M. Clagett-Dame

发表

The temporal requirement for vitamin A in the developing eye: mechanism of action in optic fissure closure and new roles for the vitamin in regulating cell proliferation and adhesion in the embryonic retina.

Angela Wai-Man See, M. Clagett-Dame, 2009, Developmental biology.

Retinoid-regulated gene expression in neural development.

M. Clagett-Dame, L. Plum, 1997, Critical reviews in eukaryotic gene expression.

The unhydrolyzable fenretinide analogue 4-hydroxybenzylretinone induces the proapoptotic genes GADD153 (CHOP) and Bcl-2-binding component 3 (PUMA) and apoptosis that is caspase- dependent and independent of the retinoic acid receptor.

Derek W. Barnett, M. Clagett-Dame, A. Anding, 2007, Cancer research.

Identification of a unique subset of 2-methylene-19-nor analogs of vitamin D with comedolytic activity in the rhino mouse.

H. DeLuca, M. Clagett-Dame, L. Plum, 2010, The Journal of investigative dermatology.

Synthesis and biological properties of 2-methylene-19-nor-25-dehydro-1alpha-hydroxyvitamin D(3)-26,23-lactones--weak agonists.

H. DeLuca, G. Chiellini, M. Clagett-Dame, 2008, Bioorganic & medicinal chemistry.

A New Vitamin D Analog, 2MD, Restores Trabecular and Cortical Bone Mass and Strength in Ovariectomized Rats With Established Osteopenia

H. DeLuca, H. Ke, M. Clagett-Dame, 2005, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Pharmacokinetics of a New Oral Vitamin D Receptor Activator (2-Methylene-19-Nor-(20S)-1α,25-Dihydroxyvitamin D3) in Patients with Chronic Kidney Disease and Secondary Hyperparathyroidism on Hemodialysis

H. DeLuca, W. Bedale, D. Coyne, 2017, Drugs in R&D.

Effect of 2‐Methylene‐19‐nor‐(20S)‐1α‐Hydroxy‐Bishomopregnacalciferol (2MbisP), an Analog of Vitamin D, on Secondary Hyperparathyroidism

Alex J. Brown, H. DeLuca, E. Slatopolsky, 2007, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

A 20S combined with a 22R configuration markedly increases both in vivo and in vitro biological activity of 1α,25-dihydroxy-22-methyl-2-methylene-19-norvitamin D3.

H. DeLuca, J. Thoden, M. Clagett-Dame, 2012, Journal of medicinal chemistry.

Responsiveness of human retinoblastoma and neuroblastoma models to a non-calcemic 19-nor Vitamin D analog

M. Lindstrom, H. DeLuca, D. Albert, 2005, The Journal of Steroid Biochemistry and Molecular Biology.

2MD, a new anabolic agent for osteoporosis treatment

H. DeLuca, N. Binkley, L. Fitzpatrick, 2006, Osteoporosis International.

The all-trans retinoic acid (atRA)-regulated gene Calmin (Clmn) regulates cell cycle exit and neurite outgrowth in murine neuroblastoma (Neuro2a) cells.

M. Marzinke, M. Clagett-Dame, 2012, Experimental cell research.

2MD (DP001), a Single Agent in the Management of Hemodialysis Patients: A Randomized Trial

R. D. Buck, H. DeLuca, R. Thadhani, 2016, American Journal of Nephrology.

Synthesis and Preliminary Chemotherapeutic Evaluation of the Fully C-Linked Glucuronide of N-(4-Hydroxyphenyl) retinamide (4- HPR)

H. Abou-Issa, M. Clagett-Dame, Joel R Walker, 2008 .

One-step immunoaffinity purification of recombinant human retinoic acid receptor gamma.

J. Repa, M. Clagett-Dame, S. Strugnell, 1997, Protein expression and purification.

2-Methylene-19-nor-1α-hydroxyvitamin D3 analogs inhibit adipocyte differentiation and PPARγ2 gene transcription

H. DeLuca, J. Ntambi, M. Clagett-Dame, 2007 .

13-Methyl-substituted des-C,D analogs of (20S)-1alpha,25-dihydroxy-2-methylene-19-norvitamin D3 (2MD): synthesis and biological evaluation.

H. DeLuca, M. Clagett-Dame, Katarzyna Plonska-Ocypa, 2009, Bioorganic & medicinal chemistry.

An unhydrolyzable analogue of N-(4-hydroxyphenyl)retinamide. synthesis and preliminary biological studies.

K. Weiss, H. Abou-Issa, M. Clagett-Dame, 2001, Bioorganic & medicinal chemistry letters.

A potent analog of 1α,25-dihydroxyvitamin D3 selectively induces bone formation

H. DeLuca, J. Pike, Hironori Yamamoto, 2002, Proceedings of the National Academy of Sciences of the United States of America.

New 2-alkylidene 1alpha,25-dihydroxy-19-norvitamin D3 analogues of high intestinal activity: synthesis and biological evaluation of 2-(3'-alkoxypropylidene) and 2-(3'-hydroxypropylidene) derivatives.

H. DeLuca, M. Clagett-Dame, R. Sicinski, 2006, Journal of medicinal chemistry.

Retinoic Acid Combined with Neurotrophin-3 Enhances the Survival and Neurite Outgrowth of Embryonic Sympathetic Neurons

L. Parada, M. Clagett-Dame, L. Plum, 2001, Experimental biology and medicine.

Novel, Selective Vitamin D Analog Suppresses Parathyroid Hormone in Uremic Animals and Postmenopausal Women

H. DeLuca, M. Clagett-Dame, D. Plowchalk, 2014, American Journal of Nephrology.

A potent analog of 1alpha,25-dihydroxyvitamin D3 selectively induces bone formation.

H. DeLuca, J. Pike, Hironori Yamamoto, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Appearance of neurons in the developing chick gut

V. Lennon, M. Clagett-Dame, M. Epstein, 1995, Developmental dynamics : an official publication of the American Association of Anatomists.

A mammalian homolog of unc-53 is regulated by all-trans retinoic acid in neuroblastoma cells and embryos

R. Merrill, M. Clagett-Dame, L. Plum, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Synthesis and biological activities of vitamin D-like inhibitors of CYP24 hydroxylase

A. Bianucci, H. DeLuca, S. Rapposelli, 2012, Steroids.

Hydrolysis of 4-HPR to atRA occurs in vivo but is not required for retinamide-induced apoptosis.

M. Highland, K. Weiss, M. Clagett-Dame, 2003, Archives of biochemistry and biophysics.

All-trans-retinol is a ligand for the retinoic acid receptors.

J. Repa, M. Clagett-Dame, K. K. Hanson, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Biologically active noncalcemic analogs of 1alpha,25-dihydroxyvitamin D with an abbreviated side chain containing no hydroxyl.

H. DeLuca, M. Clagett-Dame, J. Prahl, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Generating and characterizing retinoid receptors from Escherichia coli and insect cell expression systems.

J. Repa, M. Clagett-Dame, 1997, Methods in enzymology.

A New 1,25 Dihydroxy Vitamin D Analog with Strong Bone Anabolic Activity in OVX Rats with Little or no Bone Resorptive Activity

H. DeLuca, M. Clagett-Dame, L. Plum, 2020, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Vitamin A Deficiency Results in Meiotic Failure and Accumulation of Undifferentiated Spermatogonia in Prepubertal Mouse Testis1

K. Palczewski, W. Baehr, M. Clagett-Dame, 2011, Biology of reproduction.

Methyl substitution of the 25-hydroxy group on 2-methylene-19-nor-1alpha,25-dihydroxyvitamin D3 (2MD) reduces potency but allows bone selectivity.

H. DeLuca, M. Clagett-Dame, R. Sicinski, 2007, Archives of biochemistry and biophysics.

Defects in embryonic hindbrain development and fetal resorption resulting from vitamin A deficiency in the rat are prevented by feeding pharmacological levels of all-trans-retinoic acid.

H. DeLuca, M. Highland, M. Clagett-Dame, 1998, Proceedings of the National Academy of Sciences of the United States of America.

CHAPTER 87 – 2-Carbon-Modified Analogs of 19-Nor-1α,25-Dihydroxyvitamin D3

H. DeLuca, J. Pike, M. Clagett-Dame, 2005 .

Crk‐associated substrate (Cas) family member, NEDD9, is regulated in human neuroblastoma cells and in the embryonic hindbrain by all‐trans retinoic acid

Angela Wai-Man See, M. Clagett-Dame, M. L. Wertheim, 2004, Developmental dynamics : an official publication of the American Association of Anatomists.

26- and 27-Methyl groups of 2-substituted, 19-nor-1α,25-dihydroxylated vitamin D compounds are essential for calcium mobilization in vivo.

H. DeLuca, M. Clagett-Dame, L. Plum, 2013, Bioorganic chemistry.

Calmin expression in embryos and the adult brain, and its regulation by all‐trans retinoic acid

M. Marzinke, Angela Wai-Man See, M. Clagett-Dame, 2010, Developmental dynamics : an official publication of the American Association of Anatomists.

Selective analogs of 1α,25-dihydroxyvitamin D3 for the study of specific functions of Vitamin D

H. DeLuca, M. Clagett-Dame, L. Plum, 2007, The Journal of Steroid Biochemistry and Molecular Biology.

Teratogen-induced, dietary and genetic models of congenital diaphragmatic hernia share a common mechanism of pathogenesis.

J. Greer, A. Benachi, Robin D Clugston, 2006, The American journal of pathology.

Abnormal development of the sinuatrial venous valve and posterior hindbrain may contribute to late fetal resorption of vitamin A-deficient rat embryos.

M. Highland, M. Clagett-Dame, J. C. White, 2000, Teratology.

26-Desmethyl-2-methylene-22-ene-19-nor-1α,25-dihydroxyvitamin D3 compounds selectively active on intestine

H. DeLuca, G. Chiellini, M. Clagett-Dame, 2014, Steroids.

Use of 2MD, a Novel Oral Calcitriol Analog, in Hemodialysis Patients with Secondary Hyperparathyroidism

H. DeLuca, D. Coyne, M. Clagett-Dame, 2016, American Journal of Nephrology.

Preparation of an affinity chromatography matrix for the selective purification of the dopamine D2 receptor from bovine striatal membranes.

J. McKelvy, M. Clagett-Dame, R. Schoenleber, 1989, Biochimica et biophysica acta.

Vitamin A Deficiency Blocks the Initiation of Meiosis of Germ Cells in the Developing Rat Ovary In Vivo1

M. Clagett-Dame, Hui Li, 2009, Biology of reproduction.

Cyp26b1 Expression in Murine Sertoli Cells Is Required to Maintain Male Germ Cells in an Undifferentiated State during Embryogenesis

M. Petkovich, M. Clagett-Dame, D. Cameron, 2009, PloS one.

Solid phase-assisted synthesis and screening of a small library of N-(4-hydroxyphenyl)retinamide (4-HPR) analogs.

M. Clagett-Dame, A. Anding, J. S. Chapman, 2007, Bioorganic & medicinal chemistry letters.

A complex RARE is required for the majority of Nedd9 embryonic expression

M. Clagett-Dame, D. Knutson, Danielle C. Knutson, 2014, Transgenic Research.

All‐trans retinoic acid stimulates and maintains neurite outgrowth in nerve growth factor‐supported developing chick embryonic sympathetic neurons

M. Clagett-Dame, L. Plum, L.A. Plum, 1996, Developmental dynamics : an official publication of the American Association of Anatomists.

A nutritional model of late embryonic vitamin A deficiency produces defects in organogenesis at a high penetrance and reveals new roles for the vitamin in skeletal development.

Jeffrey C. White, Angela Wai-Man See, M. Clagett-Dame, 2008, Developmental biology.

Identification and characterization of all-trans-retinoic acid receptor transcripts and receptor protein in human neuroblastoma cells.

J. Repa, M. Clagett-Dame, J. Biedler, 1993, Archives of biochemistry and biophysics.

Improved synthesis of the C-glucuronide/glycoside of 4-hydroxybenzylretinone (4-HBR)

M. Clagett-Dame, Joel R Walker, Sureshbabu Narayanasamy, 2016, Journal of carbohydrate chemistry.

A ligand for the aryl hydrocarbon receptor isolated from lung

Richard E Peterson, H. DeLuca, W. M. Westler, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Vitamin A deficiency results in the dose-dependent acquisition of anterior character and shortening of the caudal hindbrain of the rat embryo.

M. Highland, M. Clagett-Dame, J. C. White, 2000, Developmental biology.

Role of all-trans retinoic acid in neurite outgrowth and axonal elongation.

M. Clagett-Dame, Elizabeth M. McNeill, P. D. Muley, 2006, Journal of neurobiology.

Differential activity of 2-methylene-19-nor vitamin D analogs on growth factor gene expression in rhino mouse skin and comparison to all-trans retinoic acid

H. DeLuca, M. Clagett-Dame, A. Mitzey, 2017, PloS one.

N-linked analogs of retinoid O-glucuronides: potential cancer chemopreventive/chemotherapeutic agents

J. Repa, H. Abou-Issa, M. Clagett-Dame, 1994 .

Localization of NGF receptors in normal and Alzheimer's basal forebrain with monoclonal antibodies against the truncated form of the receptor

P. Distefano, M. Clagett-Dame, R. Loy, 1990, Journal of neuroscience research.

Synthesis and preliminary chemotherapeutic evaluation of the fully C-linked glucuronide of N-(4-hydroxyphenyl)retinamide.

H. Abou-Issa, M. Clagett-Dame, Joel R Walker, 2006, Bioorganic & medicinal chemistry.

Inhibition of mammary tumor growth by a novel nontoxic retinoid: chemotherapeutic evaluation of a C-linked analog of 4-HPR-glucuronide.

M. Highland, H. Abou-Issa, M. Clagett-Dame, 2005, Anticancer research.

Chemotherapeutic evaluation of 4-hydroxybenzylretinone (4-HBR), a nonhydrolyzable C-linked analog of N-(4-hydroxyphenyl) retinamide (4-HPR) against mammary carcinogenesis.

K. Weiss, H. Abou-Issa, M. Clagett-Dame, 2001, Anticancer research.

Removal of the 20-methyl group from 2-methylene-19-nor-(20S)-1alpha,25-dihydroxyvitamin D(3) (2MD) selectively eliminates bone calcium mobilization activity.

H. DeLuca, M. Clagett-Dame, R. Sicinski, 2009, Bioorganic & Medicinal Chemistry.

The role of vitamin A in mammalian reproduction and embryonic development.

H. DeLuca, M. Clagett-Dame, 2002, Annual review of nutrition.

Vitamin A in Reproduction and Development

M. Clagett-Dame, D. Knutson, Danielle C. Knutson, 2011, Nutrients.

Nav2 hypomorphic mutant mice are ataxic and exhibit abnormalities in cerebellar development.

L. E. Talton, D. Moechars, M. Clagett-Dame, 2011, Developmental biology.

Nav2 is necessary for cranial nerve development and blood pressure regulation

D. Moechars, M. Clagett-Dame, K. Roos, 2010, Neural Development.

The atRA‐responsive gene neuron navigator 2 functions in neurite outgrowth and axonal elongation

M. Barr, M. Marzinke, K. Knobel, 2008, Developmental neurobiology.

Synthesis and receptor binding affinity of conformationally restricted retinoic acid analogues

J. Repa, M. Clagett-Dame, R. Curley, 1997 .

4-Hydroxybenzyl modification of the highly teratogenic retinoid, 4-[(1E)-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthalenyl)-1-propen-1-yl]benzoic acid (TTNPB), yields a compound that induces apoptosis in breast cancer cells and shows reduced teratogenicity.

M. Clagett-Dame, A. Anding, M. Collins, 2011, Chemical research in toxicology.

Vitamin A deficiency in the late gastrula stage rat embryo results in a one to two vertebral anteriorization that extends throughout the axial skeleton.

R. Merrill, M. Clagett-Dame, E. Breburda, 2003, Developmental biology.

Isolation and characterization of unsaturated fatty acids as natural ligands for the retinoid-X receptor.

H. DeLuca, A. Dobrzyń, J. Pike, 2003, Archives of biochemistry and biophysics.

Mice null for NEDD9 (HEF1) display extensive hippocampal dendritic spine loss and cognitive impairment

L. E. Talton, M. Clagett-Dame, A. Mitzey, 2016, Brain Research.

atRA Regulation of NEDD9, a gene involved in neurite outgrowth and cell adhesion.

M. Clagett-Dame, D. Knutson, Danielle C. Knutson, 2008, Archives of biochemistry and biophysics.

Vitamin A controls epithelial/mesenchymal interactions through Ret expression

E. Batourina, F. Costantini, M. Shy, 2001, Nature Genetics.

Vitamin A antagonizes the action of vitamin D in rats.

H. DeLuca, C. Rohde, M. Clagett-Dame, 1999, The Journal of nutrition.

9-cis-retinoic acid selectively activates the cellular retinoic acid binding protein-II gene in human neuroblastoma cells.

M. Clagett-Dame, L. Plum, 1995, Archives of biochemistry and biophysics.

14-3-3ε and NAV2 interact to regulate neurite outgrowth and axon elongation.

Mark A Marzinke, M. Marzinke, Terri Mavencamp, 2013, Archives of biochemistry and biophysics.

The vitamin D analogue 2MD increases bone turnover but not BMD in postmenopausal women with osteopenia: Results of a 1‐year phase 2 double‐blind, placebo‐controlled, randomized clinical trial

H. DeLuca, J. Aloia, N. Binkley, 2011, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Expression pattern of Nav2 in the murine CNS with development.

M. Clagett-Dame, J. Ahrens, C. Pook, 2020, Gene expression patterns : GEP.

4-oxo-fenretinide, a recently identified fenretinide metabolite, induces marked G2-M cell cycle arrest and apoptosis in fenretinide-sensitive and fenretinide-resistant cell lines.

F. Formelli, M. Clagett-Dame, A. Prinetti, 2006, Cancer research.

Identification of the porcine intestinal accessory factor that enables DNA sequence recognition by vitamin D receptor.

H. DeLuca, M. Munder, K. Hanson, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Synthesis and Biological Evaluation of Cyclopropylamine Vitamin D‐Like CYP24A1 Inhibitors

H. DeLuca, G. Nesi, S. Sestito, 2017 .

All-trans retinoic acid-responsive genes identified in the human SH-SY5Y neuroblastoma cell line and their regulated expression in the nervous system of early embryos

R. Merrill, M. Clagett-Dame, M. Kaiser, 2004, Biological chemistry.

4-HPR Is an Endoplasmic Reticulum Stress Aggravator and Sensitizes Breast Cancer Cells Resistant to TRAIL/Apo2L

M. Newton, M. Clagett-Dame, A. Anding, 2018, AntiCancer Research.

Loss of Neuron Navigator 2 Impairs Brain and Cerebellar Development

Undiagnosed Diseases Network, J. Rosenfeld, P. Striano, 2022, The Cerebellum.

Removal of the 26-methyl group from 19-nor-1α,25-dihydroxyvitamin D₃ markedly reduces in vivo calcemic activity without altering in vitro VDR binding, HL-60 cell differentiation, and transcription.

H. DeLuca, G. Chiellini, M. Clagett-Dame, 2010, Journal of medicinal chemistry.

Astrocytes as a regulated source of retinoic acid for the brain

Y. Fragoso, M. Clagett-Dame, P. McCaffery, 2012, Glia.

Monoclonal antibodies to the cell surface and a soluble form of the human nerve growth factor receptor

P. Distefano, M. Chao, M. Clagett-Dame, 1990, Journal of neuroscience research.

N-linked oligosaccharides are responsible for rat striatal dopamine D2 receptor heterogeneity.

J. McKelvy, M. Clagett-Dame, 1989, Archives of biochemistry and biophysics.

Chemopreventive activities of C-glucuronide/glycoside analogs of retinoid-O-glucuronides against breast cancer development and growth.

J. Repa, H. Abou-Issa, M. Clagett-Dame, 1996, Anticancer Research.

Analogues de 19-nor-vitamine d à cycle 1,2-cyclopentène ou 3,2-cyclopentène

M. Clagett-Dame, R. Sicinski, L. Plum, 2010 .

Analogues de 19-nor-vitamine d avec un cycle 3,2-dihydrofuran

H. DeLuca, K. Sokołowska, M. Clagett-Dame, 2009 .

Developmental regulation of human truncated nerve growth factor receptor

P. Distefano, M. Clagett-Dame, R. Loy, 1991, Annals of neurology.

Retinoic acid influences the development of the inferior olivary nucleus in the rodent.

Miyuki Yamamoto, M. Clagett-Dame, S. Hirano, 2005, Developmental biology.

The vitamin D analogue 2MD increases bone turnover but not BMD in postmenopausal women with osteopenia: Results of a 1‐year phase 2 double‐blind, placebo‐controlled, randomized clinical trial

H. DeLuca, J. Aloia, N. Binkley, 2011, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

2-Methylene-19-nor-1alpha-hydroxyvitamin D3 analogs inhibit adipocyte differentiation and PPARgamma2 gene transcription.

H. DeLuca, J. Ntambi, M. Clagett-Dame, 2007, Archives of biochemistry and biophysics.