R. Kubota

L. Liang, S. Izumo, R. Kubota, 2017, International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases.

Programmed death-1 (PD-1)/PD-1 ligand pathway-mediated immune responses against human T-lymphotropic virus type 1 (HTLV-1) in HTLV-1-associated myelopathy/tropical spastic paraparesis and carriers with autoimmune disorders.

S. Izumo, R. Kubota, M. Yoshimitsu, 2011, Human immunology.

Human T-cell lymphotropic virus type I (HTLV-I)-related clinical and laboratory findings for HTLV-I-infected blood donors.

M. Nakagawa, S. Izumo, M. Osame, 2003, Journal of acquired immune deficiency syndromes.

In vitro modulation of lymphocyte proliferation by prednisolone and interferon-α in patients with HTLV-I-associated myelopathy (HAM)

I. Maruyama, S. Sonoda, S. Izumo, 1989, Journal of Neuroimmunology.

Enhanced inhibition of lymphocyte activation byMycobacterium avium complex in human T lymphotrophic virus type I carriers

M. Osame, R. Kubota, W. Matsuyama, 2001, Thorax.

Ef fi cacy and safety of radiofrequency catheter ablation for atrial fi brillation in chronic hemodialysis patients

T. Murohara, Y. Inden, R. Kubota, 2014 .

Efficacy and safety of radiofrequency catheter ablation for atrial fibrillation in chronic hemodialysis patients.

T. Murohara, Y. Inden, R. Kubota, 2014, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

HTLV-I proviral DNA amount correlates with infiltrating CD4+ lymphocytes in the spinal cord from patients with HTLV-I-associated myelopathy

T. Fujiyoshi, S. Yashiki, S. Sonoda, 1994, Journal of Neuroimmunology.

Decrease of aquaporin‐4 and excitatory amino acid transporter‐2 indicate astrocyte dysfunction for pathogenesis of cortical degeneration in HIV‐associated neurocognitive disorders

S. Izumo, R. Kubota, K. Mori, 2017, Neuropathology : official journal of the Japanese Society of Neuropathology.

High prevalence of HTLV-1 carriers among the elderly population in Kagoshima, a highly endemic area in Japan.

E. Matsuura, H. Takashima, R. Kubota, 2022, AIDS research and human retroviruses.

Degenerate specificity of HTLV-1-specific CD8+ T cells during viral replication in patients with HTLV-1-associated myelopathy (HAM/TSP).

S. Izumo, M. Osame, R. Kubota, 2003, Blood.

replication in patients with HTLV-I-associated myelopathy ( HAM / TSP ) Degenerate specificity of HTLV-I-specific CD 8 + T cells during viral

S. Izumo, M. Osame, R. Kubota, 2002 .

Splenic gamma/delta T-cell Lymphoma Report of a Case

R. Kubota, M. Tokunaga, Y. Uemura, 1995 .

Genetic Stability of Human T Lymphotropic Virus Type I despite Antiviral Pressures by CTLs1

T. Gojobori, Kousuke Hanada, K. Arimura, 2007, The Journal of Immunology.

Severe loss of invariant NKT cells exhibiting anti-HTLV-1 activity in patients with HTLV-1-associated disorders.

A. Utsunomiya, S. Aratani, T. Nakajima, 2009, Blood.

In vivo expression of proinflammatory cytokines in HIV encephalitis: an analysis of 11 autopsy cases

H. Budka, E. Gelpí, S. Izumo, 2009, Neuropathology : official journal of the Japanese Society of Neuropathology.

Pathogenesis of human T‐lymphotropic virus type 1‐associated myelopathy/tropical spastic paraparesis

R. Kubota, 2017 .

The Effect of Human β2-Microglobulin on Major Histocompatibility Complex I Peptide Loading and the Engineering of a High Affinity Variant

Ryuji Kubota, Steven Jacobson, S. Jacobson, 1998, The Journal of Biological Chemistry.

Ischemia-induced angiogenesis is impaired in aminopeptidase A deficient mice via down-regulation of HIF-1α.

K. Naruse, K. Okumura, T. Murohara, 2010, Biochemical and biophysical research communications.

An autoaggressive process against bystander tissues in HTLV-I-infected individuals: a possible pathomechanism of HAM/TSP.

I. Maruyama, S. Izumo, M. Nagai, 1993, Medical hypotheses.

Standardization of Quantitative PCR for Human T-Cell Leukemia Virus Type 1 in Japan: a Collaborative Study

S. Saito, M. Satake, K. Yamaguchi, 2015, Journal of Clinical Microbiology.

Early diagnosis of HTLV-1-associated myelopathy (HAM/TSP) in HTLV-1 carrier clinic

S. Izumo, H. Takashima, R. Kubota, 2014, Retrovirology.

Expression of TSLC1 in patients with HAM/TSP

J. Fujisawa, E. Matsuura, S. Izumo, 2020, Journal of NeuroVirology.

Neuropathology of HTLV-1-associated myelopathy (HAM/TSP).

E. Sato, S. Izumo, M. Osame, 1997, Leukemia.

Inter- and Intra-laboratory Variability in HTLV-1 Provirus Load Quantification Using Real-Time Polymerase Chain Reaction Assays: A Multi-Center Study

M. Satake, K. Yamaguchi, S. Kamihira, 2016 .

Japan: A Collaborative Study

D. Sasaki, H. Hasegawa, T. Yamochi, 2015 .

Standardization of Quantitative PCR for Human T-cell Leukemia Virus Type 1 in 1 Japan : A Collaborative Study 2 3 Running title : Standardization of HTLV-1 qPCR 4 5

Ochiai, S. Saito, M. Satake, 2015 .

Intra‐ and inter‐laboratory variability in human T‐cell leukemia virus type‐1 proviral load quantification using real‐time polymerase chain reaction assays: A multi‐center study

M. Satake, K. Yamaguchi, S. Kamihira, 2010, Cancer science.

l-Caldesmon Regulates Proliferation and Migration of Vascular Smooth Muscle Cells and Inhibits Neointimal Formation After Angioplasty

D. Ingber, K. Okumura, T. Murohara, 2006, Arteriosclerosis, thrombosis, and vascular biology.

Establishment of a novel diagnostic test algorithm for human T-cell leukemia virus type 1 infection with line immunoassay replacement of western blotting: a collaborative study for performance evaluation of diagnostic assays in Japan

S. Saito, M. Satake, A. Utsunomiya, 2020, Retrovirology.

Proviral Features of Human T Cell Leukemia Virus Type 1 in Carriers with Indeterminate Western Blot Analysis Results

S. Saito, M. Satake, K. Yamaguchi, 2017, Journal of Clinical Microbiology.

Salvage in Patients With Primary Acute Myocardial Infarction The Impact of the Capability of Circulating Progenitor Cell to Differentiate on Myocardial

K. Okumura, T. Murohara, Y. Numaguchi, 2006 .

S. Saito, M. Satake, A. Utsunomiya, 2020, Retrovirology.

Anti-ganglionic acetylcholine receptor antibodies in functional neurological symptom disorder/conversion disorder

M. Yamakuchi, T. Hashiguchi, H. Takashima, 2023, Frontiers in Neurology.

Effects of host restriction factors and the HTLV-1 subtype on susceptibility to HTLV-1-associated myelopathy/tropical spastic paraparesis

E. Matsuura, S. Izumo, H. Takashima, 2017, Retrovirology.

Population Pharmacokinetics and Exposure-Response Relationships of Naldemedine

R. Kubota, T. Wajima, K. Fukumura, 2018, Pharmaceutical Research.

(HAM-TSP) (HTLV-1)-infected T cells in HTLV-1-associated myelopathy Frequent clonal proliferation of human T-cell leukemia virus type 1

M. Yoshida, J. Fujisawa, S. Sonoda, 2011 .

Efficacy of l‐Arginine treatment in patients with HTLV‐1‐associated neurological disease

E. Matsuura, Y. Yamano, H. Takashima, 2022, Annals of clinical and translational neurology.

Clinical Drug-Drug Interaction Studies to Evaluate the Effects of a P-Glycoprotein Inhibitor, CYP3A Inhibitors, and a CYP3A Inducer on the Pharmacokinetics of Naldemedine in Healthy Subjects

R. Kubota, Y. Tada, Eriko Ogura, 2020, Clinical Drug Investigation.

Identification and tracking of HTLV-1–infected T cell clones in virus-associated neurologic disease

S. Nakahata, H. Takashima, A. Yoshimura, 2023, JCI insight.

I. Kawase, Y. Fujio, J. Azuma, 2012, European Journal of Clinical Pharmacology.

Clinical presentation of axial myopathy in two siblings with HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)

E. Matsuura, H. Takashima, A. Yoshimura, 2015, BMC Neurology.

Reduced Expression of Excitatory Amino Acid Transporter 2 and Diffuse Microglial Activation in the Cerebral Cortex in AIDS Cases With or Without HIV Encephalitis

H. Budka, E. Gelpí, S. Izumo, 2009, Journal of neuropathology and experimental neurology.

HTLV-1-associated myelopathy/tropical spastic paraplegia with sporadic late-onset nemaline myopathy: a case report

H. Takashima, R. Kubota, A. Hashiguchi, 2023, BMC Musculoskeletal Disorders.

Iliopsoas Muscle Weakness as a Key Diagnostic Marker in HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP)

H. Takashima, R. Kubota, D. Kodama, 2023, Pathogens.

Creation and validation of a bladder dysfunction symptom score for HTLV-1-associated myelopathy/tropical spastic paraparesis

J. Kira, H. Yonezawa, Takahiko Ueno, 2020, Orphanet Journal of Rare Diseases.

Effects of host restriction factors and the HTLV-1 subtype on susceptibility to HTLV-1-associated myelopathy/tropical spastic paraparesis

E. Matsuura, S. Izumo, H. Takashima, 2017, Retrovirology.

HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP): A comparative study to identify factors that influence disease progression

E. Matsuura, S. Izumo, H. Takashima, 2016, Journal of the Neurological Sciences.

Reduced Foxp3 expression with increased cytomegalovirus-specific CTL in HTLV-I-associated myelopathy

Yuetsu Tanaka, K. Arimura, R. Hirano, 2008, Journal of Neuroimmunology.

Two cases of male hypogonadal osteoporosis

I. Kitajima, S. Izumo, S. Iwata, 1989, Journal of Bone and Mineral Metabolism.

Development of reference material with assigned value for human T‐cell leukemia virus type 1 quantitative PCR in Japan

S. Saito, M. Satake, A. Utsunomiya, 2018, Microbiology and immunology.

Population pharmacokinetics of doripenem in Japanese subjects and Monte-Carlo simulation for patients with renal impairment.

R. Kubota, T. Wajima, T. Ishibashi, 2015, Journal of Infection and Chemotherapy.

Increased activated human T cell lymphotropic virus type I (HTLV-I) Tax11-19-specific memory and effector CD8+ cells in patients with HTLV-I-associated myelopathy/tropical spastic paraparesis: correlation with HTLV-I provirus load.

T. Greten, Masahiro Nagai, S. Jacobson, 2001, The Journal of infectious diseases.

Direct visualization of antigen-specific T cells: HTLV-1 Tax11-19- specific CD8(+) T cells are activated in peripheral blood and accumulate in cerebrospinal fluid from HAM/TSP patients.

E. Jaffee, T. Greten, D. Pardoll, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Epidemiology of progressive muscular dystrophy in Okinawa, Japan. Classification with molecular biological techniques.

M. Osame, K. Nakahara, I. Higuchi, 1991, Neuroepidemiology.

Accumulation of human T-lymphotropic virus type I (HTLV-I)-infected cells in the cerebrospinal fluid during the exacerbation of HTLV-I-associated myelopathy

K. Arimura, Tomonori Nakamura, S. Izumo, 2011, Journal of NeuroVirology.

Human T-lymphotropic virus type I infections in western India.

S. Sonoda, M. Nomoto, M. Osame, 1993, AIDS.

Menin mediates Tat-induced neuronal apoptosis in brain frontal cortex of SIV-infected macaques and in Tat-treated cells

Y. Liu, Y. Shao, S. Izumo, 2017, Oncotarget.

Ablation of Angiotensin IV Receptor Attenuates Hypofibrinolysis via PAI-1 Downregulation and Reduces Occlusive Arterial Thrombosis

K. Okumura, T. Murohara, Y. Numaguchi, 2009, Arteriosclerosis, thrombosis, and vascular biology.

Demonstration of human T lymphotropic virus type I (HTLV-I) tax-specific CD8+ lymphocytes directly in peripheral blood of HTLV-I-associated myelopathy/tropical spastic paraparesis patients by intracellular cytokine detection.

S. Jacobson, R. Kubota, A. Manns, 1998, Journal of immunology.

Neuropathology of HTLV-1-associated myelopathy (HAM/TSP).

S. Izumo, R. Kubota, F. Umehara, 1997, Leukemia.

Severe loss of invariant NKT cells exhibiting anti-HTLV-1 activity in patients with HTLV-1-associated disorders.

A. Utsunomiya, S. Aratani, T. Nakajima, 2009, Blood.

Familial Clusters of HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis

E. Matsuura, S. Izumo, H. Takashima, 2014, PloS one.

S. Izumo, R. Kubota, M. Yoshimitsu, 2011, Human immunology.