Alexandra M. Nicholson

发表

Expanded GGGGCC Hexanucleotide Repeat in Noncoding Region of C9ORF72 Causes Chromosome 9p-Linked FTD and ALS

Bruce L. Miller, William W. Seeley, Adam L. Boxer, 2011, Neuron.

Loss of Tmem106b is unable to ameliorate frontotemporal dementia-like phenotypes in an AAV mouse model of C9ORF72-repeat induced toxicity

L. Petrucelli, M. Murray, D. Dickson, 2018, Acta Neuropathologica Communications.

Partial Tmem106b reduction does not correct abnormalities due to progranulin haploinsufficiency

E. Roberson, R. Rademakers, A. Arrant, 2018, Molecular Neurodegeneration.

Increased Membrane Cholesterol Might Render Mature Hippocampal Neurons More Susceptible to β-Amyloid-Induced Calpain Activation and Tau Toxicity

Adriana B Ferreira, Alexandra M. Nicholson, Adriana Ferreira, 2009, The Journal of Neuroscience.

TMEM106B p.T185S regulates TMEM106B protein levels: implications for frontotemporal dementia

B. Boeve, D. Dickson, G. Hsiung, 2013, Journal of neurochemistry.

Progranulin axis and recent developments in frontotemporal lobar degeneration

L. Petrucelli, J. Gass, R. Rademakers, 2012, Alzheimer's Research & Therapy.

TMEM106B protects C9ORF72 expansion carriers against frontotemporal dementia

Kevin F. Bieniek, M. Mesulam, L. Petrucelli, 2014, Acta Neuropathologica.

Clinical and neuropathological features of ALS/FTD with TIA1 mutations

M. Mesulam, D. Dickson, E. Bigio, 2017, Acta Neuropathologica Communications.

Genetic Screening and Functional Characterization of PDGFRB Mutations Associated with Basal Ganglia Calcification of Unknown Etiology

D. Dickson, Z. Wszolek, M. Baker, 2014, Human mutation.

Abnormal expression of homeobox genes and transthyretin in C9ORF72 expansion carriers

Kevin F. Bieniek, L. Petrucelli, Y. Asmann, 2017, Neurology: Genetics.

CHOLESTEROL AND NEURONAL SUSCEPTIBILITY TO BETA-AMYLOID TOXICITY.

Adriana B Ferreira, Alexandra M. Nicholson, Adriana Ferreira, 2010, Cognitive sciences.

Loss of Tmem106b leads to cerebellum Purkinje cell death and motor deficits

Y. Asmann, M. Murray, D. Dickson, 2021, Brain pathology.

Soluble sortilin is present in excess and positively correlates with progranulin in CSF of aging individuals

R. Petersen, D. Demontis, N. Finch, 2016, Experimental Gerontology.

Mutations in the colony stimulating factor 1 receptor (CSF1R) cause hereditary diffuse leukoencephalopathy with spheroids

R. Petersen, B. Boeve, D. Knopman, 2011, Nature Genetics.

The TMEM106B locus and TDP-43 pathology in older persons without FTLD

D. Dickson, Alexandra M. Nicholson, R. Rademakers, 2015, Neurology.

Whole-genome sequencing reveals important role for TBK1 and OPTN mutations in frontotemporal lobar degeneration without motor neuron disease

Kevin F. Bieniek, R. Petersen, B. Boeve, 2015, Acta Neuropathologica.

TIA1 Mutations in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Promote Phase Separation and Alter Stress Granule Dynamics

M. Mesulam, L. Petrucelli, R. Petersen, 2017, Neuron.

Prosaposin is a regulator of progranulin levels and oligomerization

Tanya M. Teslovich, G. Abecasis, T. Frayling, 2016, Nature Communications.

Loss of TMEM106B leads to myelination deficits: implications for frontotemporal dementia treatment strategies.

Y. Asmann, M. Murray, D. Dickson, 2020, Brain : a journal of neurology.

What we know about TMEM106B in neurodegeneration

Alexandra M. Nicholson, R. Rademakers, 2016, Acta Neuropathologica.

Progranulin protein levels are differently regulated in plasma and CSF

R. Petersen, B. Boeve, D. Knopman, 2014, Neurology.

Partial Tmem106b reduction does not correct abnormalities due to progranulin haploinsufficiency

E. Roberson, A. Arrant, Xiaolai Zhou, 2018, Molecular Neurodegeneration.

Parkinsonian features in hereditary diffuse leukoencephalopathy with spheroids (HDLS) and CSF1R mutations.

D. Dickson, B. Ghetti, R. Uitti, 2013, Parkinsonism & related disorders.

CSF1R mutations link POLD and HDLS as a single disease entity

D. Knopman, D. Dickson, Z. Wszolek, 2013, Neurology.

MRI characteristics and scoring in HDLS due to CSF1R gene mutations

D. Dickson, B. Ghetti, R. Uitti, 2012, Neurology.

The role of neurofilament light in genetic frontotemporal lobar degeneration

A. Boxer, J. Rohrer, H. Zetterberg, 2022, Brain communications.

Membrane Cholesterol Modulates β-Amyloid-dependent Tau Cleavage by Inducing Changes in the Membrane Content and Localization of N-Methyl-d-aspartic Acid Receptors*

Adriana B Ferreira, Alexandra M. Nicholson, D. Methner, 2010, The Journal of Biological Chemistry.

Genome-wide screen identifies rs646776 near sortilin as a regulator of progranulin levels in human plasma.

Allissa Dillman, Ronald C Petersen, Mark R Cookson, 2010, American journal of human genetics.

Loss of Tmem106b is unable to ameliorate frontotemporal dementia-like phenotypes in an AAV mouse model of C9ORF72-repeat induced toxicity

L. Petrucelli, M. Murray, D. Dickson, 2018, Acta neuropathologica communications.

Human Genetics as a Tool to Identify Progranulin Regulators

N. Finch, Alexandra M. Nicholson, R. Rademakers, 2011, Journal of Molecular Neuroscience.

β-Amyloid Carrying the Dutch Mutation Has Diverse Effects on Calpain-Mediated Toxicity in Hippocampal Neurons

D. Walsh, Alexandra M. Nicholson, Lindsey A. Wold, 2012, Molecular medicine.

Aβ toxicity in primary cultured neurons.

Alexandra M. Nicholson, R. C. Sinjoanu, S. Kleinschmidt, 2011, Methods in molecular biology.