D. Lonard

发表

ERK3 signals through SRC-3 coactivator to promote human lung cancer cell invasion.

I. Wistuba, B. O’Malley, M. Tsai, 2012, The Journal of clinical investigation.

CAPER Is Vital for Energy and Redox Homeostasis by Integrating Glucose-Induced Mitochondrial Functions via ERR-α-Gabpa and Stress-Induced Adaptive Responses via NF-κB-cMYC

G. Michailidis, B. O’Malley, M. Tsai, 2015, PLoS genetics.

A steroid receptor coactivator stimulator (MCB-613) attenuates adverse remodeling after myocardial infarction

B. O’Malley, Yongcheng Song, A. Sikora, 2020, Proceedings of the National Academy of Sciences.

Small molecule inhibition of the steroid receptor coactivators, SRC-3 and SRC-1.

B. O’Malley, T. Palzkill, D. Chow, 2011, Molecular endocrinology.

HER2 Signaling Drives DNA Anabolism and Proliferation through SRC-3 Phosphorylation and E2F1-Regulated Genes.

S. Hilsenbeck, C. Creighton, R. Lanz, 2016, Cancer research.

Proteasome-dependent degradation of the human estrogen receptor.

B. O’Malley, Z. Nawaz, Carolyn L. Smith, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Defining the mammalian coactivation of hepatic 12-h clock and lipid metabolism

S. Jung, N. Putluri, Bokai Zhu, 2022, Cell reports.

Atypical protein kinase C regulates dual pathways for degradation of the oncogenic coactivator SRC-3/AIB1.

B. O’Malley, M. Tsai, S. Tsai, 2008, Molecular cell.

Bufalin is a potent small-molecule inhibitor of the steroid receptor coactivators SRC-3 and SRC-1.

P. Griffin, B. O’Malley, T. Palzkill, 2014, Cancer research.

Steroid receptor coactivator 3 (SRC-3/AIB1) is enriched and functional in mouse and human Tregs

N. McKenna, B. O’Malley, Q. Feng, 2021, Scientific Reports.

Human endometrial stromal cell decidualization requires transcriptional reprogramming by PLZF†

L. D. White, R. Lanz, Q. Mo, 2017, Biology of Reproduction.

Proteomic profiling identifies key coactivators utilized by mutant ERα proteins as potential new therapeutic targets

Ross A. Hamilton, J. Lei, A. Malovannaya, 2018, Oncogene.

Spatial definition of the human progesterone receptor-B transcriptional complex

B. O’Malley, P. Yi, Xinzhe Yu, 2022, iScience.

Title : HER 2 signaling drives DNA anabolism and proliferation through SRC-3 phosphorylation and E 2 F 1-regulated genes

S. Hilsenbeck, C. Creighton, R. Lanz, 2016 .

Emerging roles of steroid receptor coactivators in stromal cell responses.

B. O’Malley, D. Lonard, A. Rohira, 2020, The Journal of endocrinology.

miRNA Regulatory Circuits in ES Cells Differentiation: A Chemical Kinetics Modeling Approach

P. Gunaratne, A. Cooney, R. Azencott, 2011, PloS one.

Gene transcription: Two worlds merged

B. O’Malley, D. Lonard, 2008, Nature.

Steroid receptor coactivator-3 inhibition generates breast cancer antitumor immune microenvironment

D. Lonard, Bert W. O’Malley, N. Sung, 2022, Breast Cancer Research.

Decidualization of human endometrial stromal cells requires steroid receptor coactivator-3

F. DeMayo, J. Lydon, Maria M. Szwarc, 2022, Frontiers in Reproductive Health.

Wound Healing-related Functions of the p160 Steroid Receptor Coactivator Family

B. O’Malley, D. Lonard, Lisa K Mullany, 2020, Endocrinology.

The 26S Proteasome Is Required for Estrogen Receptor-α and Coactivator Turnover and for Efficient Estrogen Receptor-α Transactivation

B. O’Malley, Z. Nawaz, Carolyn L. Smith, 2000 .

Control of prothoracic gland activity by juvenile hormone in fourth instar Manduca sexta larvae

G. Bhaskaran, D. Lonard, K. Dahm, 1996 .

Drug Combination in Cancer Treatment—From Cocktails to Conjugated Combinations

B. O’Malley, D. Lonard, G. Gellerman, 2021, Cancers.

A steroid receptor coactivator small molecule “stimulator” attenuates post-stroke ischemic brain injury

C. Dacso, T. Lazaro, D. Lonard, 2022, Frontiers in Molecular Neuroscience.

Nuclear receptor coregulators: judges, juries, and executioners of cellular regulation.

B. O’Malley, D. Lonard, David M Lonard, 2007, Molecular cell.

Ubiquitin- and ATP-independent proteolytic turnover of p21 by the REGgamma-proteasome pathway.

B. O’Malley, Xiaotao Li, J. Monaco, 2007, Molecular cell.

The SRC-3/AIB1 Coactivator Is Degraded in a Ubiquitin- and ATP-Independent Manner by the REGγ Proteasome

A. Malovannaya, J. Qin, B. O’Malley, 2006, Cell.

Tumor Suppressor Role for the SPOP Ubiquitin Ligase in Signal-Dependent Proteolysis of the Oncogenic Coactivator SRC-3/AIB1

B. O’Malley, Junjiang Fu, Jianming Xu, 2011, Oncogene.

USP15-dependent lysosomal pathway controls p53-R175H turnover in ovarian cancer cells

K. Wong, J. Richards, D. Lonard, 2018, Nature Communications.

Uterine function in the mouse requires speckle-type poz protein†

F. DeMayo, J. Lydon, Maria M. Szwarc, 2018, Biology of Reproduction.

Prostate cancer-associated mutations in speckle-type POZ protein (SPOP) regulate steroid receptor coactivator 3 protein turnover

M. Rubin, C. Coarfa, F. Demichelis, 2013, Proceedings of the National Academy of Sciences.

SRC-3 Coactivator Functional Lifetime Is Regulated by a Phospho-Dependent Ubiquitin Time Clock

B. O’Malley, Q. Feng, R. Wu, 2007, Cell.

The Angelman Syndrome-Associated Protein, E6-AP, Is a Coactivator for the Nuclear Hormone Receptor Superfamily

M. Tsai, Z. Nawaz, S. Tsai, 1999, Molecular and Cellular Biology.

Nuclear receptor coregulators and human disease.

R. Lanz, B. O’Malley, D. Lonard, 2008, Endocrine reviews.

A genome-scale CRISPR Cas9 dropout screen identifies synthetically lethal targets in SRC-3 inhibited cancer cells

B. O’Malley, D. Lonard, L. Qin, 2021, Communications biology.

Expanding functional diversity of the coactivators.

B. O’Malley, D. Lonard, 2005, Trends in biochemical sciences.

Emerging roles of the ubiquitin proteasome system in nuclear hormone receptor signaling.

D. Lonard, Bert W. O’Malley, B. O’Malley, 2009, Progress in molecular biology and translational science.

Nuclear Receptor Co-regulators

B. O’Malley, D. Lonard, 2014 .

Nutrigenomic Implications for Nuclear Receptor Coactivators

B. O’Malley, D. Lonard, 2011 .

Minireview: the SRC family of coactivators: an entrée to understanding a subset of polygenic diseases?

B. O’Malley, Rakesh Kumar, D. Lonard, 2010, Molecular endocrinology.

The Expanding Cosmos of Nuclear Receptor Coactivators

B. O’Malley, D. Lonard, Bert W. O'Malley, 2006, Cell.

Nuclear receptor coregulators: modulators of pathology and therapeutic targets

B. O’Malley, D. Lonard, 2012, Nature Reviews Endocrinology.

Steroid receptor coactivators – their role in immunity

D. Lonard, Bert W. O’Malley, B. O’Malley, 2022, Frontiers in Immunology.

Molecular Pathways: Targeting Steroid Receptor Coactivators in Cancer

B. O’Malley, D. Lonard, 2016, Clinical Cancer Research.

The Role of Steroid Receptor Coactivators in Hormone Dependent Cancers and Their Potential as Therapeutic Targets

B. O’Malley, D. Lonard, Lei Wang, 2016, Hormones and Cancer.

Characterization of a Steroid Receptor Coactivator Small Molecule Stimulator that Overstimulates Cancer Cells and Leads to Cell Stress and Death.

Fabio Stossi, Michael A. Mancini, Timothy Palzkill, 2015, Cancer cell.

SRC-3 coactivator regulates cell resistance to cytotoxic stress via TRAF4-mediated p53 destabilization.

M. Hung, W. Xia, B. O’Malley, 2013, Genes & development.

Steroid receptor coactivator-3 as a target for anaplastic thyroid cancer.

M. Willingham, Li Zhao, B. O’Malley, 2020, Endocrine-related cancer.

Short-term RANKL exposure initiates a neoplastic transcriptional program in the basal epithelium of the murine salivary gland.

K. Rajapakshe, C. Coarfa, M. Ittmann, 2019, Cytokine.

SRC-3 Coactivator Governs Dynamic Estrogen-Induced Chromatin Looping Interactions during Transcription.

Ross A. Hamilton, R. Lanz, B. O’Malley, 2018, Molecular cell.

REGγ modulates p53 activity by regulating its cellular localization

Shanlou Qiao, G. Gao, Honglin Luo, 2010, Journal of Cell Science.

Development of improved SRC-3 inhibitors as breast cancer therapeutic agents.

Jianming Xu, D. Lonard, Prashi Jain, 2021, Endocrine-related cancer.

Development of potent small-molecule inhibitors to drug the undruggable steroid receptor coactivator-3

B. O’Malley, T. Palzkill, Jianming Xu, 2016, Proceedings of the National Academy of Sciences.

Identification of Verrucarin A as a Potent and Selective Steroid Receptor Coactivator-3 Small Molecule Inhibitor

P. Griffin, B. O’Malley, T. Palzkill, 2014, PloS one.

Nuclear receptor coactivators: master regulators of human health and disease.

B. O’Malley, D. Lonard, S. Dasgupta, 2014, Annual review of medicine.

SRC-3 Transcription-Coupled Activation, Degradation, and the Ubiquitin Clock: Is There Enough Coactivator to Go Around in Cells?

B. O’Malley, D. Lonard, 2008, Science Signaling.

OTU Domain-containing Ubiquitin Aldehyde-binding Protein 1 (OTUB1) Deubiquitinates Estrogen Receptor (ER) α and Affects ERα Transcriptional Activity*

A. Malovannaya, J. Qin, B. O’Malley, 2009, The Journal of Biological Chemistry.

Estrogen receptor-α: molecular mechanisms and interactions with the ubiquitin proteasome system

B. O’Malley, D. Lonard, Vladimir Stanišić, 2010, Hormone molecular biology and clinical investigation.

Steroid receptor coactivators present a unique opportunity for drug development in hormone‐dependent cancers

D. Lonard, A. Rohira, 2017, Biochemical pharmacology.

Targeting SRC Coactivators Blocks the Tumor-Initiating Capacity of Cancer Stem-like Cells.

B. O’Malley, Jianming Xu, A. Lu, 2017, Cancer research.

Drug-induced PD-L1 expression and cell stress response in breast cancer cells can be balanced by drug combination

B. O’Malley, S. Han, D. Lonard, 2019, Scientific Reports.

MCB-613 exploits a collateral sensitivity in drug resistant EGFR-mutant non-small cell lung cancer through covalent inhibition of KEAP1

Katherine R. Singleton, K. Wood, G. Robert, 2023, bioRxiv.

ERK 3 signals through SRC-3 coactivator to promote human lung cancer cell invasion

I. Wistuba, B. O’Malley, M. Tsai, 2018 .

Molecular perspectives on selective estrogen receptor modulators (SERMs): progress in understanding their tissue-specific agonist and antagonist actions

Carolyn L. Smith, D. Lonard, 2002, Steroids.

A repressive role for prohibitin in estrogen signaling.

B. Katzenellenbogen, B. O’Malley, Q. Feng, 2008, Molecular endocrinology.

XBP1 links the 12-hour clock to NAFLD and regulation of membrane fluidity and lipid homeostasis

B. O’Malley, N. Putluri, Bokai Zhu, 2020, Nature Communications.

A contemporary understanding of progesterone receptor function

B. O’Malley, Xiaotao Li, D. Lonard, 2004, Mechanisms of Ageing and Development.

SRC-3 inhibition blocks tumor growth of pancreatic ductal adenocarcinoma.

Han Liang, B. O’Malley, W. Fisher, 2019, Cancer letters.

Reduction of coactivator expression by antisense oligodeoxynucleotides inhibits ERalpha transcriptional activity and MCF-7 proliferation.

B. O’Malley, C. F. Bennett, Carolyn L. Smith, 2002, Molecular endocrinology.

The REGγ inhibitor NIP30 increases sensitivity to chemotherapy in p53-deficient tumor cells

R. Moses, Geng Chen, Chuangui Wang, 2020, Nature Communications.

The 26S proteasome is required for estrogen receptor-alpha and coactivator turnover and for efficient estrogen receptor-alpha transactivation.

B. O’Malley, Z. Nawaz, D. Lonard, 2000, Molecular cell.

Inhibition of the 26S proteasome blocks progesterone receptor-dependent transcription through failed recruitment of RNA polymerase II

B. O’Malley, Z. Nawaz, D. Lonard, 2005, The Journal of Steroid Biochemistry and Molecular Biology.

Selective Estrogen Receptor Modulators 4-Hydroxytamoxifen and Raloxifene Impact the Stability and Function of SRC-1 and SRC-3 Coactivator Proteins

B. O’Malley, S. Tsai, D. Lonard, 2004, Molecular and Cellular Biology.

Targeting NSD2-mediated SRC-3 liquid–liquid phase separation sensitizes bortezomib treatment in multiple myeloma

B. O’Malley, Sheng Wang, Ying Xie, 2021, Nature Communications.

A bioluminescence reporter mouse that monitors expression of constitutively active β-catenin

J. Lydon, Maria M. Szwarc, D. Lonard, 2017, PloS one.

Proteomic analysis of coregulators bound to ERα on DNA and nucleosomes reveals coregulator dynamics.

Ross A. Hamilton, D. Edwards, D. Chan, 2013, Molecular cell.

Modulation of steroid hormone receptor activity.

B. O’Malley, D. Lonard, Vladimir Stanišić, 2010, Progress in brain research.

Specific ubiquitin-conjugating enzymes promote degradation of specific nuclear receptor coactivators.

Z. Nawaz, D. Lonard, Xiuhua Gao, 2003, Molecular endocrinology.

Multi-modulation of nuclear receptor coactivators through posttranslational modifications

B. O’Malley, S. Han, D. Lonard, 2009, Trends in Endocrinology & Metabolism.

Steroid receptor coactivator 1 is an integrator of glucose and NAD+/NADH homeostasis.

Sean M. Hartig, K. Rajapakshe, C. Coarfa, 2014, Molecular endocrinology.

Steroid Receptor Coactivator-3 (SRC-3/AIB1) as a Novel Therapeutic Target in Triple Negative Breast Cancer and Its Inhibition with a Phospho-Bufalin Prodrug

B. O’Malley, Jianming Xu, Xinglu Liu, 2015, PloS one.

Tamoxifen Inhibits ER-negative Breast Cancer Cell Invasion and Metastasis by Accelerating Twist1 Degradation

Jianming Xu, D. Lonard, Yixiang Xu, 2015, International journal of biological sciences.

USP15-dependent lysosomal pathway controls p53-R175H turnover in ovarian cancer cells

K. Wong, B. O’Malley, J. Richards, 2018, Nature Communications.

Steroid receptor coactivator 3 is a key modulator of regulatory T cell–mediated tumor evasion

R. Lanz, C. Dacso, Yan Xia, 2023, Proceedings of the National Academy of Sciences of the United States of America.

Steroid receptor coactivator 3 is a key modulator of regulatory T cell–mediated tumor evasion

R. Lanz, C. Dacso, Yan Xia, 2023, bioRxiv.

Inhibition of SRC-3 as a potential therapeutic strategy for aggressive mantle cell lymphoma

L. Alinari, Jing Chen, D. Lonard, 2023, Research square.

Comparative analysis of REG{gamma} expression in mouse and human tissues.

Guowu Yu, Xiaotao Li, Guang-lan Wang, 2010, Journal of molecular cell biology.

Comparative Analysis of REGg Expression in Mouse and Human Tissues

Guowu Yu, Xiaotao Li, Guang-lan Wang, 2010 .

Abstract LB134: Targeting coactivators to inhibit ESR1 fusion-driven breast cancer growth

Matthew V. Holt, C. Foulds, Q. Feng, 2023, Cancer Research.

Reply to: Target expression is a relevant factor in synthetic lethal screens

D. Lonard, Bert W. O’Malley, Yang Yu, 2022, Communications Biology.

Bufalin is a steroid receptor coactivator inhibitor-response.

B. O’Malley, Jianming Xu, D. Lonard, 2015, Cancer Research.

SRC-3 coactivator regulates cell resistance to cytotoxic stress via TRAF4-mediated p53 destabilization.

M. Hung, W. Xia, B. O’Malley, 2013, Genes & development.

Bufalin is a potent small-molecule inhibitor of the steroid receptor coactivators SRC-3 and SRC-1.

P. Griffin, B. O’Malley, T. Palzkill, 2014, Cancer research.

Title: Bufalin is a potent small molecule inhibitor of the steroid receptor coactivators SRC-3 and SRC-1

T. Palzkill, L. Liao, P. Hodder, 2013 .

Steroid receptor coactivators in Treg and Th17 cell biology and function

D. Lonard, Y. Gilad, Ortal Shimon, 2024, Frontiers in immunology.

Inhibition of SRC-3 as a potential therapeutic strategy for aggressive mantle cell lymphoma

L. Alinari, D. Lonard, Jin Wang, 2024, PloS one.

Steroid receptor coactivator‐2 drives epithelial reprogramming that enables murine embryo implantation

J. Lydon, Maria M. Szwarc, D. Lonard, 2023, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Lead Compound Development of SRC-3 Inhibitors with Improved Pharmacokinetic Properties and Anticancer Efficacy.

Jing Chen, D. Lonard, Jin Wang, 2024, Journal of medicinal chemistry.

Transcriptional coactivation of NRF2 signaling in cardiac fibroblasts promotes resistance to oxidative stress.

Michael J. Bolt, F. Stossi, D. Lonard, 2024, Journal of molecular and cellular cardiology.