to Mutant Huntingtin

L. Raymond, M. Hayden, B. Leavitt, 2006, Cell.

Mek1 and Mek2 Functional Redundancy in Erythropoiesis

Laurent Beuret, J. Charron, M. Espéli, 2021, Frontiers in Cell and Developmental Biology.

Map2k1 and Map2k2 genes contribute to the normal development of syncytiotrophoblasts during placentation

J. Charron, V. Nadeau, Sophie Roy, 2009, Development.

Antihypertensive drug development: current challenges and future opportunities.

R. Cody, P. Feig, Sophie Roy, 2010, Journal of the American Society of Hypertension : JASH.

Huntingtin is cleaved by caspases in the cytoplasm and translocated to the nucleus via perinuclear sites in Huntington's disease patient lymphoblasts

E. Nagata, S. Snyder, C. Ross, 2005, Neurobiology of Disease.

Huntingtin proteolysis in Huntington disease

M. Hayden, B. Leavitt, L. Ellerby, 2003, Clinical Neuroscience Research.

Caspase‐cleaved Amyloid Precursor Protein in Alzheimer's Disease

G. Robertson, Sophie Roy, C. Ayala-Grosso, 2002, Brain pathology.

A link between FXYD3 (Mat-8)-mediated Na,K-ATPase regulation and differentiation of Caco-2 intestinal epithelial cells.

K. Geering, Sophie Roy, F. Desgranges, 2009, Molecular biology of the cell.

Potent and Selective Inhibitors of Long Chain l-2-Hydroxy Acid Oxidase Reduced Blood Pressure in DOCA Salt-Treated Rats.

A. Chugh, S. Chaudhary, J. Vacca, 2011, ACS medicinal chemistry letters.

Neuroprotective effects of M826, a reversible caspase‐3 inhibitor, in the rat malonate model of Huntington's disease

G. Robertson, Yongxin Han, M. Rigby, 2004, British journal of pharmacology.

Conformational dynamics and role of the acidic pocket in ASIC pH-dependent gating

S. Bernèche, S. Kellenberger, N. Johner, 2017, Proceedings of the National Academy of Sciences.

A Combined Computational and Functional Approach Identifies New Residues Involved in pH-dependent Gating of ASIC1a*

S. Bernèche, O. Michielin, Benoîte Bargeton, 2010, The Journal of Biological Chemistry.

Programmed cell-death regulation: basic mechanisms and therapeutic opportunities

D. Nicholson, Sophie Roy, 2000 .

Neuroprotective effects of M 826 , a reversible caspase-3 inhibitor , in the rat malonate model of Huntington ’ s disease

G. Robertson, Yongxin Han, M. Rigby, 2004 .

Soluble guanylate cyclase stimulators for the treatment of hypertension: Discovery of MK-2947.

J. Metzger, K. Maloney, K. Rosauer, 2020, Bioorganic & medicinal chemistry letters.

Huntingtin interacting protein 1 can regulate neurogenesis in Drosophila

D. Nicholson, Sophie Roy, J. N. Moores, 2008, The European journal of neuroscience.

Abstract 1467: AB-16B5, a therapeutic monoclonal antibody against human clusterin that blocks the epithelial-to-mesenchymal transition

M. O’Connor-McCourt, A. Lenferink, T. Sulea, 2010 .

Chronic Antagonism of the Mineralocorticoid Receptor Ameliorates Hypertension and End Organ Damage in a Rodent Model of Salt-Sensitive Hypertension

Yonghua Zhu, M. Forrest, Daphne Szeto, 2011, Clinical and experimental hypertension.

Structural and Functional Properties of Two Human FXYD3 (Mat-8) Isoforms*

K. Geering, E. Felley-Bosco, Sophie Roy, 2006, Journal of Biological Chemistry.