Saheem A. Zaidi

发表

Understanding Water and Its Many Roles in Biological Structure: Ways to Exploit a Resource for Drug Discovery

Pietro Cozzini, Francesca Spyrakis, Glen E. Kellogg, 2015 .

Structure-Based Discovery of New Antagonist and Biased Agonist Chemotypes for the Kappa Opioid Receptor.

R. Stevens, Xi-Ping Huang, B. Roth, 2017, Journal of medicinal chemistry.

Exploration on natural product anibamine side chain modification toward development of novel CCR5 antagonists and potential anti-prostate cancer agents.

F. Zhang, Saheem A. Zaidi, Guoyan G. Xu, 2015, Bioorganic & medicinal chemistry letters.

Novel Dual-Target μ-Opioid Receptor and Dopamine D3 Receptor Ligands as Potential Nonaddictive Pharmacotherapeutics for Pain Management.

V. Katritch, A. Newman, Alessandro Bonifazi, 2021, Journal of medicinal chemistry.

Understanding ligand binding, selectivity and functions on the G protein-coupled receptors: A molecular modeling approach

Saheem A. Zaidi, S. Zaidi, 2014 .

Novel Class of Psychedelic Iboga Alkaloids Disrupts Opioid Addiction States

V. Katritch, J. Javitch, J. Pintar, 2021, bioRxiv.

Synthesis and Characterization of 5-Hydroxy-2-(2-phenylethyl)chromone (5-HPEC) and Its Analogues as Non-nitrogenous 5-HT2B Ligands.

Saheem A. Zaidi, Yan Zhang, Dwight A Williams, 2015, Journal of natural products.

Design, synthesis, and biological evaluation of 14-heteroaromatic-substituted naltrexone derivatives: pharmacological profile switch from mu opioid receptor selectivity to mu/kappa opioid receptor dual selectivity.

D. Selley, W. Dewey, Saheem A. Zaidi, 2013, Journal of medicinal chemistry.

Structure of the Nanobody-Stabilized Active State of the Kappa Opioid Receptor

Ryan T. Strachan, G. Pasternak, R. Stevens, 2018, Cell.

17-Cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-(4'-pyridylcarboxamido)morphinan (NAP) Modulating the Mu Opioid Receptor in a Biased Fashion.

D. Selley, J. Streicher, W. Dewey, 2016, ACS chemical neuroscience.

Ligand-Dependent Effects of Methionine-8 Oxidation in Parathyroid Hormone Peptide Analogs.

V. Katritch, T. Gardella, J. Vilardaga, 2020, Endocrinology.

Crystal structure of the Frizzled 4 receptor in a ligand-free state

R. Stevens, Fei Xu, V. Katritch, 2018, Nature.

Design, syntheses, and pharmacological characterization of 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(isoquinoline-3'-carboxamido)morphinan analogues as opioid receptor ligands.

G. Kellogg, D. Selley, P. Mosier, 2015, Bioorganic & medicinal chemistry.

5-Hydroxy-2-(2-phenylethyl)chromone (5-HPEC): a novel non-nitrogenous ligand for 5-HT2B receptor.

Saheem A. Zaidi, Yan Zhang, Dwight A Williams, 2014, Bioorganic & medicinal chemistry letters.

Controlling opioid receptor functional selectivity by targeting distinct subpockets of the orthosteric site

Samuel T. Slocum, G. Pasternak, B. Roth, 2021, eLife.

6β-N-Heterocyclic Substituted Naltrexamine Derivative BNAP: A Peripherally Selective Mixed MOR/KOR Ligand.

D. Selley, W. Dewey, Saheem A. Zaidi, 2016, ACS chemical neuroscience.

Dynamic Strategic Bond Analysis Yields a Ten-Step Synthesis of 20-nor-Salvinorin A, a Potent κ-OR Agonist

R. Stevens, V. Katritch, L. Bohn, 2017, ACS central science.

Novel Class of Psychedelic Iboga Alkaloids Disrupts Opioid Use

V. Katritch, J. Javitch, J. Pintar, 2021, bioRxiv.

Small molecule inhibits activity of scavenger receptor A: Lead identification and preliminary studies.

Xiaofei Yu, Saheem A. Zaidi, Xiang-Yang Wang, 2015, Bioorganic & medicinal chemistry letters.

Regio- and stereoselective syntheses of the natural product CCR5 antagonist anibamine and its three olefin isomers.

Kendra M. Haney, G. Kellogg, Saheem A. Zaidi, 2011, The Journal of organic chemistry.

Binding mode characterization of 6α- and 6β-N-heterocyclic substituted naltrexamine derivatives via docking in opioid receptor crystal structures and site-directed mutagenesis studies: application of the 'message-address' concept in development of mu opioid receptor selective antagonists.

G. Kellogg, D. Selley, P. Mosier, 2013, Bioorganic & medicinal chemistry.

Design, syntheses, and characterization of pharmacophore based chemokine receptor CCR5 antagonists as anti prostate cancer agents.

Saheem A. Zaidi, J. Ware, Zhuo Zhang, 2013, European journal of medicinal chemistry.

Structure-based design of bitopic ligands for the µ-opioid receptor

Samuel T. Slocum, B. Roth, V. Katritch, 2022, Nature.

Structural insight into the activation of a class B G-protein-coupled receptor by peptide hormones in live human cells

V. Katritch, I. Coin, Saheem A. Zaidi, 2017, eLife.

Harnessing Ion-Binding Sites for GPCR Pharmacology

Vsevolod Katritch, Bryan L Roth, Barbara Zarzycka, 2019, Pharmacological Reviews.

Structural insights into angiotensin receptor signaling modulation by balanced and biased agonists

Xi-Ping Huang, B. Roth, V. Katritch, 2023, The EMBO journal.

Structural Characterization of KOR Inactive and Active States for 3D Pharmacology and Drug Discovery.

V. Katritch, Saheem A. Zaidi, S. Zaidi, 2021, Handbook of experimental pharmacology.

Binding mode analyses of NAP derivatives as mu opioid receptor selective ligands through docking studies and molecular dynamics simulation.

Saheem A. Zaidi, Yan Zhang, Huiqun Wang, 2017, Bioorganic & medicinal chemistry.

Pharmacological and Physicochemical Properties Optimization for Dual-Target Dopamine D3 (D3R) and μ-Opioid (MOR) Receptor Ligands as Potentially Safer Analgesics.

Antonina L. Nazarova, V. Katritch, J. R. Lane, 2023, Journal of medicinal chemistry.

Understanding molecular interactions between scavenger receptor A and its natural product inhibitors through molecular modeling studies.

Xiao-mei Zhang, Xiaofei Yu, Saheem A. Zaidi, 2017, Journal of molecular graphics & modelling.

Intracellular passage of Na+ in an active state g-protein coupled receptor

Catarina A. Carvalheda, Andrei V. Pisliakov, V. Katritch, 2017, bioRxiv.