S. Clarke

发表

Sulfamethoxazole and Its Metabolite Nitroso Sulfamethoxazole Stimulate Dendritic Cell Costimulatory Signaling1

Charlotte A. Ashby, M. Pirmohamed, M. Rieder, 2007, The Journal of Immunology.

FORMATION AND PROTEIN BINDING OF THE ACYL GLUCURONIDE OF A LEUKOTRIENE B4 ANTAGONIST (SB-209247): RELATION TO SPECIES DIFFERENCES IN HEPATOTOXICITY

B. K. Park, J. Maggs, J. Kenny, 2005, Drug Metabolism and Disposition.

Characterization of the cytochrome P450 enzymes involved in the in vitro metabolism of rosiglitazone.

S. Clarke, R. Chenery, S. Baldwin, 2001, British journal of clinical pharmacology.

A critical evaluation of the experimental design of studies of mechanism based enzyme inhibition, with implications for in vitro-in vivo extrapolation.

K Rowland-Yeo, G. Tucker, A. Rostami-Hodjegan, 2006, Current drug metabolism.

In vitro assessment of human cytochrome P450.

S. Clarke, 1998, Xenobiotica; the fate of foreign compounds in biological systems.

Costimulatory Signaling Sulfamethoxazole Stimulate Dendritic Cell Sulfamethoxazole and Its Metabolite Nitroso

Charlotte A. Ashby, M. Pirmohamed, M. Rieder, 2007 .

Towards depersonalized abacavir therapy: chemical modification eliminates HLA-B*57 : 01-restricted CD8+ T-cell activation

B. K. Park, D. Naisbitt, A. Owen, 2015, AIDS.

Biarylcarbamoylindolines are novel and selective 5-HT(2C) receptor inverse agonists: identification of 5-methyl-1-[[2-[(2-methyl-3-pyridyl)oxy]- 5-pyridyl]carbamoyl]-6-trifluoromethylindoline (SB-243213) as a potential antidepressant/anxiolytic agent.

D. Middlemiss, S. Lightowler, S. Bromidge, 2000, Journal of medicinal chemistry.

Investigation of the immunogenicity of diclofenac and diclofenac metabolites.

B. K. Park, D. Naisbitt, X. Meng, 2007, Toxicology letters.

CYP4A1 gene transfection studies and the peroxisome proliferator-activated receptor: development of a high-throughput assay to detect peroxisome proliferators

G. Gibson, S. Clarke, S. Giddings, 1997, European Journal of Drug Metabolism and Pharmacokinetics.

Lactational transfer of 3,3',4,4'-tetrachloro- and 2,2',4,4',5,5'-hexachlorobiphenyl induces cytochrome P450IVA1 in neonates. Evidence for a potential synergistic mechanism.

G. Gibson, K. Haegele, S. Clarke, 1992, Biochemical pharmacology.

Multisite kinetic models for CYP3A4: simultaneous activation and inhibition of diazepam and testosterone metabolism.

J. Houston, S. Clarke, Kathryn E. Kenworthy, 2001, Drug metabolism and disposition: the biological fate of chemicals.

Nonenzymatic Formation of a Novel Hydroxylated Sulfamethoxazole Derivative in Human Liver Microsomes: Implications for Bioanalysis of Sulfamethoxazole Metabolites

B. K. Park, D. Naisbitt, J. Maggs, 2008, Drug Metabolism and Disposition.

Aldehyde Oxidase‐catalysed Oxidation of Methotrexate in the Liver of Guinea‐pig, Rabbit and Man

J. Brown, C. Beedham, S. Clarke, 1999, The Journal of pharmacy and pharmacology.

Metabolism and disposition of 14C-granisetron in rat, dog and man after intravenous and oral dosing.

R. Haddock, F. R. Woods, J. Bloomer, 1994, Xenobiotica; the fate of foreign compounds in biological systems.

6-Chloro-5-methyl-1-[[2-[(2-methyl-3-pyridyl)oxy]-5-pyridyl]carbamoyl]- indoline (SB-242084): the first selective and brain penetrant 5-HT2C receptor antagonist.

F E Blaney, S. Bromidge, I. Forbes, 1997, Journal of medicinal chemistry.

Ketoconazole and sulphaphenazole as the respective selective inhibitors of P4503A and 2C9.

G. Smith, J. Bloomer, S. Clarke, 1995, Xenobiotica; the fate of foreign compounds in biological systems.

In vitro oxidation of famciclovir and 6-deoxypenciclovir by aldehyde oxidase from human, guinea pig, rabbit, and rat liver.

M. Rashidi, J. Smith, C. Beedham, 1997, Drug metabolism and disposition: the biological fate of chemicals.

Syntheses and characterization of the acyl glucuronide and hydroxy metabolites of diclofenac.

B. K. Park, J. Maggs, X. Meng, 2004, Journal of medicinal chemistry.

In vitro identification of the human cytochrome P450 enzymes involved in the metabolism of R(+)- and S(-)-carvedilol.

S. Clarke, S E Clarke, H G Oldham, 1997, Drug metabolism and disposition: the biological fate of chemicals.

Lauric acid as a model substrate for the simultaneous determination of cytochrome P450 2E1 and 4A in hepatic microsomes.

J. Bloomer, S. Clarke, R. Chenery, 1994, Chemical research in toxicology.

Role of aldehyde oxidase in the in vitro conversion of famciclovir to penciclovir in human liver.

S. Clarke, R. Chenery, A. Harrell, 1995, Drug metabolism and disposition: the biological fate of chemicals.

Multisite kinetic analysis of interactions between prototypical CYP3A4 subgroup substrates: midazolam, testosterone, and nifedipine.

A. Galetin, J. Houston, S. Clarke, 2003, Drug metabolism and disposition: the biological fate of chemicals.

CYP3A4 drug interactions: correlation of 10 in vitro probe substrates.

J B Houston, J. Houston, J. Bloomer, 1999, British journal of clinical pharmacology.

Managing the challenge of chemically reactive metabolites in drug development

Ian D. Wilson, Alan Boobis, Chris E. P. Goldring, 2011, Nature Reviews Drug Discovery.

Utility of metabolic stability screening: comparison of in vitro and in vivo clearance

P. Jeffrey, S. Clarke, S E Clarke, 2001, Xenobiotica; the fate of foreign compounds in biological systems.

5-Chloro-N-(4-methoxy-3-piperazin-1-yl- phenyl)-3-methyl-2-benzothiophenesulfon- amide (SB-271046): a potent, selective, and orally bioavailable 5-HT6 receptor antagonist.

A. Brown, D. Middlemiss, S. Bromidge, 1999, Journal of medicinal chemistry.

Characterisation of the cytochrome P450 enzymes involved in the in vitro metabolism of granisetron.

G. Smith, J. Bloomer, S. Clarke, 1994, British journal of clinical pharmacology.

Incorporation of cytochrome b5 into rat liver microsomal membranes. Impairment of cytochrome P-450-dependent mixed function oxidase activity.

G. Gibson, S. Clarke, 1986, Biochemical pharmacology.

Quinidine and haloperidol as modifiers of CYP3A4 activity: multisite kinetic model approach.

A. Galetin, J. Houston, S. Clarke, 2002, Drug metabolism and disposition: the biological fate of chemicals.

Characterization of the inhibition of P4501A2 by furafylline.

S. Clarke, R. Chenery, A. Ayrton, 1994, Xenobiotica; the fate of foreign compounds in biological systems.

CYTOCHROME P450 GENE INDUCTION IN RATS EX VIVO ASSESSED BY QUANTITATIVE REAL-TIME REVERSE TRANSCRIPTASE-POLYMERASE CHAIN REACTION (TAQMAN)

Charlotte A. Ashby, P. Murdock, S. Hood, 2006, Drug Metabolism and Disposition.

Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.

J. Ambroso, H. Ellens, M. Reese, 2012, Chemical research in toxicology.

Cytochrome P-450 in the housefly: induction, substrate specificity and comparison to three rat hepatic isoenzymes.

G. Gibson, S. Clarke, C. Brealey, 1989, Xenobiotica; the fate of foreign compounds in biological systems.

Activation of T cells by carbamazepine and carbamazepine metabolites.

M. Pirmohamed, B. K. Park, D. Naisbitt, 2006, The Journal of allergy and clinical immunology.

Characterization of SB‐271046: A potent, selective and orally active 5‐HT6 receptor antagonist

D. Middlemiss, G. W. Price, S. Bromidge, 2000, British journal of pharmacology.

Bicyclic piperazinylbenzenesulphonamides are potent and selective 5-HT6 receptor antagonists.

S. Bromidge, F. King, G. Riley, 2002, Bioorganic & medicinal chemistry letters.

In vitro identification of the P450 enzymes responsible for the metabolism of ropinirole.

J. Bloomer, S. Clarke, R. Chenery, 1997, Drug metabolism and disposition: the biological fate of chemicals.

Expression, purification, and biochemical characterization of a human cytochrome P450 CYP2D6-NADPH cytochrome P450 reductase fusion protein.

C. Wolf, M. Paine, S. Clarke, 2001, Archives of biochemistry and biophysics.

Multiple adduction reactions of nitroso sulfamethoxazole with cysteinyl residues of peptides and proteins: implications for hapten formation.

B. K. Park, D. Naisbitt, R. Jenkins, 2009, Chemical research in toxicology.

An integrated reactive metabolite evaluation approach to assess and reduce safety risk during drug discovery and development.

Jeffrey Ambroso, Eric Yang, J. Ambroso, 2011, Chemico-biological interactions.

Phenyl benzenesulfonamides are novel and selective 5-HT6 antagonists: identification of N-(2,5-dibromo-3-fluorophenyl)-4-methoxy-3-piperazin-1-ylbenzenesulfonamide (SB-357134).

S. Bromidge, F. King, G. Riley, 2001, Bioorganic & medicinal chemistry letters.

CYTOCHROME P450 GENE INDUCTION IN RATS EX VIVO ASSESSED BY QUANTITATIVE REAL-TIME REVERSE TRANSCRIPTASE-POLYMERASE CHAIN REACTION (TAQMAN)

Charlotte A. Ashby, P. Murdock, S. Hood, 2006, Drug Metabolism and Disposition.