A. Paton

发表

Limitation of individual folding resources in the ER leads to outcomes distinct from the unfolded protein response

Shirin Doroudgar, Catherine A Makarewich, Devin Dersh, 2012, Journal of Cell Science.

BiP‐mediated closing of the Sec61 channel limits Ca2+ leakage from the ER

A. Cavalié, V. Helms, M. Jung, 2012, The EMBO journal.

Therapeutic use of a receptor mimic probiotic reduces intestinal Shiga toxin levels in a piglet model of hemolytic uremic syndrome

N. Cornick, J. Paton, A. Paton, 2014, BMC Research Notes.

Cloning and nucleotide sequence of a variant Shiga-like toxin II gene from Escherichia coli OX3:H21 isolated from a case of sudden infant death syndrome.

P. Manning, J. Paton, A. Paton, 1992, Microbial pathogenesis.

Polymerase chain reaction amplification, cloning and sequencing of variant Escherichia coli Shiga-like toxin type II operons.

P. Manning, J. Paton, A. Paton, 1993, Microbial pathogenesis.

Molecular microbiological investigation of an outbreak of hemolytic-uremic syndrome caused by dry fermented sausage contaminated with Shiga-like toxin-producing Escherichia coli

J. Lanser, J. Paton, A. Paton, 1996, Journal of clinical microbiology.

ER-Stress-Induced Differentiation Sensitizes Colon Cancer Stem Cells to Chemotherapy.

L. Vermeulen, J. Medema, G. R. van den Brink, 2015, Cell reports.

Characterization of a Novel Type IV Pilus Locus Encoded on the Large Plasmid of Locus of Enterocyte Effacement-Negative Shiga-Toxigenic Escherichia coli Strains That Are Virulent for Humans

P. Srimanote, J. Paton, A. Paton, 2002, Infection and Immunity.

Distribution of the saa Gene in Strains of Shiga Toxin-Producing Escherichia coli of Human and Bovine Origins

G. Dougan, D. Shaw, C. Jenkins, 2003, Journal of Clinical Microbiology.

Preconditioning with Endoplasmic Reticulum Stress Ameliorates Endothelial Cell Inflammation

A. Leonard, F. Fazal, J. Paton, 2014, PloS one.

Methods for detection of STEC in humans. An overview.

J. Paton, A. Paton, 2003, Methods in molecular medicine.

The COG Complex, Rab6 and COPI Define a Novel Golgi Retrograde Trafficking Pathway that is Exploited by SubAB Toxin

Richard D. Smith, V. Lupashin, Richard D Smith, 2009, Traffic.

Effects of Escherichia Coli Subtilase Cytotoxin and Shiga Toxin 2 on Primary Cultures of Human Renal Tubular Epithelial Cells

C. Silberstein, J. Paton, A. Paton, 2014, PloS one.

Structure, biological functions and applications of the AB5 toxins.

T. Beddoe, J. Rossjohn, J. Le Nours, 2010, Trends in biochemical sciences.

AB5 subtilase cytotoxin inactivates the endoplasmic reticulum chaperone BiP

J. Whisstock, T. Beddoe, J. Rossjohn, 2006, Nature.

Clathrin‐dependent trafficking of subtilase cytotoxin, a novel AB5 toxin that targets the endoplasmic reticulum chaperone BiP

J. Paton, A. Paton, C. Thorpe, 2008, Cellular microbiology.

Molecular Characterization of the Locus Encoding Biosynthesis of the Lipopolysaccharide O Antigen of Escherichia coliSerotype O113

J. Paton, A. Paton, 1999, Infection and Immunity.

Cytoprotective roles of ERK and Akt in endoplasmic reticulum stress triggered by subtilase cytotoxin.

S. Nakajima, M. Kitamura, J. Paton, 2011, Biochemical and biophysical research communications.

ASMase regulates autophagy and lysosomal membrane permeabilization and its inhibition prevents early stage non-alcoholic steatohepatitis.

C. Trautwein, M. Czaja, J. Balsinde, 2014, Journal of hepatology.

Decreased ER-associated degradation of alpha-TCR induced by Grp78 depletion with the SubAB cytotoxin.

J. Paton, A. Paton, M. Kujawa, 2008, International Journal of Biochemistry and Cell Biology.

of Akt and mTOR-Dependent Dephosphorylation β Branch of the UPR : Involvement of C / EBP B through the ATF 6 κ Activation of NF-Selective Abrogation of BiP / GRP 78 Blunts

H. Kato, J. Paton, A. Paton, 2011 .

Selective Abrogation of BiP/GRP78 Blunts Activation of NF-κB through the ATF6 Branch of the UPR: Involvement of C/EBPβ and mTOR-Dependent Dephosphorylation of Akt

S. Nakajima, H. Kato, M. Kitamura, 2011, Molecular and Cellular Biology.

A Subcytotoxic Dose of Subtilase Cytotoxin Prevents Lipopolysaccharide-Induced Inflammatory Responses, Depending on its Capacity to Induce the Unfolded Protein Response1

A. Nakao, H. Ogawa, M. Kitamura, 2009, The Journal of Immunology.

Activation of the Akt-NF-κB Pathway by Subtilase Cytotoxin through the ATF6 Branch of the Unfolded Protein Response1

S. Nakajima, M. Kitamura, J. Paton, 2009, The Journal of Immunology.

Capacity to Induce the Unfolded Protein Inflammatory Responses, Depending on its Prevents Lipopolysaccharide-Induced A Subcytotoxic Dose of Subtilase Cytotoxin

Yuko, A. Nakao, H. Ogawa, 2009 .

Suppression of cytokine responses by indomethacin in podocytes: a mechanism through induction of unfolded protein response.

M. Kitamura, J. Paton, A. Paton, 2008, American journal of physiology. Renal physiology.

Subtilase cytotoxin activates PERK, IRE1 and ATF6 endoplasmic reticulum stress‐signalling pathways

K. L. May, J. Paton, A. Paton, 2008, Cellular microbiology.

Blunted activation of NF-kappaB and NF-kappaB-dependent gene expression by geranylgeranylacetone: involvement of unfolded protein response.

M. Kitamura, J. Paton, A. Paton, 2008, Biochemical and biophysical research communications.

Suppression of cytokine response by GATA inhibitor K-7174 via unfolded protein response.

M. Kitamura, J. Paton, A. Paton, 2007, Biochemical and biophysical research communications.

Sab, a Novel Autotransporter of Locus of Enterocyte Effacement-Negative Shiga-Toxigenic Escherichia coli O113:H21, Contributes to Adherence and Biofilm Formation

J. Paton, A. Paton, S. Herold, 2009, Infection and Immunity.

Differential effects of short-chain fatty acids and iron on expression of iha in Shiga-toxigenic Escherichia coli.

P. Srimanote, J. Paton, A. Paton, 2009, Microbiology.

That Are Virulent for Humans Strains Escherichia coli Shiga-Toxigenic Locus of Enterocyte Effacement-Negative Locus Encoded on the Large Plasmid of Characterization of a Novel Type IV Pilus

P. Srimanote, J. Paton, A. Paton, 2002 .

Detection and characterization of Shiga toxigenic Escherichia coli by using multiplex PCR assays for stx1, stx2, eaeA, enterohemorrhagic E. coli hlyA, rfbO111, and rfbO157.

J. Paton, A. Paton, 1998, Journal of clinical microbiology.

Targeting GRP78 to enhance melanoma cell death

Shaun Martin, P. Lovat, D. Hill, 2010, Pigment cell & melanoma research.

Long Interleukin-22 Binding Protein Isoform-1 Is an Intracellular Activator of the Unfolded Protein Response

K. Vandenbroeck, I. Alloza, F. Borrego, 2018, Front. Immunol..

The Signal Sequence Influences Post-Translational ER Translocation at Distinct Stages

S. High, R. Zimmermann, J. Paton, 2013, PloS one.

Measuring signaling by the unfolded protein response.

M. Schröder, J. Paton, A. Paton, 2011, Methods in enzymology.

Subtilase cytotoxin activates MAP kinases through PERK and IRE1 branches of the unfolded protein response.

S. Nakajima, Shuhei Takahashi, M. Kitamura, 2011, Toxicological sciences : an official journal of the Society of Toxicology.

9-Azido Analogues of Three Sialic Acid Forms for Metabolic Remodeling of Cell-Surface Sialoglycans.

Rongbing Huang, Xing Chen, Yuntao Zhu, 2019, ACS chemical biology.

Decreased ER-associated degradation of α -TCR induced by Grp78 depletion with the SubAB cytotoxin

A. Paton, M. Kujawa, Paton, 2008 .

Structure aided design of a Neu5Gc specific lectin

C. Day, B. Schulz, M. Jennings, 2017, Scientific Reports.

Ca2+ signalling system initiated by endoplasmic reticulum stress stimulates PERK activation.

Constanza Feliziani, J. Lechleiter, M. Bollo, 2022, Cell calcium.

Peptidomimetic‐based identification of FDA‐approved compounds inhibiting IRE1 activity

E. Chevet, C. Chintha, L. Eriksson, 2020, The FEBS journal.

Shiga Toxin–producing Escherichia coli Strains Negative for Locus of Enterocyte Effacement

T. Whittam, D. Bulach, R. Robins-Browne, 2009, Emerging infectious diseases.

Shiga Toxin–producing Escherichia coli Strains Negative for Locus of Enterocyte Effacement

T. Whittam, D. Bulach, R. Robins-Browne, 2009, Emerging Infectious Diseases.

Shiga Toxigenic Escherichia coli

P. Srimanote, J. Paton, A. Paton, 2004 .

Cardiovascular , Pulmonary , and Renal Pathology Unfolded Protein Response Causes a Phenotypic Shift of Inflamed Glomerular Cells toward Redifferentiation through Dual Blockade of Akt and Smad Signaling Pathways

R. Katoh, S. Nakajima, H. Kato, 2012 .

Uptake ofStreptococcus pneumoniaeby Respiratory Epithelial Cells

A. Paton, U. M. Talbot, A. C. Paton, 1996 .

Lectin activity of the pneumococcal pilin proteins

J. Tiralongo, C. Day, L. Hartley-Tassell, 2017, Scientific Reports.

Specificity and utility of SubB2M, a new N-glycolylneuraminic acid lectin.

C. Day, M. Jennings, J. Paton, 2018, Biochemical and biophysical research communications.

The Variable Region of Pneumococcal Pathogenicity Island 1 Is Responsible for Unusually High Virulence of a Serotype 1 Isolate

Claudia Trappetti, J. Paton, A. Paton, 2016, Infection and Immunity.

The Impact of Pneumolysin on the Macrophage Response to Streptococcus pneumoniae is Strain-Dependent

R. Tweten, Claudia Trappetti, J. Paton, 2014, PloS one.

Enterobacter cloacae producing a Shiga-like toxin II-related cytotoxin associated with a case of hemolytic-uremic syndrome

J. Paton, A. Paton, 1996, Journal of clinical microbiology.

Site of Isolation Determines Biofilm Formation and Virulence Phenotypes of Streptococcus pneumoniae Serotype 3 Clinical Isolates

Claudia Trappetti, J. Paton, A. Paton, 2012, Infection and Immunity.

Isolation Site Influences Virulence Phenotype of Serotype 14 Streptococcus pneumoniae Strains Belonging to Multilocus Sequence Type 15

Claudia Trappetti, J. Paton, A. Paton, 2015, Infection and Immunity.

Detection and characterization of STEC in stool samples using PCR.

J. Paton, A. Paton, 2003, Methods in molecular medicine.

Direct Detection of Shiga Toxigenic Escherichia coliStrains Belonging to Serogroups O111, O157, and O113 by Multiplex PCR

J. Paton, A. Paton, 1999, Journal of Clinical Microbiology.

Antibodies to lipopolysaccharide block adherence of Shiga toxin-producing Escherichia coli to human intestinal epithelial (Henle 407) cells.

P. Manning, E. Voss, J. Paton, 1998, Microbial pathogenesis.

Shiga Toxin 2 and Flagellin from Shiga-Toxigenic Escherichia coli Superinduce Interleukin-8 through Synergistic Effects on Host Stress-Activated Protein Kinase Activation

A. Kane, J. Paton, A. Paton, 2010, Infection and Immunity.

Designer Probiotics and Enteric Cytoprotection

R. Morona, J. Paton, A. Paton, 2011 .

Bioengineered bugs expressing oligosaccharide receptor mimics: Toxin-binding probiotics for treatment and prevention of enteric infections

R. Morona, J. Paton, A. Paton, 2010, Bioengineered bugs.

Chaperone-Driven Degradation of a Misfolded Proinsulin Mutant in Parallel With Restoration of Wild-Type Insulin Secretion

P. Arvan, Anoop Arunagiri, Billy Tsai, 2016, Diabetes.

Genetic Diversity and Virulence Potential of Shiga Toxin-Producing Escherichia coli O113:H21 Strains Isolated from Clinical, Environmental, and Food Sources

L. Beutin, M. Rivas, P. Feng, 2014, Applied and Environmental Microbiology.

Enhanced CXC Chemokine Responses of Human Colonic Epithelial Cells to Locus of Enterocyte Effacement-Negative Shiga-Toxigenic Escherichia coli

S. McColl, J. Paton, A. Paton, 2003, Infection and Immunity.

Molecular Analysis of Shiga ToxigenicEscherichia coli O111:H− Proteins Which React with Sera from Patients with Hemolytic-Uremic Syndrome

P. Manning, E. Voss, J. Paton, 1998, Infection and Immunity.

Environmental, and Food Sources O113:H21 Strains Isolated from Clinical, Shiga Toxin-Producing Escherichia coli Genetic Diversity and Virulence Potential of

L. Beutin, S. Delannoy, P. Fach, 2014 .

Escherichia coli 83972 expressing a P fimbriae oligosaccharide receptor mimic impairs adhesion of uropathogenic E. coli.

R. Morona, G. Ulett, R. Watts, 2012, The Journal of infectious diseases.

The B Subunit of an AB5 Toxin Produced by Salmonella enterica Serovar Typhi Up-Regulates Chemokines, Cytokines, and Adhesion Molecules in Human Macrophage, Colonic Epithelial, and Brain Microvascular Endothelial Cell Lines

T. Beddoe, J. Paton, A. Paton, 2012, Infection and Immunity.

Direct detection of Escherichia coli Shiga-like toxin genes in primary fecal cultures by polymerase chain reaction

P. Manning, J. Paton, A. Paton, 1993, Journal of clinical microbiology.

Comparative toxicity and virulence of Escherichia coli clones expressing variant and chimeric Shiga-like toxin type II operons

A. J. Bourne, P. Manning, J. Paton, 1995, Infection and immunity.

Protective Immunization of Mice with an Active-Site Mutant of Subtilase Cytotoxin of Shiga Toxin-Producing Escherichia coli

J. Paton, A. Paton, U. M. Talbot, 2005, Infection and Immunity.

Role of Lipid Rafts and Flagellin in Invasion of Colonic Epithelial Cells by Shiga-Toxigenic Escherichia coli O113:H21

J. Paton, A. Paton, C. Thorpe, 2012, Infection and Immunity.

Reduced Virulence of an fliC Mutant of Shiga-Toxigenic Escherichia coli O113:H21

J. Paton, A. Paton, T. J. Rogers, 2006, Infection and Immunity.

Refinement of a therapeutic Shiga toxin-binding probiotic for human trials.

R. Morona, J. Paton, A. Paton, 2004, The Journal of infectious diseases.

Oral Administration of Formaldehyde-Killed Recombinant Bacteria Expressing a Mimic of the Shiga Toxin Receptor Protects Mice from Fatal Challenge with Shiga-ToxigenicEscherichia coli

R. Morona, J. Paton, A. Paton, 2001, Infection and Immunity.

Neutralization of Shiga Toxins Stx1, Stx2c, and Stx2e by Recombinant Bacteria Expressing Mimics of Globotriose and Globotetraose

R. Morona, J. Paton, A. Paton, 2001, Infection and Immunity.

Combined Action of Shiga Toxin Type 2 and Subtilase Cytotoxin in the Pathogenesis of Hemolytic Uremic Syndrome

J. Paton, A. Paton, E. Zotta, 2021, Toxins.

Survival rate of mice after transient colonization with Escherichia coli clones carrying variant Shiga-like toxin type II operons.

J. Paton, A. Paton, 1996, Microbial pathogenesis.

Shiga toxin 'goes retro' in human primary kidney cells.

J. Paton, A. Paton, 2006, Kidney international.

Multiplex PCR for Direct Detection of Shiga Toxigenic Escherichia coli Strains Producing the Novel Subtilase Cytotoxin

J. Paton, A. Paton, 2005, Journal of Clinical Microbiology.

Systemic effects of Subtilase cytotoxin produced by Escherichia coli O113:H21

N. Lago, A. Damiano, J. Paton, 2017, Toxicon : official journal of the International Society on Toxinology.

Produced by Escherichia coli O113:H21 Mucosa Are Induced by Subtilase Cytotoxin Selective Damage to Human Colonic Inhibition of Water Absorption and

J. Paton, A. Paton, E. Zotta, 2014 .

Inhibition of Water Absorption and Selective Damage to Human Colonic Mucosa Are Induced by Subtilase Cytotoxin Produced by Escherichia coli O113:H21

J. Paton, A. Paton, E. Zotta, 2013, Infection and Immunity.

Pathologic changes in mice induced by subtilase cytotoxin, a potent new Escherichia coli AB5 toxin that targets the endoplasmic reticulum.

J. Paton, A. Paton, Hui Wang, 2007, The Journal of infectious diseases.

Rapid detection of respiratory syncytial virus in nasopharyngeal aspirates by reverse transcription and polymerase chain reaction amplification

J. Paton, A. Paton, R. Harris, 1992, Journal of clinical microbiology.

Volume contents and index to volume 1

P. Menanteau, J. Elsen, P. Manning, 1992, Microbial Pathogenesis.

The Operon Encoding SubAB, a Novel Cytotoxin, Is Present in Shiga toxin-producing Escherichia coli Isolates from the United States

J. Ritchie, A. Paton, C. Thorpe, 2007, Journal of Clinical Microbiology.

Methods for Detection of STEC in Humans

J. Paton, A. Paton, 2017 .

Action of Shiga Toxin Type-2 and Subtilase Cytotoxin on Human Microvascular Endothelial Cells

C. Jancic, J. Paton, A. Paton, 2013, PloS one.

Instability of a Shiga toxin type 2 gene in Enterobacter cloacae

J. Paton, A. Paton, 1997, Journal of clinical microbiology.

Direct Detection ofEscherichia coli Shiga-Like ToxinGenes inPrimary FecalCultures byPolymerase ChainReaction

A. Paton, P. Goldwater, A. A. Manning, 1993 .

Comparative Characterization of Shiga Toxin Type 2 and Subtilase Cytotoxin Effects on Human Renal Epithelial and Endothelial Cells Grown in Monolayer and Bilayer Conditions

C. Jancic, J. Paton, A. Paton, 2016, PloS one.

Tissue factor–dependent procoagulant activity of subtilase cytotoxin, a potent AB5 toxin produced by shiga toxigenic Escherichia coli.

J. Paton, A. Paton, C. Thorpe, 2010, The Journal of infectious diseases.

A dietary non-human sialic acid may facilitate hemolytic-uremic syndrome.

A. Varki, J. Löfling, N. Varki, 2009, Kidney international.

Sobs Annual Report | | 2008 80 Primary

J. Whisstock, P. Taylor, L. Poston, 2022 .

Characterization of IS1203, an insertion sequence in Escherichia coli O111:H-.

J. Paton, A. Paton, 1994, Gene.

Chaperone-targeting cytotoxin and endoplasmic reticulum stress-inducing drug synergize to kill cancer cells.

M. Backer, J. Backer, J. Paton, 2009, Neoplasia.

Uptake of Streptococcus pneumoniae by respiratory epithelial cells

J. Paton, A. Paton, U. M. Talbot, 1996, Infection and immunity.

BiP and Multiple DNAJ Molecular Chaperones in the Endoplasmic Reticulum Are Required for Efficient Simian Virus 40 Infection

A. Lipovsky, D. DiMaio, W. Atwood, 2011, mBio.

Human Cytomegalovirus Specifically Controls the Levels of the Endoplasmic Reticulum Chaperone BiP/GRP78, Which Is Required for Virion Assembly

J. Alwine, Yongjun Yu, J. Paton, 2007, Journal of Virology.

The Pneumococcal Alpha-Glycerophosphate Oxidase Enhances Nasopharyngeal Colonization through Binding to Host Glycoconjugates

J. Tiralongo, C. Day, L. Hartley-Tassell, 2017, EBioMedicine.

The cholesterol-dependent cytolysins pneumolysin and streptolysin O require binding to red blood cell glycans for hemolytic activity

C. Day, L. Hartley-Tassell, C. Gillen, 2014, Proceedings of the National Academy of Sciences.

All major cholesterol-dependent cytolysins use glycans as cellular receptors

V. Nizet, C. Day, B. Kobe, 2020, Science Advances.

Pathogenesis and Diagnosis of Shiga Toxin-Producing Escherichia coli Infections

James C. Paton, J. Paton, A. Paton, 1998, Clinical Microbiology Reviews.

In Vivo Leukocyte Changes Induced by Escherichia coli Subtilase Cytotoxin

S. McColl, J. Paton, A. Paton, 2011, Infection and Immunity.

Escherichia coli Subtilase Cytotoxin Induces Apoptosis Regulated by Host Bcl-2 Family Proteins Bax/Bak

K. L. May, J. Paton, A. Paton, 2010, Infection and Immunity.

Subtilase cytotoxin cleaves newly synthesized BiP and blocks antibody secretion in B lymphocytes

H. Ploegh, C. Hu, S. Dougan, 2009, The Journal of experimental medicine.

Increased oral virulence of Escherichia coli expressing a variant Shiga-like toxin type II operon is associated with both A subunit residues Met4 and Gly102.

P. Manning, J. Paton, A. Paton, 1995, Microbial pathogenesis.

The protein kinase PERK/EIF2AK3 regulates proinsulin processing not via protein synthesis but by controlling endoplasmic reticulum chaperones

Barbara C. McGrath, D. Cavener, M. Nicolino, 2018, The Journal of Biological Chemistry.

Suppression of NF-κB by Cyclosporin A and Tacrolimus (FK506) via Induction of the C/EBP Family: Implication for Unfolded Protein Response1

M. Kitamura, N. Sawada, M. Takeda, 2009, The Journal of Immunology.

Protein Response C / EBP Family : Implication for Unfolded Tacrolimus ( FK 506 ) via Induction of the B by Cyclosporin A and κ Suppression of NF -

M. Kitamura, N. Sawada, M. Takeda, 2009 .

Vacuolation Activity and Intracellular Trafficking of ArtB, the Binding Subunit of an AB5 Toxin Produced by Salmonella enterica Serovar Typhi

T. Beddoe, J. Paton, A. Paton, 2017, Infection and Immunity.

IRE1β negatively regulates IRE1α signaling in response to endoplasmic reticulum stress

Yevgeniy V. Serebrenik, M. Seeliger, Delphine De Sutter, 2019, bioRxiv.

Phosphorylation of IRE1 at S729 regulates RIDD in B cells and antibody production after immunization

H. Ploegh, J. D. Del Valle, C. Hu, 2018, The Journal of cell biology.

Cloning, expression, purification and preliminary X-ray diffraction studies of a novel AB₅ toxin.

T. Beddoe, J. Rossjohn, D. Littler, 2013, Acta crystallographica. Section F, Structural biology and crystallization communications.

Autoinducer 2 Signaling via the Phosphotransferase FruA Drives Galactose Utilization by Streptococcus pneumoniae, Resulting in Hypervirulence

C. McDevitt, M. Oggioni, Claudia Trappetti, 2017, mBio.

HCMV specifically controls the levels of the endoplasmic reticulum chaperone BiP/GRP78 which is required for virion assembly

J. Alwine, Yongjun Yu, J. Paton, 2007 .

Calnexin Depletion by Endoplasmic Reticulum Stress During Cholestasis Inhibits the Na+‐Taurocholate Cotransporting Polypeptide

H. Vos, B. Burgering, S. V. D. van de Graaf, 2018, Hepatology communications.

Calcium Influx Caused by ER Stress Inducers Enhances Oncolytic Adenovirus Enadenotucirev Replication and Killing through PKCα Activation

B. Champion, J. Christianson, R. Cawood, 2019, Molecular therapy oncolytics.

Factor VIII exhibits chaperone-dependent and glucose-regulated reversible amyloid formation in the endoplasmic reticulum

M. Siirin, N. Volkmann, D. Hanein, 2020, bioRxiv.

Identification of markers that functionally define a quiescent multiple myeloma cell sub-population surviving bortezomib treatment

K. Moore, J. Aguirre-Ghiso, A. Chari, 2015, BMC Cancer.

Inflammatory cytokines rewire the proinsulin interaction network in human islets

P. Arvan, S. Mir, Duc T Tran, 2021, bioRxiv.

Differential Effects of Escherichia coli Subtilase Cytotoxin and Shiga Toxin 2 on Chemokine and Proinflammatory Cytokine Expression in Human Macrophage, Colonic Epithelial, and Brain Microvascular Endothelial Cell Lines

J. Paton, A. Paton, T. J. Rogers, 2014, Infection and Immunity.

Differential Effects of Escherichia coli Subtilase Cytotoxin

J. Paton, A. Paton, T. J. Rogers, 2014 .

The connector between the kinase and RNase domains of IRE1α transmits the conformational change that underlies ER stress-induced activation

H. Fazelinia, S. Tutton, C. Hu, 2020, bioRxiv.

Crosstalk between Human Microvascular Endothelial Cells and Tubular Epithelial Cells Modulates Pro-Inflammatory Responses Induced by Shiga Toxin Type 2 and Subtilase Cytotoxin

C. Jancic, J. Paton, A. Paton, 2019, Toxins.

Designer probiotics for prevention of enteric infections

R. Morona, J. Paton, A. Paton, 2006, Nature Reviews Microbiology.

The Endoplasmic Reticulum Chaperone BiP/GRP78 Is Important in the Structure and Function of the Human Cytomegalovirus Assembly Compartment

J. Alwine, J. Paton, A. Paton, 2009, Journal of Virology.

Detection and Characterization of Shiga ToxigenicEscherichia coli by Using Multiplex PCR Assays forstx1, stx2,eaeA, Enterohemorrhagic E. coli hlyA,rfbO111, andrfbO157

James C. Paton, J. Paton, A. Paton, 1998, Journal of Clinical Microbiology.

Direct Detection and Characterization of Shiga Toxigenic Escherichia coli by Multiplex PCR for stx1, stx2, eae, ehxA, and saa

J. Paton, A. Paton, 2002, Journal of Clinical Microbiology.

Opposing unfolded-protein-response signals converge on death receptor 5 to control apoptosis

D. Lawrence, P. Walter, S. Marsters, 2014, Science.

Endoplasmic reticulum stress causes insulin resistance by inhibiting delivery of newly synthesized insulin receptors to the cell surface

M. Schröder, J. Paton, A. Paton, 2020, Molecular biology of the cell.

Respiratory syncytial virus modulation of adult and neonatal lymphocyte mitogenic responses and the role of interferon-γ

A. Paton, P. Goldwater, 1990 .

Bioengineered microbes in disease therapy.

R. Morona, J. Paton, A. Paton, 2012, Trends in molecular medicine.

Sialoglycan-binding patterns of bacterial AB5 toxin B subunits correlate with host range and toxicity, indicating evolution independent of A subunits

X. Chen, T. Beddoe, Hai Yu, 2022, The Journal of biological chemistry.

Rapid evolution of bacterial AB5 toxin B subunits independent of A subunits: sialic acid binding preferences correlate with host range and toxicity

A. Varki, T. Beddoe, Hai Yu, 2021, bioRxiv.

Ferrets exclusively synthesize Neu5Ac and express naturally humanized influenza A virus receptors

L. Hartley-Tassell, S. Grimmond, S. Lukowski, 2014, Nature Communications.

ER stress causes rapid loss of intestinal epithelial stemness through activation of the unfolded protein response.

H. Clevers, D. Hommes, M. Wetering, 2013, Cell reports.

Proinsulin misfolding is an early event in the progression to type 2 diabetes

R. Kaufman, P. Arvan, Anoop Arunagiri, 2019, eLife.

Serum Neu5Gc biomarkers are elevated in primary cutaneous melanoma.

C. Day, J. Paton, A. Paton, 2022, Biochemical and biophysical research communications.

mutualism Niche engineering demonstrates a latent capacity for fungal-algal

D. Lawrence, A. Paton, Aaron S. Mendez, 2014 .

Clustering of IRE1α depends on sensing ER stress but not on its RNase activity

Y. Argon, J. Paton, A. Paton, 2019, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Physiological Exploration of the Long Term Evolutionary Selection against Expression of N-Glycolylneuraminic Acid in the Brain*♦

C. Heyser, A. Varki, H. Takematsu, 2017, The Journal of Biological Chemistry.

Anti-inflammatory subtilase cytotoxin up-regulates A20 through the unfolded protein response.

S. Nakajima, H. Kato, Shuhei Takahashi, 2010, Biochemical and biophysical research communications.

DR5 and caspase-8 are dispensable in ER stress-induced apoptosis

H. Puthalakath, J. Paton, A. Paton, 2017, Cell Death and Differentiation.

Selective Inactivation of Intracellular BiP/GRP78 Attenuates Endothelial Inflammation and Permeability in Acute Lung Injury

V. Grose, F. Fazal, Arshad Rahman, 2019, Scientific Reports.

Endoplasmic reticulum stress induces a novel Ca2+ signalling system initiated by Ca2+ microdomains

Constanza Feliziani, J. Lechleiter, M. Bollo, 2020 .

Endoplasmic reticulum stress regulates the intestinal stem cell state through CtBP2

J. Qin, E. Dekker, G. R. van den Brink, 2021, Scientific Reports.

GRP78 Is an Important Host Factor for Japanese Encephalitis Virus Entry and Replication in Mammalian Cells

A. Basu, M. Abdin, J. Paton, 2017, Journal of Virology.

An interdomain helix in IRE1α mediates the conformational change required for the sensor's activation

Deanne M. Taylor, R. Radhakrishnan, H. Fazelinia, 2021, The Journal of biological chemistry.

Acquisition of Anergy to Proinflammatory Cytokines in Nonimmune Cells through Endoplasmic Reticulum Stress Response: A Mechanism for Subsidence of Inflammation1

S. Nakajima, M. Kitamura, J. Paton, 2009, The Journal of Immunology.

Characterization of Saa, a Novel Autoagglutinating Adhesin Produced by Locus of Enterocyte Effacement-Negative Shiga-ToxigenicEscherichia coli Strains That Are Virulent for Humans

P. Srimanote, J. Paton, A. Paton, 2001, Infection and Immunity.

A New Family of Potent AB5 Cytotoxins Produced by Shiga Toxigenic Escherichia coli

P. Srimanote, J. Paton, A. Paton, 2004, The Journal of experimental medicine.

Escherichia coli Subtilase Cytotoxin

J. Paton, A. Paton, 2010, Toxins.

Incorporation of a non-human glycan mediates human susceptibility to a bacterial toxin

David F. Smith, X. Chen, A. Varki, 2008, Nature.

Molecular Characterization of a Shiga ToxigenicEscherichia coli O113:H21 Strain Lacking eaeResponsible for a Cluster of Cases of Hemolytic-Uremic Syndrome

J. Lanser, J. Paton, A. Paton, 1999, Journal of Clinical Microbiology.

Genomic Comparison of Two O111:H− Enterohemorrhagic Escherichia coli Isolates from a Historic Hemolytic-Uremic Syndrome Outbreak in Australia

Nicola K. Petty, S. Beatson, S. Bent, 2016, Infection and Immunity.

Recombinant probiotics for treatment and prevention of enterotoxigenic Escherichia coli diarrhea.

R. Morona, M. Jennings, J. Paton, 2005, Gastroenterology.

Proteostasis in dendritic cells is controlled by the PERK signaling axis independently of ATF4

Sebastien A. Choteau, P. Pierre, C. Rodríguez Rodrígues, 2020, Life Science Alliance.

Community outbreak of hemolytic uremic syndrome attributable to Escherichia coli O111:NM--South Australia 1995.

M. Beers, J. Paton, A. Paton, 1995, MMWR. Morbidity and mortality weekly report.

Developmentally regulated PERK activity renders dendritic cells insensitive to subtilase cytotoxin-induced integrated stress response

Sebastien A. Choteau, P. Pierre, E. Gatti, 2020, bioRxiv.

Induction of endoplasmic reticulum stress by deletion of Grp78 depletes Apc mutant intestinal epithelial stem cells

Amy S. Lee, J. Heijmans, V. Muncan, 2016, Oncogene.

Combined chemical–genetic approach identifies cytosolic HSP70 dependence in rhabdomyosarcoma

J. Weissman, S. Asthana, P. Wipf, 2016, Proceedings of the National Academy of Sciences.

Endoplasmic reticulum stress in the intestinal epithelium initiates purine metabolite synthesis and promotes Th17 cell differentiation in the gut.

U. Sauer, A. Kaser, P. Rosenstiel, 2023, Immunity.

IRE1α is an endogenous substrate of endoplasmic reticulum-associated degradation

S. Kersten, Pengcheng Bu, T. Iwawaki, 2015, Nature Cell Biology.

Cell surface expression of 78-kDa glucose-regulated protein (GRP78) mediates diabetic nephropathy

J. Krepinsky, K. Ask, R. Austin, 2019, The Journal of Biological Chemistry.

Respiratory syncytial virus modulation of adult and neonatal lymphocyte mitogenic responses and the role of interferon-gamma.

A. Paton, P. Goldwater, 1990, Microbial pathogenesis.

SMRT sequencing reveals differential patterns of methylation in two O111:H- STEC isolates from a hemolytic uremic syndrome outbreak in Australia

S. Beatson, B. Forde, J. Paton, 2019, Scientific Reports.

SMRT sequencing reveals differential patterns of methylation in two O111:H- Shiga toxigenic Escherichia coli isolates from a historic hemolytic uremic syndrome outbreak in Australia

S. Beatson, B. Forde, J. Paton, 2017, bioRxiv.

Simple and practical sialoglycan encoding system reveals vast diversity in nature and identifies a universal sialoglycan-recognizing probe derived from AB5 toxin B subunits

Benjamin P. Kellman, N. Lewis, T. Beddoe, 2021 .

EcxAB is a founding member of a new family of metalloprotease AB5 toxins with a hybrid cholera-like B subunit.

T. Beddoe, J. Rossjohn, D. Littler, 2013, Structure.

The signal peptide plus a cluster of positive charges in prion protein dictate chaperone-mediated Sec61 channel gating

R. Zimmermann, J. Tatzelt, J. Paton, 2019, Biology Open.

Factor VIII exhibits chaperone-dependent and glucose-regulated reversible amyloid formation in the endoplasmic reticulum.

M. Siirin, N. Volkmann, D. Hanein, 2020, Blood.

T cell receptor-mediated signaling induces GRP78 expression in T cells: the implications in maintaining T cell viability.

N. Enomoto, A. Nakao, M. Kitamura, 2008, Biochemical and biophysical research communications.

Receptor-mimic probiotics: potential therapeutics for bacterial toxin-mediated enteric diseases

R. Morona, J. Paton, A. Paton, 2010, Expert Review of Gastroenterology & Hepatology.

A recombinant probiotic for treatment and prevention of cholera.

R. Morona, J. Paton, A. Paton, 2006, Gastroenterology.

A new biological agent for treatment of Shiga toxigenic Escherichia coli infections and dysentery in humans

R. Morona, J. Paton, A. Paton, 2000, Nature Medicine.

LuxS Mediates Iron-Dependent Biofilm Formation, Competence, and Fratricide in Streptococcus pneumoniae

M. Oggioni, Claudia Trappetti, J. Paton, 2011, Infection and Immunity.

Mutation of luxS of Streptococcus pneumoniae Affects Virulence in a Mouse Model

U. H. Stroeher, A. Ogunniyi, J. Paton, 2003, Infection and Immunity.

and Model Affects Virulence in a Mouse pneumoniae Streptococcus of luxS Mutation of

U. H. Stroeher, A. Ogunniyi, J. Paton, 2003 .

Reactivity of Convalescent-Phase Hemolytic-Uremic Syndrome Patient Sera with the Megaplasmid-Encoded TagA Protein of Shiga Toxigenic Escherichia coli O157

J. Paton, A. Paton, 2002, Journal of Clinical Microbiology.

Chaperone-Mediated Sec61 Channel Gating during ER Import of Small Precursor Proteins Overcomes Sec61 Inhibitor-Reinforced Energy Barrier

S. High, R. Zimmermann, J. Paton, 2018, Cell reports.

N-glycolylneuraminic acid serum biomarker levels are elevated in breast cancer patients at all stages of disease

Jamie R. Kutasovic, C. Day, S. Lakhani, 2021, bioRxiv.

Structure–function analyses of a pertussis-like toxin from pathogenic Escherichia coli reveal a distinct mechanism of inhibition of trimeric G-proteins

Matthew D. Johnson, T. Beddoe, J. Rossjohn, 2017, The Journal of Biological Chemistry.

BiP (Grp78): A Target for Escherichia coli Subtilase Cytotoxin

J. Paton, A. Paton, Hui Wang, 2013 .

The Escherichia coli Subtilase Cytotoxin A Subunit Specifically Cleaves Cell-surface GRP78 Protein and Abolishes COOH-terminal-dependent Signaling

S. Pizzo, J. Eu, Gustaaf G. de Ridder, 2012, The Journal of Biological Chemistry.

Identification of signal peptide features for substrate specificity in human Sec62/Sec63‐dependent ER protein import

F. Förster, Nagarjuna Nagaraj, A. Cavalié, 2020, The FEBS journal.

Proteomics identifies signal peptide features determining the substrate specificity in human Sec62/Sec63-dependent ER protein import

F. Förster, Nagarjuna Nagaraj, A. Cavalié, 2019, bioRxiv.

The BiP Molecular Chaperone Plays Multiple Roles during the Biogenesis of TorsinA, an AAA+ ATPase Associated with the Neurological Disease Early-onset Torsion Dystonia*

J. Brodsky, M. Zółkiewski, L. Millen, 2014, The Journal of Biological Chemistry.

Ouabain Protects Human Renal Cells against the Cytotoxic Effects of Shiga Toxin Type 2 and Subtilase Cytotoxin

J. Paton, A. Paton, C. Ibarra, 2017, Toxins.

Up-Regulation of Both Intimin andeae-Independent Adherence of Shiga ToxigenicEscherichia coli O157 by ler and Phenotypic Impact of a Naturally Occurring ler Mutation

M. Ogierman, J. Paton, A. Paton, 2000, Infection and Immunity.

Translocated Intimin Receptors (Tir) of Shiga-Toxigenic Escherichia coli Isolates Belonging to Serogroups O26, O111, and O157 React with Sera from Patients with Hemolytic-Uremic Syndrome and Exhibit Marked Sequence Heterogeneity

P. Manning, J. Paton, A. Paton, 1998, Infection and Immunity.

Protection against Shiga-Toxigenic Escherichia coli by Non-Genetically Modified Organism Receptor Mimic Bacterial Ghosts

R. Morona, W. Lubitz, M. Jennings, 2015, Infection and Immunity.

Structural Basis of Subtilase Cytotoxin SubAB Assembly*

Matthew D. Johnson, T. Beddoe, J. Rossjohn, 2013, The Journal of Biological Chemistry.

Oscillation of mitogen-activated protein kinases in response to endoplasmic reticulum stress.

Hui Zhang, M. Kitamura, J. Paton, 2011, Analytical biochemistry.

Intermolecular disulfide-bond formation in human FICD modulates the activity of the hyperactive E234G mutant

J. Enghild, C. Scavenius, L. Ellgaard, 2017, bioRxiv.

All major cholesterol-dependent cytolysins use glycans as cellular receptors.

V. Nizet, C. Day, B. Kobe, 2020, Science advances.

Structure aided design of a Neu5Gc specific lectin

C. Day, B. Schulz, M. Jennings, 2017, Scientific Reports.

Heterogeneity of the amino-acid sequences of Escherichia coli Shiga-like toxin type-I operons.

L. Beutin, J. Paton, A. Paton, 1995, Gene.

Sequence of a variant Shiga-like toxin type-I operon of Escherichia coli O111:H-.

P. Manning, J. Paton, A. Paton, 1993, Gene.

Downregulation of gap junction expression and function by endoplasmic reticulum stress

M. Kitamura, Ying Zhu, J. Paton, 2009, Journal of cellular biochemistry.

Shiga toxin-producing Escherichia coli isolates from cases of human disease show enhanced adherence to intestinal epithelial (Henle 407) cells

J C Paton, P A Manning, P. Manning, 1997, Infection and immunity.

BiP prevents rod opsin aggregation

D. Athanasiou, N. Kanuga, M. Cheetham, 2012, Molecular biology of the cell.

Adapting the endoplasmic reticulum proteostasis rescues epilepsy-associated NMDA receptor variants

J. Paton, A. Paton, Ya-Juan Wang, 2023, bioRxiv.

Inflammatory cytokines rewire the proinsulin interaction in human islets.

R. Kaufman, P. Arvan, S. Mir, 2022, The Journal of clinical endocrinology and metabolism.

Blimp1 regulates the transition of neonatal to adult intestinal epithelium

H. Clevers, D. Hommes, M. Ferrante, 2013 .

Distribution of the saa Gene in Strains of Shiga Toxin-Producing Escherichia coli of Human and Bovine Origins

G. Dougan, D. Shaw, C. Jenkins, 2003, Journal of Clinical Microbiology.

Direct Detection and Characterization of Shiga Toxigenic Escherichia coli by Multiplex PCR for stx1, stx2, eae, ehxA, and saa

J. Paton, A. Paton, 2002, Journal of Clinical Microbiology.

Sialoglycan microarray encoding reveals differential sialoglycan binding of phylogenetically-related bacterial AB5 toxin B subunits

Benjamin P. Kellman, N. Lewis, T. Beddoe, 2021, bioRxiv.

UvA-DARE ( Digital Academic Repository ) A close-up of colon cancer

H. Clevers, D. Hommes, M. Ferrante, 2013 .

Stress-induced protein disaggregation in the endoplasmic reticulum catalysed by BiP

E. Avezov, P. Paulo, J. Paton, 2021, Nature Communications.

PUBLISHED VERSION

F. Fazal, J. Paton, A. Paton, 2014 .

Selective Inactivation of Intracellular BiP/GRP78 Attenuates Endothelial Inflammation and Permeability in Acute Lung Injury

F. Fazal, Arshad Rahman, J. Paton, 2019, Scientific Reports.

Dengue Virus Infection Induces Upregulation of GRP78, Which Acts To Chaperone Viral Antigen Production

C. Burrell, P. Zilm, A. Paton, 2009, Journal of Virology.

Preconditioning with Endoplasmic Reticulum Stress Ameliorates Endothelial Cell Inflammation

F. Fazal, A. Paton, Paul Q. Thomas, 2014, PloS one.

This information is current as Mechanism for Subsidence of Inflammation Endoplasmic Reticulum Stress Response : A Cytokines in Nonimmune Cells through Acquisition of Anergy to Proinflammatory

S. Nakajima, A. Paton, N. Hiramatsu, 2008 .

Structure–function analyses of a pertussis-like toxin from pathogenic Escherichia coli reveal a distinct mechanism of inhibition of trimeric G-proteins

Matthew D. Johnson, T. Beddoe, J. Rossjohn, 2017, The Journal of Biological Chemistry.

Chaperone-Driven Degradation of a Misfolded Proinsulin Mutant in Parallel With Restoration of Wild-Type Insulin Secretion

P. Arvan, Anoop Arunagiri, Billy Tsai, 2016, Diabetes.

Colonic stem cells in homeostasis and cancer

J. Medema, J. Heijmans, A. Paton, 2015 .

Rapid astroglial stress response and elevation of endogenous BiP levels promote neuronal survival in hippocampal slice cultures

B. Heimrich, F. Pröls, J. Paton, 2021, World Journal of Biology Pharmacy and Health Sciences.

Detection of N-glycolylneuraminic acid biomarkers in sera from patients with ovarian cancer using an engineered N-glycolylneuraminic acid-specific lectin SubB2M.

C. Day, J. Paton, A. Paton, 2018, Biochemical and biophysical research communications.

Genomic Comparison of Two O111:H− Enterohemorrhagic Escherichia coli Isolates from a Historic Hemolytic-Uremic Syndrome Outbreak in Australia

Nicola K. Petty, S. Beatson, S. Bent, 2016, Infection and Immunity.

Methods for Detection of STEC in Humans

J. Paton, A. Paton, 2003 .

Short Review on the Protection by Ouabain of E Coli Toxins

J. Paton, A. Paton, C. Ibarra, 2018 .