M. Castanedes-Casey

发表

C9ORF72 repeat expansions in mice cause TDP-43 pathology, neuronal loss, and behavioral deficits

Kevin F. Bieniek, L. Petrucelli, M. Murray, 2015, Science.

Aberrant cleavage of TDP-43 enhances aggregation and cellular toxicity

L. Petrucelli, D. Dickson, C. Link, 2009, Proceedings of the National Academy of Sciences.

Loss of Tmem106b is unable to ameliorate frontotemporal dementia-like phenotypes in an AAV mouse model of C9ORF72-repeat induced toxicity

L. Petrucelli, M. Murray, D. Dickson, 2018, Acta Neuropathologica Communications.

Aggregation-prone c9FTD/ALS poly(GA) RAN-translated proteins cause neurotoxicity by inducing ER stress

Kevin F. Bieniek, L. Petrucelli, D. Dickson, 2014, Acta Neuropathologica.

Transactivation Response DNA-Binding Protein 43 Microvasculopathy in Frontotemporal Degeneration and Familial Lewy Body Disease

D. Dickson, Wen‐lang Lin, M. Castanedes-Casey, 2009, Journal of neuropathology and experimental neurology.

(Patho‐)physiological relevance of PINK1‐dependent ubiquitin phosphorylation

Elisabeth L. Moussaud-Lamodière, D. Dickson, J. Siuda, 2015, EMBO reports.

TMEM106B p.T185S regulates TMEM106B protein levels: implications for frontotemporal dementia

B. Boeve, D. Dickson, G. Hsiung, 2013, Journal of neurochemistry.

Enhanced phosphorylation of T153 in soluble tau is a defining biochemical feature of the A152T tau risk variant

L. Petrucelli, D. Dickson, J. Fryer, 2019, Acta Neuropathologica Communications.

Severe amygdala dysfunction in a MAPT transgenic mouse model of frontotemporal dementia

L. Petrucelli, M. Murray, D. Dickson, 2014, Neurobiology of Aging.

Poly(GR) impairs protein translation and stress granule dynamics in C9orf72-associated frontotemporal dementia and amyotrophic lateral sclerosis

Mark T. W. Ebbert, L. Petrucelli, D. Dickson, 2018, Nature Medicine.

C9ORF72 poly(GA) aggregates sequester and impair HR23 and nucleocytoplasmic transport proteins

L. Petrucelli, M. Murray, D. Dickson, 2016, Nature Neuroscience.

Microglial lysosome dysfunction contributes to white matter pathology and TDP-43 proteinopathy in GRN-associated FTD

L. Petrucelli, D. Dickson, W. Shao, 2021, Cell reports.

A truncating SOD1 mutation, p.Gly141X, is associated with clinical and pathologic heterogeneity, including frontotemporal lobar degeneration

Kevin F. Bieniek, M. Murray, D. Dickson, 2015, Acta Neuropathologica.

Loss of Tmem106b exacerbates FTLD pathologies and causes motor deficits in progranulin‐deficient mice

D. Dickson, C. Lutz, G. Bu, 2020, EMBO reports.

Phosphorylated tau sites that are elevated in Alzheimer's disease fluid biomarkers are visualized in early neurofibrillary tangle maturity levels in the post mortem brain

R. Petersen, M. Murray, D. Dickson, 2022, Alzheimer's & dementia : the journal of the Alzheimer's Association.

Perry Syndrome: A Distinctive Type of TDP-43 Proteinopathy

D. Dickson, Z. Wszolek, Wen‐lang Lin, 2017, Journal of neuropathology and experimental neurology.

HDAC6 Interacts With Poly (GA) and Modulates its Accumulation in c9FTD/ALS

L. Petrucelli, D. Dickson, F. Rigo, 2022, Frontiers in Cell and Developmental Biology.

C9orf72 poly(GR) aggregation induces TDP-43 proteinopathy

L. Petrucelli, G. S. Tomassy, D. Dickson, 2020, Science Translational Medicine.

Hexanucleotide Repeat Expansions in c9FTD/ALS and SCA36 Confer Selective Patterns of Neurodegeneration In Vivo.

L. Petrucelli, D. Dickson, M. Disney, 2020, Cell reports.

Aberrant deposition of stress granule-resident proteins linked to C9orf72-associated TDP-43 proteinopathy

L. Petrucelli, D. Dickson, M. Disney, 2019, Molecular Neurodegeneration.

p62 Pathology Model in the Rat Substantia Nigra with Filamentous Inclusions and Progressive Neurodegeneration

D. Dickson, Wen‐lang Lin, K. McCarthy, 2017, PloS one.

Plasma PolyQ-ATXN3 Levels Associate With Cerebellar Degeneration and Behavioral Abnormalities in a New AAV-Based SCA3 Mouse Model

L. Petrucelli, D. Dickson, Z. Wszolek, 2022, Frontiers in Cell and Developmental Biology.

Loss of Tmem106b leads to cerebellum Purkinje cell death and motor deficits

Y. Asmann, M. Murray, D. Dickson, 2021, Brain pathology.

Galactosylceramidase deficiency and pathological abnormalities in cerebral white matter of Krabbe disease

M. Gelb, D. Iacono, M. Castanedes-Casey, 2022, Neurobiology of Disease.

Perry syndrome is a distinctive type of TDP-43 proteinopathy

Z. Wszolek, Y. Tsuboi, D. Dickson, 2017, Journal of the Neurological Sciences.

Two FTD-ALS genes converge on the endosomal pathway to induce TDP-43 pathology and degeneration

L. Petrucelli, D. Dickson, J. Fryer, 2022, Science.

Impaired dopaminergic neurotransmission and microtubule-associated protein tau alterations in human LRRK2 transgenic mice

David I. Bass, G. Schellenberg, M. Farrer, 2010, Neurobiology of Disease.

Aberrant deposition of stress granule-resident proteins linked to C9orf72-associated TDP-43 proteinopathy

L. Petrucelli, D. Dickson, M. Disney, 2019, Molecular Neurodegeneration.

An acetylation–phosphorylation switch that regulates tau aggregation propensity and function

L. Petrucelli, D. Dickson, Y. Carlomagno, 2017, The Journal of Biological Chemistry.

Surgical guide including innovative techniques for orthotopic liver transplantation in the rat: Key techniques and pitfalls in whole and split liver grafts

S. Uemoto, N. Ohashi, J. Nguyen, 2010 .

DCTN1 mutations in Perry syndrome

M. Farrer, J. Kachergus, M. Hulihan, 2009, Nature Genetics.

The AD tau core spontaneously self-assembles and recruits full-length tau to filaments

L. Petrucelli, D. Dickson, Z. Wszolek, 2021, Cell reports.

Heterochromatin anomalies and double-stranded RNA accumulation underlie C9orf72 poly(PR) toxicity

L. Petrucelli, D. Dickson, Connor H. Ludwig, 2019, Science.

Antisense transcripts of the expanded C9ORF72 hexanucleotide repeat form nuclear RNA foci and undergo repeat-associated non-ATG translation in c9FTD/ALS

Kevin F. Bieniek, L. Petrucelli, D. Dickson, 2013, Acta Neuropathologica.

Matrix metalloproteinase-9 contributes to brain extravasation and edema in fulminant hepatic failure mice.

T. Golde, C. Eckman, Dennis Dickson, 2006, Journal of hepatology.

Loss of TMEM106B leads to myelination deficits: implications for frontotemporal dementia treatment strategies.

Y. Asmann, M. Murray, D. Dickson, 2020, Brain : a journal of neurology.

Tau exhibits unique seeding properties in globular glial tauopathy

L. Petrucelli, D. Dickson, Y. Carlomagno, 2019, Acta neuropathologica communications.

Poly(Gp) Proteins Are A Useful Pharmacodynamic Marker For C9Orf72-Associated Amyotrophic Lateral Sclerosis

William T. Hu, Robert H. Brown, L. Petrucelli, 2017 .

Tau deposition drives neuropathological, inflammatory and behavioral abnormalities independently of neuronal loss in a novel mouse model

L. Petrucelli, D. Dickson, G. Bu, 2015, Human molecular genetics.

Phosphorylated tau fluid biomarker sites recognize earlier neurofibrillary tangle maturity levels in the postmortem Alzheimer’s disease brain

R. Petersen, M. Murray, D. Dickson, 2021, bioRxiv.

Adenosine monophosphate-activated protein kinase overactivation leads to accumulation of α-synuclein oligomers and decrease of neurites

D. Dickson, S. Yen, Ming Gan, 2013, Neurobiology of Aging.

Tau pathology in frontotemporal lobar degeneration with C9ORF72 hexanucleotide repeat expansion

Kevin F. Bieniek, M. Murray, D. Dickson, 2013, Acta Neuropathologica.

Poly(GR) impairs protein translation and stress granule dynamics in C9orf72-associated frontotemporal dementia and amyotrophic lateral sclerosis

L. Petrucelli, D. Dickson, A. Gitler, 2018, Nature Medicine.

Cerebellar c9RAN proteins associate with clinical and neuropathological characteristics of C9ORF72 repeat expansion carriers

Kevin F. Bieniek, L. Petrucelli, R. Petersen, 2015, Acta Neuropathologica.

Reduced orexin immunoreactivity in Perry syndrome and multiple system atrophy.

D. Dickson, Z. Wszolek, Y. Tsuboi, 2017, Parkinsonism & related disorders.

Neuronal sensitivity to TDP-43 overexpression is dependent on timing of induction

L. Petrucelli, D. Dickson, Jada Lewis, 2012, Acta Neuropathologica.

Neonatal AAV delivery of alpha-synuclein induces pathology in the adult mouse brain

D. Dickson, P. McLean, J. Fryer, 2017, Acta neuropathologica communications.

Enhanced phosphorylation of T153 in soluble tau is a defining biochemical feature of the A152T tau risk variant

L. Petrucelli, D. Dickson, J. Fryer, 2019, Acta neuropathologica communications.

Neonatal AAV delivery of alpha-synuclein induces pathology in the adult mouse brain

D. Dickson, P. McLean, J. Fryer, 2017, Acta neuropathologica communications.

Loss of Tmem106b is unable to ameliorate frontotemporal dementia-like phenotypes in an AAV mouse model of C9ORF72-repeat induced toxicity

L. Petrucelli, M. Murray, D. Dickson, 2018, Acta neuropathologica communications.

Diffuse argyrophilic grain disease with TDP-43 proteinopathy and neuronal intermediate filament inclusion disease: FTLD with mixed tau, TDP-43 and FUS pathologies

M. Baker, K. Josephs, O. Ross, 2023, Acta Neuropathologica Communications.

Galactosylceramidase deficiency and pathological abnormalities in cerebral white matter of Krabbe disease

M. Gelb, D. Iacono, M. Castanedes-Casey, 2022, Neurobiology of Disease.

Diagnosis of Alzheimer's Disease and Tauopathies on Whole Slide Histopathology Images Using a Weakly Supervised Deep Learning Algorithm.

T. Hwang, M. Castanedes-Casey, S. Koga, 2023, Laboratory investigation; a journal of technical methods and pathology.

Poly(GR) interacts with key stress granule factors promoting its assembly into cytoplasmic inclusions.

C. Brangwynne, A. Emili, L. Petrucelli, 2023, Cell reports.

Tau exhibits unique seeding properties in globular glial tauopathy

L. Petrucelli, D. Dickson, Y. Carlomagno, 2019, Acta Neuropathologica Communications.

(Patho‐)physiological relevance of PINK1‐dependent ubiquitin phosphorylation

Elisabeth L. Moussaud-Lamodière, D. Dickson, J. Siuda, 2015, EMBO Reports.

Aberrant cleavage of TDP-43 enhances aggregation and cellular toxicity

L. Petrucelli, D. Dickson, C. Link, 2009, Proceedings of the National Academy of Sciences.

Poly(GP) proteins are a useful pharmacodynamic marker for C9ORF72-associated amyotrophic lateral sclerosis

Timothy A. Miller, L. Petrucelli, J. Trojanowski, 2017, Science Translational Medicine.