P. Upton

发表

Identification of rare sequence variation underlying heritable pulmonary arterial hypertension

Henning Gall, Andrea Olschewski, Horst Olschewski, 2018, Nature Communications.

Plasma levels of apelin are reduced in patients with liver fibrosis and cirrhosis but are not correlated with circulating levels of bone morphogenetic protein 9 and 10

G. Alexander, A. Davenport, N. Morrell, 2020, Peptides.

Altered Growth Responses of Pulmonary Artery Smooth Muscle Cells From Patients With Primary Pulmonary Hypertension to Transforming Growth Factor-&bgr;1 and Bone Morphogenetic Proteins

R. Trembath, N. Morrell, N. Morgan, 2001, Circulation.

Primary Pulmonary Hypertension Is Associated With Reduced Pulmonary Vascular Expression of Type II Bone Morphogenetic Protein Receptor

R. Trembath, N. Morrell, R. Machado, 2002, Circulation.

neutrophil apoptosis Involvement of a ferroprotein sensor in hypoxia-mediated inhibition of

E. Chilvers, A. Cowburn, J. Deighton, 2013 .

Involvement of a ferroprotein sensor in hypoxia-mediated inhibition of neutrophil apoptosis.

E. Chilvers, A. Cowburn, J. Deighton, 2002, Blood.

Intersegmental vessel formation in zebrafish: requirement for VEGF but not BMP signalling revealed by selective and non‐selective BMP antagonists

J C Smith, Jessie R. Cannon, J. Smith, 2010, British journal of pharmacology.

Prostacyclin Analogues Differentially Inhibit Growth of Distal and Proximal Human Pulmonary Artery Smooth Muscle Cells

M. Yacoub, J. Polak, N. Morrell, 2000, Circulation.

Identification of a Lysosomal Pathway Regulating Degradation of the Bone Morphogenetic Protein Receptor Type II*

P. Lehner, N. Morrell, H. Durrington, 2010, The Journal of Biological Chemistry.

Characterisation and Molecular Identification of Adrenomedullin Binding Sites in the Rat Spinal Cord: A Comparison with Calcitonin Gene‐Related Peptide Receptors

D. Smith, M. Ghatei, P. Upton, 1996, Journal of neurochemistry.

Circulating adrenomedullin does not regulate systemic blood pressure but increases plasma prolactin after intravenous infusion in humans: a pharmacokinetic study.

S. Bloom, M. Ghatei, M. Ghatei, 1997, The Journal of clinical endocrinology and metabolism.

Expression of adrenomedullin (ADM) and its binding sites in the rat uterus: increased number of binding sites and ADM messenger ribonucleic acid in 20-day pregnant rats compared with nonpregnant rats.

D. Smith, M. Ghatei, A. Clark, 1997, Endocrinology.

Rat-2 fibroblasts express specific adrenomedullin receptors, but not calcitonin-gene-related-peptide receptors, which mediate increased intracellular cAMP and inhibit mitogen-activated protein kinase activity.

D. Smith, M. Ghatei, P. Upton, 1999, The Biochemical journal.

Adrenomedullin expression and growth inhibitory effects in distinct pulmonary artery smooth muscle cell subpopulations.

M. Yacoub, D. Smith, J. Polak, 2001, American journal of respiratory cell and molecular biology.

BMP-9 Induced Endothelial Cell Tubule Formation and Inhibition of Migration Involves Smad1 Driven Endothelin-1 Production

I. Adcock, M. Griffiths, N. Morrell, 2012, PloS one.

Identification of novel rare sequence variation underlying heritable pulmonary arterial hypertension

W. Ouwehand, M. Humbert, W. Seeger, 2018 .

Novel causative genes for heritable pulmonary arterial hypertension

W. Ouwehand, M. Humbert, W. Seeger, 2017, bioRxiv.

Endothelial protective factors BMP9 and BMP10 inhibit CCL2 release by human vascular endothelial cells

M. Griffiths, N. Morrell, R. Davies, 2020, Journal of Cell Science.

Functional Characterization of Bone Morphogenetic Protein Binding Sites and Smad1/5 Activation in Human Vascular Cells

R. Trembath, N. Morrell, P. Upton, 2008, Molecular Pharmacology.

Dysfunctional Smad Signaling Contributes to Abnormal Smooth Muscle Cell Proliferation in Familial Pulmonary Arterial Hypertension

N. Rudarakanchana, R. Trembath, N. Morrell, 2005, Circulation research.

Functional analysis of bone morphogenetic protein type II receptor mutations underlying primary pulmonary hypertension.

N. Rudarakanchana, R. Trembath, N. Morrell, 2002, Human molecular genetics.

4PBA Restores Signalling of a Cysteine-substituted Mutant BMPR2 Receptor Found in Patients with PAH.

N. Morrell, E. Austin, A. Rana, 2020, American journal of respiratory cell and molecular biology.

TGF-beta and BMPR-II pharmacology--implications for pulmonary vascular diseases.

N. Morrell, P. Upton, 2009, Current opinion in pharmacology.

Transcript Analysis Reveals a Specific HOX Signature Associated with Positional Identity of Human Endothelial Cells

J. Skepper, N. Morrell, E. McKinney, 2014, PloS one.

Characterization of GDF2 Mutations and Levels of BMP9 and BMP10 in Pulmonary Arterial Hypertension.

W. Ouwehand, M. Humbert, W. Seeger, 2020, American journal of respiratory and critical care medicine.

Bone Morphogenetic Protein 9 Is a Mechanistic Biomarker of Portopulmonary Hypertension

C. Huard, M. Goumans, K. Coser, 2019, American journal of respiratory and critical care medicine.

Eotaxin-1/CC Chemokine Ligand 11: A Novel Eosinophil Survival Factor Secreted by Human Pulmonary Artery Endothelial Cells1

E. Gherardi, N. Morrell, E. Chilvers, 2007, The Journal of Immunology.

Hypoxic induction of cox-2 regulates proliferation of human pulmonary artery smooth muscle cells.

G. Taylor, N. Morrell, J. Wharton, 2002, American journal of respiratory cell and molecular biology.

Altered Bone Morphogenetic Protein and Transforming Growth Factor-β Signaling in Rat Models of Pulmonary Hypertension: Potential for Activin Receptor-Like Kinase-5 Inhibition in Prevention and Progression of Disease

N. Morrell, M. Southwood, P. Upton, 2009, Circulation.

Whole genome sequencing of a sporadic primary immunodeficiency cohort

William J. Astle, Sri V. V. Deevi, Kenneth G. C. Smith, 2018, Nature.

Does BMPR2 mutation disrupt pulmonary vasculogenesis?

R. Trembath, N. Morrell, M. Southwood, 2005, Chest.

TNFα drives pulmonary arterial hypertension by suppressing the BMP type-II receptor and altering NOTCH signalling

G. Inman, N. Morrell, J. Bradley, 2017, Nature Communications.

Deficiency of Axl aggravates pulmonary arterial hypertension via BMPR2

W. Seeger, H. Ghofrani, N. Weissmann, 2021, Communications biology.

ET(A) and ET(B) receptors modulate the proliferation of human pulmonary artery smooth muscle cells.

M. Yacoub, J. Polak, N. Morrell, 2002, American journal of respiratory and critical care medicine.

Mechanism of cicaprost-induced desensitization in rat pulmonary artery smooth muscle cells involves a PKA-mediated inhibition of adenylyl cyclase.

N. Morrell, P. Upton, A. Sobolewski, 2004, American journal of physiology. Lung cellular and molecular physiology.

Angiotensin II activates MAPK and stimulates growth of human pulmonary artery smooth muscle via AT1 receptors.

M. Yacoub, J. Polak, N. Morrell, 1999, American journal of physiology. Lung cellular and molecular physiology.

Angiotensin II activates MAPK and stimulates growth of human pulmonary artery smooth muscle via AT 1 receptors

M. Yacoub, J. Polak, N. Morrell, 1999 .

Differential adrenomedullin release and endothelin receptor expression in distinct subpopulations of human airway smooth-muscle cells.

D. Smith, N. Morrell, J. Wharton, 2001, American journal of respiratory cell and molecular biology.

The Prodomain-bound Form of Bone Morphogenetic Protein 10 Is Biologically Active on Endothelial Cells

Wei Li, A. Davenport, N. Morrell, 2015, The Journal of Biological Chemistry.

Connexin-mediated regulation of the pulmonary vasculature.

P. Upton, Y. Dempsie, Patricia E. Martin, 2015, Biochemical Society transactions.

Bone morphogenetic protein receptor type II deficiency and increased inflammatory cytokine production. A gateway to pulmonary arterial hypertension.

N. Morrell, C. Shanahan, K. Bloch, 2015, American journal of respiratory and critical care medicine.

The lysosomal inhibitor, chloroquine, increases cell surface BMPR-II levels and restores BMP9 signalling in endothelial cells harbouring BMPR-II mutations

N. Morrell, B. Dunmore, M. Aldred, 2013, Human molecular genetics.

Human Pulmonary Artery Endothelial Cells Eosinophil Survival Factor Secreted by Eotaxin-1 / CC Chemokine Ligand 11 : A Novel

E. Gherardi, N. Morrell, E. Chilvers, 2007 .

Vascular remodeling and ET-1 expression in rat strains with different responses to chronic hypoxia.

J. Polak, N. Morrell, M. Wilkins, 2000, American journal of physiology. Lung cellular and molecular physiology.

Single-cell RNA sequencing profiling of mouse endothelial cells in response to pulmonary arterial hypertension

P. Carmeliet, M. Brittan, R. Lafyatis, 2021, Cardiovascular research.

ALUNG September 21/3

J. Polak, N. Morrell, S. Kotecha, 1999 .

The transforming growth factor‐β–bone morphogenetic protein type signalling pathway in pulmonary vascular homeostasis and disease

N. Morrell, P. Upton, 2013, Experimental physiology.

Circulating BMP9 Protects the Pulmonary Endothelium during Inflammation-induced Lung Injury in Mice

N. Morrell, E. Chilvers, K. Lodge, 2020, bioRxiv.

Effect of peptide YY on human renal function.

R. Playford, S. Moss, M. Ghatei, 1995, The American journal of physiology.

Circulating Bmp10 acts through endothelial Alk1 to mediate flow-dependent arterial quiescence

B. L. Roman, S. Young, P. Upton, 2013, Development.

Angiotensin II stimulates proliferation of human pulmonary artery smooth muscle cells via the AT1 receptor.

M. Yacoub, J. Polak, N. Morrell, 1998, Chest.

ET(A) and ET(B) receptors modulate the proliferation of human pulmonary artery smooth muscle cells.

M. Yacoub, J. Polak, N. Morrell, 2002, American journal of respiratory and critical care medicine.

Letter by Morrell et al Regarding Article, "Selective BMP-9 Inhibition Partially Protects Against Experimental Pulmonary Hypertension".

N. Morrell, Wei Li, P. Yu, 2019, Circulation research.

Generation of a Soluble Form of Human Endoglin Fused to Green Fluorescent Protein

N. Morrell, F. J. Fernández, C. Bernabéu, 2021, International journal of molecular sciences.

An organ-on-chip model of pulmonary arterial hypertension identifies a BMPR2-SOX17-prostacyclin signalling axis

J. Edel, A. Fellows, K. Gray, 2022, Communications Biology.

Selective enhancement of endothelial BMPR-II with BMP9 reverses pulmonary arterial hypertension

S. Gräf, N. Morrell, Matthias Mueller, 2015, Nature Medicine.

A rare homozygous missense GDF2 (BMP9) mutation causing PAH in siblings: Does BMP10 status contribute?

N. Morrell, P. Upton, A. Bates, 2022, American journal of medical genetics. Part A.

Failure of bone morphogenetic protein receptor trafficking in pulmonary arterial hypertension: potential for rescue.

N. Rudarakanchana, R. Trembath, N. Morrell, 2008, Human molecular genetics.

BMP9 mutations cause a vascular-anomaly syndrome with phenotypic overlap with hereditary hemorrhagic telangiectasia.

Brendan D. O'Fallon, P. Bayrak-Toydemir, N. Morrell, 2013, American journal of human genetics.

Whole-genome sequencing of a sporadic primary immunodeficiency cohort

William J. Astle, Sri V. V. Deevi, Kenneth G. C. Smith, 2020, Nature.

A Role for miR-145 in Pulmonary Arterial Hypertension: Evidence From Mouse Models and Patient Samples

E. Olson, E. van Rooij, J. McClure, 2012, Circulation research.

Transforming growth factor-β(1) represses bone morphogenetic protein-mediated Smad signaling in pulmonary artery smooth muscle cells via Smad3.

N. Morrell, R. Davies, T. Tajsic, 2013, American journal of respiratory cell and molecular biology.

Inactivation of platelet‐derived growth factor‐BB following modification by ADP‐ribosyltransferase

S. Johnstone, J. Macdermot, P. Upton, 2001, British journal of pharmacology.

Reduced circulating BMP10 and BMP9 and elevated endoglin are associated with disease severity, decompensation and pulmonary vascular syndromes in patients with cirrhosis

G. Alexander, A. Davenport, N. Morrell, 2020, EBioMedicine.

Bone morphogenetic protein 9 (BMP9) and BMP10 enhance tumor necrosis factor-α-induced monocyte recruitment to the vascular endothelium mainly via activin receptor-like kinase 2

N. Morrell, E. Chilvers, Z. Mallat, 2017, The Journal of Biological Chemistry.

The promise of recombinant BMP ligands and other approaches targeting BMPR-II in the treatment of pulmonary arterial hypertension

N. Morrell, Wei Li, P. Upton, 2015, Global cardiology science & practice.

Bone Morphogenetic Protein (BMP) and Activin Type II Receptors Balance BMP9 Signals Mediated by Activin Receptor-like Kinase-1 in Human Pulmonary Artery Endothelial Cells*

R. Trembath, N. Morrell, R. Davies, 2009, The Journal of Biological Chemistry.

Regulation of Bone Morphogenetic Protein 9 (BMP9) by Redox-dependent Proteolysis*

N. Morrell, Wei Li, R. Salmon, 2014, The Journal of Biological Chemistry.

Identification of MicroRNA-124 as a Major Regulator of Enhanced Endothelial Cell Glycolysis in Pulmonary Arterial Hypertension via PTBP1 (Polypyrimidine Tract Binding Protein) and Pyruvate Kinase M2

P. Carmeliet, C. Perez-Iratxeta, D. Stewart, 2017, Circulation.

Author Correction: Deficiency of Axl aggravates pulmonary arterial hypertension via BMPR2

W. Seeger, H. Ghofrani, N. Weissmann, 2021, Communications Biology.

Elabela/Toddler Is an Endogenous Agonist of the Apelin APJ Receptor in the Adult Cardiovascular System, and Exogenous Administration of the Peptide Compensates for the Downregulation of Its Expression in Pulmonary Arterial Hypertension

R. Glen, T. Carpenter, S. Sawiak, 2017, Circulation.

BMP type II receptor deficiency confers resistance to growth inhibition by TGF-β in pulmonary artery smooth muscle cells: role of proinflammatory cytokines.

N. Morrell, D. Budd, A. Holmes, 2012, American journal of physiology. Lung cellular and molecular physiology.

Mutations in Bone Morphogenetic Protein Type II Receptor Cause Dysregulation of Id Gene Expression in Pulmonary Artery Smooth Muscle Cells: Implications for Familial Pulmonary Arterial Hypertension

R. Trembath, N. Morrell, R. Davies, 2008, Circulation research.

Familial Pulmonary Arterial Hypertension Dysfunctional Smad Signaling Contributes to Abnormal Smooth Muscle Cell Proliferation

N. Rudarakanchana, R. Trembath, N. Morrell, 2005 .

An emerging class of new therapeutics targeting TGF, Activin, and BMP ligands in pulmonary arterial hypertension

N. Morrell, Wei Li, B. Dunmore, 2022, Developmental dynamics : an official publication of the American Association of Anatomists.

BMP4 inhibits proliferation and promotes myocyte differentiation of lung fibroblasts via Smad1 and JNK pathways.

R. Trembath, N. Morrell, P. Upton, 2005, American journal of physiology. Lung cellular and molecular physiology.

Approaches to treat pulmonary arterial hypertension by targeting bmpr2 - from cell membrane to nucleus.

N. Morrell, B. Dunmore, M. Toshner, 2021, Cardiovascular research.

Homozygous GDF2 nonsense mutations result in a loss of circulating BMP9 and BMP10 and are associated with either PAH or an “HHT‐like” syndrome in children

J. Bentham, P. Bayrak-Toydemir, N. Morrell, 2021, Molecular genetics & genomic medicine.

Bone Morphogenetic Protein 9 Enhances Lipopolysaccharide-Induced Leukocyte Recruitment to the Vascular Endothelium

N. Morrell, E. Chilvers, G. Nash, 2016, The Journal of Immunology.

OP-CVRE200359 2309..2325

N. Morrell, B. Dunmore, M. Toshner, 2021 .

Log-transformation improves the prognostic value of serial NT-proBNP levels in apparently stable pulmonary arterial hypertension

N. Morrell, C. Treacy, M. Toshner, 2011, Pulmonary circulation.

Angiogenesis regulation by TGFβ signalling: clues from an inherited vascular disease.

H. Arthur, P. Upton, M. Mahmoud, 2011, Biochemical Society transactions.

Targeting translational read-through of premature termination mutations in BMPR2 with PTC124 for pulmonary arterial hypertension

N. Morrell, B. Dunmore, M. Southwood, 2020, Pulmonary circulation.

A 3D tri‐culture system reveals that activin receptor‐like kinase 5 and connective tissue growth factor drive human glomerulosclerosis

J. Skepper, J. Pober, N. Morrell, 2017, The Journal of pathology.

SOX17 Deficiency Impairs Tube Network Formation Through the Reduction of Arterial Identity in Pulmonary Arterial Hypertension

M. Haimel, M. Bleda, S. Gräf, 2020 .

Protein truncating mutations in ATP13A3 promote pulmonary arterial hypertension in mice

N. Morrell, J. West, P. Vangheluwe, 2020 .

muscle cells: role of proinflammatory cytokines in pulmonary artery smooth β growth inhibition by TGF- BMP type II receptor deficiency confers resistance to

N. Morrell, D. Budd, A. Holmes, 2016 .

Functional Characterization of BMP Binding Sites and Smad1/5 Activation in Human Vascular Cells

R. Trembath, N. Morrell, P. Upton, 2007 .

Regulation of Bone Morphogenetic Protein 9 (BMP9) by Redox-dependent Proteolysis*

N. Morrell, Wei Li, R. Salmon, 2014, The Journal of Biological Chemistry.

CVR-2020-1310 Single-cell RNA-seq profiling of mouse endothelial cells in response to pulmonary arterial hypertension

P. Carmeliet, M. Brittan, J. Rodor, 2021 .

Connexin-mediated regulation of the pulmonary vasculature.

P. Upton, Y. Dempsie, P. Martin, 2015, Biochemical Society transactions.

Regulation of bone morphogenetic protein signalling in human pulmonary vascular development

R. Trembath, N. Morrell, M. Southwood, 2008, The Journal of pathology.

ATP13A3 Variants Promote Pulmonary Arterial Hypertension by Disrupting Polyamine Transport

V. Baekelandt, N. Morrell, J. West, 2023, bioRxiv.

The lysosomal inhibitor, chloroquine, increases cell surface BMPR-II levels and restores BMP9 signalling in endothelial cells harbouring BMPR-II mutations

N. Morrell, B. Dunmore, M. Aldred, 2013, Human molecular genetics.

High concentrations of soluble endoglin can inhibit BMP9 signaling in non-endothelial cells

B. Liu, N. Morrell, Wei Li, 2023, Scientific Reports.

Identification of rare sequence variation underlying heritable pulmonary arterial hypertension

N. Soranzo, Q. Waisfisz, M. Haimel, 2018, Nature Communications.

Expression of Adrenomedullin ( ADM ) and Its Binding Sites in the Rat Uterus : Increased Number of Binding Sites and ADM Messenger Ribonucleic Acid in 20-Day Pregnant Rats Compared with Nonpregnant Rats *

C. Austin, M. Ghatei, A. Clark, 1997 .