T. Ohashi

发表

Comparison of topiroxostat and allopurinol in Japanese hyperuricemic patients with or without gout: a phase 3, multicentre, randomized, double‐blind, double‐dummy, active‐controlled, parallel‐group study

T. Hosoya, Y. Ogawa, H. Hashimoto, 2016, Journal of clinical pharmacy and therapeutics.

Clinical efficacy and safety of topiroxostat in Japanese hyperuricemic patients with or without gout: a randomized, double-blinded, controlled phase 2b study

T. Hosoya, T. Ohashi, Tomomitsu Sasaki, 2016, Clinical Rheumatology.

The interactions of bromocriptine and lergotrile with dopamine and α-adrenergic receptors

F. Hata, T. Ohashi, M. Goldstein, 2005, Journal of Neural Transmission.

Defective regulation of IFNγ and IL-12 by endogenous IL-10 in progressive MS

H. Weiner, S. Khoury, M. Comabella, 2000, Neurology.

Study on zwitter-ionization of drugs. II. Synthesis and pharmacological activity of some N-[3-(5H-dibenzo[a, d]cyclohepten-5-ylidene) propyl]-N-methylamino- and N-[3-(6H-dibenz[b, e]oxepin-11-ylidene) propyl]-N-methylamino-alkanoic acid derivatives and related compounds.

T. Ohashi, H. Kato, H. Sawanishi, 1993, Chemical & pharmaceutical bulletin.

Dotinurad versus benzbromarone in Japanese hyperuricemic patient with or without gout: a randomized, double-blind, parallel-group, phase 3 study

T. Hosoya, T. Ohashi, Tomomitsu Sasaki, 2020, Clinical and Experimental Nephrology.

Clinical efficacy and safety of dotinurad, a novel selective urate reabsorption inhibitor, in Japanese hyperuricemic patients with or without gout: randomized, multicenter, double-blind, placebo-controlled, parallel-group, confirmatory phase 2 study

T. Hosoya, T. Ohashi, Tomomitsu Sasaki, 2019, Clinical and Experimental Nephrology.

Clinical efficacy and safety of dotinurad, a novel selective urate reabsorption inhibitor, in Japanese hyperuricemic patients with or without gout: an exploratory, randomized, multicenter, double-blind, placebo-controlled, parallel-group early phase 2 study

T. Hosoya, T. Ohashi, Tomomitsu Sasaki, 2019, Clinical and Experimental Nephrology.

Open-label study of long-term administration of dotinurad in Japanese hyperuricemic patients with or without gout

T. Hosoya, T. Ohashi, Tomomitsu Sasaki, 2019, Clinical and Experimental Nephrology.

Effects of RS-601, a Novel Leukotriene D4/Thromboxane A2 Dual Receptor Antagonist, on Asthmatic Responses in Guinea Pigs

T. Yamada, T. Ohashi, Hiroyuki Tanaka, 2003, Pharmacology.

Multicenter, Open-Label Study of Long-Term Topiroxostat (FYX-051) Administration in Japanese Hyperuricemic Patients with or Without Gout

T. Hosoya, Y. Ogawa, T. Ohashi, 2018, Clinical Drug Investigation.

Studies on the novel antiallergic agent HSR-609: its penetration into the central nervous system in mice and guinea pigs and its selectivity for the histamine H1-receptor.

T. Ohashi, K. Kawamura, M. Kakiuchi, 1997, Japanese journal of pharmacology.

Inhibitory Effect of HSR‐6071, A New Anti‐allergic Agent, on Experimental Asthma in Rats and Guinea‐pigs

E. Makino, T. Ohashi, H. Nagai, 1990, The Journal of pharmacy and pharmacology.

Amphoteric drugs. I. Synthesis and antiallergic activity of [4-(diphenylmethoxy)piperidino]-, [4-(diphenylmethyl)piperazinyl]- and [4-(diphenylmethylene)piperidino]alkanoic acid derivatives.

T. Ohashi, H. Kato, H. Sawanishi, 1994, Chemical & pharmaceutical bulletin.

Synthesis and thromboxane A2 antagonistic activity of [[1-aryl(or benzyl)-1-(benzenesulfonamido)methyl]phenyl]alkanoic acid derivatives.

K. Kato, S. Sakurai, T. Ohashi, 1996, Chemical & pharmaceutical bulletin.

Adrenergic mechanism in cold stored taenia caecum after rewarming.

J. T. Miyahara, T. Ohashi, S. Shibata, 1977, European journal of pharmacology.

Immunohistopathological characterization of pig pneumonia caused by a combined Aujeszky's disease virus and Actinobacillus pleuropneumoniae infection.

K. Kimura, N. Tanimura, T. Ohashi, 1997, Journal of comparative pathology.

Regulation of human interleukin-2 gene: Functional DNA sequences in the 5′ flanking region for the gene expression in activated T lymphocytes

T. Taniguchi, H. Shibuya, T. Fujita, 1986, Cell.

Amphoteric drugs. 3. Synthesis and antiallergic activity of 3-[(5,11-dihydro[1]benzoxepino[4,3-b]pyridin-11- ylidene)piperidino]propionic acid derivatives and related compounds.

T. Ohashi, H. Kato, S. Yasuda, 1995, Journal of medicinal chemistry.

Pharmacological studies on supersensitization. XI. Inhibitory effect of dibenamine on tripelennamine-N,N-dimethyl-N',N'-dibenzylethylenediamine- and N,N-dibenzyl-N', N'-dimethyl-1, 2-propanediamine-induced supersensitivity of isolated vas deferens of guinea pig.

T. Ohashi, Y. Gomi, K. Araki, 1983, Journal of pharmacobio-dynamics.

Pharmacological studies on supersensitization. X. Effect of tripelennamine, N,N-dimethyl-N',N'-dibenzylethylenediamine and N,N-dibenzyl-N',N'-dimethyl-1,2-propanediamine on the utilization of calcium in acetylcholine-induced contraction of isolated vas deferens of guinea pig.

T. Ohashi, Y. Gomi, K. Araki, 1983, Journal of Pharmacobio-Dynamics.

Pharmacological studies on supersensitization. IX. Non-specific supersensitivity of vas deferens of guinea pig induced by tripelennamine, N,N-dimethyl-N',N'-dibenzylethylenediamine and N,N-dibenzyl-N',N'-dimethyl-1,2-propanediamine.

T. Ohashi, Y. Gomi, K. Araki, 1982, Journal of pharmacobio-dynamics.

Clinical efficacy and safety of topiroxostat in Japanese male hyperuricemic patients with or without gout: an exploratory, phase 2a, multicentre, randomized, double‐blind, placebo‐controlled study

T. Hosoya, H. Hashimoto, T. Ohashi, 2016, Journal of clinical pharmacy and therapeutics.

Studies on antiallergic agents. I. Synthesis and antiallergic activity of novel pyrazine derivatives.

T. Ohashi, H. Kato, N. Iwasaki, 1990, Chemical & pharmaceutical bulletin.

Pharmacokinetic/pharmacodynamic modeling and simulation of dotinurad, a novel uricosuric agent, in healthy volunteers

I. Tamai, T. Ohashi, T. Iwanaga, 2019, Pharmacology research & perspectives.

Pharmacological studies on the novel antiallergic agent HSR-609: its effects on behavior in mice and electroencephalograms in rabbits.

T. Ohashi, K. Tanaka, M. Kakiuchi, 1997, Japanese journal of pharmacology.

Potent inhibition of spontaneous rhythmic contraction by a novel beta 2-adrenoceptor agonist, HSR-81, in pregnant rat uterus.

M. Asano, M. Asano, T. Ohashi, 1996, European journal of pharmacology.

Central nervous system effects of the novel antiallergic agent HSR-609 and typical antiallergic agents using behavioral and electroencephalographic analyses in dogs.

T. Ohashi, K. Tanaka, M. Kakiuchi, 1998, Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology.

Effects of mild and moderate renal dysfunction on pharmacokinetics, pharmacodynamics, and safety of dotinurad: a novel selective urate reabsorption inhibitor

T. Hosoya, H. Fukase, T. Ohashi, 2019, Clinical and Experimental Nephrology.

Defective regulation of IFNgamma and IL-12 by endogenous IL-10 in progressive MS.

H. Weiner, S. Khoury, M. Comabella, 2000, Neurology.

Structure and Regulation of the Genes Encoding Interleukin-2 and its Receptor

T. Taniguchi, T. Fujita, M. Hatakeyama, 1986 .

Synthesis and dual antagonistic activity against thromboxane A2 and leukotriene D4 of [4-[1-(benzenesulfonamido)alkyl]phenyl]alkanoic acid derivatives.

K. Kato, S. Sakurai, T. Ohashi, 1997, Chemical & pharmaceutical bulletin.

Ideal pharmacokinetic profile of dotinurad as a selective urate reabsorption inhibitor.

T. Ohashi, Tomomitsu Sasaki, T. Iwanaga, 2020, Drug metabolism and pharmacokinetics.

Clinical pharmacological study of dotinurad administered to male and female elderly or young subjects

T. Ohashi, Tomomitsu Sasaki, D. Okui, 2019, Clinical and Experimental Nephrology.

The effect of tulobuterol tape on histamine-induced bronchoconstriction in conscious guinea pigs: long duration of action.

T. Ohashi, K. Kawamura, S. Shimada, 1999, Japanese Journal of Pharmacology.