R. Hyland

发表

Identification of the cytochrome P450 enzymes involved in the N-oxidation of voriconazole.

D A Smith, D. Smith, B. Jones, 2003, Drug metabolism and disposition: the biological fate of chemicals.

DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS

Barry C. Jones, Jeffrey R. Koup, Dennis A. Smith, 2004, Drug Metabolism and Disposition.

Human cytochrome P450s: selectivity and measurement in vivo.

D. Smith, B. Jones, R. Hyland, 1998, Xenobiotica; the fate of foreign compounds in biological systems.

Human hepatocytes in primary culture predict lack of cytochrome P-450 3A4 induction by eletriptan in vivo.

P. Maurel, R. Hyland, A. Milton, 2000, Drug metabolism and disposition: the biological fate of chemicals.

Minimizing Polymorphic Metabolism in Drug Discovery: Evaluation of the Utility of in Vitro Methods for Predicting Pharmacokinetic Consequences Associated with CYP2D6 Metabolism

J. Gibbs, K. Youdim, R. Hyland, 2006, Drug Metabolism and Disposition.

Drug-drug interactions for UGT substrates: a pharmacokinetic explanation for typically observed low exposure (AUC i /AUC) ratios

Dennis A. Smith, J. Williams, J. Koup, 2004 .

N-alkylformamides are metabolized to N-alkylcarbamoylating species by hepatic microsomes from rodents and humans.

A. Gescher, R. Hyland, R. Dayal, 1990, Chemical research in toxicology.

Identiﬁcation of the cytochrome P450 enzymes involved in the N -demethylation of sildenaﬁl

D. Smith, R. Hyland, B. Jones, 2001 .

Evaluation of the role of the asialoglycoprotein receptor in the clearance of UK-279,276 (recombinant neutrophil inhibitory factor)

D. Walker, R. Hyland, R. Webster, 2003, Xenobiotica; the fate of foreign compounds in biological systems.

Potential role for P-glycoprotein in the nonproportional pharmacokinetics of UK-343,664 in man

D. A. Smith, D. Smith, K. Beaumont, 2001, Xenobiotica; the fate of foreign compounds in biological systems.

Identification of the cytochrome P450 enzymes involved in the N-demethylation of sildenafil.

D A Smith, D. Smith, B. Jones, 2001, British journal of clinical pharmacology.

Maraviroc: in vitro assessment of drug-drug interaction potential.

Maurice Dickins, Claire Collins, B. Jones, 2008, British journal of clinical pharmacology.

Investigation into UDP-Glucuronosyltransferase (UGT) Enzyme Kinetics of Imidazole- and Triazole-Containing Antifungal Drugs in Human Liver Microsomes and Recombinant UGT Enzymes

N. Irvine, B. Jones, R. Hyland, 2010, Drug Metabolism and Disposition.

In vitro and in vivo glucuronidation of midazolam in humans.

B. Jones, R. Hyland, S. Kempshall, 2009, British journal of clinical pharmacology.

Application of CYP3A4 in vitro data to predict clinical drug-drug interactions; predictions of compounds as objects of interaction.

Alex Phipps, R Scott Obach, Maurice Dickins, 2008, British journal of clinical pharmacology.

Progress Curve Mechanistic Modeling Approach for Assessing Time-Dependent Inhibition of CYP3A4

A. Galetin, J. Houston, H. Pertinez, 2012, Drug Metabolism and Disposition.

Excretion and Metabolism of Lersivirine (5-{[3,5-Diethyl-1-(2-hydroxyethyl)(3,5-14C2)-1H-pyrazol-4-yl]oxy}benzene-1,3-dicarbonitrile), a Next-Generation Non-Nucleoside Reverse Transcriptase Inhibitor, after Administration of [14C]Lersivirine to Healthy Volunteers

R. Labadie, I. Gardner, M. Vourvahis, 2010, Drug Metabolism and Disposition.

Optimized Assays for Human UDP-Glucuronosyltransferase (UGT) Activities: Altered Alamethicin Concentration and Utility to Screen for UGT Inhibitors

J. Bauman, R. Walsky, R. Obach, 2012, Drug Metabolism and Disposition.

Investigation of the mechanistic basis of N,N-dimethylformamide toxicity. Metabolism of N,N-dimethylformamide and its deuterated isotopomers by cytochrome P450 2E1.

A. Gescher, M. Threadgill, K. Thummel, 1993, Chemical research in toxicology.

Selective Mechanism-Based Inactivation of CYP3A4 by CYP3cide (PF-04981517) and Its Utility as an In Vitro Tool for Delineating the Relative Roles of CYP3A4 versus CYP3A5 in the Metabolism of Drugs

G. S. Walker, R. Obach, R. Walsky, 2012, Drug Metabolism and Disposition.

Medicinal chemistry approaches to avoid aldehyde oxidase metabolism.

I. Gardner, S. Bagal, K. Omoto, 2012, Bioorganic & medicinal chemistry letters.

Understanding CYP2D6 interactions.

M. D. de Groot, G. Whitlock, Florian Wakenhut, 2009, Drug discovery today.

Utility of human/human-derived reagents in drug discovery and development: An industrial perspective.

H. van de Waterbeemd, B. Jones, R. Hyland, 2006, Environmental toxicology and pharmacology.

Metabolic oxidation and toxification of N-methylformamide catalyzed by the cytochrome P450 isoenzyme CYP2E1.

A. Gescher, A. W. Smith, K. Thummel, 1992, Molecular pharmacology.

Drug–Drug Interactions: Screening for Liability and Assessment of Risk

R. Obach, K. Youdim, M. Wester, 2009 .

Development of an in vitro drug-drug interaction assay to simultaneously monitor five cytochrome P450 isoforms and performance assessment using drug library compounds.

Caroline A. Lee, Douglas Burdette, R. Hyland, 2008, Journal of pharmacological and toxicological methods.

Targeted quantitative proteomics for the analysis of 14 UGT1As and -2Bs in human liver using NanoUPLC-MS/MS with selected reaction monitoring.

Hendrik Neubert, T. Goosen, H. Neubert, 2013, Journal of proteome research.

Comparison of Different Algorithms for Predicting Clinical Drug-Drug Interactions, Based on the Use of CYP3A4 in Vitro Data: Predictions of Compounds as Precipitants of Interaction

Alex Phipps, Kuresh Youdim, Maurice Dickins, 2009, Drug Metabolism and Disposition.

Induction of Cytochrome P450: Assessment in an Immortalized Human Hepatocyte Cell Line (Fa2N4) Using a Novel Higher Throughput Cocktail Assay

K. Youdim, B. Jones, R. Hyland, 2007, Drug Metabolism and Disposition.

Interaction of terfenadine and its primary metabolites with cytochrome P450 2D6.

R. Hyland, C. A. Tyman, M. J. Ackland, 1998, Drug metabolism and disposition: the biological fate of chemicals.

Lersivirine to Healthy Volunteers

M. Vourvahis, R. Hyland, S. Kempshall, 2010 .

Reaction phenotyping in drug discovery: moving forward with confidence?

J. Bauman, R. Obach, J. Gibbs, 2003, Current drug metabolism.