A. Cooper

发表

Discovery of a novel ERK inhibitor with activity in models of acquired resistance to BRAF and MEK inhibitors.

Shuxia Zhao, Leigh Zawel, Stephen Fawell, 2013, Cancer discovery.

Discovery of novel, dual mechanism ERK inhibitors by affinity selection screening of an inactive kinase.

J. English, P. Kirschmeier, W. Windsor, 2014, Journal of medicinal chemistry.

Total synthesis of the antifungal cyclic depsipeptides Sch 57697 and aureobasidin A

A. Cooper, J. Desai, V. Girijavallabhan, 1996 .

Aminothiazole inhibitors of HCV RNA polymerase.

Patrick J. Curran, Tong Wang, A. Cooper, 2005, Bioorganic & medicinal chemistry letters.

1-Thiazol-2-yl-N-3-methyl-1H-pyrozole-5-carboxylic acid derivatives as antitumor agents.

V. Oza, A. Siddiqui, M. Patane, 2017, Bioorganic & medicinal chemistry letters.

Discovery of hydroxyaniline amides as selective Extracellular Regulated Kinase (Erk) inhibitors.

W. Windsor, A. Samatar, D. Carr, 2015, Bioorganic & medicinal chemistry letters.

Discovery of 3-morpholino-imidazole[1,5-a]pyrazine BTK inhibitors for rheumatoid arthritis.

T. Fischmann, K. Maloney, C. Garlisi, 2017, Bioorganic & medicinal chemistry letters.

A convenient degradation of polyoxin D to uracil polyoxin C: access to key intermediates and synthesis of antifungal α-aminoacyl derivatives of UPOC

D. Loebenberg, A. Cacciapuoti, A. Cooper, 1993 .

Chapter 12. Recent Advances in Antifungal Agents

D. Loebenberg, A. Cooper, V. Girijavallabhan, 1989 .

Pyrazolo[1,5-a]pyrimidine-based inhibitors of HCV polymerase.

Patrick J. Curran, J. Duca, Tong Wang, 2009, Bioorganic & medicinal chemistry letters.

Discovery of 4H-pyrazolo[1,5-a]pyrimidin-7-ones as potent inhibitors of hepatitis C virus polymerase.

J. Duca, Tong Wang, A. Cooper, 2009, Bioorganic & medicinal chemistry letters.

Discovery of novel BTK inhibitors with carboxylic acids.

T. Fischmann, K. Maloney, C. Garlisi, 2017, Bioorganic & medicinal chemistry letters.

Discovery of 8-Amino-imidazo[1,5-a]pyrazines as Reversible BTK Inhibitors for the Treatment of Rheumatoid Arthritis.

V. Hornak, T. Fischmann, K. Maloney, 2016, ACS medicinal chemistry letters.

A Facile Synthesis of o-Nitrophenylsulfenimines and Applications to Amino Acid Synthesis

A. Cooper, R. Lovey, 1994 .

Interaction of vicinal and nonvicinal amino-hydroxy group pairs in aminoglycoside-aminocyclitol antibiotics with transition metal cations. Selective N protection

W. N. Turner, P. Reichert, A. Cooper, 1978 .

Advances in the chemistry of novel broad-spectrum orally active azole antifungals: recent studies leading to the discovery of SCH 56592.

W. Haiyan, A. Cooper, J. Desai, 1997 .

Synthesis and Antifungal Properties of 14‐Aminomethyl‐Substituted Lanosterol Derivatives

D. Loebenberg, D. Feingold, A. Cooper, 1988, Annals of the New York Academy of Sciences.

Synthesis and Antifungal Properties of 14-Aminomethyl-Substituted Lanosterol Derivatives.

D. Loebenberg, D. Feingold, A. Cooper, 1989 .

The syntheses and biological properties of 1-N-(S-4-amino-2-hydroxybutyryl)-gentamicin B and 1-N-(S-3-amino-2-hydroxypropionyl)-gentamicin B.

A. Cooper, T. L. Nagabhushan, G. Miller, 1978, The Journal of antibiotics.

Selective N-actylation of gentamicin antibiotics-synthesis of 1-N-acyl derivatives.

W. N. Turner, J. Weinstein, A. Cooper, 1976, The Journal of antibiotics.

Chemical modification of some gentamicins and sisomicin at the 3''-position.

W. N. Turner, A. Cooper, J. J. Wright, 1978, The Journal of antibiotics.

New class of azaheptapyridine FPT inhibitors as potential cancer therapy agents.

P. Kirschmeier, Ming Liu, A. Nomeir, 2014, Bioorganic & Medicinal Chemistry Letters.

Discovery of C-imidazole azaheptapyridine FPT inhibitors.

W. R. Bishop, P. Kirschmeier, R. Doll, 2010, Bioorganic & medicinal chemistry letters.

Interaction of vicinal and nonvicinal amino-hydroxy group pairs in aminoglycoside-aminocyclitol antibiotics with transition metal cations. Selective N protection

W. N. Turner, P. Reichert, A. Cooper, 1978 .

Antibiotic Biosynthesis by Cofermentation of Blocked Mutants of Two Micromonospora Species

J. Waitz, A. Cooper, T. L. Nagabhushan, 1978, Antimicrobial Agents and Chemotherapy.

Some recent advances in the chemistry of antibiotics of the gentamicin series.

A. Cooper, J. J. Wright, T. L. Nagabhushan, 1979, The Japanese journal of antibiotics.

(+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H-benzo[5, 6]cyclohepta[1,2-b]- pyridin-11(R)-yl)-1-piperidinyl]-2-oxo-ethyl]-1-piperidinecarboxamid e (SCH-66336): a very potent farnesyl protein transferase inhibitor as a novel antitumor agent.

W. R. Bishop, P. Kirschmeier, L. Wang, 1998, Journal of medicinal chemistry.

Guiding farnesyltransferase inhibitors from an ECLiPS library to the catalytic zinc.

R. Doll, J. Reader, J. Baldwin, 2006, Bioorganic & medicinal chemistry letters.

Synthesis of 5,6-dihydro-11H-benzo[5,6]-cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidine-N-cyanoguanidine derivatives as inhibitors of ras farnesyl protein transferase.

W. R. Bishop, P. Weber, P. Kirschmeier, 2002, Bioorganic & medicinal chemistry letters.

Synthesis of (5,6‐Dihydro‐11H‐benzo[5,6]cyclohepta [1,2‐b]pyridin‐11‐ylidene)‐1‐piperidine‐N‐cyanoguanidine Derivatives (I) as Inhibitors of Ras Farnesyl Protein Transferase.

W. R. Bishop, P. Weber, P. Kirschmeier, 2002 .

Dissecting Therapeutic Resistance to ERK Inhibition

L. Zawel, S. Fawell, L. Jayaraman, 2016, Molecular Cancer Therapeutics.

Development of MK-8353, an orally administered ERK1/2 inhibitor, in patients with advanced solid tumors.

W. R. Bishop, R. Sullivan, K. Flaherty, 2018, JCI insight.

MK-8353: Discovery of an Orally Bioavailable Dual Mechanism ERK Inhibitor for Oncology.

K. Cox, P. Kirschmeier, R. Doll, 2018, ACS medicinal chemistry letters.

Discovery of 3(S)-thiomethyl pyrrolidine ERK inhibitors for oncology.

P. Kirschmeier, R. Doll, W. Windsor, 2018, Bioorganic & medicinal chemistry letters.

[3+2] Cycloaddition-mediated synthesis of 3-methylsulfanyl-pyrrolidine-3-carboxylic acid methyl ester

R. Doll, A. Cooper, N. Shih, 2009 .

X-Ray crystal structure determination and synthesis of the new isonitrile-containing antibiotics, hazimycin factors 5 and 6

A. McPhail, A. Cooper, M. Puar, 1983 .

Synthesis of 14-α-aminomethyl substituted lanosterol derivatives; inhibitors of fungal ergosterol biosynthesis

D. Loebenberg, D. Feingold, A. Cooper, 1989 .

Synthesis of (+)-8-methyl cercosporamide: Stereochemical correlation of natural (−)-cercosporamide with (+)-usnic acid

A. McPhail, A. Cooper, V. Girijavallabhan, 1992 .